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Amelia II: A program for missing data."},{"key":"ref21","unstructured":"Van Buuren S, Oudshoorn K. Flexible multivariate imputation by MICE. 1999."},{"key":"ref22","unstructured":"Harrell Jr FE, Harrell Jr MFE. Package \u2018Hmisc\u2019. 2014."},{"issue":"404","key":"ref23","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1080\/01621459.1988.10478722","article-title":"A Test of Missing Completely at Random for Multivariate Data with Missing Values","volume":"83","author":"RJA Little","year":"1988","journal-title":"Journal of the American Statistical Association"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s11336-010-9175-3","article-title":"Tests of homoscedasticity, normality, and missing completely at random for incomplete multivariate data","volume":"75","author":"M Jamshidian","year":"2010","journal-title":"Psychometrika"},{"issue":"5\u20136","key":"ref25","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S1532-0464(03)00034-0","article-title":"Logistic regression and artificial neural network classification models: a methodology review","volume":"35","author":"S Dreiseitl","year":"2002","journal-title":"J Biomed Inform"},{"key":"ref26","first-page":"2825","article-title":"Scikit-learn: Machine learning in Python","volume":"12","author":"F Pedregosa","year":"2011","journal-title":"The Journal of Machine Learning Research"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.2044-8317.1992.tb00992.x","article-title":"Backward, forward and stepwise automated subset selection algorithms: Frequency of obtaining authentic and noise variables","volume":"45","author":"S Derksen","year":"1992","journal-title":"British Journal of Mathematical and Statistical Psychology"},{"issue":"12","key":"ref28","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0895-4356(96)00236-3","article-title":"A simulation study of the number of events per variable in logistic regression analysis","volume":"49","author":"P Peduzzi","journal-title":"Journal of Clinical Epidemiology"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4","article-title":"Multivariable Prognostic Models: Issues In Developing Models, Evaluating Assumptions And Adequacy, And Measuring And Reducing Errors","volume":"15","author":"FE Harrell","year":"1996","journal-title":"Statistics in Medicine"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/aje\/kwu140","article-title":"Correcting for Optimistic Prediction in Small Data Sets","volume":"180","author":"GCS Smith","year":"2014","journal-title":"American journal of epidemiology"},{"issue":"13","key":"ref31","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1056\/NEJMc1415318","article-title":"Ebola Virus Disease among Children in West Africa","volume":"372","author":"WER Team","year":"2015","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3201\/eid2202.151250","article-title":"Prognostic Indicators for Ebola Patient Survival","volume":"22","author":"JC Samuel","year":"2016","journal-title":"Emerging Infectious Disease journal"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1198\/000313007X172556","article-title":"Much ado about nothing: A comparison of missing data methods and software to fit incomplete data regression models","volume":"61","author":"NJ Horton","year":"2007","journal-title":"Am Stat"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T16:47:29Z","timestamp":1655311649000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004549"}},"subtitle":[],"editor":[{"given":"Thomas S.","family":"Churcher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,18]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0004549","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,18]]}}}