{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:35:01Z","timestamp":1789425301974,"version":"build-2803163510"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0004830","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T17:45:03Z","timestamp":1469555103000},"page":"e0004830","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cytokine Profile of Children Hospitalized with Virologically-Confirmed Dengue during Two Phase III Vaccine Efficacy Trials"],"prefix":"10.1371","volume":"10","author":[{"given":"Anke","family":"Harenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aymeric","family":"de Montfort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Jantet-Blaudez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Bonaparte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Boudet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Saville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Guy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,7,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"S Bhatt","year":"2013","journal-title":"Nature"},{"key":"ref2","unstructured":"WHO (2012) Global strategy for dengue and prevention and control 2012\u20132020."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/CMR.00035-09","article-title":"Dengue virus pathogenesis: an integrated view","volume":"22","author":"BE Martina","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"ref4","first-page":"476","article-title":"Primary dengue infection: what are the clinical distinctions from secondary infection?","volume":"32","author":"C Pancharoen","year":"2001","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1574-695X.2000.tb01474.x","article-title":"Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesis","volume":"28","author":"UC Chaturvedi","year":"2000","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/01.qco.0000244047.31135.fa","article-title":"Immunopathological mechanisms in dengue and dengue hemorrhagic fever","volume":"19","author":"S Green","year":"2006","journal-title":"Curr Opin Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4269\/ajtmh.2006.74.142","article-title":"Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients","volume":"74","author":"LC Chen","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"ref8","first-page":"172","article-title":"Cytokine patterns during dengue shock syndrome","volume":"14","author":"C Suharti","year":"2003","journal-title":"Eur Cytokine Netw"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2334-8-86","article-title":"Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity","volume":"8","author":"FA Bozza","year":"2008","journal-title":"BMC Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1086\/314680","article-title":"Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity","volume":"179","author":"S Green","year":"1999","journal-title":"J Infect Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nri3014","article-title":"Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms","volume":"11","author":"AL Rothman","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/S0140-6736(07)61687-0","article-title":"Dengue","volume":"370","author":"SB Halstead","year":"2007","journal-title":"Lancet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/S1473-3099(10)70166-3","article-title":"Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes","volume":"10","author":"SB Halstead","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1128\/JVI.00220-10","article-title":"Cell type specificity and host genetic polymorphisms influence antibody-dependent enhancement of dengue virus infection","volume":"85","author":"K Boonnak","year":"2011","journal-title":"J Virol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1423-0127-20-37","article-title":"Current progress in dengue vaccines","volume":"20","author":"SW Wan","year":"2013","journal-title":"J Biomed Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/S0140-6736(14)61060-6","article-title":"Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial","volume":"384","author":"MR Capeding","year":"2014","journal-title":"Lancet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1056\/NEJMoa1411037","article-title":"Efficacy of a tetravalent dengue vaccine in children in Latin America","volume":"372","author":"L Villar","year":"2015","journal-title":"N Engl J Med"},{"key":"ref18","article-title":"Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease","author":"SR Hadinegoro","year":"2015","journal-title":"N Engl J Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1590\/S0074-02762012000100007","article-title":"Profile of circulating levels of IL-1Ra, CXCL10\/IP-10, CCL4\/MIP-1beta and CCL2\/MCP-1 in dengue fever and parvovirosis","volume":"107","author":"LM Oliveira-Pinto","year":"2012","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e52215","DOI":"10.1371\/journal.pone.0052215","article-title":"Cytokine expression profile of dengue patients at different phases of illness","volume":"7","author":"A Rathakrishnan","year":"2012","journal-title":"PLoS One"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cyto.2010.06.010","article-title":"MCP-1 and MIP-1alpha expression in a model resembling early immune response to dengue","volume":"52","author":"B Sierra","year":"2010","journal-title":"Cytokine"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nri2956","article-title":"Platelets and the immune continuum","volume":"11","author":"JW Semple","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e0004497","DOI":"10.1371\/journal.pntd.0004497","article-title":"Immune Response to Dengue Virus Infection in Pediatric Patients in New Delhi, India-Association of Viremia, Inflammatory Mediators and Monocytes with Disease Severity","volume":"10","author":"M Singla","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/infdis\/jiu088","article-title":"Ebola hemorrhagic Fever: novel biomarker correlates of clinical outcome","volume":"210","author":"AK McElroy","year":"2014","journal-title":"J Infect Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.actatropica.2015.04.023","article-title":"Circulating cytokines and chemokines associated with plasma leakage and hepatic dysfunction in Brazilian children with dengue fever","volume":"149","author":"RA Ferreira","year":"2015","journal-title":"Acta Trop"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e232","DOI":"10.1097\/INF.0b013e31826fd456","article-title":"Alteration of cytokines and chemokines during febrile episodes associated with endothelial cell damage and plasma leakage in dengue hemorrhagic fever","volume":"31","author":"P Butthep","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1099\/vir.0.82537-0","article-title":"Dengue virus (DENV) antibody-dependent enhancement of infection upregulates the production of anti-inflammatory cytokines, but suppresses anti-DENV free radical and pro-inflammatory cytokine production, in THP-1 cells","volume":"88","author":"T Chareonsirisuthigul","year":"2007","journal-title":"J Gen Virol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1086\/380762","article-title":"Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles","volume":"189","author":"TH Nguyen","year":"2004","journal-title":"J Infect Dis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/(SICI)1096-9071(199911)59:3<329::AID-JMV12>3.0.CO;2-G","article-title":"Elevated plasma interleukin-10 levels in acute dengue correlate with disease severity","volume":"59","author":"S Green","year":"1999","journal-title":"J Med Virol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1186\/1471-2334-13-341","article-title":"Serum IL-10 as a marker of severe dengue infection","volume":"13","author":"GN Malavige","year":"2013","journal-title":"BMC Infect Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/jmv.20080","article-title":"IL-10 levels in Dengue patients: some findings from the exceptional epidemiological conditions in Cuba","volume":"73","author":"AB Perez","year":"2004","journal-title":"J Med Virol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrmicro.2015.2","article-title":"Dengue vaccine: hypotheses to understand CYD-TDV-induced protection","volume":"14","author":"B Guy","year":"2016","journal-title":"Nat Rev Microbiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jcv.2014.04.002","article-title":"A strong interferon response correlates with a milder dengue clinical condition","volume":"60","author":"SI De La Cruz Hernandez","year":"2014","journal-title":"J Clin Virol"},{"key":"ref34","first-page":"67","article-title":"Markers of dengue disease severity","volume":"338","author":"A Srikiatkhachorn","year":"2010","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12929-015-0191-6","article-title":"Biomarkers of severe dengue disease\u2014a review","volume":"22","author":"DV John","year":"2015","journal-title":"J Biomed Sci"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T18:47:55Z","timestamp":1568227675000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004830"}},"subtitle":[],"editor":[{"given":"Cameron P.","family":"Simmons","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,7,26]]},"references-count":35,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,7,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0004830","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,26]]}}}