{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:56:53Z","timestamp":1787021813081,"version":"build-2736575974"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T00:00:00Z","timestamp":1444003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0004062","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T14:20:31Z","timestamp":1444054831000},"page":"e0004062","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits"],"prefix":"10.1371","volume":"9","author":[{"given":"Anna","family":"Crisford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Ebbinghaus-Kintscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Schoenhense","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Harder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Raming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ita","family":"O\u2019Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelechi","family":"Ndukwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindy","family":"Holden-Dye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,10,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00436-002-0619-2","article-title":"Cyclooctadepsipeptides\u2014a new class of anthelmintically active compounds","volume":"88","author":"A Harder","year":"2002","journal-title":"Parasitology Research"},{"key":"ref2","first-page":"339","article-title":"Antiparasitic and Antibacterial Drug Discovery: From Molecular Targets to Drug Candidates","author":"A Harder","year":"2009"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.ijpara.2006.10.013","article-title":"Effects of the novel anthelmintic emodepside on the locomotion, egg-laying behaviour and development of <italic>Caenorhabditis elegans<\/italic>","volume":"37","author":"K Bull","year":"2007","journal-title":"Int J Parasitol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1017\/S0031182002002639","article-title":"The effect of the anthelmintic emodepside at the neuromuscular junction of the parasitic nematode <italic>Ascaris suum<\/italic>","volume":"126","author":"J Willson","year":"2003","journal-title":"Parasitol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1476-5381.2011.01428.x","article-title":"On the mode of action of emodepside: Slow effects on membrane potential and voltage-activated currents in <italic>Ascaris suum<\/italic>","volume":"164","author":"SK Buxton","year":"2011","journal-title":"Brit J Pharmacol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e1138","DOI":"10.1371\/journal.pntd.0001138","article-title":"Potential drug development candidates for human soil-transmitted helminthiases","volume":"5","author":"P Olliaro","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref7","first-page":"93","article-title":"Activity of the cyclooctadepsipeptide emodepside against <italic>Onchocerca gutterosa<\/italic>, <italic>Onchocerca lienalis<\/italic> and <italic>Brugia pahangi<\/italic>","volume":"73","author":"S Townson","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1096\/fj.00-0664fje","article-title":"Latrophilin-like receptor from the parasitic nematode <italic>Haemonchus contortus<\/italic> as target for the anthelmintic depsipeptide PF1022A","volume":"15","author":"B Saeger","year":"2001","journal-title":"FASEB J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.cub.2004.07.056","article-title":"Latrotoxin receptor signaling engages the UNC-13-dependent vesicle-priming pathway in <italic>C<\/italic>. <italic>elegans<\/italic>","volume":"14","author":"J Willson","year":"2004","journal-title":"Current Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.ijpara.2007.05.006","article-title":"The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in <italic>Caenorhabditis elegans<\/italic>","volume":"37","author":"M Guest","year":"2007","journal-title":"Int J Parasitol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10158-007-0057-z","article-title":"SLO, SLO, quick, quick, slow: calcium-activated potassium channels as regulators of <italic>Caenorhabditis elegans<\/italic> behaviour and targets for anthelmintics","volume":"7","author":"L Holden-Dye","year":"2007","journal-title":"Inv Neurosci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e1001330","DOI":"10.1371\/journal.ppat.1001330","article-title":"SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in <italic>Caenorhabditis elegans slo-1<\/italic> loss of function mutants","volume":"7","author":"C Welz","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10158-012-0133-x","article-title":"Worms take to the slo lane: a perspective on the mode of action of emodepside","volume":"12","author":"L Holden-Dye","year":"2012","journal-title":"Inv Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"8415","DOI":"10.1073\/pnas.83.21.8415","article-title":"A Drosophila mutation that eliminates a calcium-dependent potassium current","volume":"83","author":"T Elkins","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nrn1992","article-title":"High-conductance potassium channels of the SLO family","volume":"7","author":"L Salkoff","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0896-6273(01)00522-0","article-title":"SLO-1 potassium channels control quantal content of neurotransmitter release at the <italic>C<\/italic>. <italic>elegans<\/italic> neuromuscular junction","volume":"32","author":"Z-W Wang","year":"2001","journal-title":"Neuron"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"20784","DOI":"10.1073\/pnas.1116795108","article-title":"Alternatively spliced domains interact to regulate BK potassium channel gating","volume":"108","author":"BE Johnson","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1124\/mol.111.071043","article-title":"Selective toxicity of the anthelmintic emodepside revealed by heterologous expression of human KCNMA1 in <italic>Caenorhabditis elegans<\/italic>","volume":"79","author":"A Crisford","year":"2011","journal-title":"Mol Pharmacol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e3401","DOI":"10.1371\/journal.pntd.0003401","article-title":"Characterization of the Ca<sup>2+<\/sup>-gated and voltage-dependent K<sup>+<\/sup>-channel Slo-1 of nematodes and its interaction with emodepside","volume":"8","author":"D Kulke","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"42115","DOI":"10.1074\/jbc.M304056200","article-title":"Functional annotation of the putative orphan <italic>Caenorhabditis elegans<\/italic> G-protein-coupled receptor C10C6.2 as a FLP15 peptide receptor","volume":"278","author":"TM Kubiak","year":"2003","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"C404","DOI":"10.1152\/ajpcell.1982.242.5.C404","article-title":"A simple method for the accurate determination of free [Ca] in Ca-EGTA solutions","volume":"242","author":"DM Bers","year":"1982","journal-title":"Am J Physiol"},{"key":"ref22","first-page":"1","article-title":"Methods in Cell Biology","author":"DM Bers","year":"2010"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e1000780","DOI":"10.1371\/journal.pgen.1000780","article-title":"The dystrophin complex controls BK channel localization and muscle activity in <italic>Caenorhabditis elegans<\/italic>","volume":"5","author":"H Kim","year":"2009","journal-title":"PLoS Genet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"16651","DOI":"10.1523\/JNEUROSCI.3211-10.2010","article-title":"A novel auxiliary subunit critical to BK channel function in <italic>Caenorhabditis elegans<\/italic>","volume":"30","author":"B Chen","year":"2010","journal-title":"J Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1113\/jphysiol.2010.194514","article-title":"BK-type calcium-activated potassium channels: coupling of metal ions and voltage sensing","volume":"588","author":"J Cui","year":"2010","journal-title":"J Physiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/0014-5793(96)00151-2","article-title":"A calcium switch for the functional coupling between \u03b1 (hslo) and \u03b2 subunits (KV, Ca\u03b2) of maxi K channels","volume":"382","author":"P Meera","year":"1996","journal-title":"FEBS Lett"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1124\/jpet.111.191072","article-title":"Penitrem A as a tool for understanding the role of large conductance Ca<sup>2+<\/sup>\/voltage-sensitive K<sup>+<\/sup> channels in vascular function","volume":"342","author":"S Asano","year":"2012","journal-title":"J Pharmacol Exp Therap"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1152\/jn.2000.83.6.3453","article-title":"Properties of a calcium-activated K<sup>+<\/sup> current on interneurons in the developing rat hippocampus","volume":"83","author":"T Aoki","year":"2000","journal-title":"J Neurophysiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/(SICI)1096-9063(199612)48:4<399::AID-PS503>3.0.CO;2-K","article-title":"Ionophore and anthelmintic activity of PF 1022A, a cyclooctadepsipeptide, are not related","volume":"48","author":"G Ge\u00dfner","year":"1996","journal-title":"Pesticide Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jmb.2006.02.037","article-title":"The SLO-1 BK channel of <italic>Caenorhabditis elegans<\/italic> is critical for muscle function and is involved in dystrophin-dependent muscle dystrophy","volume":"358","author":"M Carre-Pierrat","year":"2006","journal-title":"J Mol Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"16657","DOI":"10.1073\/pnas.1313433110","article-title":"Properties of Slo1 K<sup>+<\/sup> channels with and without the gating ring","volume":"110","author":"G Budelli","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0006-3495(84)84244-7","article-title":"Calcium domains associated with individual channels can account for anomolous voltage relations of CA-dependent responses","volume":"45","author":"JE Chad","year":"1984","journal-title":"Biophys J"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0896-6273(92)90160-F","article-title":"Calcium-activated potassium channels expressed from cloned complementary DNAs","volume":"9","author":"JP Adelman","year":"1992","journal-title":"Neuron"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.bcp.2009.01.005","article-title":"Effects of the anthelmintic drug PF1022A on mammalian tissue and cells","volume":"77","author":"R Dornetshuber","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e3276","DOI":"10.1371\/journal.pntd.0003276","article-title":"Diethylcarbamazine increases activation of voltage-activated potassium (SLO-1) currents in Ascaris suum and potentiates effects of emodepside","volume":"8","author":"SK Buxton","year":"2014","journal-title":"PLoS Negl Trop Dis"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T05:31:40Z","timestamp":1589002300000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004062"}},"subtitle":[],"editor":[{"given":"Timothy G.","family":"Geary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,10,5]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0004062","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,5]]}}}