{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:00:28Z","timestamp":1791000028735,"version":"4.1.0"},"reference-count":89,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T00:00:00Z","timestamp":1434585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0003850","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T18:11:47Z","timestamp":1434651107000},"page":"e0003850","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":50,"title":["BoHV-4-Based Vector Single Heterologous Antigen Delivery Protects STAT1(-\/-) Mice from Monkeypoxvirus Lethal Challenge"],"prefix":"10.1371","volume":"9","author":[{"given":"Valentina","family":"Franceschi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Jacca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan W.","family":"Crump","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Doronin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edguardo","family":"Hembrador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pompilio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Tebaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan D.","family":"Estep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott W.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Buller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Donofrio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,6,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2217\/fvl.12.130","article-title":"A review of experimental and natural infections of animals with monkeypox virus between 1958 and 2012","volume":"8","author":"S Parker","year":"2013","journal-title":"Future Virol"},{"key":"ref2","first-page":"17","article-title":"Human monkeypox: an emerging zoonotic disease Future Microbiol","volume":"2","author":"S Parker","year":"2007","journal-title":"Human monkeypox: an emerging zoonotic disease Future Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1056\/NEJMra020025","article-title":"Diagnosis and management of smallpox","volume":"346","author":"JG Breman","year":"2002","journal-title":"NEnglJMed"},{"issue":"Suppl 4","key":"ref4","doi-asserted-by":"crossref","first-page":"D54","DOI":"10.1016\/j.vaccine.2011.04.014","article-title":"Status of human monkeypox: clinical disease, epidemiology and research","volume":"29","author":"IK Damon","year":"2011","journal-title":"Vaccine"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1086\/498155","article-title":"Reemergence of monkeypox: prevalence, diagnostics, and countermeasures","volume":"41","author":"A Nalca","year":"2005","journal-title":"Clin Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1128\/JCM.40.8.2919-2921.2002","article-title":"Outbreaks of disease suspected of being due to human monkeypox virus infection in the Democratic Republic of Congo in 2001","volume":"40","author":"H Meyer","year":"2002","journal-title":"J Clin Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1099\/vir.0.81215-0","article-title":"A tale of two clades: monkeypox viruses","volume":"86","author":"AM Likos","year":"2005","journal-title":"J Gen Virol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.virol.2005.05.030","article-title":"Virulence differences between monkeypox virus isolates from West Africa and the Congo basin","volume":"340","author":"N Chen","year":"2005","journal-title":"Virology"},{"key":"ref9","article-title":"Human monkeypox","author":"Z Jezek","year":"1988"},{"key":"ref10","first-page":"459","article-title":"Clinico-epidemiological features of monkeypox patients with an animal or human source of infection","volume":"66","author":"Z Jezek","year":"1988","journal-title":"Bull World Health Organ"},{"key":"ref11","first-page":"537","article-title":"Multistate outbreak of monkeypox\u2014Illinois, Indiana, and Wisconsin, 2003","volume":"52","year":"2003","journal-title":"MMWR MorbMortalWklyRep"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1056\/NEJMoa032299","article-title":"The detection of monkeypox in humans in the Western Hemisphere","volume":"350","author":"KD Reed","year":"2004","journal-title":"N Engl J Med"},{"key":"ref13","article-title":"Smallpox and its eradication","author":"F Fenner","year":"1988"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/S0140-6736(11)61142-2","article-title":"Maculopapular lesions in the Central African Republic","volume":"378","author":"N Berthet","year":"2011","journal-title":"Lancet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"335","DOI":"10.7589\/0090-3558-48.2.335","article-title":"Ecology and geography of human monkeypox case occurrences across Africa","volume":"48","author":"CK Ellis","year":"2012","journal-title":"J Wildl Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.3201\/eid1610.100713","article-title":"Human monkeypox outbreak caused by novel virus belonging to Congo Basin clade, Sudan, 2005","volume":"16","author":"P Formenty","year":"2010","journal-title":"Emerg Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4269\/ajtmh.2005.73.428","article-title":"Extended interhuman transmission of monkeypox in a hospital community in the Republic of the Congo, 2003","volume":"73","author":"LA Learned","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"16262","DOI":"10.1073\/pnas.1005769107","article-title":"Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo","volume":"107","author":"AW Rimoin","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1586\/erv.09.55","article-title":"The new ACAM2000 vaccine and other therapies to control orthopoxvirus outbreaks and bioterror attacks","volume":"8","author":"L Handley","year":"2009","journal-title":"Expert Rev Vaccines"},{"key":"ref20","first-page":"329","article-title":"Birkhauser Basel","author":"LM Handley","year":"2007"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nature04295","article-title":"Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection","volume":"439","author":"KJ Stittelaar","year":"2006","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1128\/JVI.00984-08","article-title":"Coadministration of cidofovir and smallpox vaccine reduced vaccination side effects but interfered with vaccine-elicited immune responses and immunity to monkeypox","volume":"83","author":"H Wei","year":"2009","journal-title":"J Virol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"975","DOI":"10.2460\/ajvr.1983.44.06.975","article-title":"Experimental inoculation of cattle with bovine herpesvirus-4: evidence for a lymphoid-associated persistent infection","volume":"44","author":"FA Osorio","year":"1983","journal-title":"Am J Vet Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1099\/0022-1317-82-5-1181","article-title":"A bovine macrophage cell line supports bovine herpesvirus-4 persistent infection","volume":"82","author":"G Donofrio","year":"2001","journal-title":"J Gen Virol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0166-0934(01)00419-0","article-title":"Potential of bovine herpesvirus 4 as a gene delivery vector","volume":"101","author":"G Donofrio","year":"2002","journal-title":"J Virol Methods"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1128\/CVI.00200-06","article-title":"Recombinant bovine herpesvirus 4 (BoHV-4) expressing glycoprotein D of BoHV-1 is immunogenic and elicits serum-neutralizing antibodies against BoHV-1 in a rabbit model","volume":"13","author":"G Donofrio","year":"2006","journal-title":"Clin Vaccine Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1472-6750-7-68","article-title":"Establishment of a bovine herpesvirus 4 based vector expressing a secreted form of the bovine viral diarrhoea virus structural glycoprotein E2 for immunization purposes","volume":"7","author":"G Donofrio","year":"2007","journal-title":"BMC Biotechnol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"6031","DOI":"10.1016\/j.vaccine.2008.09.023","article-title":"Double immunization strategy with a BoHV-4-vectorialized secreted chimeric peptide BVDV-E2\/BoHV-1-gD","volume":"26","author":"G Donofrio","year":"2008","journal-title":"Vaccine"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1128\/CVI.00224-09","article-title":"Cellular targeting of engineered heterologous antigens is a determinant factor for bovine herpesvirus 4-based vaccine vector development","volume":"16","author":"G Donofrio","year":"2009","journal-title":"Clin Vaccine Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.vaccine.2010.11.048","article-title":"Swine adipose stromal cells loaded with recombinant bovine herpesvirus 4 virions expressing a foreign antigen induce potent humoral immune responses in pigs","volume":"29","author":"G Donofrio","year":"2011","journal-title":"Vaccine"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/neuonc\/nor219","article-title":"Herpes simplex virus type 1 thymidine kinase-armed bovine herpesvirus type 4-based vector displays enhanced oncolytic properties in immunocompetent orthotopic syngenic mouse and rat glioma models","volume":"14","author":"M Redaelli","year":"2012","journal-title":"Neuro Oncol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1016\/j.vaccine.2011.01.075","article-title":"Immunization of knock-out alpha\/beta interferon receptor mice against lethal bluetongue infection with a BoHV-4-based vector expressing BTV-8 VP2 antigen","volume":"29","author":"V Franceschi","year":"2011","journal-title":"Vaccine"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jviromet.2006.04.008","article-title":"Bovine herpesvirus 4 based vector interaction with liver cells in vitro and in vivo","volume":"136","author":"G Donofrio","year":"2006","journal-title":"J Virol Methods"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e52758","DOI":"10.1371\/journal.pone.0052758","article-title":"Clinical protection of goats against CpHV-1 induced genital disease with a BoHV-4-based vector expressing CpHV-1 gD","volume":"8","author":"G Donofrio","year":"2013","journal-title":"PLoS One"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1128\/JVI.02012-09","article-title":"A mouse model of lethal infection for evaluating prophylactics and therapeutics against Monkeypox virus","volume":"84","author":"J Stabenow","year":"2010","journal-title":"J Virol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/j.vaccine.2005.11.022","article-title":"Safety and immunogenicity of IMVAMUNE, a promising candidate as a third generation smallpox vaccine","volume":"24","author":"J Vollmar","year":"2006","journal-title":"Vaccine"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jviromet.2010.08.002","article-title":"Expression and secretion of Bluetongue virus serotype 8 (BTV-8)VP2 outer capsid protein by mammalian cells","volume":"169","author":"A Capocefalo","journal-title":"J Virol Methods"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e95779","DOI":"10.1371\/journal.pone.0095779","article-title":"In vivo image analysis of BoHV-4-based vector in mice","volume":"9","author":"V Franceschi","journal-title":"PLoS One"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1746-6148-9-6","article-title":"Bovine herpesvirus 4 glycoprotein B is indispensable for lytic replication and irreplaceable by VSVg","volume":"9","author":"V Franceschi","year":"2013","journal-title":"BMC Vet Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1038\/labinvest.3780373","article-title":"The pathology of experimental aerosolized monkeypox virus infection in cynomolgus monkeys (Macaca fascicularis)","volume":"81","author":"GM Zaucha","year":"2001","journal-title":"Lab Invest"},{"key":"ref41","first-page":"16","article-title":"Current Protocols in Molecular Biology: Wiley","author":"B Moss","year":"1998"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0042-6822(92)90445-U","article-title":"Restricted replication of ectromelia virus in cell culture correlates with mutations in virus-encoded host range gene","volume":"187","author":"W Chen","year":"1992","journal-title":"Virology"},{"key":"ref43","first-page":"41","article-title":"Kinetics of ectromelia virus (mousepox) transmission and clinical response in C57BL\/6j, BALB\/cByj and AKR\/J inbred mice","volume":"35","author":"GD Wallace","year":"1985","journal-title":"Lab Anim Sci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/gni035","article-title":"Simple and highly efficient BAC recombineering using galK selection","volume":"33","author":"S Warming","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-1-61779-876-4_11","article-title":"Mousepox, a small animal model of smallpox","volume":"890","author":"D Esteban","year":"2012","journal-title":"Methods Mol Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jviromet.2010.08.002","article-title":"Expression and secretion of Bluetongue virus serotype 8 (BTV-8)VP2 outer capsid protein by mammalian cells","volume":"169","author":"A Capocefalo","year":"2010","journal-title":"J Virol Methods"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1128\/JCM.43.7.3421-3426.2005","article-title":"Potential secondary pathogenic role for bovine herpesvirus 4","volume":"43","author":"G Donofrio","year":"2005","journal-title":"J Clin Microbiol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.1016\/j.vaccine.2013.06.052","article-title":"Efficient heterologous antigen gene delivery and expression by a replication-attenuated BoHV-4-based vaccine vector","volume":"31","author":"A Capocefalo","year":"2013","journal-title":"Vaccine"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"8172","DOI":"10.1128\/JVI.00621-10","article-title":"Identification of wild-derived inbred mouse strains highly susceptible to monkeypox virus infection for use as small animal models","volume":"84","author":"JL Americo","year":"2010","journal-title":"J Virol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"9105","DOI":"10.1128\/JVI.00162-12","article-title":"Lethal monkeypox virus infection of CAST\/EiJ mice is associated with a deficient gamma interferon response","volume":"86","author":"PL Earl","year":"2012","journal-title":"J Virol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3201\/eid1104.040907","article-title":"Experimental infection of prairie dogs with monkeypox virus","volume":"11","author":"SY Xiao","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3201\/eid1003.030878","article-title":"Monkeypox transmission and pathogenesis in prairie dogs","volume":"10","author":"J Guarner","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"e28295","DOI":"10.1371\/journal.pone.0028295","article-title":"Monkeypox disease transmission in an experimental setting: prairie dog animal model","volume":"6","author":"CL Hutson","year":"2011","journal-title":"PLoS One"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.3201\/eid1009.040310","article-title":"Experimental infection of ground squirrels (Spermophilus tridecemlineatus) with monkeypox virus","volume":"10","author":"RB Tesh","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4269\/ajtmh.2007.76.155","article-title":"Comparative pathology of North American and central African strains of monkeypox virus in a ground squirrel model of the disease","volume":"76","author":"E Sbrana","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2217\/17460913.2.1.17","article-title":"Human monkeypox: an emerging zoonotic disease","volume":"2","author":"S Parker","year":"2007","journal-title":"Future Microbiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1099\/vir.0.81090-0","article-title":"Ectromelia virus: the causative agent of mousepox","volume":"86","author":"DJ Esteban","year":"2005","journal-title":"J Gen Virol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1128\/IAI.72.3.1257-1264.2004","article-title":"STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection","volume":"72","author":"LC Gavrilescu","year":"2004","journal-title":"Infect Immun"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"11416","DOI":"10.1128\/JVI.78.20.11416-11421.2004","article-title":"Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1","volume":"78","author":"RJ Hogan","year":"2004","journal-title":"J Virol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1128\/JVI.02096-06","article-title":"Murine norovirus 1 infection is associated with histopathological changes in immunocompetent hosts, but clinical disease is prevented by STAT1-dependent interferon responses","volume":"81","author":"SM Mumphrey","year":"2007","journal-title":"J Virol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"6982","DOI":"10.4049\/jimmunol.176.11.6982","article-title":"STAT1 regulates IFN-alpha beta- and IFN-gamma-dependent control of infection with Chlamydia pneumoniae by nonhemopoietic cells","volume":"176","author":"AG Rothfuchs","year":"2006","journal-title":"J Immunol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.4049\/jimmunol.180.5.3319","article-title":"Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection","volume":"180","author":"LP Shornick","year":"2008","journal-title":"J Immunol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1620\/tjem.202.41","article-title":"STAT1 knockout mice are highly susceptible to pulmonary mycobacterial infection","volume":"202","author":"I Sugawara","year":"2004","journal-title":"Tohoku J Exp Med"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.micinf.2005.10.016","article-title":"Outcome of bovine herpesvirus 4 infection following direct viral injection in the lateral ventricle of the mouse brain","volume":"8","author":"G Donofrio","year":"2006","journal-title":"Microbes Infect"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/gt.2014.57","article-title":"Retinal transduction profiles by high-capacity viral vectors","volume":"21","author":"A Puppo","year":"2014","journal-title":"Gene Ther"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"e95779","DOI":"10.1371\/journal.pone.0095779","article-title":"In vivo image analysis of BoHV-4-based vector in mice","volume":"9","author":"V Franceschi","year":"2014","journal-title":"PLoS One"},{"key":"ref67","article-title":"Interferon Gamma Mediated BoHV-4 Replication Restriction in Bovine Endometrial Stromal Cells Is Host IDO1 Gene Expression Independent and BoHV-4 IE2 Gene Expression Dependent","author":"S Jacca","year":"2014","journal-title":"Biol Reprod"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1128\/JVI.61.2.395-404.1987","article-title":"A 14,000-Mr envelope protein of vaccinia virus is involved in cell fusion and forms covalently linked trimers","volume":"61","author":"JF Rodriguez","year":"1987","journal-title":"J Virol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1006\/smim.2000.0296","article-title":"Immunology 101 at poxvirus U: immune evasion genes","volume":"13","author":"B Moss","year":"2001","journal-title":"Semin Immunol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1006\/viro.1993.1302","article-title":"The vaccinia virus 42-kDa envelope protein is required for the envelopment and egress of extracellular virus and for virus virulence","volume":"194","author":"M Engelstad","year":"1993","journal-title":"Virology"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"7217","DOI":"10.1128\/JVI.66.12.7217-7224.1992","article-title":"Characterization of a vaccinia virus-encoded 42-kilodalton class I membrane glycoprotein component of the extracellular virus envelope","volume":"66","author":"SN Isaacs","year":"1992","journal-title":"J Virol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"5989","DOI":"10.1073\/pnas.0601025103","article-title":"Ligand-induced and nonfusogenic dissolution of a viral membrane","volume":"103","author":"M Law","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"10230","DOI":"10.1128\/JVI.78.19.10230-10237.2004","article-title":"Protective immunity to vaccinia virus induced by vaccination with multiple recombinant outer membrane proteins of intracellular and extracellular virions","volume":"78","author":"C Fogg","year":"2004","journal-title":"J Virol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/viro.1998.9516","article-title":"Neutralizing and protective antibodies directed against vaccinia virus envelope antigens","volume":"254","author":"MC Galmiche","year":"1999","journal-title":"Virology"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.4049\/jimmunol.177.4.2552","article-title":"Subunit recombinant vaccine protects against monkeypox","volume":"177","author":"JM Heraud","year":"2006","journal-title":"J Immunol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1006\/viro.1999.0096","article-title":"DNA vaccination with vaccinia virus L1R and A33R genes protects mice against a lethal poxvirus challenge","volume":"266","author":"JW Hooper","year":"2000","journal-title":"Virology"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"6829","DOI":"10.1128\/JVI.00353-08","article-title":"Differential antigen requirements for protection against systemic and intranasal vaccinia virus challenges in mice","volume":"82","author":"DR Kaufman","year":"2008","journal-title":"J Virol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.virol.2007.01.001","article-title":"Vaccination with Venezuelan equine encephalitis replicons encoding cowpox virus structural proteins protects mice from intranasal cowpox virus challenge","volume":"362","author":"NJ Thornburg","year":"2007","journal-title":"Virology"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.vaccine.2009.09.133","article-title":"Molecular smallpox vaccine delivered by alphavirus replicons elicits protective immunity in mice and non-human primates","volume":"28","author":"JW Hooper","year":"2009","journal-title":"Vaccine"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jmb.2004.05.028","article-title":"Improved prediction of signal peptides: SignalP 3.0","volume":"340","author":"JD Bendtsen","year":"2004","journal-title":"J Mol Biol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/protein\/gzh037","article-title":"Feature-based prediction of non-classical and leaderless protein secretion","volume":"17","author":"JD Bendtsen","year":"2004","journal-title":"Protein Eng Des Sel"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.rvsc.2005.04.001","article-title":"Bovine herpesvirus 4-associated postpartum metritis in a Spanish dairy herd","volume":"80","author":"A Monge","year":"2006","journal-title":"Res Vet Sci"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1177\/104063870201400602","article-title":"Seroprevalence and comparison of isolates of endometriotropic bovine herpesvirus-4","volume":"14","author":"KS Frazier","year":"2002","journal-title":"J Vet Diagn Invest"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1530\/REP-08-0171","article-title":"Bacterial infection of endometrial stromal cells influences bovine herpesvirus 4 immediate early gene activation: a new insight into bacterial and viral interaction for uterine disease","volume":"136","author":"G Donofrio","year":"2008","journal-title":"Reproduction"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1095\/biolreprod.110.086074","article-title":"The chemokine IL8 is up-regulated in bovine endometrial stromal cells by the BoHV-4 IE2 gene product, ORF50\/Rta: a step ahead toward a mechanism for BoHV-4 induced endometritis","volume":"83","author":"G Donofrio","year":"2010","journal-title":"Biol Reprod"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1095\/biolreprod.112.106740","article-title":"Bovine endometrial stromal cells support tumor necrosis factor alpha-induced bovine herpesvirus type 4 enhanced replication","volume":"88","author":"S Jacca","year":"2013","journal-title":"Biol Reprod"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"8562","DOI":"10.1016\/j.vaccine.2007.10.017","article-title":"Clinical and immunologic responses to multiple doses of IMVAMUNE (Modified Vaccinia Ankara) followed by Dryvax challenge","volume":"25","author":"SE Frey","year":"2007","journal-title":"Vaccine"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.vaccine.2006.10.047","article-title":"Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naive and vaccinia-immune individuals","volume":"25","author":"J Parrino","year":"2007","journal-title":"Vaccine"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.virol.2013.11.017","article-title":"Susceptibility of the wild-derived inbred CAST\/Ei mouse to infection by orthopoxviruses analyzed by live bioluminescence imaging","volume":"449","author":"JL Americo","year":"2014","journal-title":"Virology"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0003850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T18:44:01Z","timestamp":1748457841000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0003850"}},"subtitle":[],"editor":[{"given":"David Joseph","family":"Diemert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,18]]},"references-count":89,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0003850","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,18]]}}}