{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T04:33:04Z","timestamp":1766377984754,"version":"3.37.3"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T00:00:00Z","timestamp":1463356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["10-MIDI-0008"],"award-info":[{"award-number":["10-MIDI-0008"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pasteur Paris Univeristy (PPU)"},{"name":"EFIS-IL Fellowship"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0004716","type":"journal-article","created":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T17:46:47Z","timestamp":1463420807000},"page":"e0004716","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cathepsin B-Deficient Mice Resolve Leishmania major Inflammation Faster in a T Cell-Dependent Manner"],"prefix":"10.1371","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7040-9587","authenticated-orcid":true,"given":"Orhan","family":"Rasid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"M\u00e9riaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin M.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chlo\u00e9","family":"Borde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana S.","family":"Ciulean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Fitting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9n\u00e9dicte","family":"Manoury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marc","family":"Cavaillon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u00eblle","family":"Doyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,5,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nri933","article-title":"The immunology of susceptibility and resistance to Leishmania major in mice","volume":"2","author":"D Sacks","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/jlb.57.4.515","article-title":"The role of the innate immune response in Th1 cell development following Leishmania major infection","volume":"57","author":"T Scharton-Kersten","year":"1995","journal-title":"J Leukoc Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1084\/jem.188.8.1547","article-title":"Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: implications for the initiation of anti-Leishmania immunity","volume":"188","author":"E von Stebut","year":"1998","journal-title":"The Journal of experimental medicine"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0165-2478(02)00228-6","article-title":"Recognition of pathogen-associated molecular patterns by TLR family","volume":"85","author":"S Akira","year":"2003","journal-title":"Immunol Lett"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.1085536","article-title":"Toll-like receptor signaling pathways","volume":"300","author":"GM Barton","year":"2003","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1128\/IAI.01090-07","article-title":"Toll-like receptors and leishmaniasis","volume":"76","author":"FF Tuon","year":"2008","journal-title":"Infect Immun"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"930257","DOI":"10.1155\/2012\/930257","article-title":"Toll-like receptors in leishmania infections: guardians or promoters?","volume":"2012","author":"MS Faria","year":"2012","journal-title":"J Parasitol Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.4049\/jimmunol.182.3.1386","article-title":"TLR9-dependent activation of dendritic cells by DNA from Leishmania major favors Th1 cell development and the resolution of lesions","volume":"182","author":"FH Abou Fakher","year":"2009","journal-title":"J Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1084\/jem.20061293","article-title":"NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs","volume":"204","author":"U Schleicher","year":"2007","journal-title":"The Journal of experimental medicine"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1002\/eji.200737182","article-title":"TLR9 signaling is essential for the innate NK cell response in murine cutaneous leishmaniasis","volume":"37","author":"J Liese","year":"2007","journal-title":"European Journal of Immunology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1128\/IAI.01401-12","article-title":"Role of Toll-like receptor 9 signaling in experimental Leishmania braziliensis infection","volume":"81","author":"T Weinkopff","year":"2013","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.4049\/jimmunol.1101018","article-title":"Lymph node hypertrophy following Leishmania major infection is dependent on TLR9","volume":"188","author":"LP Carvalho","year":"2012","journal-title":"J Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.immuni.2009.09.013","article-title":"Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells","volume":"31","author":"FE Sepulveda","year":"2009","journal-title":"Immunity"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/ni.1669","article-title":"Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9","volume":"9","author":"B Park","year":"2008","journal-title":"Nat Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.bbrc.2007.12.130","article-title":"Cathepsins are required for Toll-like receptor 9 responses","volume":"367","author":"F Matsumoto","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1084\/jem.20100682","article-title":"Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase","volume":"208","author":"SE Ewald","year":"2011","journal-title":"The Journal of experimental medicine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/intimm\/13.8.975","article-title":"Treatment with cathepsin L inhibitor potentiates Th2-type immune response in Leishmania major-infected BALB\/c mice","volume":"13","author":"T Zhang","year":"2001","journal-title":"Int Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.4049\/jimmunol.161.5.2120","article-title":"Switch of CD4+ T cell differentiation from Th2 to Th1 by treatment with cathepsin B inhibitor in experimental leishmaniasis","volume":"161","author":"Y Maekawa","year":"1998","journal-title":"J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e3194","DOI":"10.1371\/journal.pntd.0003194","article-title":"Cathepsin B in Antigen-Presenting Cells Controls Mediators of the Th1 Immune Response during Leishmania major Infection","volume":"8","author":"IJ Gonzalez-Leal","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1182\/blood-2003-04-1075","article-title":"Cathepsin-B-dependent apoptosis triggered by antithymocyte globulins: a novel mechanism of T-cell depletion","volume":"102","author":"MC Michallet","year":"2003","journal-title":"Blood"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.4049\/jimmunol.1003406","article-title":"Cathepsin B controls the persistence of memory CD8+ T lymphocytes","volume":"189","author":"SM Byrne","year":"2012","journal-title":"J Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1084\/jem.20011836","article-title":"Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation","volume":"196","author":"KN Balaji","year":"2002","journal-title":"The Journal of experimental medicine"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"30485","DOI":"10.1074\/jbc.M602007200","article-title":"Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells","volume":"281","author":"K Baran","year":"2006","journal-title":"Journal of Biological Chemistry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S1074-7613(00)80020-5","article-title":"Cathepsin S required for normal MHC class II peptide loading and germinal center development","volume":"10","author":"GP Shi","year":"1999","journal-title":"Immunity"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1073\/pnas.95.8.4516","article-title":"Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation","volume":"95","author":"J Deussing","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1096\/fj.99-0970com","article-title":"Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling","volume":"14","author":"W Roth","year":"2000","journal-title":"FASEB J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.4049\/jimmunol.0901486","article-title":"Distinct protease requirements for antigen presentation in vitro and in vivo","volume":"184","author":"SP Matthews","year":"2010","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1365-3024.1985.tb00098.x","article-title":"A limiting dilution assay for quantifying Leishmania major in tissues of infected mice","volume":"7","author":"RG Titus","year":"1985","journal-title":"Parasite Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e3308","DOI":"10.1371\/journal.pntd.0003308","article-title":"TLR9 activation is triggered by the excess of stimulatory versus inhibitory motifs present in Trypanosomatidae DNA","volume":"8","author":"ME Khan","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1084\/jem.176.6.1693","article-title":"Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte\/macrophage colony-stimulating factor","volume":"176","author":"K Inaba","year":"1992","journal-title":"J Exp Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/eji.1830200812","article-title":"Accumulation of bromodeoxyuridine-labeled cells in central and peripheral lymphoid organs: minimal estimates of production and turnover rates of mature lymphocytes","volume":"20","author":"B Rocha","year":"1990","journal-title":"European Journal of Immunology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e476","DOI":"10.1371\/journal.pntd.0000476","article-title":"Comparative expression profiling of Leishmania: modulation in gene expression between species and in different host genetic backgrounds","volume":"3","author":"DP Depledge","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.micinf.2004.01.008","article-title":"Cathepsin L is crucial for a Th1-type immune response during Leishmania major infection","volume":"6","author":"K Onishi","year":"2004","journal-title":"Microbes Infect"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1084\/jem.20020327","article-title":"Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation","volume":"196","author":"AM Lennon-Dumenil","year":"2002","journal-title":"The Journal of experimental medicine"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1084\/jem.20030026","article-title":"Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1","volume":"198","author":"J Liu","year":"2003","journal-title":"J Exp Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"690","DOI":"10.4049\/jimmunol.181.1.690","article-title":"Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages","volume":"181","author":"SD Ha","year":"2008","journal-title":"J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/eji.200737662","article-title":"An essential role for transmembrane TNF in the resolution of the inflammatory lesion induced by Leishmania major infection","volume":"38","author":"C Allenbach","year":"2008","journal-title":"European Journal of Immunology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.micinf.2004.02.008","article-title":"The control of Leishmania (Leishmania) major by TNF in vivo is dependent on the parasite strain","volume":"6","author":"U Ritter","year":"2004","journal-title":"Microbes Infect"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.1365-2567.2000.00000.x","article-title":"Lysosomal cathepsin B plays an important role in antigen processing, while cathepsin D is involved in degradation of the invariant chain in ovalbumin-immunized mice","volume":"100","author":"T Zhang","year":"2000","journal-title":"Immunology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nri3469","article-title":"How B cells capture, process and present antigens: a crucial role for cell polarity","volume":"13","author":"MI Yuseff","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nrmicro2608","article-title":"Leishmaniasis: complexity at the host-pathogen interface","volume":"9","author":"P Kaye","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0966-842X(03)00075-1","article-title":"Neutrophil granulocytes\u2014Trojan horses for Leishmania major and other intracellular microbes?","volume":"11","author":"T Laskay","year":"2003","journal-title":"Trends in Microbiology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1128\/IAI.65.6.2448-2450.1997","article-title":"Efficient immunity against Leishmania major in the absence of interleukin-6","volume":"65","author":"NH Moskowitz","year":"1997","journal-title":"Infect Immun"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1128\/IAI.69.8.5189-5192.2001","article-title":"Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease","volume":"69","author":"RG Titus","year":"2001","journal-title":"Infect Immun"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1139\/W09-017","article-title":"The IL-6-deficient mouse exhibits impaired lymphocytic responses to a vaccine combining live Leishmania major and CpG oligodeoxynucleotides","volume":"55","author":"W Wu","year":"2009","journal-title":"Can J Microbiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e1000871","DOI":"10.1371\/journal.ppat.1000871","article-title":"Keratinocytes determine Th1 immunity during early experimental leishmaniasis","volume":"6","author":"JM Ehrchen","year":"2010","journal-title":"Plos Pathogens"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.4049\/jimmunol.1500509","article-title":"Multiple Cathepsins Promote Pro-IL-1beta Synthesis and NLRP3-Mediated IL-1beta Activation","volume":"195","author":"GM Orlowski","year":"2015","journal-title":"J Immunol"},{"issue":"13","key":"ref48","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.iy.13.040195.001055","article-title":"The regulation of immunity to Leishmania major","volume":"33","author":"SL Reiner","year":"1995","journal-title":"Annual Review of Immunology"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.imlet.2005.01.009","article-title":"T helper (h)1\/Th2 and Leishmania: paradox rather than paradigm","volume":"99","author":"J Alexander","year":"2005","journal-title":"Immunol Lett"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/ni725","article-title":"IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB\/c mice","volume":"2","author":"T Biedermann","year":"2001","journal-title":"Nat Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nature01152","article-title":"CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity","volume":"420","author":"Y Belkaid","year":"2002","journal-title":"Nature"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1084\/jem.20040298","article-title":"Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity","volume":"200","author":"S Mendez","year":"2004","journal-title":"The Journal of experimental medicine"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"5405","DOI":"10.4049\/jimmunol.172.9.5405","article-title":"Cathepsin-dependent apoptosis triggered by supraoptimal activation of T lymphocytes: a possible mechanism of high dose tolerance","volume":"172","author":"MC Michallet","year":"2004","journal-title":"J Immunol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/ni1107","article-title":"Serine protease inhibitor 2A is a protective factor for memory T cell development","volume":"5","author":"N Liu","year":"2004","journal-title":"Nat Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.4049\/jimmunol.0903854","article-title":"CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism","volume":"184","author":"AI Lalanne","year":"2010","journal-title":"J Immunol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1365-2249.2006.03188.x","article-title":"Cathepsins B, L and D in inflammatory bowel disease macrophages and potential therapeutic effects of cathepsin inhibition in vivo","volume":"146","author":"K Menzel","year":"2006","journal-title":"Clinical and Experimental Immunology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1006\/bbrc.2001.4787","article-title":"Significance of cathepsin B accumulation in synovial fluid of rheumatoid arthritis","volume":"283","author":"Y Hashimoto","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.4049\/jimmunol.168.8.3992","article-title":"CD8+ T cells are required for primary immunity in C57BL\/6 mice following low-dose, intradermal challenge with Leishmania major","volume":"168","author":"Y Belkaid","year":"2002","journal-title":"J Immunol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"13800","DOI":"10.1074\/jbc.M115.638395","article-title":"Cysteine Cathepsins Activate ELR Chemokines and Inactivate Non-ELR Chemokines","volume":"290","author":"U Repnik","year":"2015","journal-title":"Journal of Biological Chemistry"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T06:46:03Z","timestamp":1692341163000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004716"}},"subtitle":[],"editor":[{"given":"Christian R.","family":"Engwerda","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,5,16]]},"references-count":59,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0004716","relation":{},"ISSN":["1935-2735"],"issn-type":[{"type":"electronic","value":"1935-2735"}],"subject":[],"published":{"date-parts":[[2016,5,16]]}}}