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Faine","year":"1994"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0749-0720(15)30532-6","article-title":"Leptospirosis as a cause of reproductive failure","volume":"10","author":"WA Ellis","year":"1994","journal-title":"Vet Clin North Am Food Anim Pract"},{"issue":"1","key":"ref18","first-page":"37","article-title":"Leptospirosis: a worldwide resurgent zoonosis and important cause of acute renal failure and death in developing nations","volume":"19","author":"LS Cruz","year":"2009","journal-title":"Ethn Dis"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/01.qco.0000178824.05715.2c","article-title":"Leptospirosis","volume":"18","author":"AJ McBride","year":"2005","journal-title":"Curr Opin Infect Dis"},{"issue":"7","key":"ref20","doi-asserted-by":"crossref","first-page":"e2324","DOI":"10.1371\/journal.pntd.0002324","article-title":"Etiology of severe non-malaria febrile illness in northern 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Abela-Ridder","year":"2010","journal-title":"Int J Antimicrob Agents"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijid.2014.06.013","article-title":"Leptospirosis in Sub-Saharan Africa: a systematic review","volume":"28c","author":"SG de Vries","year":"2014","journal-title":"Int J Infect Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1136\/bmj.b2535","article-title":"Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement","volume":"339","author":"D Moher","year":"2009","journal-title":"BMJ"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.MR000001.pub2","article-title":"Handsearching versus electronic searching to identify reports of randomized trials","author":"S Hopewell","year":"2007","journal-title":"The Cochrane database of systematic reviews"},{"key":"ref27","unstructured":"United Nations Statistics Division. Composition of macro geographical (continental) regions, geographical sub-regions, and selected economic and other groupings [Website]. 2012 [cited 2014 3rd February]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/unstats.un.org\/unsd\/methods\/m49\/m49regin.htm\" xlink:type=\"simple\">http:\/\/unstats.un.org\/unsd\/methods\/m49\/m49regin.htm<\/ext-link>."},{"key":"ref28","unstructured":"Google Translate. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.translate.google.co.uk\" xlink:type=\"simple\">http:\/\/www.translate.google.co.uk<\/ext-link> Mountain View, California, USA [cited 2013 3rd June]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/translate.google.com\" xlink:type=\"simple\">http:\/\/translate.google.com<\/ext-link>."},{"key":"ref29","unstructured":"Royal Tropical Institute (KIT). Leptospira library Amsterdam: KIT Biomedical Research; 2014 [cited 2014 3rd February]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.kit.nl\/NET\/Leptospirsosis\/LeptospiraLibrary\/Strains\/AlphabeticListBySerovar\" xlink:type=\"simple\">http:\/\/www.kit.nl\/NET\/Leptospirsosis\/LeptospiraLibrary\/Strains\/AlphabeticListBySerovar<\/ext-link>."},{"key":"ref30","author":"JP Higgins","year":"2008"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"909","DOI":"10.4269\/ajtmh.2011.11-0030","article-title":"Challenges of Establishing the Correct Diagnosis of Outbreaks of Acute Febrile Illnesses in Africa: The Case of a Likely Brucella Outbreak among Nomadic Pastoralists, Northeast Kenya, March-July 2005","volume":"85","author":"MD Ari","year":"2011","journal-title":"Am J Trop Med Hyg"},{"issue":"4","key":"ref32","first-page":"370","article-title":"An anademy of ictero-hemorrhagic leptospirosis in a military group in Algeria (author&apos;s translation)","volume":"68","author":"P Aubry","year":"1975","journal-title":"Bull Soc Pathol Exot Filiales"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"275","DOI":"10.4269\/ajtmh.2011.11-0176","article-title":"Leptospirosis among hospitalized febrile patients in northern Tanzania","volume":"85","author":"HM Biggs","year":"2011","journal-title":"Am J Trop Med Hyg"},{"issue":"6","key":"ref34","doi-asserted-by":"crossref","first-page":"e724","DOI":"10.1371\/journal.pntd.0000724","article-title":"Isolation and characterization of new Leptospira genotypes from patients in mayotte (Indian Ocean)","volume":"4","author":"P Bourhy","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1128\/JCM.05931-11","article-title":"Human leptospira isolates circulating in Mayotte (Indian Ocean) have unique serological and molecular features","volume":"50","author":"P Bourhy","year":"2012","journal-title":"J Clin Microbiol"},{"issue":"8","key":"ref36","first-page":"234","article-title":"Preliminary survey of Leptospirosis and Lyme disease amongst febrile patients attending community hospital ambulatory care in Maputo, Mozambique","volume":"43","author":"M Collares-Pereira","year":"1997","journal-title":"Cent Afr J Med"},{"issue":"9","key":"ref37","first-page":"491","article-title":"Clinical leptospirosis in Kwale District, Coast Province, Kenya","volume":"46","author":"A de Geus","year":"1969","journal-title":"East Afr Med J"},{"issue":"3","key":"ref38","first-page":"125","article-title":"Clinical leptospirosis in Kenya (2): A field study in Nyanza Province","volume":"54","author":"A de Geus","year":"1977","journal-title":"East Afr Med J"},{"issue":"3","key":"ref39","first-page":"115","article-title":"Clinical leptospirosis in Kenya (1): a clinical study in Kwale District, Coast Province","volume":"54","author":"A de Geus","year":"1977","journal-title":"East Afr Med J"},{"issue":"1","key":"ref40","first-page":"51","article-title":"An etiologic study of hemoglobinuria and blackwater fever in the Kivu Mountains, Zaire","volume":"75","author":"C Delacollette","year":"1995","journal-title":"Ann Soc Belg Med Trop"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e20377","DOI":"10.1371\/journal.pone.0020377","article-title":"Seasonality of human leptospirosis in Reunion Island (Indian Ocean) and its association with meteorological data","author":"A Desvars","year":"2011","journal-title":"PLoS One"},{"issue":"9","key":"ref42","first-page":"497","article-title":"Serological evidence of human leptospirosis in Kenya","volume":"46","author":"AT Forrester","year":"1969","journal-title":"East Afr Med J"},{"issue":"4","key":"ref43","first-page":"94","article-title":"Leptospirosis in South Africa: The occurrence of cases of leptospiral meningo-encephalitis on the witwatersrand","volume":"32","author":"J Gear","year":"1958","journal-title":"S Afr Med J"},{"issue":"4","key":"ref44","first-page":"408","article-title":"Leptospirosis in rural Ghana: Part 2. 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A case report","volume":"36","author":"RC Newman","year":"1962","journal-title":"S Afr Med J"},{"issue":"5","key":"ref58","article-title":"Laboratory-based surveillance for acute febrile illness in Egypt: A focus on leptospirosis","volume":"75","author":"TM Parker","year":"2006","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"ref59","doi-asserted-by":"crossref","first-page":"390","DOI":"10.4269\/ajtmh.2007.77.390","article-title":"Concurrent infections in acute febrile illness patients in Egypt","volume":"77","author":"TM Parker","year":"2007","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"ref60","first-page":"54","article-title":"Hyos leptospirosis in Dakar [Engl. summ.]","volume":"58","author":"M Payet","year":"1965","journal-title":"Bull Soc Pathol Exot"},{"issue":"2","key":"ref61","first-page":"207","article-title":"[Leptospirosis in Dakar]","volume":"59","author":"M Payet","year":"1966","journal-title":"Bull Soc Pathol Exot Filiales"},{"issue":"3","key":"ref62","first-page":"181","article-title":"[First clinical and serological description of leptospirosis in Gabon]","volume":"87","author":"JL Perret","year":"1994","journal-title":"Bull Soc Pathol Exot"},{"issue":"3","key":"ref63","doi-asserted-by":"crossref","first-page":"163","DOI":"10.5694\/j.1326-5377.1992.tb139700.x","article-title":"Leptospirosis in the Seychelles","volume":"156","author":"TG Pinn","year":"1992","journal-title":"Med J Aust"},{"issue":"2","key":"ref64","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s13149-010-0114-4","article-title":"Surveillance \u00e9pid\u00e9miologique de la leptospirose \u00e0 la R\u00e9union, 2004\u20132008: possible impact de l&apos;\u00e9pid\u00e9mie de chikungunya sur la l\u00e9talit\u00e9 de la leptospirose","volume":"104","author":"P Renault","year":"2011","journal-title":"Bull Soc Pathol Exot"},{"issue":"41","key":"ref65","first-page":"1010","article-title":"Leptospirosis in Cape Town","volume":"40","author":"RI Samson","year":"1966","journal-title":"S Afr Med J"},{"issue":"2","key":"ref66","first-page":"227","article-title":"[Leptospirosis in the hospital environment in Dakar (results of a new survey)]","volume":"18","author":"M Sankal\u00e9","year":"1973","journal-title":"Bull Soc Med Afr Noire Lang Fr"},{"key":"ref67","first-page":"346","article-title":"Leptospirosis in Madagascar. 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Lange","year":"1987","journal-title":"Onderstepoort J Vet Res"},{"issue":"1","key":"ref85","first-page":"1","article-title":"Endemicity of leptospirosis in domestic and wild animal species from Reunion Island (Indian Ocean)","volume":"1","author":"A Desvars","year":"2013","journal-title":"Epidemiol Infect"},{"issue":"1","key":"ref86","doi-asserted-by":"crossref","first-page":"134","DOI":"10.4269\/ajtmh.2012.12-0102","article-title":"Similarities in Leptospira serogroup and species distribution in animals and humans in the Indian Ocean island of Mayotte","volume":"87","author":"A Desvars","year":"2012","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"ref87","first-page":"29","article-title":"Bacteriological survey of leptospirosis in Zaria, Nigeria","volume":"34","author":"AA Diallo","year":"1982","journal-title":"Trop Geogr Med"},{"issue":"4","key":"ref88","first-page":"343","article-title":"Three new leptospiral serovars from Kenya","volume":"33","author":"H Dikken","year":"1981","journal-title":"Trop Geogr Med"},{"issue":"4","key":"ref89","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.20506\/rst.8.4.463","article-title":"Bacteriological examination of bovine kidneys for leptospires in Plateau State, Nigeria","volume":"8","author":"AO Ezeh","year":"1989","journal-title":"Rev Sci Tech"},{"issue":"4","key":"ref90","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.20506\/rst.8.4.462","article-title":"Characterisation of leptospires isolated from cattle and man in Plateau State, Nigeria","volume":"8","author":"AO Ezeh","year":"1989","journal-title":"Rev Sci Tech"},{"issue":"4","key":"ref91","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.20506\/rst.9.4.534","article-title":"A new leptospiral serovar in the Pyrogenes serogroup isolated in Nigeria","volume":"9","author":"AO Ezeh","year":"1990","journal-title":"Rev Sci Tech"},{"issue":"3","key":"ref92","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4269\/ajtmh.2011.10-0393","article-title":"Cross-species surveillance of Leptospira in domestic and peri-domestic animals in Mahalla City, Gharbeya Governorate, Egypt","volume":"84","author":"SA Felt","year":"2011","journal-title":"Am J Trop Med Hyg"},{"issue":"20","key":"ref93","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1136\/vr.130.20.446","article-title":"Isolation of Leptospira interrogans from kidneys of Zimbabwe beef cattle","volume":"130","author":"SB Feresu","year":"1992","journal-title":"Vet Rec"},{"issue":"1","key":"ref94","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0934-8840(99)80118-2","article-title":"Identification of a serogroup bataviae Leptospira strain isolated from an ox in Zimbabwe","volume":"289","author":"SB Feresu","year":"1999","journal-title":"Zentralbl Bakteriol"},{"issue":"1","key":"ref95","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1099\/00207713-43-1-179","article-title":"A new leptospiral serovar in the Icterohaemorrhagiae serogroup isolated from an ox in Zimbabwe","volume":"43","author":"SB Feresu","year":"1993","journal-title":"Int J Syst Bacteriol"},{"issue":"1","key":"ref96","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1099\/00207713-48-1-207","article-title":"A new leptospiral serovar, ngavi, in the Tarassovi serogroup isolated from Zimbabwe oxen","volume":"48","author":"SB Feresu","year":"1998","journal-title":"Int J Syst Bacteriol"},{"issue":"1","key":"ref97","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/0034-5288(95)90038-1","article-title":"Kemp Hvd. Identification of leptospires of the Pomona and Grippotyphosa serogroups isolated from cattle in Zimbabwe","volume":"59","author":"SB Feresu","year":"1995","journal-title":"Res Vet Sci"},{"issue":"3","key":"ref98","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1099\/00207713-44-3-541","article-title":"Classification of leptospires of the pyrogenes serogroup isolated from cattle in Zimbabwe by cross-agglutinin absorption and restriction fragment length polymorphism analysis","volume":"44","author":"SB Feresu","year":"1994","journal-title":"Int J Syst Bacteriol"},{"issue":"3","key":"ref99","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1099\/00207713-46-3-694","article-title":"Two new leptospiral serovars in the Hebdomadis serogroup isolated from Zimbabwe cattle","volume":"46","author":"SB Feresu","year":"1996","journal-title":"Int J Syst Bacteriol"},{"issue":"1","key":"ref100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4102\/jsava.v70i1.747","article-title":"Three case studies involving Leptospira interrogans serovar pomona infection in mixed farming units","volume":"70","author":"B Gummow","year":"1999","journal-title":"J S Afr Vet Assoc"},{"issue":"1","key":"ref101","first-page":"57","article-title":"Leptospira Interrogans Ssp Pomona Associated with Abortion in Cattle Isolation Methods and Laboratory Animal Histo Pathology","volume":"49","author":"S Herr","year":"1982","journal-title":"Onderstepoort J Vet Res"},{"issue":"2","key":"ref102","first-page":"83","article-title":"First isolation of Leptospira interrogans serovar pomona from cattle in Botswana","volume":"54","author":"S Herr","year":"1983","journal-title":"J S Afr Vet Assoc"},{"key":"ref103","article-title":"Leptospira spp. Prevalence in Small Mammal Populations in Cotonou, Benin","author":"G Houemenou","year":"2013","journal-title":"ISRN Epidemiology"},{"issue":"1","key":"ref104","first-page":"59","article-title":"Leptospirosis as a cause of &quot;white spot&quot; kidneys in South African pig abattoirs","volume":"54","author":"P Hunter","year":"1987","journal-title":"Onderstepoort J Vet Res"},{"key":"ref105","article-title":"Leptospira interrogans at the Human-Wildlife Interface in Northern Botswana: A Newly Identified Public Health Threat","author":"S Jobbins","year":"2013","journal-title":"Zoonoses Public Health"},{"issue":"3","key":"ref106","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11250-009-9455-z","article-title":"A microbiological and serological study of leptospirosis among pigs in the Morogoro municipality, Tanzania","volume":"42","author":"MJ Kessy","year":"2010","journal-title":"Trop Anim Health Prod"},{"issue":"10","key":"ref107","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.3201\/eid1810.111898","article-title":"Pathogenic Leptospira spp. in Bats, Madagascar and Union of the Comoros","volume":"18","author":"E Lagadec","year":"2012","journal-title":"Emerg Infect Dis"},{"issue":"1","key":"ref108","first-page":"49","article-title":"Contribution to the study of leptospirosis in rats in the city of Tunis [English and German summ.]","volume":"39","author":"K Lazuga","year":"1962","journal-title":"Arch Inst Pasteur Tunis"},{"issue":"6","key":"ref109","first-page":"569","article-title":"[Anademic focus of leptospirosis at Fondem (U.R. of Cameroon)]","volume":"70","author":"J Le Bras","year":"1977","journal-title":"Bull Soc Pathol Exot Filiales"},{"key":"ref110","first-page":"40","article-title":"Characterisation of Leptospira isolates from captive giant African pouched rats, Cricetomys gambianus","volume":"96","author":"R Machang'u","year":"2002","journal-title":"ACIAR Monograph Series"},{"issue":"Suppl.1","key":"ref111","first-page":"97","article-title":"Leptospirosis in animals and humans in selected areas of Tanzania","volume":"127","author":"RS Machang'u","year":"1997","journal-title":"Belg J Zool"},{"issue":"2","key":"ref112","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.femsim.2004.02.002","article-title":"Serological and molecular characterization of leptospira serovar Kenya from captive African giant pouched rats (Cricetomys gambianus) from Morogoro Tanzania","volume":"41","author":"RS Machang'u","year":"2004","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/infdis\/123.5.548","article-title":"Canine leptospirosis in Cairo","volume":"123","author":"RR Maronpot","year":"1971","journal-title":"J Infect Dis"},{"issue":"3","key":"ref114","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1099\/ijs.0.63278-0","article-title":"New Leptospira serovar Sokoine of serogroup Icterohaemorrhagiae from cattle in Tanzania","volume":"56","author":"GF Mgode","year":"2006","journal-title":"Int J Syst Evol Microbiol"},{"key":"ref115","first-page":"17","article-title":"PCR detection of Leptospira DNA in rodents and insectivores from Tanzania","volume":"135","author":"GF Mgode","year":"2005","journal-title":"Belg J Zool"},{"issue":"1","key":"ref116","first-page":"99","article-title":"Canine leptospirosis in Tabora township [Tanzania]","volume":"32","author":"DR Mugarula","year":"1984","journal-title":"Bull Anim Health Prod Afr"},{"issue":"30","key":"ref117","first-page":"694","article-title":"First isolations of Leptospirae in Cape Town","volume":"38","author":"J Rademan","year":"1964","journal-title":"S Afr Med J"},{"issue":"11","key":"ref118","doi-asserted-by":"crossref","first-page":"e14111","DOI":"10.1371\/journal.pone.0014111","article-title":"First isolation and direct evidence for the existence of large small-mammal reservoirs of Leptospira sp. in Madagascar","volume":"5","author":"S Rahelinirina","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"ref119","first-page":"61","article-title":"Report on an outbreak of bovine leptospirosis in Kenya due to Leptospira grippotyphosa","volume":"27","author":"H Tabel","year":"1979","journal-title":"Bull Anim Health Prod Afr"},{"issue":"1","key":"ref120","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1749-4877.2008.00072.x","article-title":"Understanding and managing sanitary risks due to rodent zoonoses in an African city: beyond the Boston Model","volume":"3","author":"PJ Taylor","year":"2008","journal-title":"Integr Zool"},{"issue":"1","key":"ref121","first-page":"51","article-title":"Leptospira-Interrogans Serovar Hardjo Associated with Bovine Abortion in South Africa","volume":"52","author":"LA Te Brugge","year":"1985","journal-title":"Onderstepoort J Vet Res"},{"issue":"4","key":"ref122","first-page":"435","article-title":"Isolation of Leptospira-Canicola in Pigs and Dogs in South Africa","volume":"44","author":"WJJ Van Rensburg","year":"1973","journal-title":"J S Afr Vet Assoc"},{"issue":"Suppl. 2","key":"ref123","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/S0924-8579(07)70159-0","article-title":"Seroprevalence and reservoirs of leptospirosis in Conakry (Guinea)","volume":"29","author":"S Zimmermann","year":"2007","journal-title":"Int J Antimicrob Agents"},{"issue":"6","key":"ref124","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.4269\/ajtmh.13-0415","article-title":"Urban leptospirosis in Africa: a cross-sectional survey of <italic>Leptospira<\/italic> infection in rodents in the Kibera urban settlement, Nairobi, Kenya","volume":"89","author":"JE Halliday","year":"2013","journal-title":"Am J Trop Med Hyg"},{"issue":"11","key":"ref125","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1111\/mec.12777","article-title":"Diversification of an emerging pathogen in a biodiversity hotspot: Leptospira in endemic small mammals of Madagascar","volume":"23","author":"M Dietrich","year":"2014","journal-title":"Mol Ecol"},{"issue":"Suppl 1","key":"ref126","first-page":"422","article-title":"Rodent species and their correlation with human seropositivity for zoonotic infections in Ghana","volume":"89","author":"SC Nimo Paintsil","year":"2013","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"ref127","first-page":"127","article-title":"Surveillance of bovine leptospirosis: isolation and serodiagnosis","volume":"13","author":"ME Hatem","year":"2014","journal-title":"Global Veterinaria"},{"key":"ref128","doi-asserted-by":"crossref","first-page":"7476","DOI":"10.1136\/bmj.38251.658229.55","article-title":"Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study","volume":"329","author":"H Reyburn","year":"2004","journal-title":"BMJ"},{"issue":"1","key":"ref129","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4269\/ajtmh.2009.81.146","article-title":"Etiology of acute undifferentiated febrile illness in the Amazon basin of Ecuador","volume":"81","author":"SR Manock","year":"2009","journal-title":"Am J Trop Med Hyg"},{"issue":"4","key":"ref130","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1179\/136485906X112158","article-title":"Causes of acute, undifferentiated, febrile illness in rural Thailand: results of a prospective observational study","volume":"100","author":"C Suttinont","year":"2006","journal-title":"Ann Trop Med Parasitol"},{"issue":"6","key":"ref131","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3201\/eid1506.081405","article-title":"Murine typhus and leptospirosis as causes of acute undifferentiated fever, Indonesia","volume":"15","author":"MH Gasem","year":"2009","journal-title":"Emerg Infect Dis"},{"issue":"6","key":"ref132","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.4269\/ajtmh.2010.09-0574","article-title":"Leptospirosis as a cause of fever in urban Bangladesh","volume":"82","author":"EA Kendall","year":"2010","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"ref133","doi-asserted-by":"crossref","DOI":"10.1186\/1297-9716-44-80","article-title":"Leptospirosis in the western Indian Ocean islands: what is known so far?","volume":"44","author":"A Desvars","year":"2013","journal-title":"Vet Res"},{"key":"ref134","article-title":"Leptospira mayottensis sp. nov., a pathogenic Leptospira species isolated from humans","author":"P Bourhy","year":"2014","journal-title":"Int J Syst Evol Microbiol"},{"key":"ref135","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1475-9276-12-91","article-title":"Lack of access to health care for African indigents: a social exclusion perspective","volume":"12","author":"W Soors","year":"2013","journal-title":"International journal for equity in health"},{"issue":"5","key":"ref136","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/j.1365-3156.2010.02497.x","article-title":"How access to health care relates to under five mortality in subSaharan Africa: systematic review","volume":"15","author":"ME Rutherford","year":"2010","journal-title":"Trop Med Int Health"},{"issue":"3","key":"ref137","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1086\/499363","article-title":"Laboratory medicine in Africa: a barrier to effective health care","volume":"42","author":"CA Petti","year":"2006","journal-title":"Clin Infect Dis"},{"key":"ref138","doi-asserted-by":"crossref","first-page":"d4847","DOI":"10.1136\/bmj.d4847","article-title":"Management of adolescents and adults with febrile illness in resource limited areas","volume":"343","author":"JA Crump","year":"2011","journal-title":"BMJ"},{"issue":"2","key":"ref139","first-page":"615","article-title":"Ecology and conservation: contributions to One Health","volume":"33","author":"S Cleaveland","year":"2014","journal-title":"Revue Scientifique et Techique (International Office of Epizootics)"},{"issue":"12","key":"ref140","doi-asserted-by":"crossref","first-page":"e1000190","DOI":"10.1371\/journal.pmed.1000190","article-title":"A &quot;One Health&quot; approach to address emerging zoonoses: The HALI project in Tanzania","volume":"6","author":"JAK Mazet","year":"2009","journal-title":"PLoS Med"},{"issue":"3\u20134","key":"ref141","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.prevetmed.2010.07.003","article-title":"From \u201cone medicine\u201d to \u201cone health\u201d and systemic approaches to health and well-being","volume":"101","author":"J Zinsstag","year":"2011","journal-title":"Prev Vet Med"},{"issue":"4","key":"ref142","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.3168\/jds.2014-8168","article-title":"Effect of exposure to Neospora caninum, Salmonella, and Leptospira interrogans serovar Hardjo on the economic performance of Irish dairy herds","volume":"98","author":"E O'Doherty","year":"2015","journal-title":"J Dairy 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