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Accelerating work to overcome the global impact of neglected tropical disease: A roadmap for implementation. 2012. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/neglected_diseases\/NTD_RoadMap_2012_Fullversion.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/neglected_diseases\/NTD_RoadMap_2012_Fullversion.pdf<\/ext-link>"},{"issue":"149","key":"ref17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.actatropica.2015.05.014","article-title":"Insecticide resistance in vector Chagas disease: Evolution, mechanisms and management","volume":"21","author":"G Mougabure-Cueto","year":"2015","journal-title":"Acta Trop"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pestbp.2014.09.010","article-title":"Minireview: Mode of action of meta-diamide insecticides","volume":"121","author":"T Nakao","year":"2015","journal-title":"Pestic Biochem Physiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"20120429","DOI":"10.1098\/rstb.2012.0429","article-title":"Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth","volume":"368","author":"JP David","year":"2013","journal-title":"Phil Trans R Soc. 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