{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:45:29Z","timestamp":1793202329159,"version":"4.5.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T00:00:00Z","timestamp":1472169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","award":["2013"],"award-info":[{"award-number":["2013"]}],"id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Royal College of Physicians of Thailand"},{"name":"Roche Diagnostics (Thailand)"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0004961","type":"journal-article","created":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T17:36:07Z","timestamp":1472232967000},"page":"e0004961","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Serum Procalcitonin and Peripheral Venous Lactate for Predicting Dengue Shock and\/or Organ Failure: A Prospective Observational Study"],"prefix":"10.1371","volume":"10","author":[{"given":"Vipa","family":"Thanachartwet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varunee","family":"Desakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duangjai","family":"Sahassananda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akanitt","family":"Jittmittraphap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nittha","family":"Oer-areemitr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathaporn","family":"Osothsomboon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoon","family":"Surabotsophon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anan","family":"Wattanathum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,8,26]]},"reference":[{"key":"ref1","year":"2009"},{"key":"ref2","year":"2012"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1038\/nrmicro2460","article-title":"Dengue: a continuing global threat","volume":"8","author":"MG Guzman","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"S Bhatt","year":"2013","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/S0140-6736(05)76460-6","article-title":"Is there an inapparent dengue explosion?","volume":"353","author":"SB Halstead","year":"1999","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/004947559902900110","article-title":"Dengue haemorrhagic fever in adults: a prospective study of 110 cases","volume":"29","author":"JP Wali","year":"1999","journal-title":"Trop Doct"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1590\/S1020-49892002000400003","article-title":"Enhanced severity of secondary dengue-2 infections: death rates in 1981 and 1997 Cuban outbreaks","volume":"11","author":"MG Guzm\u00e1n","year":"2002","journal-title":"Rev Panam Salud Publica"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"621","DOI":"10.4269\/ajtmh.13-0676","article-title":"Comparing the usefulness of the 1997 and 2009 WHO dengue case classification: a systematic literature review","volume":"91","author":"O Horstick","year":"2014","journal-title":"Am J Trop Med Hyg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/QCO.0b013e32835fb938","article-title":"The pathogenesis of dengue","volume":"26","author":"S Yacoub","year":"2013","journal-title":"Curr Opin Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nrmicro3030","article-title":"Barriers to preclinical investigations of anti-dengue immunity and dengue pathogenesis","volume":"11","author":"AL St. John","year":"2013","journal-title":"Nat Rev Microbiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0140-6736(14)60572-9","article-title":"Dengue","volume":"385","author":"MG Guzman","year":"2015","journal-title":"Lancet"},{"issue":"Suppl 1","key":"ref12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1179\/2046904712Z.00000000045","article-title":"Controversies in dengue pathogenesis","volume":"32","author":"SB Halstead","year":"2012","journal-title":"Paediatr Int Child Health"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e2412","DOI":"10.1371\/journal.pntd.0002412","article-title":"Factors associated with dengue shock syndrome: a systematic review and meta-analysis","volume":"7","author":"NT Huy","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3343\/alm.2014.34.4.263","article-title":"Update on procalcitonin measurements","volume":"34","author":"M Meisner","year":"2014","journal-title":"Ann Lab Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s11845-015-1327-0","article-title":"Procalcitonin: present and future","volume":"184","author":"HH Liu","year":"2015","journal-title":"Ir J Med Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S1473-3099(12)70323-7","article-title":"Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis","volume":"13","author":"C Wacker","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1186\/s12879-015-1272-6","article-title":"Performance of C-reactive protein and procalcitonin to distinguish viral from bacterial and malarial causes of fever in Southeast Asia","volume":"15","author":"Y Lubell","year":"2015","journal-title":"BMC Infect Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/cc306","article-title":"Comparison of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations at different SOFA scores during the course of sepsis and MODS","volume":"3","author":"M Meisner","year":"1999","journal-title":"Crit Care"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1097\/01.CCM.0000126263.00551.06","article-title":"Diagnostic and prognostic value of procalcitonin in patients with septic shock","volume":"32","author":"C Clec'h","year":"2004","journal-title":"Crit Care Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s00134-009-1746-3","article-title":"Procalcitonin and C-reactive protein in severe 2009 H1N1 influenza infection","volume":"36","author":"PR Ingram","year":"2010","journal-title":"Intensive Care Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1097\/CCM.0b013e31819fcf68","article-title":"Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock","volume":"37","author":"ME Mikkelsen","year":"2009","journal-title":"Crit Care Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1186\/s12879-015-1150-2","article-title":"Identification of clinical factors associated with severe dengue among Thai adults: a prospective study","volume":"15","author":"V Thanachartwet","year":"2015","journal-title":"BMC Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/bmj.39335.541782.AD","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"335","author":"E von Elm","year":"2007","journal-title":"BMJ"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1136\/eb-2013-101637","article-title":"Reporting quality of diagnostic accuracy studies: a systematic review and meta-analysis of investigations on adherence to STARD","volume":"19","author":"DA Korevaar","year":"2014","journal-title":"Evid Based Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1128\/JCM.30.3.545-551.1992","article-title":"Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction","volume":"30","author":"RS Lanciotti","year":"1992","journal-title":"J Clin Microbiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1128\/JCM.41.8.3864-3867.2003","article-title":"Improved molecular detection of dengue virus serotype 1 variants","volume":"41","author":"JM Reynes","year":"2003","journal-title":"J Clin Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"208","DOI":"10.4269\/ajtmh.2002.66.208","article-title":"Enzyme-linked immunosorbent assay-format microneutralization test for dengue viruses","volume":"66","author":"V Vorndam","year":"2002","journal-title":"Am J Trop Med Hyg"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4269\/ajtmh.2008.79.115","article-title":"Comparative evaluation of three assays for measurement of dengue virus neutralizing antibodies","volume":"79","author":"JR Putnak","year":"2008","journal-title":"Am J Trop Med Hyg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"418","DOI":"10.4269\/ajtmh.1989.40.418","article-title":"An enzyme-linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis co-circulate","volume":"40","author":"BL Innis","year":"1989","journal-title":"Am J Trop Med Hyg"},{"key":"ref30","first-page":"602","article-title":"Factors associated with severe clinical manifestation of dengue among adults in Thailand","volume":"44","author":"KL Aung","year":"2013","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1164\/rccm.201201-0037OC","article-title":"Combination biomarkers to diagnose sepsis in the critically ill patient","volume":"186","author":"S Gibot","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1056\/NEJMra1110265","article-title":"Dengue","volume":"366","author":"CP Simmons","year":"2012","journal-title":"N Engl J Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e2023","DOI":"10.1371\/journal.pntd.0002023","article-title":"Utilities and limitations of the World Health Organization 2009 warning signs for adult dengue severity","volume":"7","author":"TL Thein","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1186\/1471-2334-13-498","article-title":"Utility of warning signs in guiding admission and predicting severe disease in adult dengue","volume":"13","author":"YS Leo","year":"2013","journal-title":"BMC Infect Dis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12879-016-1386-5","article-title":"Diagnostic accuracy of peripheral venous lactate and the 2009 WHO warning signs for identifying severe dengue in Thai adults: a prospective observational study","volume":"16","author":"V Thanachartwet","year":"2016","journal-title":"BMC Infect Dis"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e0129450","DOI":"10.1371\/journal.pone.0129450","article-title":"Prognostic value of procalcitonin in adult patients with sepsis: a systematic review and meta-analysis","volume":"10","author":"D Liu","year":"2015","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1093\/infdis\/jiv252","article-title":"Serum procalcitonin measurement and viral testing to guide antibiotic use for respiratory infections in hospitalized adults: a randomized controlled trial","volume":"212","author":"AR Branche","year":"2015","journal-title":"J Infect Dis"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1097\/00006454-199910000-00008","article-title":"Comparison of procalcitonin with C-reactive protein, interleukin 6 and interferon-alpha for differentiation of bacterial vs. viral infections","volume":"18","author":"D Gendrel","year":"1999","journal-title":"Pediatr Infect Dis J"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1086\/315215","article-title":"Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity","volume":"181","author":"DW Vaughn","year":"2000","journal-title":"J Infect Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/(SICI)1096-9071(200004)60:4<432::AID-JMV11>3.0.CO;2-7","article-title":"Prospective study of the duration and magnitude of viraemia in children hospitalised during the 1996\u20131997 dengue-2 outbreak in French Polynesia","volume":"60","author":"B Murgue","year":"2000","journal-title":"J Med Virol"},{"issue":"Suppl 2","key":"ref41","doi-asserted-by":"crossref","first-page":"S212","DOI":"10.1007\/s001340051146","article-title":"The natural elimination rate of procalcitonin in patients with normal and impaired renal function","volume":"26","author":"M Meisner","year":"2000","journal-title":"Intensive Care Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00134-006-0509-7","article-title":"Procalcitonin and C-reactive protein as markers of systemic inflammatory response syndrome severity in critically ill children","volume":"33","author":"C Rey","year":"2007","journal-title":"Intensive Care Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"804","DOI":"10.4269\/ajtmh.13-0197","article-title":"Identification of concurrent bacterial infection in adult patients with dengue","volume":"89","author":"KC See","year":"2013","journal-title":"Am J Trop Med Hyg"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4038\/cmj.v60i1.7165","article-title":"Secondary bacteraemia in adult patients with prolonged dengue fever","volume":"60","author":"R Premaratna","year":"2015","journal-title":"Ceylon Med J"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-2334-11-123","article-title":"Confirmed adult dengue deaths in Singapore: 5-year multi-center retrospective study","volume":"11","author":"YS Leo","year":"2011","journal-title":"BMC Infect Dis"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1373\/clinchem.2008.117655","article-title":"Comparison of a new procalcitonin assay from roche with the established method on the brahms kryptor","volume":"55","author":"HK de Wolf","year":"2009","journal-title":"Clin Chem"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0749-0704(03)00071-X","article-title":"Cytopathic hypoxia. Is oxygen use impaired in sepsis as a result of an acquired intrinsic derangement in cellular respiration?","volume":"18","author":"MP Fink","year":"2002","journal-title":"Crit Care Clin"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1097\/01.CCM.0000295593.25106.C4","article-title":"Oxygen consumption of human peripheral blood mononuclear cells in severe human sepsis","volume":"35","author":"I Belikova","year":"2007","journal-title":"Crit Care Med"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.bbadis.2007.08.003","article-title":"Mitochondrial and bioenergetic dysfunction in human hepatic cells infected with dengue 2 virus","volume":"1772","author":"T El-Bacha","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/jth.12178","article-title":"Dengue induces platelet activation, mitochondrial dysfunction and cell death through mechanisms that involve DC-SIGN and caspases","volume":"11","author":"ED Hottz","year":"2013","journal-title":"J Thromb Haemost"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1378\/chest.12-0878","article-title":"Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock","volume":"143","author":"MA Puskarich","year":"2013","journal-title":"Chest"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T15:32:25Z","timestamp":1601047945000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004961"}},"subtitle":[],"editor":[{"given":"William B","family":"Messer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,26]]},"references-count":51,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0004961","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,26]]}}}