{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:15:58Z","timestamp":1781576158583,"version":"3.54.5"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0004456","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T19:18:49Z","timestamp":1456168729000},"page":"e0004456","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques"],"prefix":"10.1371","volume":"10","author":[{"given":"Travis K.","family":"Warren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris A.","family":"Whitehouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Welch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay S.","family":"Charleston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Heald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald K.","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc E.","family":"Mattix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Palacios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Kugleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick L.","family":"Iversen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Bavari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,2,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.3390\/v4101878","article-title":"Forty-five years of Marburg virus research","volume":"4","author":"K Brauburger","year":"2012","journal-title":"Viruses"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.2217\/fvl.11.79","article-title":"Clinical aspects of Marburg hemorrhagic fever","volume":"6","author":"M Mehedi","year":"2011","journal-title":"Future Virol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S1473-3099(12)70018-X","article-title":"Acute liver failure, multiorgan failure, cerebral oedema, and activation of proangiogenic and antiangiogenic factors in a case of Marburg haemorrhagic fever","volume":"12","author":"J van Paassen","year":"2012","journal-title":"Lancet Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/S0140-6736(06)68546-2","article-title":"Postexposure protection against Marburg haemorrhagic fever with recombinant vesicular stomatitis virus vectors in non-human primates: an efficacy assessment","volume":"367","author":"KM Daddario-DiCaprio","year":"2006","journal-title":"Lancet"},{"issue":"Suppl 2","key":"ref5","doi-asserted-by":"crossref","first-page":"S372","DOI":"10.1086\/520608","article-title":"Marburg virus Angola infection of rhesus macaques: pathogenesis and treatment with recombinant nematode anticoagulant protein c2","volume":"196","author":"TW Geisbert","year":"2007","journal-title":"J Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/infdis\/jit465","article-title":"Protection against lethal marburg virus infection mediated by lipid encapsulated small interfering RNA","volume":"209","author":"R Ursic-Bedoya","year":"2014","journal-title":"J Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"250ra116","DOI":"10.1126\/scitranslmed.3009706","article-title":"Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA","volume":"6","author":"EP Thi","year":"2014","journal-title":"Sci Transl Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e1004463","DOI":"10.1371\/journal.ppat.1004463","article-title":"Interaction with Tsg101 is necessary for the efficient transport and release of nucleocapsids in marburg virus-infected cells","volume":"10","author":"O Dolnik","year":"2014","journal-title":"PLoS Pathog"},{"issue":"Suppl 3","key":"ref9","doi-asserted-by":"crossref","first-page":"S927","DOI":"10.1093\/infdis\/jir319","article-title":"Phosphorylation of Marburg virus NP region II modulates viral RNA synthesis","volume":"204","author":"A DiCarlo","year":"2011","journal-title":"J Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.addr.2007.09.002","article-title":"Cell penetrating peptide conjugates of steric block oligonucleotides","volume":"60","author":"B Lebleu","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1089\/oli.1.1996.6.267","article-title":"Resistance of morpholino phosphorodiamidate oligomers to enzymatic degradation","volume":"6","author":"RM Hudziak","year":"1996","journal-title":"Antisense Nucleic Acid Drug Dev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1021\/bc060138s","article-title":"Stability of cell-penetrating peptide-morpholino oligomer conjugates in human serum and in cells","volume":"18","author":"DS Youngblood","year":"2007","journal-title":"Bioconjug Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1128\/AAC.50.3.984-993.2006","article-title":"VP35 knockdown inhibits Ebola virus amplification and protects against lethal infection in mice","volume":"50","author":"S Enterlein","year":"2006","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1128\/AAC.00936-08","article-title":"Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection","volume":"53","author":"DL Swenson","year":"2009","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"11510","DOI":"10.1128\/JVI.00900-06","article-title":"Inhibition of coxsackievirus B3 in cell cultures and in mice by peptide-conjugated morpholino oligomers targeting the internal ribosome entry site","volume":"80","author":"J Yuan","year":"2006","journal-title":"Journal of Virology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1099\/vir.0.83449-0","article-title":"Morpholino oligomers targeting the PB1 and NP genes enhance the survival of mice infected with highly pathogenic influenza A H7N7 virus","volume":"89","author":"G Gabriel","year":"2008","journal-title":"Journal of General Virology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s00705-008-0067-0","article-title":"Inhibition of influenza A H3N8 virus infections in mice by morpholino oligomers","volume":"153","author":"C Lupfer","year":"2008","journal-title":"Arch Virol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.virol.2008.03.032","article-title":"Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers","volume":"376","author":"S Paessler","year":"2008","journal-title":"Virology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1089\/108729001753231696","article-title":"Inhibition of Vesivirus infections in mammalian tissue culture with antisense morpholino oligomers","volume":"11","author":"DA Stein","year":"2001","journal-title":"Antisense Nucleic Acid Drug Dev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1128\/JVI.79.8.5116-5128.2005","article-title":"Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with morpholino oligomers","volume":"79","author":"RM Kinney","year":"2005","journal-title":"Journal of Virology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"9665","DOI":"10.1128\/JVI.79.15.9665-9676.2005","article-title":"Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers","volume":"79","author":"BW Neuman","year":"2005","journal-title":"Journal of Virology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/nm.2202","article-title":"Advanced antisense therapies for postexposure protection against lethal filovirus infections","volume":"16","author":"TK Warren","year":"2010","journal-title":"Nature Medicine"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.3390\/v4112806","article-title":"Discovery and early development of AVI-7537 and AVI-7288 for the treatment of Ebola virus and Marburg virus infections","volume":"4","author":"PL Iversen","year":"2012","journal-title":"Viruses"},{"key":"ref24","unstructured":"United States National Research Council (2011) Guide for the care and use of laboratory animals."},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.3390\/v6114666","article-title":"Euthanasia assessment in ebola virus infected nonhuman primates","volume":"6","author":"TK Warren","year":"2014","journal-title":"Viruses"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0140-6736(82)91871-2","article-title":"Marburg-virus disease in Kenya","volume":"1","author":"DH Smith","year":"1982","journal-title":"Lancet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.antiviral.2012.02.004","article-title":"Advanced morpholino oligomers: a novel approach to antiviral therapy","volume":"94","author":"TK Warren","year":"2012","journal-title":"Antiviral Res"},{"issue":"Suppl 3","key":"ref28","doi-asserted-by":"crossref","first-page":"S1021","DOI":"10.1093\/infdis\/jir339","article-title":"Pathogenesis of Marburg hemorrhagic fever in cynomolgus macaques","volume":"204","author":"LE Hensley","year":"2011","journal-title":"J Infect Dis"},{"key":"ref29","article-title":"Filoviruses\u2014A Compendium of 40 Years of Epidemiological, Clinical, and Laboratory Studies","author":"JH Kuhn","year":"2008"},{"key":"ref30","first-page":"398","article-title":"Spermatogenic transmission of the &quot;Marburg virus&quot;. (Causes of &quot;Marburg simian disease&quot;)","volume":"46","author":"GA Martini","year":"1968","journal-title":"Klin Wochenschr"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/QCO.0000000000000135","article-title":"Ebola virus as a sexually transmitted infection","volume":"28","author":"KE Rogstad","year":"2015","journal-title":"Curr Opin Infect Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1056\/NEJMoa1410345","article-title":"AVI-7288 for Marburg Virus in Nonhuman Primates and Humans","volume":"373","author":"AE Heald","year":"2015","journal-title":"N Engl J Med"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T03:55:45Z","timestamp":1588996545000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004456"}},"subtitle":[],"editor":[{"given":"Anita K.","family":"McElroy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,22]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0004456","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,22]]}}}