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Proceedings of the AAPS; 2007 Nov 12\u201316, San Diego, CA, J9: Abstract No. 3732, 2007,"},{"key":"ref24","first-page":"169","article-title":"A card-agglutination test with stained trypanosomes (C.A.T.T.) for the serological diagnosis of T. B. gambiense trypanosomiasis","volume":"58","author":"E Magnus","year":"1978","journal-title":"Ann Soc Belg Med Trop"},{"key":"ref25","unstructured":"WHO report on global surveillance of epidemtic-prone infections diseases\u2014African trypanosomiasis. Control and surveillance of African trypanosomiasis: report of WHO expert committee. Geneva. 1998. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/csr\/resources\/publications\/CSR_ISR_2000_1tryps\/en\/index7.html\" xlink:type=\"simple\">http:\/\/www.who.int\/csr\/resources\/publications\/CSR_ISR_2000_1tryps\/en\/index7.html<\/ext-link>."},{"key":"ref26","first-page":"298","article-title":"Evaluation of the haematocrit centrifuge and other techniques for the field diagnosis of human trypanosomiasis and filariasis","volume":"28","author":"PT Woo","year":"1971","journal-title":"Acta Trop"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0035-9203(79)90092-0","article-title":"Trypanosoma brucei: miniature anion-exchange centrifugation technique for detection of low parasitaemias: adaptation for field use","volume":"73","author":"WH Lumsden","year":"1979","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref28","article-title":"Clinical trials: a practical approach","author":"SJ Pocock","year":"1991"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e383","DOI":"10.1371\/journal.pntd.0000383","article-title":"Cardiac alterations in human African trypanosomiasis (T.b. gambiense) with respect to the disease stage and antiparasitic treatment","volume":"3","author":"JA Blum","year":"2009","journal-title":"PLoS Negl Trop Dis"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T21:52:36Z","timestamp":1540331556000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004362"}},"subtitle":[],"editor":[{"given":"Carlos","family":"Franco-Paredes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,16]]},"references-count":29,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0004362","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,16]]}}}