{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:24:31Z","timestamp":1791239071413,"version":"4.1.0"},"reference-count":16,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T00:00:00Z","timestamp":1457568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0004429","type":"journal-article","created":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T18:38:58Z","timestamp":1457635138000},"page":"e0004429","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["Funding and Innovation in Diseases of Neglected Populations: The Paradox of Cryptococcal Meningitis"],"prefix":"10.1371","volume":"10","author":[{"given":"Marcio L.","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,3,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.tim.2014.01.001","article-title":"A neglected epidemic: fungal infections in HIV\/AIDS","volume":"22","author":"D Armstrong-James","year":"2014","journal-title":"Trends Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/QAD.0b013e328322ffac","article-title":"Estimation of the current global burden of cryptococcal meningitis among persons living with HIV\/AIDS","volume":"23","author":"BJ Park","year":"2009","journal-title":"AIDS"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1590\/0001-3765201520140704","article-title":"Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis","volume":"87","author":"AC Colombo","year":"2015","journal-title":"An Acad Bras Cienc"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.fgb.2014.12.001","article-title":"Toward improved anti-cryptococcal drugs: Novel molecules and repurposed drugs","volume":"78","author":"DJ Krysan","year":"2015","journal-title":"Fungal Genet Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2217\/fmb.11.162","article-title":"Research trends on pathogenic Cryptococcus species in the last 20 years: a global analysis with focus on Brazil","volume":"7","author":"PC Albuquerque","year":"2012","journal-title":"Future Microbiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1126\/science.aaa6097","article-title":"Infectious Disease. How to bolster the antifungal pipeline","volume":"347","author":"DW Denning","year":"2015","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S1473-3099(14)70945-4","article-title":"Management of Cryptococcus gattii meningoencephalitis","volume":"15","author":"C Franco-Paredes","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1093\/jac\/dkv040","article-title":"Introduction of an antifungal stewardship programme targeting high-cost antifungals at a tertiary hospital in Cambridge, England","volume":"70","author":"C Micallef","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1179\/204777312X13419245939566","article-title":"Amphotericin B still in the headlines","volume":"106","author":"L Romani","year":"2012","journal-title":"Pathog Glob Health"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jcrc.2010.08.005","article-title":"The value of amphotericin B in the treatment of invasive fungal infections","volume":"26","author":"M Klepser","year":"2011","journal-title":"J Crit Care"},{"key":"ref11","unstructured":"Global Action Fund for Fungal Infections (2014) Limited availability of generic antifungals across the world. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.gaffi.org\/limited-availability-of-generic-antifungals-across-the-world\/\" xlink:type=\"simple\">http:\/\/www.gaffi.org\/limited-availability-of-generic-antifungals-across-the-world\/<\/ext-link>."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"a019653","DOI":"10.1101\/cshperspect.a019653","article-title":"Antifungal pharmacokinetics and pharmacodynamics","volume":"5","author":"AJ Lepak","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1086\/507895","article-title":"Symptomatic relapse of HIV-associated cryptococcal meningitis after initial fluconazole monotherapy: the role of fluconazole resistance and immune reconstitution","volume":"43","author":"T Bicanic","year":"2006","journal-title":"Clin Infect Dis"},{"key":"ref14","unstructured":"Moran M, Chapan N, Abela-Oversteegen L, Chowdhary V, Doubell A, et al. (2015) G-FINDER: Neglected Disease Research and Developent: the Ebola Effect. G-FINDER. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.policycures.org\/downloads\/Y8%20GFINDER%20full%20report%20web.pdf\" xlink:type=\"simple\">http:\/\/www.policycures.org\/downloads\/Y8%20GFINDER%20full%20report%20web.pdf<\/ext-link>."},{"key":"ref15","unstructured":"WHO (2014) How many TB cases and deaths are there? <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/gho\/tb\/epidemic\/cases_deaths\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/gho\/tb\/epidemic\/cases_deaths\/en\/<\/ext-link>."},{"key":"ref16","unstructured":"WHO (2015) Malaria. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/mediacentre\/factsheets\/fs094\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/mediacentre\/factsheets\/fs094\/en\/<\/ext-link>."}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T22:29:15Z","timestamp":1655245755000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004429"}},"subtitle":[],"editor":[{"given":"Joseph M.","family":"Vinetz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,10]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0004429","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,10]]}}}