{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:30:52Z","timestamp":1792737052996,"version":"4.5.0"},"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T00:00:00Z","timestamp":1473292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001655","name":"German Academic Exchange Service","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0004991","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T13:40:36Z","timestamp":1473342036000},"page":"e0004991","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":44,"title":["Protective and Pathogenic Roles of CD8+ T Lymphocytes in Murine Orientia tsutsugamushi Infection"],"prefix":"10.1371","volume":"10","author":[{"given":"Matthias","family":"Hauptmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Kolbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Lilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wozniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Gharaibeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Fleischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian A.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,9,8]]},"reference":[{"issue":"8","key":"ref1","doi-asserted-by":"crossref","first-page":"e3064","DOI":"10.1371\/journal.pntd.0003064","article-title":"Dissemination of <italic>Orientia tsutsugamushi<\/italic> and inflammatory responses in a murine model of scrub typhus","volume":"8","author":"CA Keller","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"e1466","DOI":"10.1371\/journal.pntd.0001466","article-title":"<italic>Orientia tsutsugamushi<\/italic> in human scrub typhus eschars shows tropism for dendritic cells and monocytes rather than endothelium","volume":"6","author":"DH Paris","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/modpathol.3880385","article-title":"Identification of the target cells of <italic>Orientia tsutsugamushi<\/italic> in human cases of scrub typhus","volume":"14","author":"CG Moron","year":"2001","journal-title":"Mod Pathol"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1046\/j.1365-3156.1998.00231.x","article-title":"Electron-microscopic examination of <italic>Rickettsia tsutsugamushi<\/italic>-infected human liver","volume":"3","author":"E Pongponratn","year":"1998","journal-title":"Trop Med Int Health"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1128\/JCM.01040-07","article-title":"Acute Renal Failure Due to Acute Tubular Necrosis Caused by Direct Invasion of <italic>Orientia tsutsugamushi<\/italic>","volume":"46","author":"D-M Kim","year":"2008","journal-title":"J Clin Microbiol"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"e2966","DOI":"10.1371\/journal.pntd.0002966","article-title":"A Hematogenously Disseminated <italic>Orientia tsutsugamsushi<\/italic>-Infected Murine Model of Scrub Typhus","volume":"8","author":"TR Shelite","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S1607-551X(08)70103-7","article-title":"Immunohistochemical study of scrub typhus: a report of two cases","volume":"24","author":"BY Tseng","year":"2008","journal-title":"Kaohsiung J Med Sci"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1128\/IAI.55.10.2490-2495.1987","article-title":"Establishment and characterization of a T-cell line specific for <italic>Rickettsia tsutsugamushi<\/italic>","volume":"55","author":"K Kodama","year":"1987","journal-title":"Infect Immun"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"e3191","DOI":"10.1371\/journal.pntd.0003191","article-title":"Strong type 1, but impaired type 2, immune responses contribute to <italic>Orientia tsutsugamushi<\/italic>-induced pathology in mice","volume":"8","author":"L Soong","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1128\/IAI.46.1.237-244.1984","article-title":"Gamma interferon production in response to homologous and heterologous strain antigens in mice chronically infected with <italic>Rickettsia tsutsugamushi<\/italic>","volume":"46","author":"BA Palmer","year":"1984","journal-title":"Infect Immun"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1128\/IAI.43.1.59-65.1984","article-title":"Production of gamma interferon in mice immune to <italic>Rickettsia tsutsugamushi<\/italic>","volume":"43","author":"BA Palmer","year":"1984","journal-title":"Infect Immun"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001731","article-title":"Activation of Indoleamine 2,3-Dioxygenase in Patients with Scrub Typhus and its Role in Growth Restriction of <italic>Orientia tsutsugamushi<\/italic>","volume":"6","author":"T Prachason","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1128\/IAI.26.2.744-750.1979","article-title":"Host defenses in experimental scrub typhus: role of normal and activated macrophages","volume":"26","author":"CA Nacy","year":"1979","journal-title":"Infect Immun"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.4049\/jimmunol.136.4.1418","article-title":"Mechanisms of immunity to rickettsial infection: characterization of a cytotoxic effector cell","volume":"136","author":"FM Rollwagen","year":"1986","journal-title":"J Immunol"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"465","DOI":"10.4269\/ajtmh.2005.72.465","article-title":"Activation of Cytotoxic Lymphocytes in Patients with Scrub Typhus","volume":"72","author":"M de Fost","year":"2005","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"e1789","DOI":"10.1371\/journal.pntd.0001789","article-title":"Phenotypic Characterization of Peripheral T Cells and Their Dynamics in Scrub Typhus Patients","volume":"6","author":"B-A Cho","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"e8547","DOI":"10.1371\/journal.pone.0008547","article-title":"Adipose Tissue Serves as a Reservoir for Recrudescent <italic>Rickettsia prowazekii<\/italic> Infection in a Mouse Model","volume":"5","author":"Y Bechah","year":"2010","journal-title":"PLoS One"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3346\/jkms.2012.27.3.231","article-title":"Persistence of <italic>Orientia tsutsugamushi<\/italic> in humans","volume":"27","author":"MH Chung","year":"2012","journal-title":"J Korean Med Sci"},{"issue":"3","key":"ref19","first-page":"294","article-title":"Persistence of <italic>Rickettsia tsutsugamushi<\/italic> in tissues of patients recovered from scrub typhus","volume":"56","author":"JE Smadel","year":"1952","journal-title":"Am J Hyg"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.7883\/yoken1952.32.179","article-title":"Persistence and reactivation of <italic>Rickettsia tsutsugamushi<\/italic> infections in laboratory mice","volume":"32","author":"A Shirai","year":"1979","journal-title":"Jpn J Med Sci Biol"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4049\/jimmunol.59.2.109","article-title":"The long persistence of <italic>Rickettsia orientalis<\/italic> in the blood and tissues of infected animals","volume":"59","author":"JP Fox","year":"1948","journal-title":"J Immunol"},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1182\/blood.V85.10.2742.bloodjournal85102742","article-title":"Assessment of aldehyde dehydrogenase in viable cells","volume":"85","author":"RJ Jones","year":"1995","journal-title":"Blood"},{"issue":"8","key":"ref23","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/0145-2126(85)90072-4","article-title":"4-Hydroperoxycyclophosphamide inhibits proliferation by human granulocyte-macrophage colony-forming cells (GM-CFC) but spares more primitive progenitor cells","volume":"9","author":"MY Gordon","year":"1985","journal-title":"Leuk Res"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1084\/jem.155.1.276","article-title":"In vitro effects of 4-hydroperoxycyclophosphamide on human immunoregulatory T subset function. I. Selective effects on lymphocyte function in T-B cell collaboration","volume":"155","author":"H Ozer","year":"1982","journal-title":"J Exp Med"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1172\/JCI112922","article-title":"Selective effects of cyclophosphamide therapy on activation, proliferation, and differentiation of human B cells","volume":"79","author":"LP Zhu","year":"1987","journal-title":"J Clin Invest"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1365-2915.2010.00941.x","article-title":"Identification of potential hosts and vectors of scrub typhus and tick-borne spotted fever group rickettsiae in eastern Taiwan","volume":"25","author":"CC Kuo","year":"2011","journal-title":"Med Vet Entomol"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3347\/kjp.2010.48.3.237","article-title":"Serosurveillance of scrub typhus in small mammals collected from military training sites near the DMZ, Northern Gyeonggi-do, Korea, and analysis of the relative abundance of chiggers from mammals examined","volume":"48","author":"HC Kim","year":"2010","journal-title":"Korean J Parasitol"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"e54570","DOI":"10.1371\/journal.pone.0054570","article-title":"An intradermal inoculation model of scrub typhus in Swiss CD-1 mice demonstrates more rapid dissemination of virulent strains of <italic>Orientia tsutsugamushi<\/italic>","volume":"8","author":"P Sunyakumthorn","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.micpath.2005.08.004","article-title":"Survival of two Orientia tsutsugamushi bacterial strains that infect mouse macrophages with varying degrees of virulence","volume":"39","author":"M Fukuhara","year":"2005","journal-title":"Microbial pathogenesis"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1128\/IAI.19.2.583-588.1978","article-title":"Host defenses in experimental scrub typhus: genetics of natural resistance to infection","volume":"19","author":"MG Groves","year":"1978","journal-title":"Infection and immunity"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1128\/IAI.57.5.1476-1482.1989","article-title":"Characterization of factors determining <italic>Rickettsia tsutsugamushi<\/italic> pathogenicity for mice","volume":"57","author":"MG Groves","year":"1989","journal-title":"Infect Immun"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-62703-481-4_12","article-title":"Safe and effective mouse footpad inoculation","author":"KM Long","year":"2013","journal-title":"Mouse Models of Innate Immunity: Methods and Protocols"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jim.2007.08.004","article-title":"Hock immunization: a humane alternative to mouse footpad injections","volume":"328","author":"T Kamala","year":"2007","journal-title":"J Immunol Methods"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"972","DOI":"10.4269\/ajtmh.14-0806","article-title":"Clinical and epidemiological characteristics of scrub typhus and murine typhus among hospitalized patients with acute undifferentiated fever in northern Vietnam","volume":"92","author":"S Hamaguchi","year":"2015","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1128\/JCM.00997-08","article-title":"<italic>Orientia tsutsugamushi<\/italic> bacteremia and cytokine levels in Vietnamese scrub typhus patients","volume":"47","author":"S Kramme","year":"2009","journal-title":"J Clin Microbiol"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1148\/rg.271065074","article-title":"Scrub Typhus: Clinical, Pathologic, and Imaging Findings","volume":"27","author":"YJ Jeong","year":"2007","journal-title":"Radiographics"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1053\/crad.1999.0336","article-title":"Scrub typhus: radiological and clinical findings","volume":"55","author":"Y Choi","year":"2000","journal-title":"Clin Radiol"},{"issue":"36","key":"ref38","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.3748\/wjg.v18.i36.5138","article-title":"Scrub typhus hepatitis confirmed by immunohistochemical staining","volume":"18","author":"J-H Chung","year":"2012","journal-title":"World J Gastroenterol"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3947\/ic.2009.41.2.99","article-title":"Cholestatic hepatitis caused by Tongyeong strain of <italic>Orientia tsutsugamushi<\/italic>","volume":"41","author":"K Joo","year":"2009","journal-title":"Infection and Chemotherapy"},{"issue":"8","key":"ref40","doi-asserted-by":"crossref","first-page":"e0003971","DOI":"10.1371\/journal.pntd.0003971","article-title":"A systematic review of mortality from untreated scrub typhus (<italic>Orientia tsutsugamushi<\/italic>)","volume":"9","author":"AJ Taylor","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"e0004467","DOI":"10.1371\/journal.pntd.0004467","article-title":"IL-33-Dependent Endothelial Activation Contributes to Apoptosis and Renal Injury in <italic>Orientia tsutsugamushi<\/italic>-Infected Mice","volume":"10","author":"TR Shelite","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"ref42","unstructured":"Gharaibeh M, Hagedorn M, Lilla S, Hauptmann M, Heine H, Fleischer B, et al. IAI in revision."},{"issue":"s3","key":"ref43","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.1086\/596576","article-title":"Scrub Typhus: The Geographic Distribution of Phenotypic and Genotypic Variants of <italic>Orientia tsutsugamushi<\/italic>","volume":"48","author":"DJ Kelly","year":"2009","journal-title":"Clin Infect Dis"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"936","DOI":"10.4269\/ajtmh.2005.73.936","article-title":"Protection against scrub typhus by a plasmid vaccine encoding the 56-KD outer membrane protein antigen gene","volume":"73","author":"YS Ni","year":"2005","journal-title":"Am J Trop Med Hyg"},{"issue":"6268","key":"ref45","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/344742a0","article-title":"\u03b22-microglobulin deficient mice lack CD4-8+ cytolytic T cells","volume":"344","author":"M Zijlstra","year":"1990","journal-title":"Nature"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00281-015-0480-x","article-title":"The role of CD8 T lymphocytes in rickettsial infections","volume":"37","author":"D Walker","year":"2015","journal-title":"Semin Immunopathol"},{"issue":"4","key":"ref47","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1074-7613(00)80289-7","article-title":"Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice","volume":"6","author":"Y-H Chen","year":"1997","journal-title":"Immunity"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S1074-7613(00)80290-3","article-title":"CD1d1 Mutant Mice Are Deficient in Natural T Cells That Promptly Produce IL-4","volume":"6","author":"SK Mendiratta","year":"1997","journal-title":"Immunity"},{"issue":"12","key":"ref49","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nrmicro1046","article-title":"Iron and microbial infection","volume":"2","author":"UE Schaible","year":"2004","journal-title":"Nat Rev Micro"},{"key":"ref50","article-title":"Version 4.0 of PaxDb: Protein abundance data, integrated across model organisms, tissues, and cell-lines","author":"M Wang","year":"2015","journal-title":"PROTEOMICS"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1084\/jem.180.2.699","article-title":"Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha\/beta+ cells in the liver of mice","volume":"180","author":"T Ohteki","year":"1994","journal-title":"The Journal of Experimental Medicine"},{"issue":"10","key":"ref52","doi-asserted-by":"crossref","first-page":"5447","DOI":"10.1128\/IAI.71.10.5447-5455.2003","article-title":"Role of CD1d-restricted NKT cells in microbial immunity","volume":"71","author":"M Skold","year":"2003","journal-title":"Infect Immun"},{"issue":"1","key":"ref53","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1128\/IAI.14.1.39-46.1976","article-title":"Host defenses in experimental scrub typhus: role of cellular immunity in heterologous protection","volume":"14","author":"A Shirai","year":"1976","journal-title":"Infect Immun"},{"issue":"3","key":"ref54","doi-asserted-by":"crossref","first-page":"568","DOI":"10.4269\/ajtmh.1985.34.568","article-title":"Immunological Studies of Experimental Tsutsugamushi Disease in Congenitally Athymic (Nude) Mice","volume":"34","author":"Y Kobayashi","year":"1985","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"issue":"11","key":"ref55","doi-asserted-by":"crossref","first-page":"5314","DOI":"10.4049\/jimmunol.158.11.5314","article-title":"Role of T lymphocyte subsets in immunity to spotted fever group Rickettsiae","volume":"158","author":"H Feng","year":"1997","journal-title":"The Journal of Immunology"},{"issue":"3","key":"ref56","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1128\/IAI.69.3.1841-1846.2001","article-title":"Critical Role of Cytotoxic T Lymphocytes in Immune Clearance of Rickettsial Infection","volume":"69","author":"DH Walker","year":"2001","journal-title":"Infect Immun"},{"issue":"9","key":"ref57","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/labinvest.3780144","article-title":"Establishment of a Novel Endothelial Target Mouse Model of a Typhus Group Rickettsiosis: Evidence for Critical Roles for Gamma Interferon and CD8 T Lymphocytes","volume":"80","author":"DH Walker","year":"2000","journal-title":"Lab Invest"},{"issue":"3","key":"ref58","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF00145675","article-title":"A comparative view of <italic>Rickettsia tsutsugamushi<\/italic> and the other groups of rickettsiae","volume":"7","author":"A Tamura","year":"1991","journal-title":"Eur J Epidemiol"},{"issue":"3","key":"ref59","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1099\/00207713-45-3-589","article-title":"Classification of <italic>Rickettsia tsutsugamushi<\/italic> in a new genus, <italic>Orientia<\/italic> gen. nov., as <italic>Orientia tsutsugamushi<\/italic> comb. nov","volume":"45","author":"A Tamura","year":"1995","journal-title":"Int J Syst Bacteriol"},{"key":"ref60","first-page":"48","article-title":"Rickettsioses: pathogenesis, immunity, and vaccine development","volume":"55","author":"G Valbuena","year":"2013","journal-title":"Acta Med Costarric"},{"issue":"6915","key":"ref61","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nature01152","article-title":"CD4+CD25+ regulatory T cells control <italic>Leishmania major<\/italic> persistence and immunity","volume":"420","author":"Y Belkaid","year":"2002","journal-title":"Nature"},{"issue":"2","key":"ref62","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.clim.2004.08.006","article-title":"Differential expression of interferon-\u03b3 and interferon-\u03b3-inducing cytokines in Thai patients with scrub typhus or leptospirosis","volume":"113","author":"W Chierakul","year":"2004","journal-title":"Clin Immunol"},{"issue":"12","key":"ref63","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1128\/JCM.35.12.3320-3322.1997","article-title":"Increased levels of macrophage colony-stimulating factor, gamma interferon, and tumor necrosis factor alpha in sera of patients with <italic>Orientia tsutsugamushi<\/italic> infection","volume":"35","author":"H Iwasaki","year":"1997","journal-title":"J Clin Microbiol"},{"issue":"6","key":"ref64","first-page":"385","article-title":"Clinical manifestation and complications of rickettsiosis in Southern Taiwan","volume":"101","author":"L Hsin-Chun","year":"2002","journal-title":"J Formos Med Assoc"},{"issue":"6","key":"ref65","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/j.1440-1746.2005.03802.x","article-title":"Direct cytopathic liver injury and acute respiratory distress syndrome associated with gilliam-type tsutsugamushi disease","volume":"20","author":"H Watanabe","year":"2005","journal-title":"J Gastroenterol Hepatol"},{"issue":"4953","key":"ref66","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1126\/science.1691527","article-title":"Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice","volume":"248","author":"T Moriyama","year":"1990","journal-title":"Science"},{"issue":"5","key":"ref67","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1084\/jem.178.5.1541","article-title":"Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis","volume":"178","author":"K Ando","year":"1993","journal-title":"The Journal of Experimental Medicine"},{"issue":"3","key":"ref68","doi-asserted-by":"crossref","first-page":"e1000836","DOI":"10.1371\/journal.ppat.1000836","article-title":"T Cell-Dependence of Lassa Fever Pathogenesis","volume":"6","author":"L Flatz","year":"2010","journal-title":"PLoS Pathog"},{"issue":"12","key":"ref69","doi-asserted-by":"crossref","first-page":"e1002457","DOI":"10.1371\/journal.ppat.1002457","article-title":"Inflammatory monocytes and neutrophils are licensed to kill during memory responses in vivo","volume":"7","author":"E Narni-Mancinelli","year":"2011","journal-title":"PLoS Pathog"},{"issue":"9","key":"ref70","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1084\/jem.20070204","article-title":"Memory CD8+ T cells mediate antibacterial immunity via CCL3 activation of TNF\/ROI+ phagocytes","volume":"204","author":"E Narni-Mancinelli","year":"2007","journal-title":"The Journal of experimental medicine"},{"issue":"3","key":"ref71","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0168-8278(02)00424-5","article-title":"The presence of an intrahepatic cytotoxic T lymphocyte response is associated with low viral load in patients with chronic hepatitis C virus infection","volume":"38","author":"AJ Freeman","year":"2003","journal-title":"J Hepatol"},{"issue":"3","key":"ref72","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.4049\/jimmunol.166.3.1813","article-title":"Activated Antigen-Specific CD8+ T Cells Persist in the Lungs Following Recovery from Respiratory Virus Infections","volume":"166","author":"RJ Hogan","year":"2001","journal-title":"The Journal of Immunology"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3389\/fimmu.2013.00475","article-title":"Clonal Exhaustion as a Mechanism to Protect Against Severe Immunopathology and Death from an Overwhelming CD8 T Cell Response","volume":"4","author":"M Cornberg","year":"2013","journal-title":"Front Immunol"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T20:52:30Z","timestamp":1692478350000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004991"}},"subtitle":[],"editor":[{"given":"Nicholas P.","family":"Day","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,9,8]]},"references-count":73,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,9,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0004991","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,8]]}}}