{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T01:16:32Z","timestamp":1778980592012,"version":"3.51.4"},"reference-count":106,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T00:00:00Z","timestamp":1432252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0003788","type":"journal-article","created":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T18:00:19Z","timestamp":1432317619000},"page":"e0003788","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Pan-phylum Comparison of Nematode Metabolic Potential"],"prefix":"10.1371","volume":"9","author":[{"given":"Rahul","family":"Tyagi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce A.","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren G.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makedonka","family":"Mitreva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,5,22]]},"reference":[{"key":"ref1","first-page":"5","article-title":"Recent developments in marine benthic biodiversity research","volume":"19","author":"PJD Lambshead","year":"1993","journal-title":"Oceanis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S0140-6736(06)68653-4","article-title":"Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm","volume":"367","author":"J Bethony","year":"2006","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.biotechadv.2009.03.005","article-title":"Advanced in silico analysis of expressed sequence tag (EST) data for parasitic nematodes of major socio-economic importance\u2014fundamental insights toward biotechnological outcomes","volume":"27","author":"S Ranganathan","year":"2009","journal-title":"Biotechnol Adv"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e1582","DOI":"10.1371\/journal.pntd.0001582","article-title":"A research agenda for helminth diseases of humans: the problem of helminthiases","volume":"6","author":"S Lustigman","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e577","DOI":"10.1016\/j.ijid.2013.03.003","article-title":"Towards global Guinea worm eradication in 2015: the experience of South Sudan","volume":"17","author":"N Awofeso","year":"2013","journal-title":"Int J Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e2264","DOI":"10.1371\/journal.pntd.0002264","article-title":"Global elimination of lymphatic filariasis: a &quot;mass uprising of compassion&quot;","volume":"7","author":"DG Addiss","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/2229-5070.113917","article-title":"Mass drug administration for elimination of lymphatic filariasis: Recent experiences from a district of West Bengal, India","volume":"3","author":"S Ghosh","year":"2013","journal-title":"Trop Parasitol"},{"key":"ref8","first-page":"171","article-title":"Coverage and awareness of and compliance with mass drug administration for elimination of lymphatic filariasis in Burdwan District, West Bengal, India","volume":"31","author":"RN Roy","year":"2013","journal-title":"J Health Popul Nutr"},{"key":"ref9","first-page":"381","article-title":"Progress towards eliminating onchocerciasis in the WHO Region of the Americas: verification by WHO of elimination of transmission in Colombia","volume":"88","year":"2013","journal-title":"Wkly Epidemiol Rec"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e1621","DOI":"10.1371\/journal.pntd.0001621","article-title":"Soil-transmitted helminth reinfection after drug treatment: a systematic review and meta-analysis","volume":"6","author":"TW Jia","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.ijpara.2006.06.010","article-title":"Understanding anthelmintic resistance: the need for genomics and genetics","volume":"36","author":"JS Gilleard","year":"2006","journal-title":"Int J Parasitol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.vetpar.2013.07.037","article-title":"Lack of efficacy of monepantel against Teladorsagia circumcincta and Trichostrongylus colubriformis","volume":"198","author":"I Scott","year":"2013","journal-title":"Vet Parasitol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.ijpara.2004.08.001","article-title":"Monitoring drug efficacy and early detection of drug resistance in human soil-transmitted nematodes: a pressing public health agenda for helminth control","volume":"34","author":"M Albonico","year":"2004","journal-title":"Int J Parasitol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1179\/000349804225003253","article-title":"An investigation of persistent microfilaridermias despite multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana","volume":"98","author":"K Awadzi","year":"2004","journal-title":"Ann Trop Med Parasitol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/QCO.0b013e328358993a","article-title":"Human soil-transmitted helminths: implications of mass drug administration","volume":"25","author":"J Vercruysse","year":"2012","journal-title":"Curr Opin Infect Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/0020-7519(95)00071-9","article-title":"Costs of major parasites to the Australian livestock industries","volume":"25","author":"RS McLeod","year":"1995","journal-title":"Int J Parasitol"},{"key":"ref17","first-page":"127","article-title":"Plant and soil nematodes: societal impact and focus for the future","volume":"26","author":"KR Barker","year":"1994","journal-title":"J Nematol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0065-308X(10)73008-6","article-title":"The drugs we have and the drugs we need against major helminth infections","volume":"73","author":"J Keiser","year":"2010","journal-title":"Adv Parasitol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1517\/14656560902722463","article-title":"Pharmacotherapy of helminth infection","volume":"10","author":"E van den Enden","year":"2009","journal-title":"Expert Opin Pharmacother"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e1003505","DOI":"10.1371\/journal.ppat.1003505","article-title":"Discovery of anthelmintic drug targets and drugs using chokepoints in nematode metabolic pathways","volume":"9","author":"CM Taylor","year":"2013","journal-title":"PLoS Pathog"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.chom.2009.01.004","article-title":"Host-parasite interactions revealed by Plasmodium falciparum metabolomics","volume":"5","author":"KL Olszewski","year":"2009","journal-title":"Cell Host Microbe"},{"issue":"Suppl 1","key":"ref22","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.1080\/13693780802455313","article-title":"Aspergillus fumigatus metabolism: clues to mechanisms of in vivo fungal growth and virulence","volume":"47","author":"SD Willger","year":"2009","journal-title":"Med Mycol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/msb.2013.62","article-title":"Metabolic reconstruction identifies strain-specific regulation of virulence in Toxoplasma gondii","volume":"9","author":"C Song","year":"2013","journal-title":"Mol Syst Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0169-4758(89)90080-X","article-title":"Xenobiotic metabolism in helminths","volume":"5","author":"WY Precious","year":"1989","journal-title":"Parasitol Today"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0166-6851(01)00252-3","article-title":"Antioxidant enzyme families in parasitic nematodes","volume":"114","author":"K Henkle-D\u00fchrsen","year":"2001","journal-title":"Mol Biochem Parasitol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0065-308X(03)54003-9","article-title":"Nematoda: genes, genomes and the evolution of parasitism","volume":"54","author":"ML Blaxter","year":"2003","journal-title":"Adv Parasitol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/ng.227","article-title":"The Pristionchus pacificus genome provides a unique perspective on nematode lifestyle and parasitism","volume":"40","author":"C Dieterich","year":"2008","journal-title":"Nat Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ng.769","article-title":"The draft genome of the parasitic nematode Trichinella spiralis","volume":"43","author":"M Mitreva","year":"2011","journal-title":"Nat Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.molbiopara.2007.11.001","article-title":"The canine hookworm genome: analysis and classification of Ancylostoma caninum survey sequences","volume":"157","author":"S Abubucker","year":"2008","journal-title":"Mol Biochem Parasitol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.ijpara.2006.03.002","article-title":"Identification and analysis of genes expressed in the adult filarial parasitic nematode Dirofilaria immitis","volume":"36","author":"Y Yin","year":"2006","journal-title":"Int J Parasitol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"D720","DOI":"10.1093\/nar\/gkr1194","article-title":"<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/Nematode.net\" xlink:type=\"simple\">Nematode.net<\/ext-link> update 2011: addition of data sets and tools featuring next-generation sequencing data","volume":"40","author":"J Martin","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e21832","DOI":"10.1371\/journal.pone.0021832","article-title":"HelmCoP: an online resource for helminth functional genomics and drug and vaccine targets prioritization","volume":"6","author":"S Abubucker","year":"2011","journal-title":"PLoS One"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"D698","DOI":"10.1093\/nar\/gku1128","article-title":"<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/Helminth.net\" xlink:type=\"simple\">Helminth.net<\/ext-link>: expansions to <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/Nematode.net\" xlink:type=\"simple\">Nematode.net<\/ext-link> and an introduction to <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/Trematode.net\" xlink:type=\"simple\">Trematode.net<\/ext-link>","volume":"43","author":"J Martin","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nature01644","article-title":"Sequencing and comparison of yeast species to identify genes and regulatory elements","volume":"423","author":"M Kellis","year":"2003","journal-title":"Nature"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature10530","article-title":"A high-resolution map of human evolutionary constraint using 29 mammals","volume":"478","author":"K Lindblad-Toh","year":"2011","journal-title":"Nature"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"M Kanehisa","year":"2006","journal-title":"Nucl Acids Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1038\/ng1472","article-title":"A transcriptomic analysis of the phylum Nematoda","volume":"36","author":"J Parkinson","year":"2004","journal-title":"Nature Genetics"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"D109","DOI":"10.1093\/nar\/gkr988","article-title":"KEGG for integration and interpretation of large-scale molecular data sets","volume":"40","author":"M Kanehisa","year":"2012","journal-title":"Nucleic acids research"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/1471-2164-11-307","article-title":"Characterizing Ancylostoma caninum transcriptome and exploring nematode parasitic adaptation","volume":"11","author":"Z Wang","year":"2010","journal-title":"BMC Genomics"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1101\/gr.138420.112","article-title":"Analysis of gene expression from the Wolbachia genome of a filarial nematode supports both metabolic and defensive roles within the symbiosis","volume":"22","author":"AC Darby","year":"2012","journal-title":"Genome Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.exger.2005.09.006","article-title":"Alternate metabolism during the dauer stage of the nematode Caenorhabditis elegans","volume":"40","author":"AM Burnell","year":"2005","journal-title":"Exp Gerontol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/32160","article-title":"A molecular evolutionary framework for the phylum Nematoda","volume":"392","author":"ML Blaxter","year":"1998","journal-title":"Nature"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/ng.2875","article-title":"Genome of the human hookworm Necator americanus","volume":"46","author":"YT Tang","year":"2014","journal-title":"Nature Genetics"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature10553","article-title":"Ascaris suum draft genome","volume":"479","author":"AR Jex","year":"2011","journal-title":"Nature"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e1002219","DOI":"10.1371\/journal.ppat.1002219","article-title":"Genomic insights into the origin of parasitism in the emerging plant pathogen Bursaphelenchus xylophilus","volume":"7","author":"T Kikuchi","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ng.2585","article-title":"Genomics of Loa loa, a Wolbachia-free filarial parasite of humans","volume":"45","author":"CA Desjardins","year":"2013","journal-title":"Nat Genet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1186\/1471-2164-9-525","article-title":"NemaPath: online exploration of KEGG-based metabolic pathways for nematodes","volume":"9","author":"T Wylie","year":"2008","journal-title":"BMC Genomics"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ng.1065","article-title":"Whole-genome sequence of Schistosoma haematobium","volume":"44","author":"ND Young","year":"2012","journal-title":"Nat Genet"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1128\/JB.184.2.519-524.2002","article-title":"Synthesis of triacylglycerols by the acyl-coenzyme A:diacyl-glycerol acyltransferase Dga1p in lipid particles of the yeast Saccharomyces cerevisiae","volume":"184","author":"D Sorger","year":"2002","journal-title":"J Bacteriol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0166-6851(97)00091-1","article-title":"The incorporation, modification and turnover of fatty acids in adult Schistosoma mansoni","volume":"88","author":"JF Brouwers","year":"1997","journal-title":"Mol Biochem Parasitol"},{"key":"ref51","author":"J Barrett","year":"1981"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0005-2760(70)90170-0","article-title":"Lipid metabolism in the parasitic and free-living flatworms, Schistosoma mansoni and Dugesia dorotocephala","volume":"210","author":"F Meyer","year":"1970","journal-title":"Biochim Biophys Acta"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature12031","article-title":"The genomes of four tapeworm species reveal adaptations to parasitism","volume":"496","author":"IJ Tsai","year":"2013","journal-title":"Nature"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.molbiopara.2007.05.002","article-title":"Expressed sequence tag (EST) analysis of the pine wood nematode Bursaphelenchus xylophilus and B. mucronatus","volume":"155","author":"T Kikuchi","year":"2007","journal-title":"Mol Biochem Parasitol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/1471-2148-9-212","article-title":"Molecular phylogeny of beetle associated diplogastrid nematodes suggests host switching rather than nematode-beetle coevolution","volume":"9","author":"WE Mayer","year":"2009","journal-title":"BMC Evol Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/1471-2148-11-239","article-title":"Computational archaeology of the Pristionchus pacificus genome reveals evidence of horizontal gene transfers from insects","volume":"11","author":"C R\u00f6delsperger","year":"2011","journal-title":"BMC Evol Biol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/1471-2164-13-254","article-title":"Divergent gene expression in the conserved dauer stage of the nematodes Pristionchus pacificus and Caenorhabditis elegans","volume":"13","author":"A Sinha","year":"2012","journal-title":"BMC Genomics"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0925-4439(99)00064-2","article-title":"Immunogenic glycoconjugates implicated in parasitic nematode diseases","volume":"1455","author":"A Dell","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"ref59","article-title":"Essentials of Glycobiology","author":"RD Cummings","year":"2009"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0020-7519(96)00009-4","article-title":"Lectin staining of trichostrongylid nematode eggs of sheep: rapid identification of Haemonchus contortus eggs with peanut agglutinin","volume":"26","author":"DG Palmer","year":"1996","journal-title":"Int J Parasitol"},{"key":"ref61","article-title":"Essentials of Glycobiology","author":"RD Cummings","year":"2009"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4161\/cib.4.2.14547","article-title":"Evolution of glycosaminoglycans: Comparative biochemical study","volume":"4","author":"S Yamada","year":"2011","journal-title":"Commun Integr Biol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"11911","DOI":"10.1074\/jbc.M111.312918","article-title":"Engineering mammalian mucin-type O-glycosylation in plants","volume":"287","author":"Z Yang","year":"2012","journal-title":"J Biol Chem"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1101\/gr.2050304","article-title":"Computational Analysis of Plasmodium falciparum Metabolism: Organizing Genomic Information to Facilitate Drug Discovery","volume":"14","author":"I Yeh","year":"2004","journal-title":"Genome Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1371\/journal.pbio.0030121","article-title":"The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode","volume":"3","author":"J Foster","year":"2005","journal-title":"PLoS Biol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s13199-010-0067-1","article-title":"The Wolbachia endosymbiont as an anti-filarial nematode target","volume":"51","author":"BE Slatko","year":"2010","journal-title":"Symbiosis"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2148-9-23","article-title":"Systematic analysis of insertions and deletions specific to nematode proteins and their proposed functional and evolutionary relevance","volume":"9","author":"Z Wang","year":"2009","journal-title":"BMC Evol Biol"},{"key":"ref68","first-page":"93","author":"R Komuniecki","year":"1996"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.molbiopara.2007.08.002","article-title":"Molecular and biochemical characterization of nematode cofactor independent phosphoglycerate mutases","volume":"156","author":"S Raverdy","year":"2007","journal-title":"Mol Biochem Parasitol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/prot.21278","article-title":"Indel-based targeting of essential proteins in human pathogens that have close host orthologue(s): discovery of selective inhibitors for Leishmania donovani elongation factor-1alpha","volume":"67","author":"D Nandan","year":"2007","journal-title":"Proteins"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature10553","article-title":"Ascaris suum draft genome","volume":"479","author":"AR Jex","year":"2011","journal-title":"Nature"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"e1409","DOI":"10.1371\/journal.pntd.0001409","article-title":"A deep sequencing approach to comparatively analyze the transcriptome of lifecycle stages of the filarial worm, Brugia malayi","volume":"5","author":"YJ Choi","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1101\/gr.088112.108","article-title":"Massively parallel sequencing of the polyadenylated transcriptome of C. elegans","volume":"19","author":"LW Hillier","year":"2009","journal-title":"Genome Res"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"e44720","DOI":"10.1371\/journal.pone.0044720","article-title":"Metabolic rate regulates L1 longevity in C. elegans","volume":"7","author":"I Lee","year":"2012","journal-title":"PLoS One"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/1471-2164-13-184","article-title":"Transcription profiling reveals stage- and function-dependent expression patterns in the filarial nematode Brugia malayi","volume":"13","author":"BW Li","year":"2012","journal-title":"BMC Genomics"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1101\/gr.1524804","article-title":"Comparative Genomics of Gene Expression in the Parasitic and Free-living Nematodes Strongyloides stercoralis and Caenorhabditis elegans","volume":"14","author":"M Mitreva","year":"2004","journal-title":"Genome Res"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"e2678","DOI":"10.1371\/journal.pntd.0002678","article-title":"Genome-wide tissue-specific gene expression, co-expression and regulation of co-expressed genes in adult nematode Ascaris suum","volume":"8","author":"BA Rosa","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref78","first-page":"197","article-title":"Molecular Medical Parasitology","author":"NS Carter","year":"2003"},{"key":"ref79","first-page":"733","article-title":"In vitro reactivation of Ancylostoma caninum tissue-arrested third-stage larvae by transforming growth factor-beta","volume":"87","author":"P Arasu","year":"2001","journal-title":"J Parasitol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0014-4894(02)00008-5","article-title":"Immunoaffinity-isolated antigens induce protective immunity against larval Strongyloides stercoralis in mice","volume":"100","author":"DR Herbert","year":"2002","journal-title":"Exp Parasitol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0165-2478(96)02676-4","article-title":"The multidrug transporters\u2014proteins of an ancient immune system","volume":"54","author":"B Sarkadi","year":"1996","journal-title":"Immunol Lett"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2174\/1389200023337171","article-title":"Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes","volume":"3","author":"TH Rushmore","year":"2002","journal-title":"Curr Drug Metab"},{"key":"ref83","first-page":"170","article-title":"Catalase: structure, properties, functions","volume":"60","author":"D Scibior","year":"2006","journal-title":"Postepy Hig Med Dosw (Online)"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF00966084","article-title":"The structural and functional heterogeneity of glutamic acid decarboxylase: a review","volume":"16","author":"MG Erlander","year":"1991","journal-title":"Neurochem Res"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jsb.2010.07.008","article-title":"Structural and functional analysis of three \u03b2-glucosidases from bacterium Clostridium cellulovorans, fungus Trichoderma reesei and termite Neotermes koshunensis","volume":"173","author":"WY Jeng","year":"2011","journal-title":"J Struct Biol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0014-5793(01)02249-9","article-title":"Involvement of mitochondrial ferredoxin and Cox15p in hydroxylation of heme O","volume":"492","author":"MH Barros","year":"2001","journal-title":"FEBS Lett"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"W182","DOI":"10.1093\/nar\/gkm321","article-title":"KAAS: an automatic genome annotation and pathway reconstruction server","volume":"35","author":"Y Moriya","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1093\/bioinformatics\/btq266","article-title":"DETECT\u2014a density estimation tool for enzyme classification and its application to Plasmodium falciparum","volume":"26","author":"SS Hung","year":"2010","journal-title":"Bioinformatics"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1093\/bioinformatics\/bts510","article-title":"EFICAz2.5: application of a high-precision enzyme function predictor to 396 proteomes","volume":"28","author":"N Kumar","year":"2012","journal-title":"Bioinformatics"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.1093\/nar\/gkg847","article-title":"Enzyme-specific profiles for genome annotation: PRIAM","volume":"31","author":"C Claudel-Renard","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"D504","DOI":"10.1093\/nar\/gkj126","article-title":"Pathguide: a pathway resource list","volume":"34","author":"GD Bader","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1093\/bioinformatics\/bts421","article-title":"AraPath: a knowledgebase for pathway analysis in Arabidopsis","volume":"28","author":"L Lai","year":"2012","journal-title":"Bioinformatics"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1471-2164-5-93","article-title":"GOLD.db: genomics of lipid-associated disorders database","volume":"5","author":"H Hackl","year":"2004","journal-title":"BMC Genomics"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"D742","DOI":"10.1093\/nar\/gkr1014","article-title":"The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway\/genome databases","volume":"40","author":"R Caspi","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"D428","DOI":"10.1093\/nar\/gki072","article-title":"Reactome: a knowledgebase of biological pathways","volume":"33","author":"G Joshi-Tope","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"D284","DOI":"10.1093\/nar\/gki078","article-title":"The PANTHER database of protein families, subfamilies, functions and pathways","volume":"33","author":"H Mi","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1186\/1471-2105-11-449","article-title":"Consistency, comprehensiveness, and compatibility of pathway databases","volume":"11","author":"D Soh","year":"2010","journal-title":"BMC Bioinformatics"},{"issue":"Suppl 3","key":"ref98","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1471-2105-13-S3-S2","article-title":"Metabolic network alignment in large scale by network compression","volume":"13","author":"F Ay","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1089\/cmb.2010.0280","article-title":"SubMAP: aligning metabolic pathways with subnetwork mappings","volume":"18","author":"F Ay","year":"2011","journal-title":"J Comput Biol"},{"key":"ref100","doi-asserted-by":"crossref","unstructured":"Baldan P, Cocco N, Simeoni M (2012) Comparison of Metabolic Pathways by Considering Potential Fluxes. Biological Processes &amp; Petri Nets.","DOI":"10.1007\/978-3-642-40465-8_1"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"SF Altschul","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"ref102","author":"TH Cormen","year":"2001"},{"key":"ref103","unstructured":"Team RC (2012) R: A Language and Environment for Statistical Computing. Vienna, Austria."},{"key":"ref104","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1741-7007-4-41","article-title":"Composition-based statistics and translated nucleotide searches: improving the TBLASTN module of BLAST","volume":"4","author":"EM Gertz","year":"2006","journal-title":"BMC Biol"},{"key":"ref105","first-page":"205","article-title":"A new generation of homology search tools based on probabilistic inference","volume":"23","author":"SR Eddy","year":"2009","journal-title":"Genome Inform"},{"key":"ref106","article-title":"Essentials of Glycobiology","author":"RD Cummings","year":"2009"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0003788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T23:38:40Z","timestamp":1652053120000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0003788"}},"subtitle":[],"editor":[{"given":"Timothy G.","family":"Geary","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,5,22]]},"references-count":106,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0003788","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,22]]}}}