{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:13:47Z","timestamp":1789913627275,"version":"4.0.1"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T00:00:00Z","timestamp":1464134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004904","name":"Direction G\u00e9n\u00e9rale de la Comp\u00e9titivit\u00e9, de l\u2019Industrie et des Services","doi-asserted-by":"publisher","award":["No. 072906234"],"award-info":[{"award-number":["No. 072906234"]}],"id":[{"id":"10.13039\/501100004904","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006137","name":"D\u00e9partement Soutien et Formation, Institut de Recherche pour le D\u00e9veloppement","doi-asserted-by":"publisher","award":["5045"],"award-info":[{"award-number":["5045"]}],"id":[{"id":"10.13039\/501100006137","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0004614","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T17:46:40Z","timestamp":1464198400000},"page":"e0004614","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Recombinant Forms of Leishmania amazonensis Excreted\/Secreted Promastigote Surface Antigen (PSA) Induce Protective Immune Responses in Dogs"],"prefix":"10.1371","volume":"10","author":[{"given":"Elodie","family":"Petitdidier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Pagniez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Papierok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Vincendeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Loup","family":"Lemesre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Bras-Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,5,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e35671","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"J Alvar","year":"2012","journal-title":"PLoS One"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.ijpara.2007.04.003","article-title":"Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies","volume":"37","author":"PA Bates","year":"2007","journal-title":"Int J Parasitol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1111\/j.1462-5822.2008.01132.x","article-title":"Leishmania chitinase facilitates colonization of sand fly vectors and enhances transmission to mice","volume":"10","author":"ME Rogers","year":"2008","journal-title":"Cell Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev.micro.55.1.453","article-title":"Molecular aspects of parasite-vector and vector-host interactions in leishmaniasis","volume":"55","author":"D Sacks","year":"2001","journal-title":"Annu Rev Microbiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nrmicro1748","article-title":"Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?","volume":"5","author":"F Chappuis","year":"2007","journal-title":"Nat Rev Microbiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.pt.2012.08.007","article-title":"Canine leishmaniosis in the Old and New Worlds: unveiled similarities and differences","volume":"28","author":"F Dantas-Torres","year":"2012","journal-title":"Trends Parasitol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0169-4758(00)01637-9","article-title":"The strange case of Leishmania chagasi","volume":"16","author":"IL Mauricio","year":"2000","journal-title":"Parasitol Today"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/0035-9203(90)90120-4","article-title":"Leishmania infantum as a cause of cutaneous leishmaniasis","volume":"84","author":"JA Rioux","year":"1990","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"892817","DOI":"10.1155\/2012\/892817","article-title":"Development of Vaccines against Visceral Leishmaniasis","volume":"2012","author":"KJ Evans","year":"2012","journal-title":"J Trop Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.pt.2011.04.001","article-title":"Urban parasitology: visceral leishmaniasis in Brazil","volume":"27","author":"MO Harhay","year":"2011","journal-title":"Trends Parasitol"},{"key":"ref11","first-page":"69","article-title":"Vaccines for canine leishmaniasis","volume":"3","author":"CB Palatnik-de-Sousa","year":"2012","journal-title":"Front Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/1756-3305-4-197","article-title":"One Health: the global challenge of epidemic and endemic leishmaniasis","volume":"4","author":"CB Palatnik-de-Sousa","year":"2011","journal-title":"Parasit Vectors"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e584","DOI":"10.1371\/journal.pntd.0000584","article-title":"Control of visceral leishmaniasis in latin america-a systematic review","volume":"4","author":"GA Romero","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.actatropica.2012.02.003","article-title":"A cross-sectional sero-epidemiological study of canine leishmaniasis in Greek mainland","volume":"122","author":"LV Athanasiou","year":"2012","journal-title":"Acta Trop"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.pt.2015.03.007","article-title":"Uniting mathematics and biology for control of visceral leishmaniasis","volume":"31","author":"KS Rock","year":"2015","journal-title":"Trends Parasitol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.vetpar.2013.05.008","article-title":"Vaccination with LiESP\/QA-21 (CaniLeish reduces the intensity of infection in Phlebotomus perniciosus fed on Leishmania infantum infected dogs\u2014a preliminary xenodiagnosis study","volume":"197","author":"G Bongiorno","year":"2013","journal-title":"Vet Parasitol"},{"issue":"Suppl 1","key":"ref17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/00034983.1995.11813017","article-title":"Vaccines against leishmaniasis","volume":"89","author":"F Modabber","year":"1995","journal-title":"Ann Trop Med Parasitol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1128\/IAI.68.4.1760-1764.2000","article-title":"Comparison of the immune profile of nonhealing cutaneous Leishmaniasis patients with those with active lesions and those who have recovered from infection","volume":"68","author":"S Ajdary","year":"2000","journal-title":"Infect Immun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4269\/ajtmh.1995.53.273","article-title":"Characterization of the immune response in subjects with self-healing cutaneous leishmaniasis","volume":"53","author":"EM Carvalho","year":"1995","journal-title":"Am J Trop Med Hyg"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0165-2478(98)00132-1","article-title":"T-cell response in human leishmaniasis","volume":"65","author":"A Kharazmi","year":"1999","journal-title":"Immunol Lett"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1046\/j.1365-2249.1999.00844.x","article-title":"Leishmanin skin test lymphoproliferative responses and cytokine production after symptomatic or asymptomatic Leishmania major infection in Tunisia","volume":"116","author":"A Sassi","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.vetimm.2008.10.309","article-title":"Effective humoral and cellular immunoprotective responses in Li ESAp-MDP vaccinated protected dogs","volume":"128","author":"G Bourdoiseau","year":"2009","journal-title":"Vet Immunol Immunopathol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4267\/2042\/47687","article-title":"Canine leishmaniosis due to Leishmania infantum:immunotherapy trials","volume":"157","author":"G Bourdoiseau","year":"2004","journal-title":"Bull Acad Vet France"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e92708","DOI":"10.1371\/journal.pone.0092708","article-title":"In vitro evaluation of a soluble Leishmania promastigote surface antigen as a potential vaccine candidate against human leishmaniasis","volume":"9","author":"R Chamakh-Ayari","year":"2014","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.vetimm.2005.03.001","article-title":"Lymphocytes of dogs immunised with purified excreted-secreted antigens of Leishmania infantum co-incubated with Leishmania infected macrophages produce IFN gamma resulting in nitric oxide-mediated amastigote apoptosis","volume":"106","author":"P Holzmuller","year":"2005","journal-title":"Vet Immunol Immunopathol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4267\/2042\/47822","article-title":"Results of vaccination against canine visceral leishmaniasis (Leishmania infantum) in enzootic areas","volume":"159","author":"C Hugnet","year":"2006","journal-title":"Bull Acad Vet France"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1016\/j.vaccine.2004.11.061","article-title":"Protection against experimental visceral leishmaniasis infection in dogs immunized with purified excreted secreted antigens of Leishmania infantum promastigotes","volume":"23","author":"JL Lemesre","year":"2005","journal-title":"Vaccine"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1016\/j.vaccine.2007.02.083","article-title":"Long-lasting protection against canine visceral leishmaniasis using the LiESAp-MDP vaccine in endemic areas of France: double-blind randomised efficacy field trial","volume":"25","author":"JL Lemesre","year":"2007","journal-title":"Vaccine"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4269\/ajtmh.1999.60.41","article-title":"Leishmania spp: completely defined medium without serum and macromolecules (CDM\/LP) for the continuous in vitro cultivation of infective promastigote forms","volume":"60","author":"T Merlen","year":"1999","journal-title":"Am J Trop Med Hyg"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e3213","DOI":"10.1371\/journal.pntd.0003213","article-title":"A randomised, double-blind, controlled efficacy trial of the LiESP\/QA-21 vaccine in naive dogs exposed to two leishmania infantum transmission seasons","volume":"8","author":"G Oliva","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.vetpar.2015.01.003","article-title":"Canine Leishmania vaccines: still a long way to go","volume":"208","author":"L Gradoni","year":"2015","journal-title":"Vet Parasitol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.meegid.2014.02.017","article-title":"Identification and characterization of new Leishmania promastigote surface antigens, LaPSA-38S and LiPSA-50S, as major immunodominant excreted\/secreted components of L. amazonensis and L. infantum","volume":"24","author":"R Bras-Goncalves","year":"2014","journal-title":"Infect Genet Evol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/1471-2148-8-292","article-title":"The promastigote surface antigen gene family of the Leishmania parasite: differential evolution by positive selection and recombination","volume":"8","author":"A Devault","year":"2008","journal-title":"BMC Evol Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1046\/j.1432-1327.1998.2510389.x","article-title":"Cloning, sequencing, and expression of the PSA genes from Leishmania infantum","volume":"251","author":"A Jimenez-Ruiz","year":"1998","journal-title":"Eur J Biochem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0166-6851(92)90252-F","article-title":"Loss of the GP46\/M-2 surface membrane glycoprotein gene family in the Leishmania braziliensis complex","volume":"50","author":"D McMahon-Pratt","year":"1992","journal-title":"Mol Biochem Parasitol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0166-6851(94)90100-7","article-title":"Characterization of a polymorphic family of integral membrane proteins in promastigotes of different Leishmania species","volume":"67","author":"FM Symons","year":"1994","journal-title":"Mol Biochem Parasitol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1128\/IAI.66.7.3279-3289.1998","article-title":"Human and murine immune responses to a novel Leishmania major recombinant protein encoded by members of a multicopy gene family","volume":"66","author":"JR Webb","year":"1998","journal-title":"Infect Immun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.4049\/jimmunol.172.8.4902","article-title":"A leucine-rich repeat motif of Leishmania parasite surface antigen 2 binds to macrophages through the complement receptor 3","volume":"172","author":"L Kedzierski","year":"2004","journal-title":"J Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.molbiopara.2004.05.004","article-title":"Genetic complementation of Leishmania deficient in PSA (GP46) restores their resistance to lysis by complement","volume":"137","author":"LM Lincoln","year":"2004","journal-title":"Mol Biochem Parasitol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1574-695X.1998.tb01129.x","article-title":"The Leishmania promastigote surface antigen-2 (PSA-2) is specifically recognised by Th1 cells in humans with naturally acquired immunity to L. major","volume":"20","author":"M Kemp","year":"1998","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1128\/IAI.63.11.4261-4267.1995","article-title":"Protective vaccination with promastigote surface antigen 2 from Leishmania major is mediated by a TH1 type of immune response","volume":"63","author":"E Handman","year":"1995","journal-title":"Infect Immun"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"8393","DOI":"10.1073\/pnas.87.21.8393","article-title":"Molecular cloning and characterization of the immunologically protective surface glycoprotein GP46\/M-2 of Leishmania amazonensis","volume":"87","author":"KL Lohman","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref43","first-page":"99","article-title":"Vaccine Development Against Leishmania donovani","volume":"3","author":"A Das","year":"2012","journal-title":"Front Immunol"},{"issue":"Suppl 1","key":"ref44","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/j.ijantimicag.2010.06.024","article-title":"Leishmaniasis vaccines: past, present and future","volume":"36","author":"F Modabber","year":"2010","journal-title":"Int J Antimicrob Agents"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.vaccine.2009.09.071","article-title":"Immunotherapy with the saponin enriched-Leishmune vaccine versus immunochemotherapy in dogs with natural canine visceral leishmaniasis","volume":"28","author":"GP Borja-Cabrera","year":"2010","journal-title":"Vaccine"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1016\/j.vaccine.2006.02.034","article-title":"Acylated and deacylated saponins of Quillaja saponaria mixture as adjuvants for the FML-vaccine against visceral leishmaniasis","volume":"24","author":"E Oliveira-Freitas","year":"2006","journal-title":"Vaccine"},{"key":"ref47","article-title":"Methods for the culture in vitro of different stages of tissue parasites","author":"JL Lemesre","year":"1994"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1297-9716-45-69","article-title":"The protective immune response produced in dogs after primary vaccination with the LiESP\/QA-21 vaccine (CaniLeish remains effective against an experimental challenge one year later","volume":"45","author":"V Martin","year":"2014","journal-title":"Vet Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e943","DOI":"10.1371\/journal.pntd.0000943","article-title":"Vaccines for the leishmaniases: proposals for a research agenda","volume":"5","author":"CH Costa","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1586\/14760584.7.6.833","article-title":"FML vaccine against canine visceral leishmaniasis: from second-generation to synthetic vaccine","volume":"7","author":"CB Palatnik-de-Sousa","year":"2008","journal-title":"Expert Rev Vaccines"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1016\/j.vaccine.2005.07.001","article-title":"Failure of a multi-subunit recombinant leishmanial vaccine (MML) to protect dogs from Leishmania infantum infection and to prevent disease progression in infected animals","volume":"23","author":"L Gradoni","year":"2005","journal-title":"Vaccine"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1016\/j.vaccine.2005.12.039","article-title":"Vaccination with a preparation based on recombinant cysteine peptidases and canine IL-12 does not protect dogs from infection with Leishmania infantum","volume":"24","author":"J Poot","year":"2006","journal-title":"Vaccine"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1086\/344312","article-title":"Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission","volume":"186","author":"O Courtenay","year":"2002","journal-title":"J Infect Dis"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1177\/030098588402100113","article-title":"Visceral leishmaniasis in the German shepherd dog. I. Infection, clinical disease, and clinical pathology","volume":"21","author":"CM Keenan","year":"1984","journal-title":"Vet Pathol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1016\/j.vaccine.2005.05.011","article-title":"Leishmune vaccine blocks the transmission of canine visceral leishmaniasis: absence of Leishmania parasites in blood, skin and lymph nodes of vaccinated exposed dogs","volume":"23","author":"FS Nogueira","year":"2005","journal-title":"Vaccine"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1016\/j.vaccine.2003.11.039","article-title":"Effective immunotherapy against canine visceral leishmaniasis with the FML-vaccine","volume":"22","author":"GP Borja-Cabrera","year":"2004","journal-title":"Vaccine"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1016\/S0264-410X(03)00046-X","article-title":"IgG1\/IgG2 antibody dichotomy in sera of vaccinated or naturally infected dogs with visceral leishmaniosis","volume":"21","author":"C de Oliveira Mendes","year":"2003","journal-title":"Vaccine"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1016\/j.vaccine.2007.06.005","article-title":"Immunotherapy against experimental canine visceral leishmaniasis with the saponin enriched-Leishmune vaccine","volume":"25","author":"FN Santos","year":"2007","journal-title":"Vaccine"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1189\/jlb.0611326","article-title":"Secreted virulence factors and immune evasion in visceral leishmaniasis","volume":"91","author":"U Lambertz","year":"2012","journal-title":"J Leukoc Biol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"R35","DOI":"10.1186\/gb-2008-9-2-r35","article-title":"Proteomic analysis of the secretome of Leishmania donovani","volume":"9","author":"JM Silverman","year":"2008","journal-title":"Genome Biol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.bbrc.2006.01.005","article-title":"Identification of a new developmentally regulated Leishmania major large RAB GTPase","volume":"341","author":"M Chenik","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.4049\/jimmunol.138.5.1587","article-title":"Structural and antigenic characterization of a species- and promastigote-specific Leishmania mexicana amazonensis membrane protein","volume":"138","author":"LP Kahl","year":"1987","journal-title":"J Immunol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/eji.1830270409","article-title":"Interleukin-10 and interleukin-4 inhibit intracellular killing of Leishmania infantum and Leishmania major by human macrophages by decreasing nitric oxide generation","volume":"27","author":"I Vouldoukis","year":"1997","journal-title":"Eur J Immunol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0304-4017(00)00312-5","article-title":"Infection of a canine macrophage cell line with leishmania infantum: determination of nitric oxide production and anti-leishmanial activity","volume":"92","author":"E Pinelli","year":"2000","journal-title":"Vet Parasitol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"5249","DOI":"10.1128\/JCM.42.11.5249-5255.2004","article-title":"Quantification of Leishmania infantum DNA by a real-time PCR assay with high sensitivity","volume":"42","author":"C Mary","year":"2004","journal-title":"J Clin Microbiol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1128\/CDLI.8.4.828-831.2001","article-title":"Real-time PCR as a new tool for quantifying Leishmania infantum in liver in infected mice","volume":"8","author":"S Bretagne","year":"2001","journal-title":"Clin Diagn Lab Immunol"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T16:35:38Z","timestamp":1692376538000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004614"}},"subtitle":[],"editor":[{"given":"Hechmi","family":"Louzir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,5,25]]},"references-count":66,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0004614","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,25]]}}}