{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T23:08:50Z","timestamp":1794092930776,"version":"4.8.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:00:00Z","timestamp":1455840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0004457","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T18:39:45Z","timestamp":1455907185000},"page":"e0004457","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Assessment of Point-of-Care Diagnostics for G6PD Deficiency in Malaria Endemic Rural Eastern Indonesia"],"prefix":"10.1371","volume":"10","author":[{"given":"Ari W.","family":"Satyagraha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkasha","family":"Sadhewa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalie","family":"Elvira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqbal","family":"Elyazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denny","family":"Feriandika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ungke","family":"Antonjaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Oyong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Decy","family":"Subekti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail E.","family":"Rozi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo J.","family":"Domingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alida R.","family":"Harahap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Kevin","family":"Baird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(08)60073-2","article-title":"Glucose-6-phosphate dehydrogenase deficiency","volume":"371","author":"MD Cappellini","year":"2008","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2165\/11536520-000000000-00000","article-title":"Medications and glucose-6-phosphate dehydrogenase deficiency: and evidence-based review","volume":"33","author":"I Youngster","year":"2010","journal-title":"Drug Saf"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/B978-0-12-407826-0.00004-7","article-title":"G6PD deficiency: global distribution, genetic variants and primaquine therapy","volume":"81","author":"RE Howes","year":"2013","journal-title":"Adv Parasitol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1086\/379714","article-title":"Primaquine therapy for malaria","volume":"37","author":"JK Baird","year":"2004","journal-title":"Clin Infect Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1126\/science.124.3220.484-a","article-title":"Enzymatic deficiency in primaquine-sensitive erythrocytes","volume":"124","author":"AS Alving","year":"1956","journal-title":"Science"},{"key":"ref6","first-page":"171","article-title":"The hemolytic effect of primaquine. II. The natural course of hemolytic anemia and mechanism of its self-limited character","volume":"44","author":"R Dern","year":"1954","journal-title":"J Lab Clin Med"},{"key":"ref7","first-page":"621","article-title":"Mitigation of the haemolytic effect of primaquine and enhancement of its action against exoerythrocytic forms of the Chesson strain of Plasmodium vivax by intermittent regimens of drug administration","volume":"22","author":"AS Alving","year":"1960","journal-title":"Bull WHO"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1182\/blood.V25.1.92.92","article-title":"The course of experimentally induced hemolytic anemia in a primaquine-sensitive Caucasian: a case study","volume":"25","author":"I Pannacciulli","year":"1965","journal-title":"Blood"},{"key":"ref9","first-page":"80","article-title":"Primaquine sensitivity in Caucasians: hemolytic reactions induced by primaquine in G6PD deficient subjects","volume":"70","author":"JN George","year":"1967","journal-title":"J Lab Clin Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1172\/JCI104969","article-title":"Relationship between age and enzymatic activities in human erythrocytes from normal and fava bean-sensitive subject","volume":"43","author":"A Bonsignore","year":"1964","journal-title":"J Clin Invest"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1172\/JCI105786","article-title":"In vivo liability of glucose-6-phosphate dehydrogenase in Gd<sup>A-<\/sup> and Gd<sup>Mediterranean<\/sup> deficiency","volume":"47","author":"S Piomelli","year":"1968","journal-title":"J Clin Invest"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1056\/NEJM196706152762402","article-title":"Nature of hemolytic crises and the fate of G6PD deficient, drug-damaged erythrocytes in Sardinians","volume":"276","author":"E Salvidio","year":"1967","journal-title":"New Engl J Med"},{"key":"ref13","first-page":"415","article-title":"Malaria in Laos. Primaquine sensitivity of the Laotians and Japanese","volume":"42","author":"I Ebisawa","year":"1972","journal-title":"Jpn J Exp Med"},{"key":"ref14","first-page":"726","article-title":"Hemolytic crisis in a Zanzibari Arab girl with G6PD deficiency and sickle cell trait","volume":"45","author":"SA Chopra","year":"1968","journal-title":"East Afr Med J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1177\/000992286700600416","article-title":"Malaria prophylaxis and treatment in G6PD deficiency: an observation on the toxicity of chloroquine and primaquine","volume":"6","author":"M Ziai","year":"1967","journal-title":"Clin Pediatr"},{"key":"ref16","first-page":"134","article-title":"Sensitivity to primaquine in Ceylonese children due to deficiency of erythrocytic glucose-6-phosphate dehydrogenase deficiency","volume":"13","author":"KP Abeyarantne","year":"1968","journal-title":"Ceylon Med J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1093\/cid\/cis615","article-title":"Postmortem characterization of patients with a clinical diagnosis of Plasmodium vivax: to what extent does this parasite kill?","volume":"55","author":"MV Lacerda","year":"2012","journal-title":"Clin Infect Dis"},{"key":"ref18","first-page":"391","article-title":"Clinical problems associated with the use of primaquine as a tissue schizontocidal and gametocytocidal drug","volume":"59","author":"DF Clyde","year":"1981","journal-title":"Bull WHO"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e1001339","DOI":"10.1371\/journal.pmed.1001339","article-title":"G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical-based map","volume":"9","author":"RE Howes","year":"2012","journal-title":"PLoS Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/B978-0-12-397900-1.00003-7","article-title":"Plasmodium vivax: clinical spectrum, risk factors and pathogenesis","volume":"80","author":"NM Anstey","year":"2012","journal-title":"Adv Parasitol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1128\/CMR.00074-12","article-title":"Evidence and implications of mortality associated with acute Plasmodium vivax malaria","volume":"26","author":"JK Baird","year":"2013","journal-title":"Clin Microbiol Rev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e3071","DOI":"10.1371\/journal.pntd.0003071","article-title":"Is Plasmodium vivax a severe malaria?: a systematic review and meta-analysis","volume":"8","author":"C Naing","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref23","first-page":"35pp","article-title":"Global Technical Strategy for Malaria 2016\u20132030","year":"2015"},{"key":"ref24","article-title":"A Technical Brief","year":"2015"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1182\/blood.V28.4.553.553","article-title":"A series of new screening procedures for pyruvate kinase deficiency, glucose-6-phosphate dehydrogenase deficiency, and glutathione reductase deficiency","volume":"28","author":"E Beutler","year":"1966","journal-title":"Blood"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1186\/1475-2875-12-391","article-title":"G6PD testing in support of treatment and elimination of malaria: recommendations for evaluation of G6PD tests","volume":"12","author":"GJ Domingo","year":"2013","journal-title":"Malaria J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1475-2875-12-112","article-title":"Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report","volume":"12","author":"L von Seidlein","year":"2013","journal-title":"Malaria J"},{"key":"ref28","unstructured":"World Health Organization. 2015. Point-of-care G6PD testing to support safe use of primaquine for the treatment of vivax malaria. WHO Evidence Review Group meeting report 8\u20139 October 2014, WHO\/UNAIDS Building, Geneva, Switzerland (<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/malaria\/mpac\/mpac-march2015-erg-g6pd.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/malaria\/mpac\/mpac-march2015-erg-g6pd.pdf<\/ext-link> accessed 26 October 2015)."},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e0003602","DOI":"10.1371\/journal.pntd.0003602","article-title":"G6PD deficiency at Sumba in eastern Indonesia is prevalent, diverse and severe: implications for primaquine therapy against relapsing vivax malaria","volume":"9","author":"AW Satyagraha","year":"2015","journal-title":"PLOS Negl Trop Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.trsl.2014.09.009","article-title":"Non-inferiority of glucose-6-phosphate dehydrogenase deficiency diagnosis by a point-of-care rapid test vs the laboratory fluorescent spot test demonstrated by copper inhibition in normal human red blood cells","volume":"165","author":"JK Baird","year":"2015","journal-title":"Transl Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1093\/genetics\/162.4.1849","article-title":"Nucleotide variability at G6PD and the signature of malaria selection in humans","volume":"162","author":"MA Saunders","year":"2002","journal-title":"Genetics"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1365-2141.2000.01870.x","article-title":"Rapid detection of a-thalassaemia deletions and a-globin gene triplication by multiplex polymerase chain reactions","volume":"108","author":"YT Liu","year":"2000","journal-title":"Brit J Haematol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-4615-0059-9_4","article-title":"Alpha thalassemia in Indonesia: phenotypes and molecular defects","volume":"531","author":"I Setianingsih","year":"2003","journal-title":"Adv Exp Med Biol"},{"key":"ref34","first-page":"405","article-title":"Semiquantitative screening test for G6PD deficiency detects severe deficiency but misses a substantial proportion of partially-deficient females","volume":"34","author":"O Ainoon","year":"2003","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref35","article-title":"Encyclopedia of Malaria","author":"JK Baird","year":"2014"},{"key":"ref36","article-title":"Point-of-care G6PD diagnostics for Plasmodium vivax malaria is clinical and public health urgency","author":"JK Baird","journal-title":"BMC Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e116143","DOI":"10.1371\/journal.pone.0116143","article-title":"Field trial evaluation of the performances of point-of-care tests for screening G6PD deficiency in Cambodia","volume":"9","author":"A Roca-Feltrer","year":"2014","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e0125796","DOI":"10.1371\/journal.pone.0125796","article-title":"Evaluation of the diagnostic accuracy of the CareStart G6PD deficiency rapid diagnostic test (RDT) in a malaria endemic area in Ghana, Africa","volume":"10","author":"D Adu-Gyasi","year":"2015","journal-title":"PLoS One"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4269\/ajtmh.14-0100","article-title":"Performance of the CareStart glucose-6-phosphate dehydrogenase (G6PD) rapid diagnostic test in Gressier, Haiti","volume":"91","author":"ME von Fricken","year":"2014","journal-title":"Am J Trop Med Hyg"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"818","DOI":"10.4269\/ajtmh.14-0696","article-title":"Suitability of capillary blood for quantitative assessment of G6PD activity and performances of G6PD point-of-care tests","volume":"92","author":"G Bancone","year":"2015","journal-title":"Am J Trop Med Hyg"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T16:49:16Z","timestamp":1654361356000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004457"}},"subtitle":[],"editor":[{"given":"Photini","family":"Sinnis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,19]]},"references-count":40,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0004457","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,19]]}}}