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WHO\/HTM\/NTD\/2012.1. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/whqlibdoc.who.int\/hq\/2012\/WHO_HTM_NTD_2012.1_eng.pdf\" xlink:type=\"simple\">http:\/\/whqlibdoc.who.int\/hq\/2012\/WHO_HTM_NTD_2012.1_eng.pdf<\/ext-link> Accessed on 25 January 2015."},{"key":"ref3","unstructured":"UNITING TO COMBAT NTDs (2012) London Declaration on neglected tropical diseases. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/unitingtocombatntds.org\/sites\/default\/files\/resource_file\/london_declaration_on_ntds.pdf\" xlink:type=\"simple\">http:\/\/unitingtocombatntds.org\/sites\/default\/files\/resource_file\/london_declaration_on_ntds.pdf<\/ext-link> Accessed on 23 May 2014."},{"key":"ref4","year":"2013"},{"key":"ref5","unstructured":"UNITING TO COMBAT NTDs (2014) Delivering on promises and driving progress. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/unitingtocombatntds.org\/resource\/delivering-promises-and-driving-progress-second-progress-report\" xlink:type=\"simple\">http:\/\/unitingtocombatntds.org\/resource\/delivering-promises-and-driving-progress-second-progress-report<\/ext-link> Accessed on 25 January 2015."},{"key":"ref6","unstructured":"WHO (2013) APOC\u2014status of onchocerciasis in APOC countries. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/apoc\/onchocerciasis\/status\/en\/index.html\" xlink:type=\"simple\">http:\/\/www.who.int\/apoc\/onchocerciasis\/status\/en\/index.html<\/ext-link> Accessed on 25 January 2015."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.pt.2012.04.005","article-title":"The onchocerciasis chronicle: from the beginning to the end?","volume":"28","author":"A Crump","year":"2012","journal-title":"Trends Parasitol"},{"key":"ref8","unstructured":"WHO\/APOC (2010) Report of the external mid-term evaluation of the African Programme for Onchocerciasis Control. JAF16.8. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/apoc\/MidtermEvaluation_29Oct2010_final_printed.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/apoc\/MidtermEvaluation_29Oct2010_final_printed.pdf<\/ext-link> Accessed on 25 January 2015."},{"key":"ref9","unstructured":"WHO (2014) Neglected Tropical Diseases\u2014WHO declares Ecuador free of onchocerciasis (river blindness). <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/neglected_diseases\/ecuador_free_from_onchocerciasis\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/neglected_diseases\/ecuador_free_from_onchocerciasis\/en\/<\/ext-link> Accessed on 14 October 2014."},{"key":"ref10","first-page":"381","article-title":"Progress towards eliminating onchocerciasis in the WHO Region of the Americas: verification by WHO of elimination of transmission in Colombia","volume":"88","year":"2013","journal-title":"Wkly Epidemiol Rec"},{"key":"ref11","unstructured":"The Carter Center (2014) Current transmission status in the 13 foci of the Americas\u2014geographic distribution of onchocerciasis in the Americas. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cartercenter.org\/resources\/pdfs\/health\/river_blindness\/OEPA-foci.pdf\" xlink:type=\"simple\">http:\/\/www.cartercenter.org\/resources\/pdfs\/health\/river_blindness\/OEPA-foci.pdf<\/ext-link> Accessed on 14 October 2014."},{"key":"ref12","unstructured":"PAHO\/WHO (2013) 52nd Directing Council (65th session of the regional committee, 30 September-4 October 2013, Washington DC, USA)\u2014towards the elimination of onchocerciasis (river blindness) in the Americas. CD52\/INF\/4. Pan American Health Organization\/World Health Organization. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.paho.org\/hq\/index.php?option=com_docman&task=doc_view&gid=24390&Itemid=\" xlink:type=\"simple\">http:\/\/www.paho.org\/hq\/index.php?option=com_docman&amp;task=doc_view&amp;gid=24390&amp;Itemid=<\/ext-link> Accessed on 25 January 2015."},{"key":"ref13","unstructured":"WHO (2011) 64th World Health Assembly (16\u201324 May 2011, Geneva, Switzerland)\u2014progress report: onchocerciasis control through ivermectin distribution. A64\/26. WHO. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/apps.who.int\/gb\/ebwha\/pdf_files\/WHA64\/A64_26-en.pdf\" xlink:type=\"simple\">http:\/\/apps.who.int\/gb\/ebwha\/pdf_files\/WHA64\/A64_26-en.pdf<\/ext-link> Accessed on 25 January 2015."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e497","DOI":"10.1371\/journal.pntd.0000497","article-title":"Feasibility of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: first evidence from studies in Mali and Senegal","volume":"3","author":"L Diawara","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e1825","DOI":"10.1371\/journal.pntd.0001825","article-title":"Proof-of-principle of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: final results of a study in Mali and Senegal","volume":"6","author":"MO Traor\u00e9","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref16","unstructured":"Ernst Str\u00fcngmann Forum (2010) Disease eradication in the context of global health in the 21st century (August 29-September 3, 2010, Frankfurt am Main, Germany). <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.esforum.de\/forums\/esf07_disease_eradication.html\" xlink:type=\"simple\">http:\/\/www.esforum.de\/forums\/esf07_disease_eradication.html<\/ext-link> Accessed on 20 May 2014."},{"key":"ref17","unstructured":"Damian Walker, Julia Lupp (2013) Guide to preparing an eradication investment case. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/eic-guidelines.org\/Guide%20to%20Preparing%20an%20EIC_Draft%208.pdf\" xlink:type=\"simple\">http:\/\/eic-guidelines.org\/Guide%20to%20Preparing%20an%20EIC_Draft%208.pdf<\/ext-link> Accessed on 25 January 2015."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e2446","DOI":"10.1371\/journal.pntd.0002446","article-title":"Developing eradication investment cases for onchocerciasis, lymphatic filariasis, and human African trypanosomiasis: rationale and main challenges","volume":"7","author":"F Tediosi","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref19","unstructured":"WHO (2012) Report of the WHO Strategic and Technical Advisory Group for Neglected Tropical Diseases (24\u201325 April 2012, Geneva, Switzerland). WHO. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/entity\/neglected_diseases\/NTD_STAG_Report_2012.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/entity\/neglected_diseases\/NTD_STAG_Report_2012.pdf<\/ext-link> Accessed on 25 January 2015."},{"key":"ref20","unstructured":"The Carter Center (2013) Fighting disease: Ethiopia\u2014eliminating river blindness. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cartercenter.org\/countries\/ethiopia-health-river-blindness.html\" xlink:type=\"simple\">http:\/\/www.cartercenter.org\/countries\/ethiopia-health-river-blindness.html<\/ext-link> Accessed on 20 April 2014."},{"key":"ref21","unstructured":"Uganda Ministry of Health (2010) Health Sector Strategic Plan III, 2010\/11-2014\/15. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.health.go.ug\/docs\/HSSP_III_2010.pdf\" xlink:type=\"simple\">http:\/\/www.health.go.ug\/docs\/HSSP_III_2010.pdf<\/ext-link> Accessed on 25 January 2015."},{"key":"ref22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0169-2607(90)90030-D","article-title":"ONCHOSIM: a model and computer simulation program for the transmission and control of onchocerciasis","volume":"31","author":"AP Plaisier","year":"1990","journal-title":"Comput Methods Programs Biomed"},{"key":"ref23","unstructured":"WHO (2008) APOC\u2014community-directed treatment with ivermectin (CDTI) projects. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/apoc\/cdti\/projects\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/apoc\/cdti\/projects\/en\/<\/ext-link> Accessed on 23 May 2014."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1186\/1756-3305-7-325","article-title":"The geographic distribution of onchocerciasis in the 20 participating countries of the African Programme for Onchocerciasis Control: (1) priority areas for ivermectin treatment","volume":"7","author":"M Noma","year":"2014","journal-title":"Parasit Vectors"},{"key":"ref25","unstructured":"UN (2013) Population growth rates. World Population Prospects: the 2012 revision. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/esa.un.org\/wpp\/Excel-Data\/population.htm\" xlink:type=\"simple\">http:\/\/esa.un.org\/wpp\/Excel-Data\/population.htm<\/ext-link> Accessed on 23 May 2014."},{"key":"ref26","unstructured":"WHO\/APOC (2011) Report of the CSA advisory group on onchocerciasis elimination\u2014Annex 1. Predicting the end date of ivermectin treatment in APOC projects. JAF17.7(ii). WHO\/APOC."},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e2168","DOI":"10.1371\/journal.pntd.0002168","article-title":"Onchocerciasis: the pre-control association between prevalence of palpable nodules and skin microfilariae","volume":"7","author":"LE Coffeng","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref28","unstructured":"WHO (2014) APOC\u2014community-directed distributor (CDDs). <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/apoc\/cdti\/cdds\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/apoc\/cdti\/cdds\/en\/<\/ext-link> Accessed on 20 October 2014."},{"key":"ref29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijantimicag.2007.08.023","article-title":"Ivermectin: 25 years and still going strong","volume":"31","author":"S Omura","year":"2008","journal-title":"Int J Antimicrob Agents"},{"key":"ref30","unstructured":"William R.Brieger (2000) Implementation and sustainability of Community-Directed Treatment of Onchocerciasis with ivermectin: a multicountry report. TDR\/AFT\/RP\/96.1. Geneva:UNICEF\/UNDP\/World Bank\/WHO Special Programme for Research and Training in Tropical Diseases."},{"key":"ref31","unstructured":"WHO (2014) APOC\u2014how community-directed treatment with ivermectin (CDTI) began. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/apoc\/cdti\/history\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/apoc\/cdti\/history\/en\/<\/ext-link> Accessed on 20 October 2014."},{"key":"ref32","article-title":"Disease eradication in the 21st century: implications for global health","author":"P Strebel","year":"2011"},{"key":"ref33","unstructured":"WHO\/APOC (2007) Revitalising health care delivery in sub-Saharan Africa: the potential of community-directed interventions to strengthen health systems. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/apoc\/publications\/EN_HealthCare07_7_3_08.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/apoc\/publications\/EN_HealthCare07_7_3_08.pdf<\/ext-link> Accessed on 25 January 2015."},{"key":"ref34","unstructured":"WHO\/APOC (2014) 19th session of Joint Action Forum (11\u201313 December 2013, Brazzaville, Congo)\u2014Final communique. WHO\/APOC. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/entity\/apoc\/about\/structure\/jaf\/Final_Communique_JAF19_Final_English_140114.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/entity\/apoc\/about\/structure\/jaf\/Final_Communique_JAF19_Final_English_140114.pdf<\/ext-link> Accessed 20 April 2014."},{"key":"ref35","unstructured":"WHO\/APOC (2012) 18th session of the Joint Action Forum (Bujumbura, Burundi, 11\u201313 December 2012)\u2014Final communique. WHO\/APOC. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/entity\/apoc\/about\/structure\/jaf\/Final_Communique_JAF_18_English_final_with_annexes.pdf?ua=1\" xlink:type=\"simple\">http:\/\/www.who.int\/entity\/apoc\/about\/structure\/jaf\/Final_Communique_JAF_18_English_final_with_annexes.pdf?ua=1<\/ext-link> Accessed on 25 January 2015."},{"key":"ref36","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0035-9203(94)90172-4","article-title":"The impact of five years of annual ivermectin treatment on skin microfilarial loads in the onchocerciasis focus of Asubende, Ghana","volume":"88","author":"ES Alley","year":"1994","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/infdis\/172.1.204","article-title":"Irreversible effects of ivermectin on adult parasites in onchocerciasis patients in the Onchocerciasis Control Programme in West Africa","volume":"172","author":"AP Plaisier","year":"1995","journal-title":"J Infect Dis"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e115886","DOI":"10.1371\/journal.pone.0115886","article-title":"Elimination of african onchocerciasis: modeling the impact of increasing the frequency of ivermectin mass treatment","volume":"9","author":"LE Coffeng","year":"2014","journal-title":"PLoS One"},{"key":"ref39","unstructured":"WHO\/APOC (2010) Conceptual and operational framework of onchocerciasis elimination with ivermectin treatment. WHO\/APOC\/MG\/10.1. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/apoc\/oncho_elimination_report_english.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/apoc\/oncho_elimination_report_english.pdf<\/ext-link> Accessed on 25 January 2015."},{"key":"ref40","unstructured":"OEPA (2011) Guide for the detection of a potential recrudescence during the period of Post Treatment Surveillance (PTS). <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.oepa.net\/Documentos\/GuiaVEPT\/Guide_Detection_Potential_Recrudescence_During_PTS_Englishversion.pdf\" xlink:type=\"simple\">http:\/\/www.oepa.net\/Documentos\/GuiaVEPT\/Guide_Detection_Potential_Recrudescence_During_PTS_Englishversion.pdf<\/ext-link> Accessed on 25 January 2015."},{"key":"ref41","unstructured":"Merck (2011) 2011 Corporate Responsibility Report. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.merckresponsibility.com\/downloads\/MRK_Report_Builder_Full_120824.pdf\" xlink:type=\"simple\">http:\/\/www.merckresponsibility.com\/downloads\/MRK_Report_Builder_Full_120824.pdf<\/ext-link> Accessed on 25 January 2015."},{"key":"ref42","unstructured":"WHO\/APOC (2013) The World Health Organization Year 2013 Progress Report. JAF19.5. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/entity\/apoc\/publications\/JAF195_EN_APOC_PR2013_OK.pdf?ua=1\" xlink:type=\"simple\">http:\/\/www.who.int\/entity\/apoc\/publications\/JAF195_EN_APOC_PR2013_OK.pdf?ua=1<\/ext-link> Accessed on 25 January 2015."},{"key":"ref43","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1756-3305-5-53","article-title":"Long term impact of large scale community-directed delivery of doxycycline for the treatment of onchocerciasis","volume":"5","author":"F Tamarozzi","year":"2012","journal-title":"Parasit Vectors"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4269\/ajtmh.2004.71.211","article-title":"Human loiasis in a Cameroonian village: a double-blind, placebo-controlled, crossover clinical trial of a three-day albendazole regimen","volume":"71","author":"TE Tabi","year":"2004","journal-title":"Am J Trop Med Hyg"},{"key":"ref45","unstructured":"WHO (2014) Neglected Tropical Diseases\u2014PCT databank: lymphatic filariasis. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/neglected_diseases\/preventive_chemotherapy\/lf\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/neglected_diseases\/preventive_chemotherapy\/lf\/en\/<\/ext-link> Accessed on 29 September 2014."},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.1371\/journal.pntd.0000072","article-title":"Genetic selection of low fertile Onchocerca volvulus by ivermectin treatment","volume":"1","author":"C Bourguinat","year":"2007","journal-title":"PLoS Negl Trop Dis"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Walker M, Specht S, Churcher TS, Hoerauf A, Taylor MJ, Basanez MG (2014) Therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness. Clin Infect Dis. ciu1152 [pii]. Epub ahead of print.","DOI":"10.1093\/cid\/ciu1152"},{"key":"ref48","unstructured":"DNDi (2014) Bayer and DNDi sign first agreement to develop an innovative oral treatment for human river blindness. 9 December 2014. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.dndi.org\/media-centre\/press-releases\/2040-pr-bayer-filaria.html\" xlink:type=\"simple\">http:\/\/www.dndi.org\/media-centre\/press-releases\/2040-pr-bayer-filaria.html<\/ext-link> Accessed on 17 January 2014."},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e2953","DOI":"10.1371\/journal.pntd.0002953","article-title":"A randomized, single-ascending-dose, ivermectin-controlled, double-blind study of moxidectin in Onchocerca volvulus infection","volume":"8","author":"K Awadzi","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1586\/eri.11.30","article-title":"Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs","volume":"9","author":"CD Mackenzie","year":"2011","journal-title":"Expert Rev Anti Infect Ther"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1086\/509325","article-title":"Recent updates on onchocerciasis: diagnosis and treatment","volume":"44","author":"DN Udall","year":"2007","journal-title":"Clin Infect Dis"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1086\/505081","article-title":"Field applicability of a rapid-format anti-Ov-16 antibody test for the assessment of onchocerciasis control measures in regions of endemicity","volume":"194","author":"EM Lipner","year":"2006","journal-title":"J Infect Dis"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"20120137","DOI":"10.1098\/rstb.2012.0137","article-title":"Towards the endgame and beyond: complexities and challenges for the elimination of infectious diseases","volume":"368","author":"P Klepac","year":"2013","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref54","unstructured":"WHO\/APOC (2006) 12th session of the Joint Action Forum (5\u20138 December 2006, Dar-es-Salaam, Tanzania). JAF12.9. WHO\/APOC. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/siteresources.worldbank.org\/EXTGLOREGPARPROG\/Resources\/apoc_so.pdf\" xlink:type=\"simple\">http:\/\/siteresources.worldbank.org\/EXTGLOREGPARPROG\/Resources\/apoc_so.pdf<\/ext-link> Accessed on 23 May 2014."},{"key":"ref55","unstructured":"WHO\/APOC (2012) Strategic Plan of Action and Budget 2016\u20132025 for elimination of onchocerciasis in Africa. JAF18.9 (ii). Ouagadougou: WHO\/APOC. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/apoc\/en_apoc_strategic_plan_2013_ok.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/apoc\/en_apoc_strategic_plan_2013_ok.pdf<\/ext-link> Accessed on 25 January 2015."},{"key":"ref56","unstructured":"WHO\/APOC (2013) Concept note: transforming APOC into a new regional entity for oncho &amp; LF elimination and support to other PC\/NTD. JAF 19.7. Ouagadougou: WHO\/APOC. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/apoc\/en_concept_note_ok.pdf\" xlink:type=\"simple\">www.who.int\/apoc\/en_concept_note_ok.pdf<\/ext-link> Accessed on 25 January 2015."}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0003777","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T00:00:00Z","timestamp":1430956800000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0003664","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T21:14:25Z","timestamp":1588972465000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0003664"}},"subtitle":[],"editor":[{"given":"Patrick J.","family":"Lammie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,10]]},"references-count":56,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0003664","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pntd.0003777","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,10]]}}}