{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:52:12Z","timestamp":1773071532881,"version":"3.50.1"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T00:00:00Z","timestamp":1478736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0004983","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T18:45:46Z","timestamp":1478803546000},"page":"e0004983","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Comparative Bioinformatics Analysis of Transcription Factor Genes Indicates Conservation of Key Regulatory Domains among Babesia bovis, Babesia microti, and Theileria equi"],"prefix":"10.1371","volume":"10","author":[{"given":"Heba F.","family":"Alzan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald P.","family":"Knowles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos E.","family":"Suarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,11,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1146\/annurev-ento-010814-021110","article-title":"Vector ecology of equine piroplasmosis","volume":"60","author":"GA Scoles","year":"2015","journal-title":"Annual review of entomology"},{"issue":"1\u20132","key":"ref2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.vetpar.2011.05.032","article-title":"Emerging perspectives in the research of bovine babesiosis and anaplasmosis","volume":"180","author":"CE Suarez","year":"2011","journal-title":"Vet Parasitol"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"e148","DOI":"10.1371\/journal.ppat.0030148","article-title":"Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa","volume":"3","author":"KA Brayton","year":"2007","journal-title":"PLoS Pathog"},{"issue":"18","key":"ref4","doi-asserted-by":"crossref","first-page":"9102","DOI":"10.1093\/nar\/gks700","article-title":"Sequencing of the smallest Apicomplexan genome from the human pathogen Babesia microti","volume":"40","author":"E Cornillot","year":"2012","journal-title":"Nucleic acids research"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"e72657","DOI":"10.1371\/journal.pone.0072657","article-title":"Whole genome mapping and re-organization of the nuclear and mitochondrial genomes of Babesia microti isolates","volume":"8","author":"E Cornillot","year":"2013","journal-title":"PloS one"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1186\/1471-2164-13-603","article-title":"Comparative genomic analysis and phylogenetic position of Theileria equi","volume":"13","author":"LS Kappmeyer","year":"2012","journal-title":"BMC genomics"},{"key":"ref7","article-title":"The nucleosome landscape of Plasmodium falciparum reveals chromatin architecture and dynamics of regulatory sequences","author":"PR Kensche","year":"2015","journal-title":"Nucleic acids research"},{"issue":"13","key":"ref8","doi-asserted-by":"crossref","first-page":"8271","DOI":"10.1093\/nar\/gku500","article-title":"The Cryptosporidium parvum ApiAP2 gene family: insights into the evolution of apicomplexan AP2 regulatory systems","volume":"42","author":"J Oberstaller","year":"2014","journal-title":"Nucleic acids research"},{"issue":"24","key":"ref9","doi-asserted-by":"crossref","first-page":"8393","DOI":"10.1073\/pnas.0801993105","article-title":"Specific DNA-binding by apicomplexan AP2 transcription factors","volume":"105","author":"EK De Silva","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"461979","DOI":"10.1155\/2011\/461979","article-title":"Emerging functions of transcription factors in malaria parasite","volume":"2011","author":"R Tuteja","year":"2011","journal-title":"Journal of biomedicine & biotechnology"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1111\/j.1462-5822.2008.01203.x","article-title":"Transcriptional control and gene silencing in Plasmodium falciparum","volume":"10","author":"BI Coleman","year":"2008","journal-title":"Cellular microbiology"},{"issue":"6","key":"ref12","first-page":"633","article-title":"The AP2\/EREBP family of plant transcription factors","volume":"379","author":"JL Riechmann","year":"1998","journal-title":"Biological chemistry"},{"issue":"13","key":"ref13","doi-asserted-by":"crossref","first-page":"7076","DOI":"10.1073\/pnas.94.13.7076","article-title":"The AP2 domain of APETALA2 defines a large new family of DNA binding proteins in Arabidopsis","volume":"94","author":"JK Okamuro","year":"1997","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"18","key":"ref14","doi-asserted-by":"crossref","first-page":"5484","DOI":"10.1093\/emboj\/17.18.5484","article-title":"A novel mode of DNA recognition by a \u03b2\u2010sheet revealed by the solution structure of the GCC\u2010box binding domain in complex with DNA","volume":"17","author":"MD Allen","year":"1998","journal-title":"The EMBO Journal"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jmb.2009.11.004","article-title":"Structural determinants of DNA binding by a P. falciparum ApiAP2 transcriptional regulator","volume":"395","author":"SE Lindner","year":"2010","journal-title":"Journal of molecular biology"},{"issue":"24","key":"ref16","doi-asserted-by":"crossref","first-page":"8393","DOI":"10.1073\/pnas.0801993105","article-title":"Specific DNA-binding by apicomplexan AP2 transcription factors","volume":"105","author":"EK De Silva","year":"2008","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"9","key":"ref17","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1105\/tpc.6.9.1211","article-title":"Control of Arabidopsis flower and seed development by the homeotic gene APETALA2","volume":"6","author":"KD Jofuku","year":"1994","journal-title":"The Plant cell"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jmb.2004.11.045","article-title":"PfMyb1, a Plasmodium falciparum transcription factor, is required for intra-erythrocytic growth and controls key genes for cell cycle regulation","volume":"346","author":"M Gissot","year":"2005","journal-title":"Journal of molecular biology"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.parint.2007.11.005","article-title":"High mobility group box (HMGB) proteins of Plasmodium falciparum: DNA binding proteins with pro-inflammatory activity","volume":"57","author":"K Kumar","year":"2008","journal-title":"Parasitology international"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1128\/EC.5.4.672-682.2006","article-title":"High-mobility-group box nuclear factors of Plasmodium falciparum","volume":"5","author":"S Briquet","year":"2006","journal-title":"Eukaryotic cell"},{"issue":"5639","key":"ref21","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1126\/science.1087025","article-title":"Discovery of gene function by expression profiling of the malaria parasite life cycle","volume":"301","author":"KG Le Roch","year":"2003","journal-title":"Science"},{"issue":"13","key":"ref22","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1093\/nar\/gki709","article-title":"Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains","volume":"33","author":"S Balaji","year":"2005","journal-title":"Nucleic acids research"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/1471-2164-8-163","article-title":"The relationships between the isoelectric point and: length of proteins, taxonomy and ecology of organisms","volume":"8","author":"J Kiraga","year":"2007","journal-title":"BMC Genomics"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2010.11.014","article-title":"The Apicomplexan AP2 family: integral factors regulating Plasmodium development","volume":"176","author":"HJ Painter","year":"2011","journal-title":"Molecular and biochemical parasitology"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"e1001165","DOI":"10.1371\/journal.ppat.1001165","article-title":"Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite","volume":"6","author":"TL Campbell","year":"2010","journal-title":"PLoS Pathog"},{"issue":"7491","key":"ref26","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nature12920","article-title":"A transcriptional switch underlies commitment to sexual development in malaria parasites","volume":"507","author":"BF Kafsack","year":"2014","journal-title":"Nature"},{"issue":"8","key":"ref27","doi-asserted-by":"crossref","first-page":"e0003933","DOI":"10.1371\/journal.pntd.0003933","article-title":"ApiAP2 Factors as Candidate Regulators of Stochastic Commitment to Merozoite Production in Theileria annulata","volume":"9","author":"M Pieszko","year":"2015","journal-title":"PLoS neglected tropical diseases"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1111\/j.1365-2958.2009.06609.x","article-title":"Identification of a transcription factor in the mosquito-invasive stage of malaria parasites","volume":"71","author":"M Yuda","year":"2009","journal-title":"Molecular microbiology"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/j.1365-2958.2009.07005.x","article-title":"Transcription factor AP2-Sp and its target genes in malarial sporozoites","volume":"75","author":"M Yuda","year":"2010","journal-title":"Molecular microbiology"},{"issue":"2","key":"ref30","first-page":"223","article-title":"One billion years of Myb","volume":"13","author":"JS Lipsick","year":"1996","journal-title":"Oncogene"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0166-6851(94)00047-Q","article-title":"A Plasmodium falciparum gene encoding a high mobility group protein box","volume":"71","author":"JF Kun","year":"1995","journal-title":"Molecular and biochemical parasitology"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1016\/S0021-9258(19)39758-3","article-title":"Duplicated NHP6 genes of Saccharomyces cerevisiae encode proteins homologous to bovine high mobility group protein 1","volume":"265","author":"D Kolodrubetz","year":"1990","journal-title":"The Journal of biological chemistry"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0006-291X(92)91153-H","article-title":"Characterization of a cDNA clone from the haemoparasite Babesia bovis encoding a protein containing an "HMG-Box"","volume":"184","author":"BP Dalrymple","year":"1992","journal-title":"Biochemical and biophysical research communications"},{"issue":"7491","key":"ref34","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nature12970","article-title":"A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium","volume":"507","author":"A Sinha","year":"2014","journal-title":"Nature"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0065-308X(08)60285-7","article-title":"The piroplasms: life cycle and sexual stages","volume":"23","author":"H Mehlhorn","year":"1984","journal-title":"Advances in parasitology"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.exppara.2012.10.007","article-title":"Validation of BdCCp2 as a marker for Babesia divergens sexual stages in ticks","volume":"133","author":"CA Becker","year":"2013","journal-title":"Experimental parasitology"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T02:30:07Z","timestamp":1657679407000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004983"}},"subtitle":[],"editor":[{"given":"Elizabeth A.","family":"Winzeler","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,11,10]]},"references-count":36,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0004983","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,10]]}}}