{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T22:05:27Z","timestamp":1775513127852,"version":"3.50.1"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T00:00:00Z","timestamp":1442188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0004054","type":"journal-article","created":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T18:43:30Z","timestamp":1442256210000},"page":"e0004054","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["A Proteomic Analysis of the Body Wall, Digestive Tract, and Reproductive Tract of Brugia malayi"],"prefix":"10.1371","volume":"9","author":[{"given":"C. Paul","family":"Morris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasisekhar","family":"Bennuru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura E.","family":"Kropp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse A.","family":"Zweben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaojing","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebekah T.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"King","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy D.","family":"Veenstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas B.","family":"Nutman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Mitre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,9,14]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMra1200391","article-title":"Disease eradication","volume":"368","author":"DR Hopkins","year":"2013","journal-title":"The New England journal of medicine"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1365-3024.2009.01133.x","article-title":"Filariasis and lymphoedema","volume":"31","author":"KM Pfarr","year":"2009","journal-title":"Parasite immunology"},{"issue":"5845","key":"ref3","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1126\/science.1145406","article-title":"Draft genome of the filarial nematode parasite Brugia malayi","volume":"317","author":"E Ghedin","year":"2007","journal-title":"Science"},{"issue":"23","key":"ref4","doi-asserted-by":"crossref","first-page":"9649","DOI":"10.1073\/pnas.1011481108","article-title":"Stage-specific proteomic expression patterns of the human filarial parasite Brugia malayi and its endosymbiont Wolbachia","volume":"108","author":"S Bennuru","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"e410","DOI":"10.1371\/journal.pntd.0000410","article-title":"Brugia malayi excreted\/secreted proteins at the host\/parasite interface: stage- and gender-specific proteomic profiling","volume":"3","author":"S Bennuru","year":"2009","journal-title":"PLoS neglected tropical diseases"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ng.2585","article-title":"Genomics of Loa loa, a Wolbachia-free filarial parasite of humans","volume":"45","author":"CA Desjardins","year":"2013","journal-title":"Nature genetics"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.ijpara.2012.06.004","article-title":"Multiplex proteomics analysis of gender-associated proteins in Brugia malayi","volume":"42","author":"D Jiang","year":"2012","journal-title":"International journal for parasitology"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.ijpara.2007.09.010","article-title":"Localization of gender-regulated gene expression in the filarial nematode Brugia malayi","volume":"38","author":"D Jiang","year":"2008","journal-title":"International journal for parasitology"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/1471-2164-13-184","article-title":"Transcription profiling reveals stage- and functiondependent expression patterns in the filarial nematode brugia malayi","volume":"13","author":"BW Li","year":"2012","journal-title":"BMC genomics"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molbiopara.2008.02.007","article-title":"The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products","volume":"160","author":"JP Hewitson","year":"2008","journal-title":"Molecular and biochemical parasitology"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1086\/386346","article-title":"Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of worms","volume":"189","author":"A Loukas","year":"2004","journal-title":"The Journal of infectious diseases"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1365-3024.2011.01295.x","article-title":"Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus","volume":"33","author":"CC Bassetto","year":"2011","journal-title":"Parasite immunology"},{"issue":"48","key":"ref13","doi-asserted-by":"crossref","first-page":"9057","DOI":"10.1016\/j.vaccine.2011.09.020","article-title":"The recombinant gut-associated M17 leucine aminopeptidase in combination with different adjuvants confers a high level of protection against Fasciola hepatica infection in sheep","volume":"29","author":"G Maggioli","year":"2011","journal-title":"Vaccine"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.molbiopara.2007.11.011","article-title":"Fasciola hepatica leucine aminopeptidase, a promising candidate for vaccination against ruminant fasciolosis","volume":"158","author":"D Acosta","year":"2008","journal-title":"Molecular and biochemical parasitology"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0020-7519(03)00171-1","article-title":"Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines","volume":"33","author":"JP Dalton","year":"2003","journal-title":"International journal for parasitology"},{"issue":"9","key":"ref16","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1096\/fj.09-131433","article-title":"An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection","volume":"23","author":"MS Pearson","year":"2009","journal-title":"FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"issue":"10","key":"ref17","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1086\/651953","article-title":"Neutralizing antibodies to the hookworm hemoglobinase Na-APR-1: implications for a multivalent vaccine against hookworm infection and schistosomiasis","volume":"201","author":"MS Pearson","year":"2010","journal-title":"The Journal of infectious diseases"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s10142-010-0172-5","article-title":"The gene structure and promoter region of the vaccine target aminopeptidase H11 from the blood-sucking nematode parasite of ruminants, Haemonchus contortus","volume":"10","author":"QJ Zhou","year":"2010","journal-title":"Functional & integrative genomics"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0165-2478(03)00084-1","article-title":"Immunogenicity of polymerizable synthetic peptides derived from a vaccine candidate against schistosomiasis: the asparaginyl endopeptidase (Sm32)","volume":"88","author":"N Chacon","year":"2003","journal-title":"Immunology letters"},{"issue":"3\u20134","key":"ref20","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0264-410X(01)00345-0","article-title":"DNA vaccination with asparaginyl endopeptidase (Sm32) from the parasite Schistosoma mansoni: anti-fecundity effect induced in mice","volume":"20","author":"K Chlichlia","year":"2001","journal-title":"Vaccine"},{"issue":"20","key":"ref21","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1021\/ac025747h","article-title":"Empirical statistical model to estimate the accuracy of peptide identifications made by MS\/MS and database search","volume":"74","author":"A Keller","year":"2002","journal-title":"Analytical chemistry"},{"issue":"17","key":"ref22","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1021\/ac0341261","article-title":"A statistical model for identifying proteins by tandem mass spectrometry","volume":"75","author":"AI Nesvizhskii","year":"2003","journal-title":"Analytical chemistry"},{"issue":"50","key":"ref23","doi-asserted-by":"crossref","first-page":"18928","DOI":"10.1073\/pnas.0606379103","article-title":"Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors","volume":"103","author":"AC Paoletti","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1186\/1471-2105-13-308","article-title":"Estimating relative abundances of proteins from shotgun proteomics data","volume":"13","author":"S McIlwain","year":"2012","journal-title":"BMC bioinformatics"},{"issue":"14","key":"ref25","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.1021\/ac0498563","article-title":"A model for random sampling and estimation of relative protein abundance in shotgun proteomics","volume":"76","author":"H Liu","year":"2004","journal-title":"Analytical chemistry"},{"issue":"43","key":"ref26","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"A Subramanian","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref27","first-page":"211","article-title":"The Biology of Nematodes","author":"EA Munn","year":"2002"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2307\/3279332","article-title":"The ultrastructure of adult Brugia malayi (Brug, 1927) (Nematoda: Filarioidea)","volume":"61","author":"AL Vincent","year":"1975","journal-title":"The Journal of parasitology"},{"issue":"7","key":"ref29","doi-asserted-by":"crossref","first-page":"e758","DOI":"10.1371\/journal.pntd.0000758","article-title":"Asymmetric Wolbachia segregation during early Brugia malayi embryogenesis determines its distribution in adult host tissues","volume":"4","author":"F Landmann","year":"2010","journal-title":"PLoS neglected tropical diseases"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"e1174","DOI":"10.1371\/journal.pntd.0001174","article-title":"Tissue and stage-specific distribution of Wolbachia in Brugia malayi","volume":"5","author":"K Fischer","year":"2011","journal-title":"PLoS neglected tropical diseases"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bbapap.2004.10.004","article-title":"Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage","volume":"1703","author":"H Weissbach","year":"2005","journal-title":"Biochimica et biophysica acta"},{"key":"ref32","doi-asserted-by":"crossref","DOI":"10.1142\/9781848160866_0002","article-title":"Lymphatic-dwelling Filariae","author":"AL Scott","year":"2000"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"e2678","DOI":"10.1371\/journal.pntd.0002678","article-title":"Genome-wide tissue-specific gene expression, co-expression and regulation of co-expressed genes in adult nematode Ascaris suum","volume":"8","author":"BA Rosa","year":"2014","journal-title":"PLoS neglected tropical diseases"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1749-6632.2012.06526.x","article-title":"Myosin light chain kinase: pulling the strings of epithelial tight junction function","volume":"1258","author":"KE Cunningham","year":"2012","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"G983","DOI":"10.1152\/ajpgi.00356.2006","article-title":"Role of myosin regulatory light chain and Rac1 in the migration of polyamine-depleted intestinal epithelial cells","volume":"292","author":"RM Ray","year":"2007","journal-title":"American journal of physiology Gastrointestinal and liver physiology"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"436","DOI":"10.2353\/ajpath.2009.080171","article-title":"Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion","volume":"174","author":"BA Babbin","year":"2009","journal-title":"The American journal of pathology"},{"issue":"3","key":"ref37","first-page":"439","article-title":"Calsequestrin distribution, structure and function, its role in normal and pathological situations and the effect of thyroid hormones","volume":"60","author":"P Novak","year":"2011","journal-title":"Physiological research \/ Academia Scientiarum Bohemoslovaca"},{"key":"ref38","article-title":"Functional and phylogenetic characterization of proteins detected in various nematode intestinal compartments","author":"BA Rosa","year":"2015","journal-title":"Molecular & cellular proteomics: MCP"},{"key":"ref39","doi-asserted-by":"crossref","article-title":"The C. elegans intestine","author":"JD McGhee","DOI":"10.1895\/wormbook.1.133.1"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"e9267","DOI":"10.1371\/journal.pone.0009267","article-title":"Allyl isothiocyanate that induces GST and UGT expression confers oxidative stress resistance on C. elegans, as demonstrated by nematode biosensor","volume":"5","author":"K Hasegawa","year":"2010","journal-title":"PloS one"},{"issue":"13","key":"ref41","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.1073\/pnas.89.13.5837","article-title":"Identification of the major soluble cuticular glycoprotein of lymphatic filarial nematode parasites (gp29) as a secretory homolog of glutathione peroxidase","volume":"89","author":"E Cookson","year":"1992","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref42","article-title":"Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: Implications for the development of vaccines against helminths","author":"DJ Diemert","year":"2012","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.exppara.2013.05.018","article-title":"Vaccination with intestinal tract antigens does not induce protective immunity in a permissive model of filariasis","volume":"135","author":"CP Morris","year":"2013","journal-title":"Experimental parasitology"},{"issue":"13","key":"ref44","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0020-7519(01)00272-7","article-title":"Immunisation of mice with fractions derived from the intestines of Dirofilaria immitis","volume":"31","author":"S McGonigle","year":"2001","journal-title":"International journal for parasitology"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.exppara.2004.12.003","article-title":"Setaria cervi: immunoprophylactic potential of glutathione-S-transferase against filarial parasite Brugia malayi","volume":"109","author":"S Gupta","year":"2005","journal-title":"Experimental parasitology"},{"issue":"6","key":"ref46","doi-asserted-by":"crossref","first-page":"e457","DOI":"10.1371\/journal.pntd.0000457","article-title":"Evaluation of Wuchereria bancrofti GST as a vaccine candidate for lymphatic filariasis","volume":"3","author":"A Veerapathran","year":"2009","journal-title":"PLoS neglected tropical diseases"},{"issue":"4","key":"ref47","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1182\/blood.V94.4.1418","article-title":"A novel serpin expressed by blood-borne microfilariae of the parasitic nematode Brugia malayi inhibits human neutrophil serine proteinases","volume":"94","author":"X Zang","year":"1999","journal-title":"Blood"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.molbiopara.2005.01.018","article-title":"An aspartyl protease inhibitor of Ostertagia ostertagi: molecular cloning, analysis of stage and tissue specific expression and vaccine trial","volume":"141","author":"V De Maere","year":"2005","journal-title":"Molecular and biochemical parasitology"},{"issue":"8","key":"ref49","doi-asserted-by":"crossref","first-page":"e800","DOI":"10.1371\/journal.pntd.0000800","article-title":"The Onchocerca volvulus cysteine proteinase inhibitor, Ov-CPI-2, is a target of protective antibody response that increases with age","volume":"4","author":"F Cho-Ngwa","year":"2010","journal-title":"PLoS neglected tropical diseases"},{"issue":"Pt 3","key":"ref50","first-page":"371","article-title":"Cloning and expression of cystatin, a potent cysteine protease inhibitor from the gut of Haemonchus contortus","volume":"122","author":"GF Newlands","year":"2001","journal-title":"Parasitology"},{"key":"ref51","article-title":"Secretory products of helminth parasites as immunomodulators","author":"W Harnett","year":"2014","journal-title":"Molecular and biochemical parasitology"},{"issue":"11","key":"ref52","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1128\/IAI.63.11.4417-4422.1995","article-title":"Onchocerca volvulus larval antigen, OvB20, induces partial protection in a rodent model of onchocerciasis","volume":"63","author":"MJ Taylor","year":"1995","journal-title":"Infection and immunity"},{"issue":"1","key":"ref53","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1365-3024.1996.d01-10.x","article-title":"Characterization of a secreted antigen of Onchocerca volvulus with host-protective potential","volume":"18","author":"RE Jenkins","year":"1996","journal-title":"Parasite immunology"},{"issue":"3","key":"ref54","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1128\/CMR.00002-13","article-title":"A comprehensive, model-based review of vaccine and repeat infection trials for filariasis","volume":"26","author":"CP Morris","year":"2013","journal-title":"Clinical microbiology reviews"},{"key":"ref55","doi-asserted-by":"crossref","DOI":"10.1142\/p048","article-title":"Lymphatic Filariasis","author":"TB Nutman","year":"2000"},{"key":"ref56","article-title":"The Biology of Nematodes","author":"DL Lee","year":"2002"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.molbiopara.2010.12.007","article-title":"Characterization of the DMAE-modified juvenile excretory-secretory protein Juv-p120 of Litomosoides sigmodontis","volume":"176","author":"U Wagner","year":"2011","journal-title":"Molecular and biochemical parasitology"},{"issue":"1","key":"ref58","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1101\/gad.2.1.93","article-title":"Identification and intracellular localization of the unc-22 gene product of Caenorhabditis elegans","volume":"2","author":"DG Moerman","year":"1988","journal-title":"Genes & development"},{"issue":"6","key":"ref59","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1091\/mbc.E06-02-0114","article-title":"Caenorhabditis elegans kettin, a large immunoglobulin-like repeat protein, binds to filamentous actin and provides mechanical stability to the contractile apparatuses in body wall muscle","volume":"17","author":"K Ono","year":"2006","journal-title":"Molecular biology of the cell"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T08:36:34Z","timestamp":1599554194000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004054"}},"subtitle":[],"editor":[{"given":"Makedonka","family":"Mitreva","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,9,14]]},"references-count":59,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,9,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0004054","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,14]]}}}