{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:45:09Z","timestamp":1766087109099},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T00:00:00Z","timestamp":1462752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Training and Research on Tropical Disease (TDR) UPND\/WB\/WHO\/TDR Program"},{"name":"National Ministry of Health of Argentina"},{"name":"Ministry of Health of the Province of Salta"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0004651","type":"journal-article","created":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T17:31:09Z","timestamp":1462815069000},"page":"e0004651","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Electrocardiographic Abnormalities and Treatment with Benznidazole among Children with Chronic Infection by Trypanosoma cruzi: A Retrospective Cohort Study"],"prefix":"10.1371","volume":"10","author":[{"given":"Lisandro D.","family":"Colantonio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilda","family":"Prado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa L.","family":"Segura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Sosa-Estani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,5,9]]},"reference":[{"issue":"4","key":"ref1","first-page":"359","article-title":"Hist\u00f3ria natural da doen\u00e7a de Chagas","volume":"65","author":"JC Pinto Dias","year":"1995","journal-title":"Arq Bras Cardiol"},{"key":"ref2","unstructured":"Silveira AC. O controle da doen\u00e7a de Chagas nos pa\u00edses do Cone Sul da Am\u00e9rica: hist\u00f3ria de uma iniciativa internacional, 1991\/2001. Uberaba: Faculdade de Medicina do Tri\u00e2ngulo Mineiro, Funda\u00e7\u00e3o de Ensino e Pesquisa de Uberaba; 2002. 316 p. p."},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1751-2824.2007.00052.x","article-title":"The globalization of Chagas disease","volume":"2","author":"GA Schmunis","year":"2007","journal-title":"ISBT Science Series"},{"key":"ref4","unstructured":"World Health Organization, UNICEF\/UNDP\/World Bank\/WHO Special Programme for Research and Training in Tropical Diseases, Pan American Health Organization. Reporte del grupo de trabajo cient\u00edfico sobre la enfermedad de Chagas: 17\u201320 de abril de 2005, actualizado en julio de 2007, Buenos Aires, Argentina. Geneva: World Health Organization; 2007. 96 p. p."},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"e1498","DOI":"10.1371\/journal.pntd.0001498","article-title":"Chagas disease: &quot;the new HIV\/AIDS of the Americas&quot;","volume":"6","author":"PJ Hotez","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"issue":"9723","key":"ref6","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0140-6736(10)60061-X","article-title":"Chagas disease","volume":"375","author":"A Rassi Jr.","year":"2010","journal-title":"Lancet"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S1473-3099(13)70002-1","article-title":"Global economic burden of Chagas disease: a computational simulation model","volume":"13","author":"BY Lee","year":"2013","journal-title":"Lancet Infect Dis"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1590\/S0074-02762011000600001","article-title":"Chronic phase of Chagas disease: why should it be treated? A comprehensive review","volume":"106","author":"JR Coura","year":"2011","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nrcardio.2012.109","article-title":"Diagnosis and management of Chagas disease and cardiomyopathy","volume":"9","author":"AL Ribeiro","year":"2012","journal-title":"Nat Rev Cardiol"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1097\/INF.0b013e3181ad8425","article-title":"Chagas disease as a cause of symptomatic chronic myocardopathy in Mexican children","volume":"28","author":"PM Salazar-Schettino","year":"2009","journal-title":"Pediatr Infect Dis J"},{"issue":"9","key":"ref11","first-page":"1037","article-title":"Clinical predictors of chronic chagasic myocarditis progression","volume":"58","author":"R Viotti","year":"2005","journal-title":"Rev Esp Cardiol"},{"issue":"Suppl 1","key":"ref12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1590\/S0074-02762009000900023","article-title":"Therapy, diagnosis and prognosis of chronic Chagas disease: insight gained in Argentina","volume":"104","author":"S Sosa-Estani","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0002-8703(94)90521-5","article-title":"Treatment of chronic Chagas&apos; disease with benznidazole: clinical and serologic evolution of patients with long-term follow-up","volume":"127","author":"R Viotti","year":"1994","journal-title":"Am Heart J"},{"issue":"9039","key":"ref14","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/S0140-6736(96)04128-1","article-title":"Randomised trial of efficacy of benznidazole in treatment of early <italic>Trypanosoma cruzi<\/italic> infection","volume":"348","author":"AL de Andrade","year":"1996","journal-title":"Lancet"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"526","DOI":"10.4269\/ajtmh.1998.59.526","article-title":"Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas&apos; disease","volume":"59","author":"Estani S Sosa","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"ref16","first-page":"CD003463","article-title":"Trypanocidal drugs for chronic asymptomatic <italic>Trypanosoma cruzi<\/italic> infection","volume":"5","author":"JC Villar","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"issue":"20","key":"ref17","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1056\/NEJMoa1313122","article-title":"Randomized trial of posaconazole and benznidazole for chronic Chagas&apos; disease","volume":"370","author":"I Molina","year":"2014","journal-title":"N Engl J Med"},{"issue":"2","key":"ref18","first-page":"1","article-title":"I Latin American Guidelines for the diagnosis and treatment of Chagas&apos; heart disease","volume":"97","author":"JP Andrade","year":"2011","journal-title":"Arq Bras Cardiol"},{"issue":"26","key":"ref19","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1056\/NEJMct1014204","article-title":"Antitrypanosomal therapy for chronic Chagas&apos; disease","volume":"364","author":"C Bern","year":"2011","journal-title":"N Engl J Med"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1128\/AAC.49.4.1521-1528.2005","article-title":"Treatment with benznidazole during the chronic phase of experimental Chagas&apos; disease decreases cardiac alterations","volume":"49","author":"S Garcia","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"issue":"14","key":"ref21","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1056\/NEJMoa1507574","article-title":"Randomized Trial of Benznidazole for Chronic Chagas&apos; Cardiomyopathy","volume":"373","author":"CA Morillo","year":"2015","journal-title":"N Engl J Med"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1056\/NEJMra1410150","article-title":"Chagas&apos; Disease","volume":"373","author":"C Bern","year":"2015","journal-title":"N Engl J Med"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1590\/S1020-49891998001100005","article-title":"Diagnostic electrocardiography in epidemiological studies of Chagas&apos; disease: multicenter evaluation of a standardized method","volume":"4","author":"JO Lazzari","year":"1998","journal-title":"Rev Panam Salud Publica"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1097\/EDE.0b013e3181ba333c","article-title":"On the distinction between interaction and effect modification","volume":"20","author":"TJ VanderWeele","year":"2009","journal-title":"Epidemiology"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"724","DOI":"10.7326\/0003-4819-144-10-200605160-00006","article-title":"Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial","volume":"144","author":"R Viotti","year":"2006","journal-title":"Ann Intern Med"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1590\/S0037-86821997000200009","article-title":"Estudo comparativo controlado com emprego de benznidazole, nifurtimox e placebo, na forma cr\u00f4nica da doen\u00e7a de Chagas, em uma \u00e1rea de campo com transmiss\u00e3o interrompida. I. Avalia\u00e7\u00e3o preliminar","volume":"30","author":"JR Coura","year":"1997","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4236\/ojs.2013.32017","article-title":"The Statistical Analysis of Interval-Censored Failure Time Data with Applications","volume":"3","author":"RS Singh","year":"2013","journal-title":"Open J Stat"},{"key":"ref28","author":"D Collett","year":"2003"},{"issue":"3","key":"ref29","first-page":"201","article-title":"Estudo comparativo de tr\u00eas c\u00f3digos para leitura de eletrocardiogramas na doen\u00e7a de Chagas cr\u00f4nica","volume":"14","author":"JG Goncalves","year":"2003","journal-title":"Rev Panam Salud Publica"},{"issue":"5","key":"ref30","first-page":"609","article-title":"Expert Rev Anti Infect Ther","volume":"9","author":"PM Guedes","year":"2011","journal-title":"Expert Rev Anti Infect Ther"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"292138","DOI":"10.1155\/2012\/292138","article-title":"Therapy of chagas disease: implications for levels of prevention","volume":"2012","author":"S Sosa-Estani","year":"2012","journal-title":"J Trop Med"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"594","DOI":"10.4269\/ajtmh.2004.71.594","article-title":"Short report: benznidazole efficacy among <italic>Trypanosoma cruzi<\/italic>-infected adolescents after a six-year follow-up","volume":"71","author":"AL Andrade","year":"2004","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1128\/AAC.01662-13","article-title":"Towards a paradigm shift in the treatment of chronic Chagas disease","volume":"58","author":"R Viotti","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"issue":"6","key":"ref34","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/jac\/dkp357","article-title":"Use of benznidazole to treat chronic Chagas&apos; disease: a systematic review with a meta-analysis","volume":"64","author":"JA Perez-Molina","year":"2009","journal-title":"J Antimicrob Chemother"},{"key":"ref35","unstructured":"Gu\u00edas para la atenci\u00f3n al paciente infectado con <italic>Trypanosoma cruzi<\/italic> (Enfermedad de Chagas) Buenos Aires, Argentina: Ministerio de Salud de la Naci\u00f3n; 2012. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.msal.gob.ar\/images\/stories\/bes\/graficos\/0000000622cnt-03-guia-para-la-atencion-al-paciente-con-chagas.pdf\" xlink:type=\"simple\">http:\/\/www.msal.gob.ar\/images\/stories\/bes\/graficos\/0000000622cnt-03-guia-para-la-atencion-al-paciente-con-chagas.pdf<\/ext-link>."},{"key":"ref36","unstructured":"Riarte A. TRAENA\u2013placebo-controlled evaluation of impact of benznidazole treatment on long term disease progression in adults with chronic Chagas disease (abstract). American Society of Tropical Medicine and Hygiene (ASTMH), 62nd Annual Meeting. Washington, DC, USA: ASTMH; 2013."},{"issue":"10","key":"ref37","doi-asserted-by":"crossref","first-page":"e0139363","DOI":"10.1371\/journal.pone.0139363","article-title":"Course of Chronic <italic>Trypanosoma cruzi<\/italic> Infection after Treatment Based on Parasitological and Serological Tests: A Systematic Review of Follow-Up Studies","volume":"10","author":"Y Sguassero","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/01.qco.0000247592.21295.a5","article-title":"Etiological treatment in patients infected by <italic>Trypanosoma cruzi<\/italic>: experiences in Argentina","volume":"19","author":"S Sosa-Estani","year":"2006","journal-title":"Curr Opin Infect Dis"},{"issue":"11","key":"ref39","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.pt.2005.08.013","article-title":"Where do we stand on the autoimmunity hypothesis of Chagas disease?","volume":"21","author":"F Kierszenbaum","year":"2005","journal-title":"Trends Parasitol"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/eurheartj\/ehs291","article-title":"Right bundle branch block: prevalence, risk factors, and outcome in the general population: results from the Copenhagen City Heart Study","volume":"34","author":"BE Bussink","year":"2013","journal-title":"Eur Heart J"},{"issue":"5","key":"ref41","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1590\/S0037-86822009000500002","article-title":"Etiological treatment of young women infected with <italic>Trypanosoma cruzi<\/italic>, and prevention of congenital transmission","volume":"42","author":"S Sosa-Estani","year":"2009","journal-title":"Rev Soc Bras Med Trop"},{"issue":"11","key":"ref42","doi-asserted-by":"crossref","first-page":"e3312","DOI":"10.1371\/journal.pntd.0003312","article-title":"Trypanocide treatment of women infected with <italic>Trypanosoma cruzi<\/italic> and its effect on preventing congenital Chagas","volume":"8","author":"DL Fabbro","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"ref43","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1590\/0074-02760140347","article-title":"Prevention of congenital Chagas through treatment of girls and women of childbearing age","volume":"110","author":"G Moscatelli","year":"2015","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"1","key":"ref44","first-page":"5","article-title":"Cardiovascular Research Publications from Latin America between 1999 and 2008. A Bibliometric Study","volume":"104","author":"LD Colantonio","year":"2015","journal-title":"Arq Bras Cardiol"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T11:02:52Z","timestamp":1589022172000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004651"}},"subtitle":[],"editor":[{"given":"Marleen","family":"Boelaert","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,5,9]]},"references-count":44,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0004651","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,9]]}}}