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5&apos;-methylthioadenosine phosphorylase","volume":"52","author":"R Guan","year":"2013","journal-title":"Biochemistry"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1128\/EC.00308-13","article-title":"Inhibition and structure of Toxoplasma gondii purine nucleoside phosphorylase","volume":"13","author":"TM Donaldson","year":"2014","journal-title":"Eukaryot Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1021\/bi902041j","article-title":"Conformational States of Human Purine Nucleoside Phosphorylase at Rest, at Work and with Transition State Analogues","volume":"49","author":"AA Edwards","year":"2010","journal-title":"Biochemistry"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1182\/blood-2009-02-207654","article-title":"Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM","volume":"114","author":"R Alonso","year":"2009","journal-title":"Blood"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1073\/pnas.0913439107","article-title":"Four generations of transition-state analogues for human purine nucleoside phosphorylase","volume":"107","author":"MC Ho","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref43","first-page":"1807","article-title":"Ann Oncol","volume":"25","author":"R Dummer","year":"2014","journal-title":"Ann Oncol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0166-6851(02)00010-5","article-title":"Nucleoside hydrolase from <italic>Leishmania (L<\/italic>.<italic>) donovani<\/italic> is an antigen diagnostic for visceral leishmaniasis","volume":"120","author":"DM Santana","year":"2002","journal-title":"Mol Biochem Parasitol"},{"key":"ref45","article-title":"In The leishmaniasis","volume":"Vol.2","author":"DJ Bradley","year":"1987"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e94596","DOI":"10.1371\/journal.pone.0094596","article-title":"Combination of Liposomal CpG Oligodeoxynucleotide 2006 and Miltefosine Induces Strong Cell-Mediated Immunity during Experimental Visceral Leishmaniasis","volume":"9","author":"R Shivahare","year":"2014","journal-title":"PLoS ONE"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/sj.icb7100011","article-title":"Balancing immunity and pathology in visceral leishmaniasis","volume":"85","author":"AC Stanley","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/jac\/dkr409","article-title":"The in vivo activity of 1,3,4-thiadiazolium-2-aminide compounds in the treatment of cutaneous and visceral leishmaniasis","volume":"67","author":"RF Rodrigues","year":"2012","journal-title":"J Antimicrob 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dogs","volume":"125","author":"E Sanchez-Robert","year":"2008","journal-title":"Vet Immunol Immunopathol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.vetimm.2006.10.001","article-title":"Analysis of the cytokine profile in spleen cells from dogs naturally infected by Leishmania chagasi","volume":"115","author":"RS Lage","year":"2007","journal-title":"Vet Immunol Immunopathol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"9375","DOI":"10.1073\/pnas.0703678104","article-title":"Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy","volume":"104","author":"J Lukes","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.provac.2009.07.019","article-title":"Nucleoside hydrolase DNA vaccine against visceral leishmaniasis","volume":"1","author":"GP Borja-Cabrera","year":"2009","journal-title":"Proc. Vaccinol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"571242","DOI":"10.4061\/2011\/571242","article-title":"Use of antimony in the treatment of leishmaniasis: current status and future directions","volume":"2011","author":"AK Haldar","year":"2011","journal-title":"Mol Biol Int"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.vetpar.2014.08.022","article-title":"Immunological profile of resistance and susceptibility in naturally infected dogs by Leishmania infantum","volume":"205","author":"GG de Almeida Leal","year":"2014","journal-title":"Vet Parasitol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1053\/rvsc.2000.0419","article-title":"Canine leishmaniasis transmission: higher infectivity amongst naturally infected dogs to sand flies is associated with lower proportions of T helper cells","volume":"69","author":"JL Guarga","year":"2000","journal-title":"Res Vet Sci"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.4049\/jimmunol.1300768","article-title":"Tissue requirements for establishing long-term CD4+ T cell-mediated immunity following Leishmania donovani infection","volume":"192","author":"PT Bunn","year":"2014","journal-title":"J Immunol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"e3198","DOI":"10.1371\/journal.pntd.0003198","article-title":"Leishmania specific CD4 T cells release IFN\u03b3 that limits parasite replication in patients with visceral leishmaniasis","volume":"8","author":"R Kumar","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1128\/CMR.19.1.111-126.2006","article-title":"Drug resistance in leishmaniasis","volume":"19","author":"SL Croft","year":"2006","journal-title":"Clin Microbiol Rev"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1182\/blood-2005-03-1309","article-title":"A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine)","volume":"106","author":"V Gandhi","year":"2005","journal-title":"Blood"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1590\/S0074-02762008000400008","article-title":"In vitro and in vivo activity of meglumine antimoniate produced at Farmanguinhos-Fiocruz, Brazil, against Leishmania (Leishmania) amazonensis, L (L.) chagasi and L (Viannia) braziliensis","volume":"103","author":"E Morais-Teixeira","year":"2008","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/jac\/dkr409","article-title":"The in vivo activity of 1,3,4-thiadiazolium-2-aminide compounds in the treatment of cutaneous and visceral leishmaniasis","volume":"67","author":"RF Rodrigues","year":"2012","journal-title":"J Antimicrob. Chemother"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1590\/0074-0276108052013014","article-title":"Biodistribution of meglumine antimoniate in healthy and Leishmania (Leishmania) infantum chagasi-infected BALB\/c mice","volume":"108","author":"SE Borborema","year":"2013","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.parint.2015.03.005","article-title":"Finding of leishmanicidal activity of 14-hydroxylunularin in mice experimentally infected with Leishmania infantum","volume":"64","author":"ME Serna","year":"2015","journal-title":"Parasitol Int"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1590\/S0036-46651999000100007","article-title":"Nephrotoxicity attributed to meglumine antimoniate (Glucantime) in the treatment of generalized cutaneous leishmaniasis","volume":"41","author":"ML Rodrigues","year":"1999","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"e48780","DOI":"10.1371\/journal.pone.0048780","article-title":"<italic>In Vitro<\/italic> and <italic>In Vivo<\/italic> Activity of an Organic Tellurium Compound on <italic>Leishmania (Leishmania) chagasi<\/italic>","volume":"7","author":"IAS Pimentel","year":"2012","journal-title":"PloS ONE"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1056\/NEJMoa066536","article-title":"Injectable paromomycin for Visceral leishmaniasis in India","volume":"356","author":"S Sundar","year":"2007","journal-title":"N Engl J Med"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1128\/AAC.01499-13","article-title":"Hepatotoxicity of pentavalent antimonial drug: possible role of residual Sb(III) and protective effect of ascorbic acid","volume":"58","author":"KC Kato","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"e1688","DOI":"10.1371\/journal.pntd.0001688","article-title":"Monitoring toxicity associated with parenteral sodium stibogluconate in the day-case management of returned travellers with New World cutaneous leishmaniasis [corrected]","volume":"6","author":"ES Wise","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref71","first-page":"147","article-title":"Renal involvement in leishmaniasis: a review of the literature","volume":"4","author":"A Clementi","year":"2011","journal-title":"NDT Plus"},{"key":"ref72","unstructured":"Minist\u00e9rio da Sa\u00fade. Secretaria de Vigil\u00e2ncia em Sa\u00fade. Tratamento. In: Manual da Vigilancia da Leishmaniose tegumentar Americana. 2.\u00aa edi\u00e7\u00e3o atualizada. S\u00e9rie A. Normas e Manuais T\u00e9cnicos. Bras\u00edlia\u2014DF 2007; pp: 78\u201379 <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ebah.com.br\/content\/\u2026\/manual-leishmaniose\" xlink:type=\"simple\">www.ebah.com.br\/content\/\u2026\/manual-leishmaniose<\/ext-link>"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1177\/096032719201100409","article-title":"Subacute toxicity of pentavalent antimony compounds in rats","volume":"11","author":"A alKhawajah","year":"1992","journal-title":"Hum Exp Toxicol"},{"key":"ref74","first-page":"365","article-title":"A comparative study between the efficacy of pentamidine isothionate given in three doses for one week and N-methil-glucamine in a dose of 20mgSbV\/day for 20 days to treat cutaneous leishmaniasis","volume":"36","author":"CD de Paula","year":"2003","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref75","first-page":"298","article-title":"Renal function in patients with mucocutaneous leishmaniasis treated with pentavalent antimony compounds","volume":"27","author":"JP Veiga","year":"1985","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1189\/jlb.1010568","article-title":"Identification of hamster inducible nitric oxide synthase (iNOS) promoter sequences that influence basal and inducible iNOS expression","volume":"92","author":"OA Saldarriaga","year":"2012","journal-title":"J Leukoc Biol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1297-9716-42-39","article-title":"Mehanisms of resitance and susceptibility to experimental visceral leishmaniosis: BALB\/c mouse versus Syrian hamster model","volume":"42","author":"A Nieto","year":"2011","journal-title":"Vet Res"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T22:33:13Z","timestamp":1567463593000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004297"}},"subtitle":[],"editor":[{"given":"Michael P","family":"Pollastri","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,23]]},"references-count":77,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0004297","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,23]]}}}