{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:08:03Z","timestamp":1774066083642,"version":"3.50.1"},"reference-count":105,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T00:00:00Z","timestamp":1455062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0004406","type":"journal-article","created":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T19:05:02Z","timestamp":1455131102000},"page":"e0004406","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Comparative Transcriptomic Exploration Reveals Unique Molecular Adaptations of Neuropathogenic Trichobilharzia to Invade and Parasitize Its Avian Definitive Host"],"prefix":"10.1371","volume":"10","author":[{"given":"Roman","family":"Leontovy\u010d","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil D.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasi K.","family":"Korhonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross S.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libor","family":"Mike\u0161","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Ka\u0161n\u00fd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Hor\u00e1k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin B.","family":"Gasser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,2,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1051\/parasite\/1998054349","article-title":"Trichobilharzia regenti n. sp. (Schistosomatidae, Bilharziellinae), a new nasal schistosome from Europe","volume":"5","author":"P Horak","year":"1998","journal-title":"Parasite"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0065-308X(02)52012-1","article-title":"Biology of the schistosome genus <italic>Trichobilharzia<\/italic>","volume":"52","author":"P Horak","year":"2002","journal-title":"Adv Parasitol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.meegid.2010.08.001","article-title":"Molecular diversity of Trichobilharzia franki in two intermediate hosts (Radix auricularia and Radix peregra): a complex of species","volume":"10","author":"D Jouet","year":"2010","journal-title":"Infect Genet Evol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1645\/GE-2297.1","article-title":"Detection of European Trichobilharzia schistosomes (T. franki, T. szidati, and T. regenti) based on novel genome sequences","volume":"96","author":"A V Korsunenko","year":"2010","journal-title":"J Parasitol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1079\/JOH2005327","article-title":"Identification of an avian schistosome recovered from Aythya novaeseelandia and infectivity of its miracidia to Lymnaea tomentosa snails","volume":"80","author":"NE Davis","year":"2006","journal-title":"J Helminthol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/zph.12020","article-title":"Avian schistosomes and human cercarial dermatitis in a wildlife refuge in Mazandaran Province, northern Iran","volume":"60","author":"S Gohardehi","year":"2013","journal-title":"Zoonoses Public Health"},{"issue":"Pt 6","key":"ref7","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1017\/S0031182099005132","article-title":"<italic>Trichobilharzia regenti<\/italic>, a pathogen of the avian and mammalian central nervous systems","volume":"119","author":"P Horak","year":"1999","journal-title":"Parasitology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1079\/JOH2002113","article-title":"Neurotropic behaviour of <italic>Trichobilharzia regenti<\/italic> in ducks and mice","volume":"76","author":"K Hradkova","year":"2002","journal-title":"J Helminthol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s00436-009-1343-y","article-title":"In vitro cultivation of early schistosomula of nasal and visceral bird schistosomes (Trichobilharzia spp., Schistosomatidae)","volume":"104","author":"M Chanov\u00e1","year":"2009","journal-title":"Parasitol Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1365-2427.2010.02545.x","article-title":"Snails, waterfowl and cercarial dermatitis","volume":"56","author":"P Hor\u00e1k","year":"2011","journal-title":"Freshw Biol. Blackwell Publishing Ltd"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.pt.2012.12.002","article-title":"Swimmer\u2019s itch: etiology, impact, and risk factors in Europe","volume":"29","author":"M Soldanova","year":"2013","journal-title":"Trends Parasitol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1128\/CMR.00043-14","article-title":"Avian schistosomes and outbreaks of cercarial dermatitis","volume":"28","author":"P Horak","year":"2015","journal-title":"Clin Microbiol Rev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1708-8305.1996.tb00731.x","article-title":"Schistosomiasis in Travelers and Expatriates","volume":"3","author":"Jelinek","year":"1996","journal-title":"J Travel Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00436-002-0607-6","article-title":"Variations in immunofluorescent antibody response against <italic>Trichobilharzia<\/italic> and Schistosoma antigens in compatible and incompatible hosts","volume":"88","author":"P Kourilov\u00e1","year":"2002","journal-title":"Parasitol Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF00260453","article-title":"Biology and development of Trichobilharzia Szidati N. Sp. (Trematoda, Schistosmatidae), a parasite causing dermatitis in man","volume":"15","author":"W Neuhaus","year":"1952","journal-title":"Z Parasitenkd"},{"key":"ref16","first-page":"337","article-title":"Parasitology","author":"JR Lawson","year":"1980"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/1756-3305-4-162","article-title":"Secretory glands in cercaria of the neuropathogenic schistosome Trichobilharzia regenti\u2014ultrastructural characterization, 3-D modelling, volume and pH estimations","volume":"4","author":"A Ligasova","year":"2011","journal-title":"Parasit Vectors"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s00436-005-1347-1","article-title":"In vitro stimulation of penetration gland emptying by Trichobilharzia szidati and T. regenti (Schistosomatidae) cercariae. Quantitative collection and partial characterization of the products","volume":"96","author":"L Mikes","year":"2005","journal-title":"Parasitol Res"},{"key":"ref19","first-page":"205","article-title":"Advances in parasitology","author":"M Kasny","year":"2009"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ijpara.2008.06.010","article-title":"The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome <italic>Trichobilharzia regenti<\/italic>","volume":"39","author":"K Doleckova","year":"2009","journal-title":"Int J Parasitol"},{"issue":"Pt 2","key":"ref21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1017\/S0031182097002059","article-title":"Cercaria-schistosomulum surface transformation of <italic>Trichobilharzia szidati<\/italic> and its putative immunological impact","volume":"116","author":"P Horak","year":"1998","journal-title":"Parasitology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/269147a0","article-title":"Blood flukes have a double outer membrane","volume":"269","author":"DJ Mclaren","year":"1977","journal-title":"Nature."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0166-6851(92)90202-U","article-title":"The reversible effect of glucose on the energy metabolism of <italic>Schistosoma mansoni<\/italic> cercariae and schistosomula","volume":"51","author":"AM Horemans","year":"1992","journal-title":"Mol Biochem Parasitol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0166-6851(93)90032-S","article-title":"Expression of <italic>Schistosoma mansoni<\/italic> genes involved in anaerobic and oxidative glucose metabolism during the cercaria to adult transformation","volume":"60","author":"PJ Skelly","year":"1993","journal-title":"Mol Biochem Parasitol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e1274","DOI":"10.1371\/journal.pntd.0001274","article-title":"Gene expression patterns in larval Schistosoma mansoni associated with infection of the mammalian host","volume":"5","author":"SJ Parker-Manuel","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.exppara.2011.04.006","article-title":"<italic>Trichobilharzia regenti<\/italic>: host immune response in the pathogenesis of neuroinfection in mice","volume":"128","author":"L Lichtenbergova","year":"2011","journal-title":"Exp Parasitol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"105","DOI":"10.14411\/fp.2007.014","article-title":"Terminal phase of bird schistosomiasis caused by Trichobilharzia regenti (Schistosomatidae) in ducks (Anas platyrhynchos f. domestica)","volume":"54","author":"M Chanova","year":"2007","journal-title":"Folia Parasitol (Praha)"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s004360100431","article-title":"Histopathology of CNS and nasal infections caused by <italic>Trichobilharzia regenti<\/italic> in vertebrates","volume":"87","author":"L Kolarova","year":"2001","journal-title":"Parasitol Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"AM Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"ref30","unstructured":"FastQC. A quality control tool for high throughput sequence data. Babraham Bioinforma Web site <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/\" xlink:type=\"simple\">http\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/<\/ext-link>."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1089\/cmb.2013.0084","article-title":"Assembling single-cell genomes and mini-metagenomes from chimeric MDA products","volume":"20","author":"S Nurk","year":"2013","journal-title":"J Comput Biol"},{"key":"ref32","first-page":"1","article-title":"A Reference-Free Algorithm for Computational Normalization arXiv : 1203","author":"CT Brown","year":"2012"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1093\/bioinformatics\/bts094","article-title":"Oases: robust de novo RNA-seq assembly across the dynamic range of expression levels","volume":"28","author":"MH Schulz","year":"2012","journal-title":"Bioinformatics"},{"key":"ref34","first-page":"3150","article-title":"Bioinformatics","author":"L Fu","year":"2012"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/nprot.2013.084","article-title":"De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis","volume":"8","author":"BJ Haas","year":"2013","journal-title":"Nat Protoc"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/bioinformatics\/btm071","article-title":"CEGMA: a pipeline to accurately annotate core genes in eukaryotic genomes","volume":"23","author":"G Parra","year":"2007","journal-title":"Bioinformatics"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"D7","DOI":"10.1093\/nar\/gkt1146","article-title":"Database resources of the National Center for Biotechnology Information","volume":"42","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"ref38","unstructured":"Smit AFA, Hubley R GP. RepeatMasker Open-3.0. [<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.repeatmasker.org\" xlink:type=\"simple\">http:\/\/www.repeatmasker.org<\/ext-link>] webcite."},{"key":"ref39","doi-asserted-by":"crossref","first-page":"R89","DOI":"10.1186\/gb-2013-14-8-r89","article-title":"The genome and developmental transcriptome of the strongylid nematode <italic>Haemonchus contortus<\/italic>","volume":"14","author":"EM Schwarz","year":"2013","journal-title":"Genome Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"bar009","DOI":"10.1093\/database\/bar009","article-title":"UniProt Knowledgebase: a hub of integrated protein data","volume":"2011","author":"M Magrane","year":"2011","journal-title":"Database (Oxford)"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"D227","DOI":"10.1093\/nar\/gkp971","article-title":"MEROPS: the peptidase database","volume":"38","author":"ND Rawlings","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"M Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/bioinformatics\/17.9.847","article-title":"InterProScan\u2014an integration platform for the signature-recognition methods in InterPro","volume":"17","author":"EM Zdobnov","year":"2001","journal-title":"Bioinformatics"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e21800","DOI":"10.1371\/journal.pone.0021800","article-title":"REVIGO summarizes and visualizes long lists of gene ontology terms","volume":"6","author":"F Supek","year":"2011","journal-title":"PLoS One"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/1471-2105-10-274","article-title":"MultiLoc2: integrating phylogeny and Gene Ontology terms improves subcellular protein localization prediction","volume":"10","author":"T Blum","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"B Li","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"MD Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"ref48","article-title":"R: A Language and Environment for Statistical Computing","year":"2008"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1186\/1471-2105-12-480","article-title":"GC-content normalization for RNA-Seq data","volume":"12","author":"D Risso","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/bib\/bbs046","article-title":"A comprehensive evaluation of normalization methods for Illumina high-throughput RNA sequencing data analysis","volume":"14","author":"M-A Dillies","year":"2013","journal-title":"Brief Bioinform"},{"key":"ref51","unstructured":"Alexa A and Rahnenfuhrer J. topGO: Enrichment analysis for Gene Ontology. R package version 2.20.0. [Internet]. 2010. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.bioconductor.org\/packages\/release\/bioc\/html\/topGO.html\" xlink:type=\"simple\">http:\/\/www.bioconductor.org\/packages\/release\/bioc\/html\/topGO.html<\/ext-link>"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ng.1065","article-title":"Whole-genome sequence of <italic>Schistosoma haematobium<\/italic>","volume":"44","author":"ND Young","year":"2012","journal-title":"Nat Genet"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature08160","article-title":"The genome of the blood fluke <italic>Schistosoma mansoni<\/italic>","volume":"460","author":"M Berriman","year":"2009","journal-title":"Nature"},{"key":"ref54","first-page":"345","article-title":"The Schistosoma japonicum genome reveals features of host-parasite interplay","volume":"460","year":"2009","journal-title":"Nature. Macmillan Publishers Limited"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1017\/S0031182007002910","article-title":"Comparison of cysteine peptidase activities in <italic>Trichobilharzia regenti<\/italic> and <italic>Schistosoma mansoni<\/italic> cercariae","volume":"134","author":"M Kasny","year":"2007","journal-title":"Parasitology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"94","DOI":"10.14411\/fp.2007.012","article-title":"Peptidases of Trichobilharzia regenti (Schistosomatidae) and its molluscan host Radix peregra S. Lat. (Lymnaeidae): construction and screening of cDNA library from intramolluscan stages of the parasite","volume":"54","author":"K Doleckova","year":"2007","journal-title":"Folia Parasitol (Praha)"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.biochi.2007.08.013","article-title":"Differential use of protease families for invasion by schistosome cercariae","volume":"90","author":"J Dvor\u00e1k","year":"2008","journal-title":"Biochimie"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1471-4922(02)00019-3","article-title":"Invasion of skin by schistosome cercariae: some neglected facts","volume":"19","author":"RS Curwen","year":"2003","journal-title":"Trends Parasitol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"24618","DOI":"10.1074\/jbc.M202364200","article-title":"Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes","volume":"277","author":"JP Salter","year":"2002","journal-title":"J Biol Chem"},{"key":"ref60","first-page":"301","article-title":"The role of bovines in human <italic>Schistosoma japonicum<\/italic> infection in the Peoples\u2019 Republic of China","volume":"81","author":"DJ Gray","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"R65","DOI":"10.1186\/gb-2007-8-4-r65","article-title":"Gene expression patterns during adaptation of a helminth parasite to different environmental niches","volume":"8","author":"ER Jolly","year":"2007","journal-title":"Genome Biol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2164-10-128","article-title":"Developmental gene expression profiles of the human pathogen <italic>Schistosoma japonicum<\/italic>","volume":"10","author":"GN Gobert","year":"2009","journal-title":"BMC Genomics"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/ng1237","article-title":"Transcriptome analysis of the acoelomate human parasite <italic>Schistosoma mansoni<\/italic>","volume":"35","author":"S Verjovski-Almeida","year":"2003","journal-title":"Nat Genet"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0166-6851(84)90121-X","article-title":"The energy metabolism of <italic>Fasciola hepatica<\/italic> during its development in the final host","volume":"13","author":"AG Tielens","year":"1984","journal-title":"Mol Biochem Parasitol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1017\/S0031182001007211","article-title":"<italic>Fasciola hepatica<\/italic> miracidia are dependent on respiration and endogenous glycogen degradation for their energy generation","volume":"122","author":"H Boyunaga","year":"2001","journal-title":"Parasitology"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1590\/S0074-02762002000900014","article-title":"Clustering of <italic>Schistosoma mansoni<\/italic> mRNA sequences and analysis of the most transcribed genes: Implications in metabolism and biology of different developmental stages","volume":"97","author":"F Prosdocimi","year":"2002","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"Pt 2","key":"ref67","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1017\/S0031182000062582","article-title":"The enigmatic presence of all gluconeogenic enzymes in <italic>Schistosoma mansoni<\/italic> adults","volume":"102","author":"AG Tielens","year":"1991","journal-title":"Parasitology"},{"key":"ref68","first-page":"85","article-title":"Properties of gluconeogenesis enzymes from flatworms","volume":"37","author":"EA Burenina","year":"2001","journal-title":"Zh Evol Biokhim Fiziol"},{"issue":"Pt 3","key":"ref69","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1017\/S0031182000061497","article-title":"Aerobic to anaerobic transition in the carbohydrate metabolism of <italic>Schistosoma mansoni<\/italic> cercariae during transformation in vitro","volume":"98","author":"BE Van Oordt","year":"1989","journal-title":"Parasitology"},{"key":"ref70","article-title":"Parasitic flatworms: molecular biology, biochemistry, immunology and physiology","author":"A. G. M. Tielens","year":"2006"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0065-308X(08)60306-1","article-title":"Amino acid metabolism in helminths","volume":"30","author":"J Barrett","year":"1991","journal-title":"Adv Parasitol. ENGLAND"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0166-6851(99)00100-0","article-title":"Analysis of the gene expression profile of <italic>Schistosoma mansoni<\/italic> cercariae using the expressed sequence tag approach","volume":"103","author":"TM Santos","year":"1999","journal-title":"Mol Biochem Parasitol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0166-6851(89)90008-X","article-title":"Rapid changes in the expression of a gene encoding a calcium-binding protein in <italic>Schistosoma mansoni<\/italic>","volume":"34","author":"D Ram","year":"1989","journal-title":"Mol Biochem Parasitol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF00380799","article-title":"Schistosoma mansoni: localization of calcium-detecting reagents in electron-lucent areas of specific preacetabular gland granules","volume":"54","author":"CH Dorsey","year":"1977","journal-title":"Z Parasitenkd"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S0169-4758(98)01321-0","article-title":"Schistosomes: unanswered questions on the basic biology of the host-parasite relationship","volume":"14","author":"J Modha","year":"1998","journal-title":"Parasitol Today"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0014-4894(74)90036-8","article-title":"<italic>Schistosoma mansoni<\/italic>: effect of some cations on the proteolytic enzymes of cercariae","volume":"35","author":"MH Dresden","year":"1974","journal-title":"Exp Parasitol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1042\/bj2310047","article-title":"Proteinases from invasive larvae of the trematode parasite <italic>Schistosoma mansoni<\/italic> degrade connective-tissue and basement-membrane macromolecules","volume":"231","author":"JH McKerrow","year":"1985","journal-title":"Biochem J"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0925-4439(93)90087-H","article-title":"Characterization of Ca(2+)-dependent neutral protease (calpain) from human blood flukes, Schistosoma mansoni","volume":"1181","author":"AA Siddiqui","year":"1993","journal-title":"Biochim Biophys Acta"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1017\/S1462399409001082","article-title":"Adhesion of <italic>Plasmodium falciparum<\/italic>-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications","volume":"11","author":"JA Rowe","year":"2009","journal-title":"Expert Rev Mol Med"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0092-8674(00)81279-9","article-title":"Cell adhesion: the molecular basis of tissue architecture and morphogenesis","volume":"84","author":"BM Gumbiner","year":"1996","journal-title":"Cell"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1161\/CIRCRESAHA.108.188144","article-title":"Guidance of vascular development: lessons from the nervous system","volume":"104","author":"B Larrivee","year":"2009","journal-title":"Circ Res"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.conb.2010.04.011","article-title":"Setting up presynaptic structures at specific positions","volume":"20","author":"C-Y Ou","year":"2010","journal-title":"Curr Opin Neurobiol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0020-7519(00)00031-X","article-title":"Induction cues for tegument formation during the transformation of <italic>Schistosoma mansoni<\/italic> cercariae","volume":"30","author":"PJ Skelly","year":"2000","journal-title":"Int J Parasitol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.pt.2004.03.004","article-title":"Blood \u201cn\u201d guts: an update on schistosome digestive peptidases","volume":"20","author":"CR Caffrey","year":"2004","journal-title":"Trends Parasitol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.ijpara.2005.02.018","article-title":"Multiple cathepsin B isoforms in schistosomula of <italic>Trichobilharzia regenti<\/italic>: identification, characterisation and putative role in migration and nutrition","volume":"35","author":"J Dvorak","year":"2005","journal-title":"Int J Parasitol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jmb.2004.04.063","article-title":"Inactive enzyme-homologues find new function in regulatory processes","volume":"340","author":"B Pils","year":"2004","journal-title":"J Mol Biol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00436-010-1943-6","article-title":"Cathepsins B1 and B2 in the neuropathogenic schistosome <italic>Trichobilharzia regenti<\/italic>: distinct gene expression profiles and presumptive roles throughout the life cycle","volume":"107","author":"K Doleckov\u00e1","year":"2010","journal-title":"Parasitol Res"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/3284308","article-title":"Proteinases secreted by <italic>Fasciola hepatica<\/italic> degrade extracellular matrix and basement membrane components","volume":"83","author":"P Berasa\u00edn","year":"1997","journal-title":"J Parasitol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1074\/jbc.M308831200","article-title":"Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propetide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells","volume":"279","author":"PR Collins","year":"2004","journal-title":"J Biol Chem"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1432-1033.1995.490_2.x","article-title":"Purification and characterization of acid cysteine protease from metacercariae of the mammalian trematode parasite <italic>Paragonimus westermani<\/italic>","volume":"233","author":"K Yamakami","year":"1995","journal-title":"Eur J Biochem"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1017\/S0031182001007521","article-title":"<italic>Schistosoma japonicum<\/italic> cathepsin D aspartic protease cleaves human IgG and other serum components","volume":"122","author":"CK Verity","year":"2001","journal-title":"Parasitology"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"39316","DOI":"10.1074\/jbc.M607128200","article-title":"A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite","volume":"281","author":"M Delcroix","year":"2006","journal-title":"J Biol Chem"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/gb-2011-12-10-r107","article-title":"The draft genome of the carcinogenic human liver fluke <italic>Clonorchis sinensis<\/italic>","volume":"12","author":"X Wang","year":"2011","journal-title":"Genome Biol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000472399","article-title":"A single PCR marker in strong allelic association with the infantile form of neuronal ceroid lipofuscinosis facilitates reliable prenatal diagnostics and disease carrier identification","volume":"1","author":"J Vesa","year":"1993","journal-title":"Eur J Hum Genet"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ymgme.2004.06.013","article-title":"Niemann-Pick type C disease: importance of N-glycosylation sites for function and cellular location of the NPC2 protein","volume":"83","author":"K Chikh","year":"2004","journal-title":"Mol Genet Metab"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1038\/ncomms5378","article-title":"The <italic>Opisthorchis viverrini<\/italic> genome provides insights into life in the bile duct","volume":"5","author":"ND Young","year":"2014","journal-title":"Nat Commun"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/BJ20050051","article-title":"A short guided tour through functional and structural features of saposin-like proteins","volume":"389","author":"H Bruhn","year":"2005","journal-title":"Biochem J"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0005-2760(92)90210-M","article-title":"Activator proteins and topology of lysosomal sphingolipid catabolism","volume":"1126","author":"W Furst","year":"1992","journal-title":"Biochim Biophys Acta"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1002\/j.1460-2075.1992.tb05432.x","article-title":"Primary and secondary structure of the pore-forming peptide of pathogenic <italic>Entamoeba histolytica<\/italic>","volume":"11","author":"M Leippe","year":"1992","journal-title":"EMBO J"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1016\/j.ijid.2007.10.007","article-title":"Saposin-like proteins are expressed in the gastrodermis of <italic>Schistosoma mansoni<\/italic> and are immunogenic in natural infections","volume":"12","author":"TA Don","year":"2008","journal-title":"Int J Infect Dis"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1645\/GE-3113","article-title":"Molecular cloning of a member of the <italic>Fasciola hepatica<\/italic> saposin-like protein family","volume":"89","author":"AM Espino","year":"2003","journal-title":"J Parasitol"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S0022-2836(03)00216-X","article-title":"Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease","volume":"327","author":"BL Mark","year":"2003","journal-title":"J Mol Biol"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"10195","DOI":"10.1523\/JNEUROSCI.0822-13.2013","article-title":"Gangliosides and gangliosidoses: principles of molecular and metabolic pathogenesis","volume":"33","author":"K Sandhoff","year":"2013","journal-title":"J Neurosci"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0925-4439(99)00074-5","article-title":"Biochemical consequences of mutations causing the GM2 gangliosidoses","volume":"1455","author":"DJ Mahuran","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0166-6851(88)90145-4","article-title":"Purification, characterization, and immunochemical studies of beta-N-acetyl-D-hexosaminidase from the parasitic nematode <italic>Trichinella spiralis<\/italic>","volume":"31","author":"ML Rhoads","year":"1988","journal-title":"Mol Biochem Parasitol"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T08:39:44Z","timestamp":1718354384000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004406"}},"subtitle":[],"editor":[{"given":"Matty","family":"Knight","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,10]]},"references-count":105,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0004406","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,10]]}}}