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Available at <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/CRAN.R-project.org\/package=gplots\" xlink:type=\"simple\">http:\/\/CRAN.R-project.org\/package=gplots<\/ext-link>. gplots: Various R programming tools for plotting data. 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