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Nutrition of leptospira canicola","volume":"88","author":"OH Stalheim","year":"1964","journal-title":"J Bacteriol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1590\/S0074-0276108042013007","article-title":"Ionic imbalance and lack of effect of adjuvant treatment with methylene blue in the hamster model of leptospirosis","volume":"108","author":"CS Santos","year":"2013","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"7","DOI":"10.7589\/0090-3558-38.1.7","article-title":"Diagnosis and seroprevalence of leptospirosis in California sea lions from coastal California","volume":"38","author":"AM Colagross-Schouten","year":"2002","journal-title":"J Wildl Dis"},{"key":"ref84","first-page":"16","article-title":"Metabolic sequelae of experimental leptospirosis in grivet monkeys","volume":"61","author":"P Hambleton","year":"1980","journal-title":"Br J Exp Pathol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1128\/IAI.7.6.886-897.1973","article-title":"Growth requirements of pathogenic Leptospira","volume":"7","author":"JL Staneck","year":"1973","journal-title":"Infect Immun"},{"key":"ref86","first-page":"531","article-title":"Chemotherapeutic activity of certain organic selenium compounds in experimental leptospirosis","volume":"7","author":"FC Goble","year":"1967","journal-title":"Antimicrob Agents Chemother (Bethesda)"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1179\/000349809X12554106963717","article-title":"Hypomagnesaemia in the first 10 days of severe leptospirosis","volume":"103","author":"SB Craig","year":"2009","journal-title":"Ann Trop Med Parasitol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.3390\/nu5124836","article-title":"Vitamin B(12) and folic acid imbalance modifies NK cytotoxicity, lymphocytes B and lymphoprolipheration in aged rats","volume":"5","author":"T Partearroyo","year":"2013","journal-title":"Nutrients"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1046\/j.1365-2249.1999.00870.x","article-title":"Immunomodulation by vitamin B12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment","volume":"116","author":"J Tamura","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.4049\/jimmunol.173.5.3186","article-title":"Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro","volume":"173","author":"C Courtemanche","year":"2004","journal-title":"J Immunol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1753-4887.1993.tb03109.x","article-title":"Vitamin B6 and immune competence","volume":"51","author":"LC Rall","year":"1993","journal-title":"Nutr Rev"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/infdis\/118.2.206","article-title":"Nutritional requirements of Leptospirae. IV. Vitamin requirements of Leptospira pomona and its growth in a minimal medium","volume":"118","author":"RE Wooley","year":"1968","journal-title":"J Infect Dis"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1128\/JB.93.5.1598-1606.1967","article-title":"Growth of pathogenic Leptospira in chemically defined media","volume":"93","author":"E Shenberg","year":"1967","journal-title":"J Bacteriol"},{"key":"ref94","first-page":"39","article-title":"Nutrition of leptospira pomona and growth of 13 other serotypes: a serum-free medium employing oleic albumin complex","volume":"26","author":"HC Ellinghausen Jr.","year":"1965","journal-title":"Am J Vet Res"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1128\/jb.83.3.668-672.1962","article-title":"Nutrition of Leptospira pomona. 1. A chemically defined substitute for rabbit serum ultrafiltrate","volume":"83","author":"RC Johnson","year":"1962","journal-title":"J Bacteriol"},{"key":"ref96","first-page":"299","article-title":"Studies on the metabolism of leptospirae. I. Vitamin B12 as a growth factor","volume":"11","author":"B Babudieri","year":"1961","journal-title":"Int Z Vitaminforsch Beih"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3181\/00379727-82-20021","article-title":"Nutrition of Leptospira canicola. III. 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