{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:28:16Z","timestamp":1790188096531,"version":"4.1.0"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0003800","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T18:19:47Z","timestamp":1435342787000},"page":"e0003800","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["A Rodent Model of Chikungunya Virus Infection in RAG1 -\/- Mice, with Features of Persistence, for Vaccine Safety Evaluation"],"prefix":"10.1371","volume":"9","author":[{"given":"Robert L.","family":"Seymour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Paige","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria D. H.","family":"Alcorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott C.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,6,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1099\/vir.0.82714-0","article-title":"Genetic divergence of Chikungunya viruses in India (1963\u20132006) with special reference to the 2005\u20132006 explosive epidemic","volume":"88","author":"VA Arankalle","year":"2007","journal-title":"J Gen Virol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1099\/vir.0.015743-0","article-title":"Re-emergence of Chikungunya virus in South-east Asia: virological evidence from Sri Lanka and Singapore","volume":"91","author":"HC Hapuarachchi","year":"2009","journal-title":"J Gen Virol"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1056\/NEJMp078013","article-title":"Chikungunya outbreaks\u2013the globalization of vectorborne diseases","volume":"356","author":"RN Charrel","year":"2007","journal-title":"N Engl J Med"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1473-3099(07)70107-X","article-title":"Chikungunya, an epidemic arbovirosis","volume":"7","author":"G Pialoux","year":"2007","journal-title":"Lancet Infect Dis"},{"issue":"9916","key":"ref5","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0140-6736(14)60185-9","article-title":"Chikungunya in the Americas","volume":"383","author":"I Leparc-Goffart","year":"2014","journal-title":"Lancet"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"e2921","DOI":"10.1371\/journal.pntd.0002921","article-title":"Arrival of chikungunya virus in the new world: prospects for spread and impact on public health","volume":"8","author":"SC Weaver","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1177\/0883073808314151","article-title":"Neurologic manifestations of pediatric chikungunya infection","volume":"23","author":"S Robin","year":"2008","journal-title":"J Child Neurol"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1111\/j.1742-1241.2011.02792.x","article-title":"Rheumatic- musculoskeletal pain and disorders in a na\u00efve group of individuals 15 months following a Chikungunya viral epidemic in south India: a population based observational study","volume":"65","author":"AJ Mathew","year":"2011","journal-title":"Int J Clin Pract"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/infdis\/jiq042","article-title":"Persistent arthralgia Induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor","volume":"203","author":"A Chow","year":"2011","journal-title":"J Infect Dis"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1089\/vim.2010.0123","article-title":"Role of proinflammatory cytokines and chemokines in chronic arthropathy in CHIKV infection","volume":"24","author":"IK Chaaitanya","year":"2011","journal-title":"Viral Immunol"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1371\/journal.ppat.0040029","article-title":"A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease","volume":"4","author":"T Couderc","year":"2008","journal-title":"PLoS Pathog"},{"issue":"16","key":"ref12","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1016\/j.vaccine.2011.01.076","article-title":"Probing the attenuation and protective efficacy of a candidate chikungunya virus vaccine in mice with compromised interferon (IFN) signaling","volume":"29","author":"CD Partidos","year":"2011","journal-title":"Vaccine"},{"issue":"7","key":"ref13","doi-asserted-by":"crossref","first-page":"e1002142","DOI":"10.1371\/journal.ppat.1002142","article-title":"Novel Chikungunya Vaccine Candidate with an IRES-Based Attenuation and Host Range Alteration Mechanism","volume":"7","author":"K Plante","year":"2011","journal-title":"PLoS Pathog"},{"issue":"16","key":"ref14","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.1128\/JVI.02603-09","article-title":"Chikungunya virus arthritis in adult wild-type mice","volume":"84","author":"J Gardner","year":"2010","journal-title":"J Virol"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ajpath.2010.11.018","article-title":"A mouse model of chikungunya virus-induced musculoskeletal inflammatory disease: evidence of arthritis, tenosynovitis, myositis, and persistence","volume":"178","author":"TE Morrison","year":"2011","journal-title":"Am J Pathol"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/infdis\/jir470","article-title":"Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis","volume":"204","author":"NE Rulli","year":"2011","journal-title":"J Infect Dis"},{"issue":"10","key":"ref17","doi-asserted-by":"crossref","first-page":"5914","DOI":"10.4049\/jimmunol.0900255","article-title":"Persistent Chronic inflammation and infection by chikungunya arthritogenic alphavirus in spite of a robust host innate immune response","volume":"184","author":"JJ Hoarau","year":"2010","journal-title":"J Immunol"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1172\/JCI40104","article-title":"Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages","volume":"120","author":"K Labadie","year":"2010","journal-title":"J Clin Invest"},{"issue":"11","key":"ref19","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1002\/art.34631","article-title":"Gene profiling of chikungunya virus arthritis reveals significant overlap with rheumatoid arthritis","volume":"64","author":"HI Nakaya","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.4049\/jimmunol.1202177","article-title":"A pathogenic role for CD4+ T cells during Chikungunya virus infection in mice","volume":"190","author":"TH Teo","year":"2013","journal-title":"J Immunol"},{"issue":"24","key":"ref21","doi-asserted-by":"crossref","first-page":"13878","DOI":"10.1128\/JVI.02666-13","article-title":"Chronic joint disease caused by persistent Chikungunya virus infection is controlled by the adaptive immune response","volume":"87","author":"DW Hawman","year":"2013","journal-title":"J Virol"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0264-410X(86)90003-4","article-title":"Development of an attenuated strain of chikungunya virus for use in vaccine production","volume":"4","author":"NH Levitt","year":"1986","journal-title":"Vaccine"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"681","DOI":"10.4269\/ajtmh.2000.62.681","article-title":"Phase II safety and immunogenicity study of live chikungunya virus vaccine TSI-GSD-218","volume":"62","author":"R Edelman","year":"2000","journal-title":"Am J Trop Med Hyg"},{"issue":"12","key":"ref24","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1093\/infdis\/jiu014","article-title":"Chikungunya Vaccine Candidate is Highly Attenuated and Protects Nonhuman Primates Against Telemetrically-monitored Disease Following a Single Dose","volume":"209","author":"CJ Roy","year":"2014","journal-title":"J Infect Dis"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1089\/vbz.2006.6.325","article-title":"Infectious clones of Chikungunya virus (La R\u00e9union isolate) for vector competence studies","volume":"6","author":"K Tsetsarkin","year":"2006","journal-title":"Vector Borne Zoonotic Dis"},{"key":"ref26","first-page":"797","article-title":"Diagnostic procedures for viral, rickettsial and chlamydial infections","author":"BJ Beaty","year":"1989"},{"issue":"29","key":"ref27","doi-asserted-by":"crossref","first-page":"12048","DOI":"10.1073\/pnas.1101089108","article-title":"Critical role for macrophage migration inhibitory factor (MIF) in Ross River virus-induced arthritis and myositis","volume":"108","author":"LJ Herrero","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4269\/ajtmh.2008.79.133","article-title":"An animal model for studying the pathogenesis of chikungunya virus infection","volume":"79","author":"SA Ziegler","year":"2008","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1086\/431153","article-title":"Persistent West Nile virus infection in the golden hamster: studies on its mechanism and possible implications for other flavivirus infections","volume":"192","author":"RB Tesh","year":"2005","journal-title":"J Infect Dis"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"320","DOI":"10.4269\/ajtmh.2005.72.320","article-title":"Persistent shedding of West Nile virus in urine of experimentally infected hamsters","volume":"72","author":"JH Tonry","year":"2005","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1086\/648731","article-title":"Persistent infection with West Nile virus years after initial infection","volume":"201","author":"K Murray","year":"2010","journal-title":"J Infect Dis"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0003800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T12:09:49Z","timestamp":1589026189000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0003800"}},"subtitle":[],"editor":[{"given":"David Joseph","family":"Diemert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,26]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0003800","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,26]]}}}