{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:41:33Z","timestamp":1762101693209},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T00:00:00Z","timestamp":1428364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0003675","type":"journal-article","created":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T18:57:10Z","timestamp":1428433030000},"page":"e0003675","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Autophagy Protects Monocytes from Wolbachia Heat Shock Protein 60\u2013Induced Apoptosis and Senescence"],"prefix":"10.1371","volume":"9","author":[{"given":"Vijayan","family":"Kamalakannan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abijit","family":"Shiny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subash","family":"Babu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rangarajan Badri","family":"Narayanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,4,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1016\/j.vaccine.2009.05.015","article-title":"Immunization with inflammatory proteome of <italic>Brugia malayi<\/italic> adult worm induces a Th1\/Th2-immune response and confers protection against the filarial infection","volume":"27","author":"MK Sahoo","year":"2009","journal-title":"Vaccine"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1365-3156.2005.01426.x","article-title":"Physical and psychosocial burden due to lymphatic filariasis as perceived by patients and medical experts","volume":"10","author":"Kumari A Krishna","year":"2005","journal-title":"Trop Med Int Health"},{"key":"ref3","first-page":"1","article-title":"Onchocerciasis and its control. In Report of a WHO Expert Committee on Onchocerciasis Control","volume":"852","year":"1995","journal-title":"World Health Organ. Tech. Rep. Ser."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nri1183","article-title":"Immune regulation by helminth parasites: cellular and molecular mechanisms","volume":"3","author":"RM Maizels","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1002\/1521-4141(200009)30:9<2669::AID-IMMU2669>3.0.CO;2-1","article-title":"Alternatively activated macrophages induced by nematode infection inhibit proliferation via cell-to-cell contact","volume":"30","author":"Loke ASM P\u2019ng","year":"2000","journal-title":"Eur J Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.4049\/jimmunol.171.4.1950","article-title":"Brugia malayi microfilariae induce cell death in human dendritic cells, inhibit their ability to make IL-12 and IL-10, and reduce their capacity to activate CD4+ T cells","volume":"171","author":"RT Semnani","year":"2003","journal-title":"J Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1128\/IAI.69.9.5813-5822.2001","article-title":"Filarial antigens impair the function of human dendritic cells during differentiation","volume":"69","author":"RT Semnani","year":"2001","journal-title":"Infect Immun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1128\/IAI.01106-05","article-title":"Filaria-induced monocyte dysfunction and its reversal following treatment","volume":"74","author":"RT Semnani","year":"2006","journal-title":"Infect Immun"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.micinf.2012.01.008","article-title":"<italic>Wolbachia<\/italic> heat shock protein 60 induces pro-inflammatory cytokines and apoptosis in monocytes in vitro","volume":"14","author":"V Kamalakannan","year":"2012","journal-title":"Microbes Infect"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1128\/IAI.73.6.3385-3393.2005","article-title":"Diminished monocyte function in microfilaremic patients with lymphatic filariasis and its relationship to altered lymphoproliferative responses","volume":"73","author":"B Sasisekhar","year":"2005","journal-title":"Infect Immun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"4924","DOI":"10.4049\/jimmunol.174.8.4924","article-title":"Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo","volume":"174","author":"MD Taylor","year":"2005","journal-title":"J Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/S0140-6736(01)06899-4","article-title":"Severe reactions to filarial chemotherapy and release of <italic>Wolbachia<\/italic> endosymbionts into blood","volume":"358","author":"HF Cross","year":"2001","journal-title":"Lancet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0035-9203(00)90200-1","article-title":"New insights into the natural history and pathology of bancroftian filariasis: implications for clinical management and filariasis control programmes","volume":"94","author":"G Dreyer","year":"2000","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1126\/science.1068732","article-title":"The role of endosymbiotic <italic>Wolbachia<\/italic> bacteria in the pathogenesis of river blindness","volume":"295","author":"AV Saint Andre","year":"2002","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0167-5699(90)90050-J","article-title":"Heat shock proteins and the immune response","volume":"11","author":"SH Kaufmann","year":"1990","journal-title":"Immunol Today"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1600-065X.1991.tb00823.x","article-title":"Heat-Shock Protein 60: Implications for Pathogenesis of and Protection against Bacterial Infections","volume":"121","author":"SH Kaufmann","year":"1991","journal-title":"Immunol Rev"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"5689","DOI":"10.1128\/IAI.62.12.5689-5693.1994","article-title":"Bacterial heat shock proteins directly induce cytokine mRNA and interleukin-1 secretion in macrophage cultures","volume":"62","author":"C Retzlaff","year":"1994","journal-title":"Infect Immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1161\/01.CIR.99.12.1560","article-title":"Endothelial cytotoxicity mediated by serum antibodies to heat shock proteins of <italic>Escherichia coli<\/italic> and <italic>Chlamydia pneumoniae<\/italic> immune reactions to heat shock proteins as a possible link between infection and atherosclerosis","volume":"99","author":"M Mayr","year":"1999","journal-title":"Circulation"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.coi.2004.05.007","article-title":"Heat-shock proteins and the host\u2013pathogen interaction during bacterial infection","volume":"16","author":"GR Stewart","year":"2004","journal-title":"Curr Opin Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nri1593","article-title":"Heat-shock proteins induce T-cell regulation of chronic inflammation","volume":"5","author":"EW Van","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.exppara.2006.12.006","article-title":"Brugia malayi <italic>Wolbachia<\/italic> hsp60 IgG antibody and isotype reactivity in different clinical groups infected or exposed to human bancroftian lymphatic filariasis","volume":"116","author":"N Suba","year":"2007","journal-title":"Exp Parasitol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.micinf.2011.07.004","article-title":"Recombinant <italic>Wolbachia<\/italic> heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis","volume":"13","author":"C Shiny","year":"2011","journal-title":"Microbes Infect"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"437","DOI":"10.4049\/jimmunol.173.1.437","article-title":"The major surface protein of <italic>Wolbachia<\/italic> endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4","volume":"173","author":"NW Brattig","year":"2004","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1172\/JCI5310","article-title":"Chlamydial and human heat shock protein 60 activates human vascular endothelium, smooth muscle cells, and macrophages","volume":"103","author":"A Kol","year":"1999","journal-title":"J Clin Invest"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.4049\/jimmunol.162.6.3212","article-title":"Human 60-kDa heat-shock protein: a danger signal to the innate immune system","volume":"162","author":"W Chen","year":"1999","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1002\/eji.200425101","article-title":"Heat shock protein 60 from <italic>Chlamydia pneumoniae<\/italic> elicits an unusual set of inflammatory responses via Toll-like receptor 2 and 4 in vivo","volume":"34","author":"CUP da Costa","year":"2004","journal-title":"Eur J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/infdis\/170.1.247","article-title":"Og4C3 circulating antigen: a marker of infection and adult worm burden in <italic>Wuchereria bancrofti<\/italic> filariasis","volume":"170","author":"S Chanteau","year":"1994","journal-title":"J Infect Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0161-5890(00)00039-0","article-title":"NF-\u03baB is essential for induction of pro-inflammatory cytokine genes by filarial parasitic sheath proteins","volume":"37","author":"K Narayanan","year":"2000","journal-title":"Mol Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo","volume":"92","author":"GP Dimri","year":"1995","journal-title":"Proc Natl Acad Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.micinf.2003.11.003","article-title":"Pathogenesis and host responses in human onchocerciasis: impact of Onchocerca filariae and <italic>Wolbachia<\/italic> endobacteria","volume":"6","author":"NW Brattig","year":"2004","journal-title":"Microbes Infect"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"31332","DOI":"10.1074\/jbc.M103217200","article-title":"Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll\/interleukin-1 receptor signaling pathway in innate immune cells","volume":"276","author":"RM Vabulas","year":"2001","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.4049\/jimmunol.175.2.1170","article-title":"Diminished expression and function of TLR in lymphatic filariasis: a novel mechanism of immune dysregulation","volume":"175","author":"S Babu","year":"2005","journal-title":"J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"554","DOI":"10.4049\/jimmunol.168.2.554","article-title":"Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines","volume":"168","author":"KA Zarember","year":"2002","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.molimm.2010.09.008","article-title":"Differential regulation of TLR4 expression in human B cells and monocytes","volume":"48","author":"LM Ganley-Leal","year":"2010","journal-title":"Mol Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/infdis\/jiu208","article-title":"Filarial Antigens Mediate Apoptosis of Human Monocytes Through Toll-Like Receptor 4","volume":"210","author":"MA Das","year":"2014","journal-title":"J Infect Dis"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ccr.2006.08.015","article-title":"Reactive oxygen species in cancer cells: live by the sword, die by the sword","volume":"10","author":"PT Schumacker","year":"2006","journal-title":"Cancer cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature09973","article-title":"TLR signaling augments macrophage bactericidal activity through mitochondrial ROS","volume":"472","author":"AP West","year":"2011","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1074-5521(98)90615-9","article-title":"Caspases: key mediators of apoptosis","volume":"5","author":"NA Thornberry","year":"1998","journal-title":"Chem Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e794","DOI":"10.1038\/cddis.2013.334","article-title":"Activation of TLR4 signaling promotes gastric cancer progression by inducing mitochondrial ROS production","volume":"4","author":"X Yuan","year":"2013","journal-title":"Cell Death Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1089\/ars.2006.8.1997","article-title":"Neuronal life-and-death signaling, apoptosis, and neurodegenerative disorders","volume":"8","author":"MP Mattson","year":"2006","journal-title":"Antioxid Redox Signal"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000129697","article-title":"Senescence, apoptosis or autophagy?","volume":"54","author":"JM Vicencio","year":"2008","journal-title":"Gerontology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cell.2005.02.003","article-title":"Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors","volume":"120","author":"J Campisi","year":"2005","journal-title":"Cell"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1093\/clinids\/23.5.1007","article-title":"Diethylcarbamazine-induced reversal of early lymphatic dysfunction in a patient with bancroftian filariasis: Assessment with use of lymphoscintigraphy","volume":"23","author":"TA Moore","year":"1996","journal-title":"Clin Infect Dis"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.febslet.2010.01.017","article-title":"mTOR regulation of autophagy","volume":"584","author":"CH Jung","year":"2010","journal-title":"FEBS Lett"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"5943","DOI":"10.4049\/jimmunol.176.10.5943","article-title":"Class I and III phosphatidylinositol 3\u2032-kinase play distinct roles in TLR signaling pathway","volume":"176","author":"CC Kuo","year":"2006","journal-title":"J Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1165\/rcmb.2008-0290OC","article-title":"Participation of Mammalian Target of Rapamycin Complex 1 in Toll-Like Receptor 2\u2013and 4\u2013Induced Neutrophil Activation and Acute Lung Injury","volume":"41","author":"E Lorne","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/ni.2004","article-title":"The helminth product ES-62 protects against septic shock via Toll-like receptor 4-dependent autophagosomal degradation of the adaptor MyD88","volume":"12","author":"P Puneet","year":"2011","journal-title":"Nat Immunol"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0003675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T07:56:38Z","timestamp":1691567798000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0003675"}},"subtitle":[],"editor":[{"given":"Benjamin L","family":"Makepeace","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,7]]},"references-count":47,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0003675","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,7]]}}}