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J. Trop. Med. Hyg"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1590\/S0074-02762002000200004","article-title":"Cotton Rats (<italic>Sigmodon hispidus<\/italic>) and Black Rats (<italic>Rattus rattus<\/italic>) as Possible Reservoirs of <italic>Leishmania<\/italic> spp. in Lara State, Venezuela","volume":"97","author":"H de Lima","year":"2002","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.vetpar.2005.01.005","article-title":"PCR-based diagnosis for detection of <italic>Leishmania<\/italic> in skin and blood of rodents from an endemic area of cutaneous and visceral leishmaniasis in Brazil","volume":"129","author":"FS Oliveira","year":"2005","journal-title":"Vet Parasitol"},{"key":"ref39","first-page":"1","article-title":"Biology of the Kinetoplastida","author":"R Lainson","year":"1979"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0021-9975(96)80088-0","article-title":"Dissemination of <italic>Leishmania (Viannia) braziliensis<\/italic>","volume":"115","author":"MC Almeida","year":"1996","journal-title":"J Comp Pathol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0035-9203(64)90003-3","article-title":"The Epidemiology of Dermal Leishmaniasis in British Honduras: II. Reservoir-Hosts of <italic>Leishmania mexicana<\/italic> among the Forest Rodents","volume":"58","author":"R Lainson","year":"1964","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref42","first-page":"387","article-title":"Leishmaniose tegumentar (LT). Zoonose de roedores silvestres (<italic>Oryzomys goeldi<\/italic> Thomas) na Amaz\u00f4nia","volume":"70","author":"F Nery-Guimar\u00e3es","year":"1966","journal-title":"O Hospital"},{"key":"ref43","first-page":"1","article-title":"The Leishmaniases in Biology and Medicine: Volume I Biology and Epidemiology","author":"R Lainson","year":"1987"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pt.2006.12.010","article-title":"Sand flies and <italic>Leishmania<\/italic>: specific versus permissive vectors","volume":"23","author":"P Volf","year":"2007","journal-title":"Trends Parasitol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1590\/S0074-02762007000500001","article-title":"The leishmaniases\u2014survival and expansion in a changing world. A mini-review","volume":"102","author":"JJ Shaw","year":"2007","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0035-9203(87)90133-7","article-title":"Leishmaniasis in Brazil. XXIV. Natural flagellate infections of sandflies (Diptera: Psychodidae) in Par\u00e1 State, with particular reference to the role of <italic>Psychodopygus wellcomei<\/italic> as the vector of <italic>Leishmania braziliensis<\/italic> in the Serra dos Caraj\u00e1s","volume":"81","author":"L Ryan","year":"1987","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0035-9203(79)90225-6","article-title":"Leishmaniasis in Brazil: XIII. Isolation of <italic>Leishmania<\/italic> from armadillos (<italic>Dasypus novemcinctus<\/italic>), and observations on the epidemiology of cutaneous leishmaniasis in north Para State","volume":"73","author":"R Lainson","year":"1979","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1098\/rspb.1979.0107","article-title":"Leishmania in phlebotomid sandflies. VII. On the taxonomic status of <italic>Leishmania peruviana<\/italic>, causative agent of Peruvian &apos;uta&apos;, as indicated by its development in the sandfly, <italic>Lutzomyia longipalpis<\/italic>","volume":"206","author":"R Lainson","year":"1979","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"ref49","first-page":"232","author":"JJ Shaw","year":"1981"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1365-2915.1992.tb00606.x","article-title":"Host preferences of the phlebotomine sandfly <italic>Lutzomyia longipalpis<\/italic> in Amazonian Brazil","volume":"6","author":"RJ Quinnell","year":"1992","journal-title":"Med Vet Entomol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1046\/j.1365-2915.1999.00169.x","article-title":"Host and\/or site loyalty of <italic>Lutzomyia whitmani<\/italic> (Diptera: Psychodidae) in Brazil","volume":"13","author":"DH Campbell-Lendrum","year":"1999","journal-title":"Med Vet Entomol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"530","DOI":"10.4269\/ajtmh.1999.61.530","article-title":"Is the domestic dog (<italic>Canis familiaris<\/italic>) a reservoir host of American cutaneous leishmaniasis? 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