{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:50:24Z","timestamp":1792018224579,"version":"4.4.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T00:00:00Z","timestamp":1423180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0003514","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T21:13:15Z","timestamp":1423257195000},"page":"e0003514","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["IL-33\/ST2 Correlates with Severity of Haemorrhagic Fever with Renal Syndrome and Regulates the Inflammatory Response in Hantaan Virus-Infected Endothelial Cells"],"prefix":"10.1371","volume":"9","author":[{"given":"Yusi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boquan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,2,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/0042-6822(83)90514-7","article-title":"Analysis of Hantaan virus RNA: evidence for a new genus of bunyaviridae","volume":"131","author":"CS Schmaljohn","year":"1983","journal-title":"Virology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrmicro3066","article-title":"Uncovering the mysteries of hantavirus infections","volume":"11","author":"A Vaheri","year":"2013","journal-title":"Nat Rev Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.virusres.2013.03.020","article-title":"Serum TNF-alpha, sTNFR1, IL-6, IL-8 and IL-10 levels in hemorrhagic fever with renal syndrome","volume":"175","author":"I Kyriakidis","year":"2013","journal-title":"Virus Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1471-2334-11-142","article-title":"Serum levels of inflammatory and regulatory cytokines in patients with hemorrhagic fever with renal syndrome","volume":"11","author":"A Saksida","year":"2011","journal-title":"BMC Infect Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.bjid.2012.10.002","article-title":"Determination of urine tumor necrosis factor, IL-6, IL-8, and serum IL-6 in patients with hemorrhagic fever with renal syndrome","volume":"16","author":"W Fan","year":"2012","journal-title":"Braz J Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1177\/147323001204000227","article-title":"Elevated serum concentrations of inflammatory cytokines and chemokines in patients with haemorrhagic fever with renal syndrome","volume":"40","author":"PZ Wang","year":"2012","journal-title":"J Int Med Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"697837","DOI":"10.1155\/2014\/697837","article-title":"Hantaan virus infection induces CXCL10 expression through TLR3, RIG-I, and MDA-5 pathways correlated with the disease severity","volume":"2014","author":"Y Zhang","year":"2014","journal-title":"Mediators Inflamm"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1160\/TH09-09-0640","article-title":"Hantavirus regulation of endothelial cell functions","volume":"102","author":"ER Mackow","year":"2009","journal-title":"Thromb Haemost"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","article-title":"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines","volume":"23","author":"J Schmitz","year":"2005","journal-title":"Immunity"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.immuni.2009.06.011","article-title":"IL-33 raises alarm","volume":"31","author":"M Lamkanfi","year":"2009","journal-title":"Immunity"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1161\/ATVBAHA.112.253427","article-title":"Interleukin-33 drives a proinflammatory endothelial activation that selectively targets nonquiescent cells","volume":"33","author":"J Pollheimer","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e60963","DOI":"10.1371\/journal.pone.0060963","article-title":"A novel interleukin 33\/ST2 signaling regulates inflammatory response in human corneal epithelium","volume":"8","author":"J Lin","year":"2013","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/bbrc.1999.1469","article-title":"Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7\/GM","volume":"264","author":"S Tominaga","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1006\/geno.2000.6269","article-title":"The cloning and nucleotide sequence of human ST2L cDNA","volume":"67","author":"H Li","year":"2000","journal-title":"Genomics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.4049\/jimmunol.0802387","article-title":"Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells","volume":"183","author":"D Prefontaine","year":"2009","journal-title":"J Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.4049\/jimmunol.1000730","article-title":"IL-33 exacerbates eosinophil-mediated airway inflammation","volume":"185","author":"B Stolarski","year":"2010","journal-title":"J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"5743","DOI":"10.4049\/jimmunol.0903818","article-title":"IL-33 mediates inflammatory responses in human lung tissue cells","volume":"185","author":"A Yagami","year":"2010","journal-title":"J Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.3346\/jkms.2011.26.9.1132","article-title":"Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis","volume":"26","author":"YS Hong","year":"2011","journal-title":"J Korean Med Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1089\/jir.2011.0109","article-title":"Serum IL-33 levels are associated with liver damage in patients with chronic hepatitis B","volume":"32","author":"J Wang","year":"2012","journal-title":"J Interferon Cytokine Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"819636","DOI":"10.1155\/2012\/819636","article-title":"Serum IL-33 levels are associated with liver damage in patients with chronic hepatitis C","volume":"2012","author":"J Wang","year":"2012","journal-title":"Mediators Inflamm"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1093\/infdis\/jis682","article-title":"Interleukin 33 mediates type 2 immunity and inflammation in the central nervous system of mice infected with Angiostrongylus cantonensis","volume":"207","author":"H Peng","year":"2013","journal-title":"J Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4049\/jimmunol.1202806","article-title":"The IL-33\/ST2 pathway controls coxsackievirus B5-induced experimental pancreatitis","volume":"191","author":"R Sesti-Costa","year":"2013","journal-title":"J Immunol"},{"key":"ref23","first-page":"141","article-title":"Significance of interleukin-33 and its related cytokines in patients with breast cancers","volume":"5","author":"J Liu","year":"2014","journal-title":"Front Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jad.2013.12.042","article-title":"A preliminary report of increased plasma levels of IL-33 in bipolar disorder: further evidence of pro-inflammatory status","volume":"157","author":"IG Barbosa","year":"2014","journal-title":"J Affect Disord"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1086\/595834","article-title":"Cellular immune response to Hantaan virus nucleocapsid protein in the acute phase of hemorrhagic fever with renal syndrome: correlation with disease severity","volume":"199","author":"M Wang","year":"2009","journal-title":"J Infect Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1093\/infdis\/jis475","article-title":"Hantaan virus RNA load in patients having hemorrhagic fever with renal syndrome: correlation with disease severity","volume":"207","author":"J Yi","year":"2013","journal-title":"J Infect Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e73958","DOI":"10.1371\/journal.pone.0073958","article-title":"Elevated Plasma Soluble Sema4D\/CD100 Levels Are Associated with Disease Severity in Patients of Hemorrhagic Fever with Renal Syndrome","volume":"8","author":"B Liu","year":"2013","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1128\/CMR.00062-09","article-title":"A global perspective on hantavirus ecology, epidemiology, and disease","volume":"23","author":"CB Jonsson","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cardiores.2004.09.017","article-title":"Lysophosphatidylcholine posttranscriptionally inhibits interferon-gamma-induced IP-10, Mig and I-Tac expression in endothelial cells","volume":"65","author":"AM Sheikh","year":"2005","journal-title":"Cardiovasc Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nri2692","article-title":"Disease-associated functions of IL-33: the new kid in the IL-1 family","volume":"10","author":"FY Liew","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1126\/science.1215418","article-title":"The alarmin interleukin-33 drives protective antiviral CD8(+) T cell responses","volume":"335","author":"WV Bonilla","year":"2012","journal-title":"Science"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1476-9255-8-22","article-title":"Role of IL-33 in inflammation and disease","volume":"8","author":"AM Miller","year":"2011","journal-title":"J Inflamm (Lond)"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.3390\/v3071059","article-title":"T cells and pathogenesis of hantavirus cardiopulmonary syndrome and hemorrhagic fever with renal syndrome","volume":"3","author":"M Terajima","year":"2011","journal-title":"Viruses"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.clim.2006.02.010","article-title":"Dynamic changes of apoptosis-inducing ligands and Th1\/Th2 like subpopulations in Hantaan virus-induced hemorrhagic fever with renal syndrome","volume":"119","author":"JM Liu","year":"2006","journal-title":"Clin Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1182\/blood-2009-02-203372","article-title":"Interleukin-33 induces angiogenesis and vascular permeability through ST2\/TRAF6-mediated endothelial nitric oxide production","volume":"114","author":"YS Choi","year":"2009","journal-title":"Blood"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"26369","DOI":"10.1074\/jbc.M704916200","article-title":"Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation","volume":"282","author":"H Hayakawa","year":"2007","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0014-5793(93)81333-U","article-title":"Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1","volume":"318","author":"K Yanagisawa","year":"1993","journal-title":"FEBS Lett"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1600-065X.2008.00694.x","article-title":"Hantavirus-induced immunity in rodent reservoirs and humans","volume":"225","author":"G Schonrich","year":"2008","journal-title":"Immunol Rev"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e93810","DOI":"10.1371\/journal.pone.0093810","article-title":"Involvement of the Akt\/NF-kappaB Pathways in the HTNV-Mediated Increase of IL-6, CCL5, ICAM-1, and VCAM-1 in HUVECs","volume":"9","author":"H Yu","year":"2014","journal-title":"PLoS One"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0003514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T18:13:42Z","timestamp":1566324822000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0003514"}},"subtitle":[],"editor":[{"given":"Kristy O.","family":"Murray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,2,6]]},"references-count":39,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0003514","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,6]]}}}