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World Health Organization."},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e88065","DOI":"10.1371\/journal.pone.0088065","article-title":"Spatio-temporal clustering of hand, foot, and mouth disease at the county level in Guangxi, China","volume":"9","author":"YH Xie","year":"2014","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"20745","DOI":"10.2807\/1560-7917.ES2014.19.12.20745","article-title":"Atypical hand, foot, and mouth disease associated with coxsackievirus A6 infection, Edinburgh, United Kingdom, January to February 2014","volume":"19","author":"C Sinclair","year":"2014","journal-title":"Euro surveillance: bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"48","DOI":"10.7883\/yoken.JJID.2003.48","article-title":"Seasonal models of herpangina and hand-foot-mouth disease to simulate annual fluctuations in urban warming in 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