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Larsen","year":"1998"},{"key":"ref81","first-page":"169","article-title":"A microflocculation test for syphilis using cardiolipin antigen","volume":"27","author":"A Harris","year":"1946","journal-title":"J Vener Dis Inf"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1086\/655832","article-title":"Novel Treponema pallidum serologic tests: a paradigm shift in syphilis screening for the 21st century","volume":"51","author":"AC Sena","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref83","unstructured":"Centers for Disease C, Prevention (2008) Syphilis testing algorithms using treponemal tests for initial screening\u2014four laboratories, New York City, 2005\u20132006. MMWR Morbidity and mortality weekly report 57: 872."},{"key":"ref84","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2105\/AJPH.29.2.143","article-title":"Results of Venereal Disease Control in Canada","volume":"29","author":"G Bates","year":"1939","journal-title":"Am J Public Health Nations Health"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2105\/AJPH.26.4.329","article-title":"Health Security","volume":"26","author":"T Parran","year":"1936","journal-title":"Am J Public Health Nations Health"},{"key":"ref86","first-page":"246","article-title":"Seropositive syphilis in Finland 1939\u20131944 in the light of blood donor volunteer material","volume":"28","author":"T Putkonen","year":"1950","journal-title":"Ann Med Exp Biol Fenn"},{"key":"ref87","article-title":"On the Wasserman and Khan reactions during pregnancy","author":"K Pentinnen","year":"1946"},{"key":"ref88","first-page":"70","article-title":"Significance of false positive syphilis reactions and anticardiolipin antibodies in a nationwide series of pregnant women","volume":"15","author":"P Koskela","year":"1988","journal-title":"J Rheumatol"},{"key":"ref89","first-page":"113","article-title":"Sero-reactivity for Syphilis in Bombay","volume":"34","author":"MD Mungale","year":"1958","journal-title":"Br J Vener Dis"},{"key":"ref90","first-page":"79","article-title":"Venereal diseases in India","volume":"32","author":"RV Rajam","year":"1956","journal-title":"Br J Vener Dis"},{"key":"ref91","first-page":"215","article-title":"Prevalence of Syphilis in Different Classes of Population","volume":"40","author":"N Bhargava","year":"1974","journal-title":"Indian Journal of Dermatology, Venereology, and Leprology"},{"key":"ref92","article-title":"Serological survey for syphilis amongst antenatal cases in selected hospitals of Delhi","volume":"33","author":"S Chakraborty","year":"1989","journal-title":"Indian journal of public health"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1136\/sti.2007.025551","article-title":"Declining trends in syphilis prevalence among antenatal women in northern India: a 10-year analysis from a tertiary healthcare centre","volume":"83","author":"S Sethi","year":"2007","journal-title":"Sex Transm Infect"},{"key":"ref94","first-page":"519","article-title":"The venereal disease problem in Japan","volume":"19","author":"Y Tanami","year":"1958","journal-title":"Bull World Health Organ"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.0954-6820.1943.tb16879.x","article-title":"On the Frequency of Seropositive Syphilis in Norway in Presumably Healthy Adults","volume":"114","author":"O Hartmann","year":"1943","journal-title":"Acta Medica Scandinavica"},{"key":"ref96","first-page":"100","article-title":"Serological syphilis control in pregnancy in Bergen, Norway","volume":"31","author":"TM Vogelsang","year":"1950","journal-title":"Acta Derm Venereol Suppl (Stockh)"},{"key":"ref97","first-page":"10","article-title":"Treponemal immobilization test in expectant mothers; results in 142 reactors to standard serological tests","volume":"35","author":"J Eng","year":"1959","journal-title":"Br J Vener Dis"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00007435-198311000-00001","article-title":"Economic evaluation of maternal screening to prevent congenital syphilis","volume":"10","author":"B Stray-Pedersen","year":"1983","journal-title":"Sex Transm Dis"},{"key":"ref99","first-page":"93","article-title":"Treponematosis in Singapore","volume":"36","author":"LM Ram","year":"1960","journal-title":"Br J Vener Dis"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1046\/j.1537-2995.1990.30991048793.x","article-title":"Syphilis and blood transfusion: a global perspective","volume":"30","author":"A De Schryver","year":"1990","journal-title":"Transfusion"},{"key":"ref101","first-page":"2181","article-title":"Syphilis In the Bantu of Soweto","volume":"47","author":"L Eisenberg","year":"1973","journal-title":"S Afr Med J"},{"key":"ref102","unstructured":"National Department of Health (2006) The National Antenatal Sentinel HIV and Syphilis Prevalence Survey, South Africa."},{"key":"ref103","unstructured":"National Department of Health (2008) The National Antenatal Sentinel HIV and Syphilis Prevalence Survey, South Africa."},{"key":"ref104","unstructured":"National Department of Health (2009) The National Antenatal Sentinel HIV and Syphilis Prevalence Survey, South Africa."},{"key":"ref105","unstructured":"National Department of Health (2010) The National Antenatal Sentinel HIV and Syphilis Prevalence Survey, South Africa. Department of Health."},{"key":"ref106","unstructured":"National Department of Health (2011) The National Antenatal Sentinel HIV and Syphilis Prevalence Survey, South Africa, 2010."},{"key":"ref107","unstructured":"National Department of Health (2012) The National Antenatal Sentinel HIV and Syphilis Prevalence Survey, South Africa, 2011."},{"key":"ref108","first-page":"1191","article-title":"Detection of biological false positive syphilis serum reactions","volume":"74","author":"H Brede","year":"1974","journal-title":"S Afr Med J"},{"key":"ref109","first-page":"81","article-title":"The Incidence of Venereal Disease in Scotland","volume":"16","author":"TF Dewar","year":"1923","journal-title":"Proc R Soc Med"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1136\/bmj.1.4877.1470","article-title":"The prevention of congenital syphilis","volume":"1","author":"RS Morton","year":"1954","journal-title":"Br Med J"},{"key":"ref111","first-page":"189","article-title":"Trends in the prevalence of venereal diseases in England and Wales","volume":"38","author":"RR Willcox","year":"1962","journal-title":"Br J Vener Dis"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1471-0528.1973.tb15972.x","article-title":"Serological tests for treponemal disease in pregnancy","volume":"80","author":"MJ Hare","year":"1973","journal-title":"J Obstet Gynaecol Br Commonw"},{"key":"ref113","first-page":"420","article-title":"Serological tests for syphilis in pregnancy. False and missed positive reactions","volume":"49","author":"CB Schofield","year":"1973","journal-title":"Br J Vener Dis"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1136\/jcp.42.12.1281","article-title":"Serological screening tests for syphilis in pregnancy: results of a five year study (1983\u201387) in the Oxford region","volume":"42","author":"P Bowell","year":"1989","journal-title":"J Clin Pathol"},{"key":"ref115","first-page":"260","article-title":"Studies on syphilis in the Eastern Health District of Baltimore city; syphilis among parturient women as an index of the trend of syphilis in the community","volume":"46","author":"GM Leiby","year":"1947","journal-title":"Am J Hyg"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2105\/AJPH.79.4.467","article-title":"Race and the prevalence of syphilis seroreactivity in the United States population: a national sero-epidemiologic study","volume":"79","author":"RA Hahn","year":"1989","journal-title":"Am J Public Health"},{"key":"ref117","first-page":"202","article-title":"A Review of Venereal Disease in the African","volume":"8","author":"W Cowan","year":"1962","journal-title":"Cent Afr J M"},{"key":"ref118","first-page":"248","article-title":"Syphilis in pregnancy: a medical audit in a rural district","volume":"39","author":"S Rutgers","year":"1993","journal-title":"Cent Afr J Med"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1471-2334-10-127","article-title":"The burden and risk factors of sexually transmitted infections and reproductive tract infections among pregnant women in Zimbabwe","volume":"10","author":"N Kurewa","year":"2010","journal-title":"BMC Infect Dis"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1758-2652-13-45","article-title":"Sexual behaviour does not reflect HIV-1 prevalence differences: a comparison study of Zimbabwe and Tanzania","volume":"13","author":"MP Mapingure","year":"2010","journal-title":"J Int AIDS Soc"},{"key":"ref121","first-page":"90","article-title":"Field efficiency of syphilis screening in antenatal care: lessons from Gutu District in Zimbabwe","volume":"49","author":"F Majoko","year":"2003","journal-title":"Cent Afr J Med"},{"key":"ref122","first-page":"24","article-title":"Seroprevalence and risk factors of syphilis infection in pregnant women delivering at Harare Maternity Hospital, Zimbabwe","volume":"51","author":"L Pham","year":"2005","journal-title":"Cent Afr J Med"},{"key":"ref123","first-page":"476","article-title":"Syphilis as a Canadian Problem","volume":"42","author":"FE Cormia","year":"1940","journal-title":"Can Med Assoc J"},{"key":"ref124","first-page":"150","article-title":"Venereal diseases in Canada","volume":"32","author":"RH Allen","year":"1956","journal-title":"Br J Vener Dis"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"30","DOI":"10.14745\/ccdr.v41i02a03","article-title":"Infectious syphilis in Canada: 2003\u20132012","volume":"41","author":"S Totten","year":"2015","journal-title":"Canada Communicable Disease Report"},{"key":"ref126","first-page":"182","article-title":"World health and treponematoses","volume":"37","author":"T Guthe","year":"1951","journal-title":"J Soc Hyg"},{"key":"ref127","article-title":"Sexually transmitted infections in Europe, 1990\u20132009","year":"2011"},{"key":"ref128","article-title":"Sexually transmitted infections, including HIV and blood-borne viruses","year":"2014"},{"key":"ref129","first-page":"75","article-title":"Epidemiology of infectious syphilis in Singapore","volume":"62","author":"T Thirumoorthy","year":"1986","journal-title":"Genitourin Med"},{"key":"ref130","first-page":"453","article-title":"Syphilis in South Africa","volume":"14","author":"F Purcell","year":"1940","journal-title":"South African Medical Journal"},{"key":"ref131","first-page":"248","article-title":"The colour of disease: syphilis and racism in South Africa, 1880\u20131950","volume":"xii","author":"K Jochelson","year":"2001"},{"key":"ref132","first-page":"3","article-title":"Communicable Diseases Communique","volume":"2","year":"2003","journal-title":"Communicable Diseases Communique"},{"key":"ref133","article-title":"Atlas of epidemic Britain: a twentieth century picture","author":"M Smallman-Raynor","year":"2012"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T10:52:43Z","timestamp":1567853563000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004711"}},"subtitle":[],"editor":[{"given":"Pamela L. 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