{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:32:43Z","timestamp":1790271163792,"version":"4.1.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T00:00:00Z","timestamp":1457654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0004492","type":"journal-article","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T18:41:58Z","timestamp":1457721718000},"page":"e0004492","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":41,"title":["Effect of Two or Six Doses 800 mg of Albendazole Every Two Months on Loa loa Microfilaraemia: A Double Blind, Randomized, Placebo-Controlled Trial"],"prefix":"10.1371","volume":"10","author":[{"given":"Joseph","family":"Kamgno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Nguipdop-Djomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raceline","family":"Gounoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathurin","family":"T\u00e9jiokem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette C.","family":"Kuesel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,3,11]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"e1210","DOI":"10.1371\/journal.pntd.0001210","article-title":"The geographic distribution of Loa loa in Africa: results of large-scale implementation of the Rapid Assessment Procedure for Loiasis (RAPLOA)","volume":"5","author":"HG Zoure","year":"2011","journal-title":"PLoS neglected tropical diseases"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1179\/136485906X112194","article-title":"Loiasis","volume":"100","author":"M Boussinesq","year":"2006","journal-title":"Annals of tropical medicine and parasitology"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/infdis\/154.1.10","article-title":"Loa loa infection in temporary residents of endemic regions: recognition of a hyperresponsive syndrome with characteristic clinical manifestations","volume":"154","author":"TB Nutman","year":"1986","journal-title":"The Journal of infectious diseases"},{"issue":"2","key":"ref4","first-page":"179","article-title":"Loasis as a possible trigger of African endomyocardial fibrosis: a case report from Nigeria","volume":"38","author":"JJ Andy","year":"1981","journal-title":"Acta tropica"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1475-2883-5-6","article-title":"A possible case of spontaneous Loa loa encephalopathy associated with a glomerulopathy","volume":"5","author":"T Lukiana","year":"2006","journal-title":"Filaria journal"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1179\/136485907X154511","article-title":"Loiasis\u2014a neglected and under-estimated affliction: endemicity, morbidity and perceptions in eastern Cameroon","volume":"101","author":"I Takougang","year":"2007","journal-title":"Annals of tropical medicine and parasitology"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/infdis\/169.3.604","article-title":"Effectiveness of diethylcarbamazine in treating loiasis acquired by expatriate visitors to endemic regions: long-term follow-up","volume":"169","author":"AD Klion","year":"1994","journal-title":"The Journal of infectious diseases"},{"key":"ref8","unstructured":"ICH (International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use) (1996) Guideline for Good Clinical Practice, E6, R1, 1996. www.ich.org<\/ext-link>."},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"684","DOI":"10.4269\/ajtmh.1991.44.684","article-title":"Five cases of encephalitis during treatment of loiasis with diethylcarbamazine","volume":"44","author":"B Carme","year":"1991","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1177\/004947558201200107","article-title":"Ascending paralysis associated with diethylcarbamazine treatment of M. loa loa infection","volume":"12","author":"SL Stanley Jr.","year":"1982","journal-title":"Tropical doctor"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0035-9203(96)90219-9","article-title":"Ivermectin-based control of onchocerciasis in northern Cameroon: individual factors influencing participation in community treatment","volume":"90","author":"J Gardon","year":"1996","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"461","DOI":"10.4269\/ajtmh.1998.58.461","article-title":"Three probable cases of Loa loa encephalopathy following ivermectin treatment for onchocerciasis","volume":"58","author":"M Boussinesq","year":"1998","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"Suppl 1","key":"ref13","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1475-2883-2-S1-S4","article-title":"Clinical picture, epidemiology and outcome of Loa-associated serious adverse events related to mass ivermectin treatment of onchocerciasis in Cameroon","volume":"2","author":"M Boussinesq","year":"2003","journal-title":"Filaria journal"},{"issue":"3","key":"ref14","first-page":"105","article-title":"Secondary effects of the treatment of hypermicrofilaremic loiasis using ivermectin","volume":"88","author":"M Ducorps","year":"1995","journal-title":"Bull Soc Pathol Exot"},{"issue":"9070","key":"ref15","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0140-6736(96)11094-1","article-title":"Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection","volume":"350","author":"J Gardon","year":"1997","journal-title":"Lancet"},{"issue":"Suppl 1","key":"ref16","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/1475-2883-2-S1-S7","article-title":"Loa loa encephalopathy temporally related to ivermectin administration reported from onchocerciasis mass treatment programs from 1989 to 2001: implications for the future","volume":"2","author":"NA Twum-Danso","year":"2003","journal-title":"Filaria journal"},{"key":"ref17","unstructured":"World Health Organization (2012) Accelerating work to overcome the global impact of neglected tropical diseases. A roadmap for implementation. World Health Organization. Available: http:\/\/www.who.int\/neglected_diseases\/NTD_RoadMap_2012_Fullversion.pdf<\/ext-link>."},{"key":"ref18","unstructured":"Mectizan Expert Committee and APOC Technical Consultative Committee (2004) Recommendations for the treatment of onchocerciasis with Mectizan in areas co-endemic for onchocerciasis and Loiasis."},{"key":"ref19","unstructured":"World Health Organization (2012) Provisional strategy for interruption lymphatic filariasis transmission in loiasis-endemic countries. Report of the meeting on lymphatic filariasis, malaria and integrated vector management, Accra, Ghana, March 2012. http:\/\/www.who.int\/iris\/bitstream\/10665\/75139\/3\/WHO_HTM_NTD_PCT_2012.6_eng.pdf?ua=1<\/ext-link>."},{"key":"ref20","unstructured":"World Health Organization (2012) Provisional strategy for interruption lymphatic filariasis transmission in loiasis-endemic countries. Report of the meeting on lymphatic filariasis, malaria and integrated vector management, Accra, Ghana, March 2012. http:\/\/www.who.int\/iris\/bitstream\/10665\/75139\/3\/WHO_HTM_NTD_PCT_2012.6_eng.pdf?ua=1<\/ext-link>."},{"key":"ref21","unstructured":"World Health Organization (2013) Report of the sixth meeting of the WHO Strategic and Technical Advisory Group for Neglected Tropical Diseases."},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"e497","DOI":"10.1371\/journal.pntd.0000497","article-title":"Feasibility of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: first evidence from studies in Mali and Senegal","volume":"3","author":"L Diawara","year":"2009","journal-title":"PLoS neglected tropical diseases"},{"issue":"9","key":"ref23","doi-asserted-by":"crossref","first-page":"e1825","DOI":"10.1371\/journal.pntd.0001825","article-title":"Proof-of-principle of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: final results of a study in Mali and Senegal","volume":"6","author":"MO Traore","year":"2012","journal-title":"PLoS neglected tropical diseases"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1756-3305-5-28","article-title":"Impact of long-term treatment of onchocerciasis with ivermectin in Kaduna State, Nigeria: first evidence of the potential for elimination in the operational area of the African Programme for Onchocerciasis Control","volume":"5","author":"AH Tekle","year":"2012","journal-title":"Parasites & vectors"},{"key":"ref25","unstructured":"African Programme for Onchocerciasis Control (APOC) (2014) Rerport of the 38th session of the technical consultative committee (TCC), March 2014. http:\/\/www.who.int\/entity\/apoc\/about\/structure\/tcc\/tcc38_final_report_130814.pdf?ua=1<\/ext-link>."},{"key":"ref26","unstructured":"African Programme for Onchocerciasis Control (APOC) (2012) Final Communiqu\u00e9, Eighteenth Session of the Joint Action Forum 11\u201313 December 2012. http:\/\/www.who.int\/apoc\/publications\/recommendations\/en\/index.html<\/ext-link>."},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/infdis\/168.1.202","article-title":"Albendazole in human loiasis: results of a double-blind, placebo-controlled trial","volume":"168","author":"AD Klion","year":"1993","journal-title":"The Journal of infectious diseases"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1051\/parasite\/200209159","article-title":"Effect of a single dose (600 mg) of albendazole on Loa loa microfilaraemia","volume":"9","author":"J Kamgno","year":"2002","journal-title":"Parasite"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4269\/ajtmh.2004.71.211","article-title":"Human loiasis in a Cameroonian village: a double-blind, placebo-controlled, crossover clinical trial of a three-day albendazole regimen","volume":"71","author":"TE Tabi","year":"2004","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"7","key":"ref30","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1179\/000349802125001933","article-title":"Effects of a 3-day regimen of albendazole (800 mg daily) on Loa loa microfilaraemia","volume":"96","author":"L Tsague-Dongmo","year":"2002","journal-title":"Annals of tropical medicine and parasitology"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.4269\/ajtmh.2009.09-0356","article-title":"Loa loa microfilarial periodicity in ivermectin-treated patients: comparison between those developing and those free of serious adverse events","volume":"81","author":"J Kamgno","year":"2009","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"2\u20133","key":"ref32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0001-706X(03)00031-7","article-title":"Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics","volume":"86","author":"AD Dayan","year":"2003","journal-title":"Acta tropica"},{"issue":"Suppl","key":"ref33","doi-asserted-by":"crossref","first-page":"S113","DOI":"10.1017\/S0031182000007290","article-title":"Albendazole: a review of anthelmintic efficacy and safety in humans","volume":"121","author":"J Horton","year":"2000","journal-title":"Parasitology"},{"issue":"2","key":"ref34","first-page":"226","article-title":"Albendazole, a broad-spectrum anthelmintic, in the treatment of intestinal nematode and cestode infection: a multicenter study in 480 patients","volume":"8","author":"SC Jagota","year":"1986","journal-title":"Clinical therapeutics"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"568","DOI":"10.4269\/ajtmh.2003.68.568","article-title":"Frequency, severity, and costs of adverse reactions following mass treatment for lymphatic filariasis using diethylcarbamazine and albendazole in Leogane, Haiti, 2000","volume":"68","author":"SI McLaughlin","year":"2003","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"10","key":"ref36","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.trstmh.2008.04.039","article-title":"Impact of two rounds of mass treatment with diethylcarbamazine plus albendazole on Wuchereria bancrofti infection and the sensitivity of immunochromatographic test in Malindi, Kenya","volume":"102","author":"SM Njenga","year":"2008","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0020-7519(01)00131-X","article-title":"The biochemical basis of anthelmintic action and resistance","volume":"31","author":"P Koehler","year":"2001","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1090-0233(05)80005-X","article-title":"Modes of Action of Anthelmintic Drugs","volume":"154","author":"R Martin","year":"1997","journal-title":"The Veterinary Journal"},{"issue":"9","key":"ref39","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/bdd.327","article-title":"Dose dependent pharmacokinetics of albendazole in human","volume":"23","author":"A Mirfazaelian","year":"2002","journal-title":"Biopharm Drug Dispos"},{"issue":"5","key":"ref40","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/bdd.355","article-title":"Time dependent pharmacokinetics of albendazole in human","volume":"24","author":"A Mirfazaelian","year":"2003","journal-title":"Biopharm Drug Dispos"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/clpt.1990.38","article-title":"Albendazole treatment of echinococcosis in humans: effects on microsomal metabolism and drug tolerance","volume":"47","author":"U Steiger","year":"1990","journal-title":"Clin Pharmacol Ther"},{"issue":"Suppl 1","key":"ref42","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1475-2883-2-S1-S5","article-title":"Possible pathogenic pathways in the adverse clinical events seen following ivermectin administration to onchocerciasis patients","volume":"2","author":"CD Mackenzie","year":"2003","journal-title":"Filaria journal"},{"issue":"8317","key":"ref43","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0140-6736(83)92753-8","article-title":"Comparison of flubendazole and diethylcarbamazine in treatment of onchocerciasis","volume":"1","author":"A Dominguez-Vazquez","year":"1983","journal-title":"Lancet"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s13199-010-0067-1","article-title":"The Wolbachia endosymbiont as an anti-filarial nematode target","volume":"51","author":"BE Slatko","year":"2010","journal-title":"Symbiosis"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00430-007-0062-1","article-title":"Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study","volume":"197","author":"A Hoerauf","year":"2008","journal-title":"Medical microbiology and immunology"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00436-008-1217-8","article-title":"Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulus","volume":"104","author":"A Hoerauf","year":"2009","journal-title":"Parasitology research"},{"issue":"4","key":"ref47","doi-asserted-by":"crossref","first-page":"e660","DOI":"10.1371\/journal.pntd.0000660","article-title":"Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial","volume":"4","author":"JD Turner","year":"2010","journal-title":"PLoS neglected tropical diseases"},{"issue":"286","key":"ref48","doi-asserted-by":"crossref","first-page":"286re4","DOI":"10.1126\/scitranslmed.aaa3480","article-title":"Point-of-care quantification of blood-borne filarial parasites with a mobile phone microscope","volume":"7","author":"MV D'Ambrosio","year":"2015","journal-title":"Sci Transl Med"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:41:24Z","timestamp":1588966884000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004492"}},"subtitle":[],"editor":[{"given":"Patrick J.","family":"Lammie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,11]]},"references-count":48,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0004492","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,11]]}}}