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Geopolitical Assessments; 2008. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.geopolitical-assessments.com\/Pakistan_s_Tribal_Areas.pdf\" xlink:type=\"simple\">http:\/\/www.geopolitical-assessments.com\/Pakistan_s_Tribal_Areas.pdf<\/ext-link>"},{"key":"ref11","unstructured":"Refugees UNHCf. UNHCR Global Trends; 2012. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.unhcr.org.uk\/fileadmin\/user_upload\/pdf\/UNHCR_Global_Trends_2012.pdf\" xlink:type=\"simple\">http:\/\/www.unhcr.org.uk\/fileadmin\/user_upload\/pdf\/UNHCR_Global_Trends_2012.pdf<\/ext-link>."},{"key":"ref12","unstructured":"Agency UTUR. Emergency Response for Internally Displaced Persons from North Waziristan Agency in Pakistan. 2014. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.unhcr.org\/53da47479.pdf\" xlink:type=\"simple\">http:\/\/www.unhcr.org\/53da47479.pdf<\/ext-link>."},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1371\/journal.pmed.0050127","article-title":"Plasmodium vivax and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea","volume":"5","author":"B Genton","year":"2008","journal-title":"PLoS Med"},{"issue":"Suppl 1","key":"ref14","first-page":"7","article-title":"Severe Malaria","volume":"19","year":"2014","journal-title":"Trop Med Int Health"},{"issue":"24","key":"ref15","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1056\/NEJMoa0804915","article-title":"A trial of combination antimalarial therapies in children from Papua New Guinea","volume":"359","author":"HA Karunajeewa","year":"2008","journal-title":"N Engl J Med"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0166-6851(93)90050-8","article-title":"Identification of the four human malaria parasite species in field samples by the polymerase chain reaction and detection of a high prevalence of mixed infections","volume":"58","author":"G Snounou","year":"1993","journal-title":"Mol Biochem Parasitol"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1086\/341938","article-title":"of microscopy error on estimates of protective efficacy in malaria-prevention trials","volume":"186","author":"C Ohrt","year":"2002","journal-title":"J Infect Dis"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"525","DOI":"10.4269\/ajtmh.2009.81.525","article-title":"Prevalence of antimalarial drug resistance mutations in Plasmodium vivax and P. falciparum from a malaria-endemic 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