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Vibrio cholerae","volume":"186","author":"CM Lauriano","year":"2004","journal-title":"Journal of bacteriology"},{"issue":"3","key":"ref81","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1046\/j.1365-2958.1999.01624.x","article-title":"Steps in the development of a Vibrio cholerae El Tor biofilm","volume":"34","author":"PI Watnick","year":"1999","journal-title":"Molecular microbiology"},{"issue":"8","key":"ref82","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1128\/IAI.59.8.2727-2736.1991","article-title":"Roles of motility and flagellar structure in pathogenicity of Vibrio cholerae: analysis of motility mutants in three animal models","volume":"59","author":"K Richardson","year":"1991","journal-title":"Infection and immunity"},{"issue":"Pt 10","key":"ref83","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1099\/13500872-142-10-2767","article-title":"Motility mutants of Vibrio cholerae O1 have reduced adherence in vitro to human small intestinal epithelial cells as demonstrated by ELISA","volume":"142","author":"T Postnova","year":"1996","journal-title":"Microbiology"},{"issue":"24","key":"ref84","doi-asserted-by":"crossref","first-page":"8185","DOI":"10.1128\/JB.00948-08","article-title":"Genetic analysis of Vibrio cholerae monolayer formation reveals a key role for DeltaPsi in the transition to permanent attachment","volume":"190","author":"KL Van Dellen","year":"2008","journal-title":"Journal of bacteriology"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1038\/ncomms5913","article-title":"Vibrio cholerae use pili and flagella synergistically to effect motility switching and conditional surface attachment","volume":"5","author":"AS Utada","year":"2014","journal-title":"Nature communications"},{"issue":"11","key":"ref86","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1128\/JB.181.11.3606-3609.1999","article-title":"A role for the mannose-sensitive hemagglutinin in biofilm formation by Vibrio cholerae El Tor","volume":"181","author":"PI Watnick","year":"1999","journal-title":"Journal of bacteriology"},{"issue":"7","key":"ref87","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1128\/AEM.67.7.3220-3225.2001","article-title":"The mannose-sensitive hemagglutinin of Vibrio cholerae promotes adherence to zooplankton","volume":"67","author":"DA Chiavelli","year":"2001","journal-title":"Applied and environmental microbiology"},{"issue":"6","key":"ref88","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/j.1365-2958.1995.mmi_17061133.x","article-title":"Single amino acid substitutions in the N-terminus of Vibrio cholerae TcpA affect colonization, autoagglutination, and serum resistance","volume":"17","author":"SL Chiang","year":"1995","journal-title":"Molecular microbiology"},{"issue":"1","key":"ref89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsb.2011.04.008","article-title":"The physical basis of type 4 pilus-mediated microcolony formation by Vibrio cholerae O1","volume":"175","author":"BA Jude","year":"2011","journal-title":"Journal of structural biology"},{"issue":"19","key":"ref90","doi-asserted-by":"crossref","first-page":"5260","DOI":"10.1128\/JB.00378-11","article-title":"Protection and attachment of Vibrio cholerae mediated by the toxin-coregulated pilus in the infant mouse model","volume":"193","author":"SJ Krebs","year":"2011","journal-title":"Journal of bacteriology"},{"issue":"6","key":"ref91","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1365-2958.1994.tb00492.x","article-title":"TcpA pilin sequences and colonization requirements for O1 and O139 vibrio cholerae","volume":"13","author":"JA Rhine","year":"1994","journal-title":"Molecular microbiology"},{"issue":"9","key":"ref92","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.1128\/IAI.73.9.5873-5882.2005","article-title":"Cyclic diguanylate regulates Vibrio cholerae virulence gene expression","volume":"73","author":"AD Tischler","year":"2005","journal-title":"Infection and immunity"},{"issue":"15","key":"ref93","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.1128\/JB.184.15.4104-4113.2002","article-title":"The Vibrio cholerae vieSAB locus encodes a pathway contributing to cholera toxin production","volume":"184","author":"AD Tischler","year":"2002","journal-title":"Journal of bacteriology"},{"issue":"4","key":"ref94","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1128\/IAI.01337-07","article-title":"Role of cyclic Di-GMP during el tor biotype Vibrio cholerae infection: characterization of the in vivo-induced cyclic Di-GMP phosphodiesterase CdpA","volume":"76","author":"R Tamayo","year":"2008","journal-title":"Infection and immunity"},{"issue":"4","key":"ref95","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.chom.2007.09.004","article-title":"Genes induced late in infection increase fitness of Vibrio cholerae after release into the environment","volume":"2","author":"S Schild","year":"2007","journal-title":"Cell host & microbe"},{"issue":"8","key":"ref96","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1128\/IAI.67.8.3733-3739.1999","article-title":"Vibrio cholerae intestinal population dynamics in the suckling mouse model of infection","volume":"67","author":"MJ Angelichio","year":"1999","journal-title":"Infection and immunity"},{"issue":"12","key":"ref97","doi-asserted-by":"crossref","first-page":"5542","DOI":"10.1128\/IAI.01094-07","article-title":"Regulatory networks controlling Vibrio cholerae virulence gene expression","volume":"75","author":"JS Matson","year":"2007","journal-title":"Infection and immunity"},{"issue":"3","key":"ref98","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2217\/17460913.2.3.335","article-title":"Regulation of virulence in Vibrio cholerae: the ToxR regulon","volume":"2","author":"BM Childers","year":"2007","journal-title":"Future microbiology"},{"issue":"2","key":"ref99","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1073\/pnas.95.2.730","article-title":"TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae","volume":"95","author":"CC Hase","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"ref100","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1046\/j.1365-2958.2001.02518.x","article-title":"Overlapping binding sites for the virulence gene regulators AphA, AphB and cAMP-CRP at the Vibrio cholerae tcpPH promoter","volume":"41","author":"G Kovacikova","year":"2001","journal-title":"Molecular microbiology"},{"issue":"2","key":"ref101","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1128\/JB.163.2.580-585.1985","article-title":"Genetic analysis of the cholera toxin-positive regulatory gene toxR","volume":"163","author":"VL Miller","year":"1985","journal-title":"Journal of bacteriology"},{"issue":"3","key":"ref102","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1128\/jb.171.3.1288-1293.1989","article-title":"Identification of toxS, a regulatory gene whose product enhances toxR-mediated activation of the cholera toxin promoter","volume":"171","author":"VL Miller","year":"1989","journal-title":"Journal of bacteriology"},{"issue":"12","key":"ref103","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1073\/pnas.88.12.5403","article-title":"Regulatory cascade controls virulence in Vibrio cholerae","volume":"88","author":"VJ DiRita","year":"1991","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6","key":"ref104","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0092-8674(00)81551-2","article-title":"Regulation and temporal expression patterns of Vibrio cholerae virulence genes during infection","volume":"99","author":"SH Lee","year":"1999","journal-title":"Cell"},{"issue":"2","key":"ref105","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nrmicro1598","article-title":"H-NS, the genome sentinel","volume":"5","author":"CJ Dorman","year":"2007","journal-title":"Nature reviews Microbiology"},{"issue":"15","key":"ref106","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1128\/JB.182.15.4295-4303.2000","article-title":"Vibrio cholerae H-NS silences virulence gene expression at multiple steps in the ToxR regulatory cascade","volume":"182","author":"MB Nye","year":"2000","journal-title":"Journal of bacteriology"},{"issue":"1","key":"ref107","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1046\/j.1365-2958.2002.02721.x","article-title":"Regulation of gene expression in Vibrio cholerae by ToxT involves both antirepression and RNA polymerase stimulation","volume":"43","author":"RR Yu","year":"2002","journal-title":"Molecular microbiology"},{"issue":"13","key":"ref108","doi-asserted-by":"crossref","first-page":"4736","DOI":"10.1128\/JB.00089-08","article-title":"Integration host factor positively regulates virulence gene expression in Vibrio cholerae","volume":"190","author":"E Stonehouse","year":"2008","journal-title":"Journal of bacteriology"},{"issue":"4","key":"ref109","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1128\/JB.01343-09","article-title":"H-NS binding and repression of the ctx promoter in Vibrio cholerae","volume":"193","author":"EA Stonehouse","year":"2011","journal-title":"Journal of bacteriology"},{"issue":"2","key":"ref110","doi-asserted-by":"crossref","first-page":"e0118295","DOI":"10.1371\/journal.pone.0118295","article-title":"RNA-Seq Analysis Identifies New Genes Regulated by the Histone-Like Nucleoid Structuring Protein (H-NS) Affecting Vibrio cholerae Virulence, Stress Response and Chemotaxis","volume":"10","author":"H Wang","year":"2015","journal-title":"PloS one"},{"issue":"7","key":"ref111","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1128\/AEM.07629-11","article-title":"The histone-like nucleoid structuring protein (H-NS) is a repressor of Vibrio cholerae exopolysaccharide biosynthesis (vps) genes","volume":"78","author":"H Wang","year":"2012","journal-title":"Applied and environmental microbiology"},{"key":"ref112","article-title":"Repression by H-NS of genes required for the biosynthesis of the Vibrio cholerae biofilm matrix is modulated by the second messenger cyclic diguanylic acid","author":"JC Ayala","year":"2015","journal-title":"Molecular microbiology"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.gdata.2015.05.039","article-title":"RNA-Seq analysis and whole genome DNA-binding profile of the histone-like nucleoid structuring protein (H-NS)","volume":"5","author":"JC Ayala","year":"2015","journal-title":"Genomics data"},{"issue":"7","key":"ref114","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1128\/JB.02439-14","article-title":"Identification and characterization of VpsR and VpsT binding sites in Vibrio cholerae","volume":"197","author":"D Zamorano-Sanchez","year":"2015","journal-title":"Journal of bacteriology"},{"issue":"5","key":"ref115","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrmicro3007","article-title":"Genome architecture and global gene regulation in bacteria: making progress towards a unified model?","volume":"11","author":"CJ Dorman","year":"2013","journal-title":"Nature reviews Microbiology"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.genet.36.032902.111815","article-title":"DNA topology-mediated control of global gene expression in Escherichia coli","volume":"36","author":"GW Hatfield","year":"2002","journal-title":"Annual review of genetics"},{"issue":"3","key":"ref117","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0092-8674(02)00829-2","article-title":"Parallel quorum sensing systems converge to regulate virulence in Vibrio cholerae","volume":"110","author":"MB Miller","year":"2002","journal-title":"Cell"},{"issue":"4","key":"ref118","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1101\/gad.2015011","article-title":"AphA and LuxR\/HapR reciprocally control quorum sensing in vibrios","volume":"25","author":"ST Rutherford","year":"2011","journal-title":"Genes & development"},{"issue":"1","key":"ref119","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cell.2004.06.009","article-title":"The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae","volume":"118","author":"DH Lenz","year":"2004","journal-title":"Cell"},{"issue":"4","key":"ref120","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1046\/j.1365-2958.2002.03229.x","article-title":"Regulation of virulence gene expression in Vibrio cholerae by quorum sensing: HapR functions at the aphA promoter","volume":"46","author":"G Kovacikova","year":"2002","journal-title":"Molecular microbiology"},{"issue":"2","key":"ref121","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1128\/IAI.00429-09","article-title":"The virulence transcriptional activator AphA enhances biofilm formation by Vibrio cholerae by activating expression of the biofilm regulator VpsT","volume":"78","author":"M Yang","year":"2010","journal-title":"Infection and immunity"},{"issue":"7","key":"ref122","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1128\/JB.01756-07","article-title":"Quorum sensing controls biofilm formation in Vibrio cholerae through modulation of cyclic di-GMP levels and repression of vpsT","volume":"190","author":"CM Waters","year":"2008","journal-title":"Journal of bacteriology"},{"issue":"4","key":"ref123","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1128\/MMBR.00024-06","article-title":"How phosphotransferase system-related protein phosphorylation regulates carbohydrate metabolism in bacteria","volume":"70","author":"J Deutscher","year":"2006","journal-title":"Microbiology and molecular biology reviews: MMBR"},{"issue":"Pt 9","key":"ref124","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1099\/mic.0.2007\/006668-0","article-title":"The cyclic AMP receptor protein modulates quorum sensing, motility and multiple genes that affect intestinal colonization in Vibrio cholerae","volume":"153","author":"W Liang","year":"2007","journal-title":"Microbiology"},{"issue":"19","key":"ref125","doi-asserted-by":"crossref","first-page":"6374","DOI":"10.1128\/JB.186.19.6374-6382.2004","article-title":"Transcriptional regulation of Vibrio cholerae hemagglutinin\/protease by the cyclic AMP receptor protein and RpoS","volume":"186","author":"AJ Silva","year":"2004","journal-title":"Journal of bacteriology"},{"issue":"27","key":"ref126","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1016\/j.febslet.2008.10.008","article-title":"Cyclic AMP post-transcriptionally regulates the biosynthesis of a major bacterial autoinducer to modulate the cell density required to activate quorum sensing","volume":"582","author":"W Liang","year":"2008","journal-title":"FEBS letters"},{"issue":"6","key":"ref127","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1046\/j.1365-2958.2002.02857.x","article-title":"Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae","volume":"43","author":"DS Merrell","year":"2002","journal-title":"Molecular microbiology"},{"issue":"4","key":"ref128","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1128\/IAI.01356-09","article-title":"Vibrio cholerae phosphoenolpyruvate phosphotransferase system control of carbohydrate transport, biofilm formation, and colonization of the germfree mouse intestine","volume":"78","author":"L Houot","year":"2010","journal-title":"Infection and immunity"},{"issue":"22","key":"ref129","doi-asserted-by":"crossref","first-page":"7482","DOI":"10.1128\/AEM.01564-07","article-title":"The cyclic AMP receptor protein modulates colonial morphology in Vibrio cholerae","volume":"73","author":"W Liang","year":"2007","journal-title":"Applied and environmental microbiology"},{"issue":"12","key":"ref130","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1128\/JB.00213-10","article-title":"The phosphoenolpyruvate phosphotransferase system regulates Vibrio cholerae biofilm formation through multiple independent pathways","volume":"192","author":"L Houot","year":"2010","journal-title":"Journal of bacteriology"},{"issue":"1","key":"ref131","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1128\/JB.01410-07","article-title":"A novel role for enzyme I of the Vibrio cholerae phosphoenolpyruvate phosphotransferase system in regulation of growth in a biofilm","volume":"190","author":"L Houot","year":"2008","journal-title":"Journal of bacteriology"},{"issue":"3","key":"ref132","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1574-6976.2008.00101.x","article-title":"The phosphate regulon and bacterial virulence: a regulatory network connecting phosphate homeostasis and pathogenesis","volume":"32","author":"MG Lamarche","year":"2008","journal-title":"FEMS microbiology reviews"},{"issue":"6","key":"ref133","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1111\/j.1365-2958.2010.07310.x","article-title":"PhoB regulates both environmental and virulence gene expression in Vibrio cholerae","volume":"77","author":"JT Pratt","year":"2010","journal-title":"Molecular microbiology"},{"issue":"17","key":"ref134","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.1128\/JB.00092-09","article-title":"Cell envelope perturbation induces oxidative stress and changes in iron homeostasis in Vibrio cholerae","volume":"191","author":"AE Sikora","year":"2009","journal-title":"Journal of bacteriology"},{"issue":"1","key":"ref135","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1365-2958.2005.04846.x","article-title":"Bile acids stimulate biofilm formation in Vibrio cholerae","volume":"59","author":"DT Hung","year":"2006","journal-title":"Molecular microbiology"},{"issue":"7","key":"ref136","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1128\/IAI.01664-14","article-title":"Bile acids and bicarbonate inversely regulate intracellular cyclic di-GMP in Vibrio cholerae","volume":"82","author":"BJ Koestler","year":"2014","journal-title":"Infection and immunity"},{"issue":"1","key":"ref137","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1128\/IAI.02617-14","article-title":"Host intestinal signal-promoted biofilm dispersal induces Vibrio cholerae colonization","volume":"83","author":"AJ Hay","year":"2015","journal-title":"Infection and immunity"},{"issue":"3","key":"ref138","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1128\/IAI.65.3.1131-1134.1997","article-title":"Bile affects production of virulence factors and motility of Vibrio cholerae","volume":"65","author":"S Gupta","year":"1997","journal-title":"Infection and immunity"},{"issue":"4","key":"ref139","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1128\/IAI.01435-06","article-title":"Effect of fatty acids and cholesterol present in bile on expression of virulence factors and motility of Vibrio cholerae","volume":"75","author":"A Chatterjee","year":"2007","journal-title":"Infection and immunity"},{"issue":"5","key":"ref140","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1128\/JB.181.5.1508-1514.1999","article-title":"Environmental signals modulate ToxT-dependent virulence factor expression in Vibrio cholerae","volume":"181","author":"DA Schuhmacher","year":"1999","journal-title":"Journal of bacteriology"},{"key":"ref141","article-title":"The mechanism for inhibition of Vibrio cholerae ToxT activity by the unsaturated fatty acid components of bile","author":"SC Plecha","year":"2015","journal-title":"Journal of bacteriology"},{"issue":"9","key":"ref142","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1128\/IAI.00409-09","article-title":"Bicarbonate Induces Vibrio cholerae virulence gene expression by enhancing ToxT activity","volume":"77","author":"BH Abuaita","year":"2009","journal-title":"Infection and immunity"},{"issue":"22","key":"ref143","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1128\/JB.01824-14","article-title":"Bicarbonate increases binding affinity of Vibrio cholerae ToxT to virulence gene promoters","volume":"196","author":"JJ Thomson","year":"2014","journal-title":"Journal of bacteriology"},{"issue":"4","key":"ref144","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrmicro2538","article-title":"Mucin dynamics and enteric pathogens","volume":"9","author":"MA McGuckin","year":"2011","journal-title":"Nature reviews Microbiology"},{"issue":"5","key":"ref145","doi-asserted-by":"crossref","first-page":"G922","DOI":"10.1152\/ajpgi.2001.280.5.G922","article-title":"The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo","volume":"280","author":"C Atuma","year":"2001","journal-title":"American journal of physiology Gastrointestinal and liver physiology"},{"issue":"4","key":"ref146","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0966-842X(00)01721-2","article-title":"The suckling mouse model of cholera","volume":"8","author":"KE Klose","year":"2000","journal-title":"Trends in microbiology"},{"issue":"1","key":"ref147","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00047-10","article-title":"Back to the future: studying cholera pathogenesis using infant rabbits","volume":"1","author":"JM Ritchie","year":"2010","journal-title":"mBio"},{"issue":"25","key":"ref148","doi-asserted-by":"crossref","first-page":"8736","DOI":"10.1073\/pnas.0803281105","article-title":"A defined transposon mutant library and its use in identifying motility genes in Vibrio cholerae","volume":"105","author":"DE Cameron","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"ref149","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1046\/j.1365-2958.1998.00726.x","article-title":"Use of signature-tagged transposon mutagenesis to identify Vibrio cholerae genes critical for colonization","volume":"27","author":"SL Chiang","year":"1998","journal-title":"Molecular microbiology"},{"issue":"6","key":"ref150","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.chom.2013.11.001","article-title":"Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host","volume":"14","author":"Y Fu","year":"2013","journal-title":"Cell host & microbe"},{"issue":"2","key":"ref151","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.chom.2011.07.007","article-title":"RNA-Seq-based monitoring of infection-linked changes in Vibrio cholerae gene expression","volume":"10","author":"A Mandlik","year":"2011","journal-title":"Cell host & microbe"},{"issue":"7","key":"ref152","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1073\/pnas.91.7.2634","article-title":"Use of genetic recombination as a reporter of gene expression","volume":"91","author":"A Camilli","year":"1994","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"ref153","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1365-2958.1995.mmi_18040671.x","article-title":"Use of recombinase gene fusions to identify Vibrio cholerae genes induced during infection","volume":"18","author":"A Camilli","year":"1995","journal-title":"Molecular microbiology"},{"issue":"12","key":"ref154","doi-asserted-by":"crossref","first-page":"6889","DOI":"10.1073\/pnas.111581598","article-title":"Selection for in vivo regulators of bacterial virulence","volume":"98","author":"SH Lee","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"46","key":"ref155","doi-asserted-by":"crossref","first-page":"18229","DOI":"10.1073\/pnas.0705636104","article-title":"An in vivo expression technology screen for Vibrio cholerae genes expressed in human volunteers","volume":"104","author":"MJ Lombardo","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"9","key":"ref156","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1073\/pnas.84.9.2833","article-title":"Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin","volume":"84","author":"RK Taylor","year":"1987","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"ref157","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jmb.2011.03.027","article-title":"Crystal structure of the Vibrio cholerae colonization factor TcpF and identification of a functional immunogenic site","volume":"409","author":"CJ Megli","year":"2011","journal-title":"Journal of molecular biology"},{"issue":"8","key":"ref158","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1128\/IAI.00048-10","article-title":"Growth in a biofilm induces a hyperinfectious phenotype in Vibrio cholerae","volume":"78","author":"R Tamayo","year":"2010","journal-title":"Infection and immunity"},{"issue":"4","key":"ref159","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S1534-5807(03)00295-8","article-title":"Quorum sensing-dependent biofilms enhance colonization in Vibrio cholerae","volume":"5","author":"J Zhu","year":"2003","journal-title":"Developmental cell"},{"issue":"5","key":"ref160","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1128\/IAI.06277-11","article-title":"The Vibrio cholerae Pst2 phosphate transport system is upregulated in biofilms and contributes to biofilm-induced hyperinfectivity","volume":"80","author":"B Mudrak","year":"2012","journal-title":"Infection and immunity"},{"issue":"14","key":"ref161","doi-asserted-by":"crossref","first-page":"5018","DOI":"10.1073\/pnas.0308052101","article-title":"Both chemotaxis and net motility greatly influence the infectivity of Vibrio cholerae","volume":"101","author":"SM Butler","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"8","key":"ref162","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrmicro1207","article-title":"Going against the grain: chemotaxis and infection in Vibrio cholerae","volume":"3","author":"SM Butler","year":"2005","journal-title":"Nature reviews Microbiology"},{"issue":"1","key":"ref163","doi-asserted-by":"crossref","first-page":"e1002373","DOI":"10.1371\/journal.ppat.1002373","article-title":"The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces","volume":"8","author":"E Wong","year":"2012","journal-title":"PLoS pathogens"},{"issue":"4","key":"ref164","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1758-2229.2012.00356.x","article-title":"Role of GbpA protein, an important virulence-related colonization factor, for Vibrio cholerae&apos;s survival in the aquatic environment","volume":"4","author":"M Stauder","year":"2012","journal-title":"Environmental microbiology reports"},{"issue":"11","key":"ref165","doi-asserted-by":"crossref","first-page":"4968","DOI":"10.1128\/IAI.01615-07","article-title":"Intestinal adherence of Vibrio cholerae involves a coordinated interaction between colonization factor GbpA and mucin","volume":"76","author":"R Bhowmick","year":"2008","journal-title":"Infection and immunity"},{"issue":"28","key":"ref166","doi-asserted-by":"crossref","first-page":"9769","DOI":"10.1073\/pnas.0802241105","article-title":"Mucosal penetration primes Vibrio cholerae for host colonization by repressing quorum sensing","volume":"105","author":"Z Liu","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"16","key":"ref167","doi-asserted-by":"crossref","first-page":"5024","DOI":"10.1128\/jb.178.16.5024-5026.1996","article-title":"Effect of viscosity on swimming by the lateral and polar flagella of Vibrio alginolyticus","volume":"178","author":"T Atsumi","year":"1996","journal-title":"Journal of bacteriology"},{"issue":"12","key":"ref168","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1128\/JB.183.12.3784-3790.2001","article-title":"Flagellum-independent surface migration of Vibrio cholerae and Escherichia coli","volume":"183","author":"II Brown","year":"2001","journal-title":"Journal of bacteriology"},{"issue":"11","key":"ref169","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1128\/jb.173.11.3311-3317.1991","article-title":"Cloning and nucleotide sequence of the Vibrio cholerae hemagglutinin\/protease (HA\/protease) gene and construction of an HA\/protease-negative strain","volume":"173","author":"CC Hase","year":"1991","journal-title":"Journal of bacteriology"},{"issue":"Pt 7","key":"ref170","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1099\/mic.0.26086-0","article-title":"Haemagglutinin\/protease expression and mucin gel penetration in El Tor biotype Vibrio cholerae","volume":"149","author":"AJ Silva","year":"2003","journal-title":"Microbiology"},{"issue":"3","key":"ref171","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1128\/IAI.02841-14","article-title":"Vibrio cholerae Represses Polysaccharide Synthesis To Promote Motility in Mucosa","volume":"83","author":"Z Liu","year":"2015","journal-title":"Infection and immunity"},{"issue":"10","key":"ref172","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1128\/JB.187.10.3551-3555.2005","article-title":"Virulence and the environment: a novel role for Vibrio cholerae toxin-coregulated pili in biofilm formation on chitin","volume":"187","author":"G Reguera","year":"2005","journal-title":"Journal of bacteriology"},{"issue":"5","key":"ref173","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1073\/pnas.052694299","article-title":"Quorum-sensing regulators control virulence gene expression in Vibrio cholerae","volume":"99","author":"J Zhu","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"ref174","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1128\/IAI.60.2.472-478.1992","article-title":"Vibrio cholerae hemagglutinin\/protease, colonial variation, virulence, and detachment","volume":"60","author":"RA Finkelstein","year":"1992","journal-title":"Infection and immunity"},{"issue":"8","key":"ref175","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1128\/IAI.65.8.3474-3477.1997","article-title":"Adherence of Vibrio cholerae to cultured differentiated human intestinal cells: an in vitro colonization model","volume":"65","author":"JA Benitez","year":"1997","journal-title":"Infection and immunity"},{"issue":"16","key":"ref176","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/S0264-410X(96)00105-3","article-title":"Tagging a Vibrio cholerae El Tor candidate vaccine strain by disruption of its hemagglutinin\/protease gene using a novel reporter enzyme: Clostridium thermocellum endoglucanase A","volume":"14","author":"A Robert","year":"1996","journal-title":"Vaccine"},{"issue":"5","key":"ref177","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1046\/j.1365-2958.1997.6402011.x","article-title":"Characterization of hapR, a positive regulator of the Vibrio cholerae HA\/protease gene hap, and its identification as a functional homologue of the Vibrio harveyi luxR gene","volume":"26","author":"MG Jobling","year":"1997","journal-title":"Molecular microbiology"},{"issue":"4","key":"ref178","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1073\/pnas.80.4.1092","article-title":"Vibrio cholerae hemagglutinin\/lectin\/protease hydrolyzes fibronectin and ovomucin: F.M. Burnet revisited","volume":"80","author":"RA Finkelstein","year":"1983","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"22","key":"ref179","doi-asserted-by":"crossref","first-page":"6911","DOI":"10.1128\/JB.00747-09","article-title":"Levels of the secreted Vibrio cholerae attachment factor GbpA are modulated by quorum-sensing-induced proteolysis","volume":"191","author":"BA Jude","year":"2009","journal-title":"Journal of bacteriology"},{"issue":"33","key":"ref180","doi-asserted-by":"crossref","first-page":"10491","DOI":"10.1073\/pnas.1512424112","article-title":"In situ proteolysis of the Vibrio cholerae matrix protein RbmA promotes biofilm recruitment","volume":"112","author":"DR Smith","year":"2015","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"ref181","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1128\/JB.05900-11","article-title":"Interaction of the histone-like nucleoid structuring protein and the general stress response regulator RpoS at Vibrio cholerae promoters that regulate motility and hemagglutinin\/protease expression","volume":"194","author":"H Wang","year":"2012","journal-title":"Journal of bacteriology"},{"issue":"10","key":"ref182","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1371\/journal.ppat.0020109","article-title":"RpoS controls the Vibrio cholerae mucosal escape response","volume":"2","author":"AT Nielsen","year":"2006","journal-title":"PLoS pathogens"},{"issue":"5","key":"ref183","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1128\/JB.00993-13","article-title":"The LuxR-type regulator VpsT negatively controls the transcription of rpoS, encoding the general stress response regulator, in Vibrio cholerae biofilms","volume":"196","author":"H Wang","year":"2014","journal-title":"Journal of bacteriology"},{"issue":"22","key":"ref184","doi-asserted-by":"crossref","first-page":"7335","DOI":"10.1128\/JB.00360-08","article-title":"Role of the histone-like nucleoid structuring protein in the regulation of rpoS and RpoS-dependent genes in Vibrio cholerae","volume":"190","author":"AJ Silva","year":"2008","journal-title":"Journal of bacteriology"},{"issue":"8","key":"ref185","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1128\/IAI.01620-07","article-title":"Vibrio cholerae RND family efflux systems are required for antimicrobial resistance, optimal virulence factor production, and colonization of the infant mouse small intestine","volume":"76","author":"XR Bina","year":"2008","journal-title":"Infection and immunity"},{"issue":"18","key":"ref186","doi-asserted-by":"crossref","first-page":"10220","DOI":"10.1073\/pnas.170219997","article-title":"Altered expression of the ToxR-regulated porins OmpU and OmpT diminishes Vibrio 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