{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:13:00Z","timestamp":1790298780542,"version":"4.1.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T00:00:00Z","timestamp":1475712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"NIH NIAID","doi-asserted-by":"publisher","award":["AI101772 and AI117445"],"award-info":[{"award-number":["AI101772 and AI117445"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32-AI060549"],"award-info":[{"award-number":["T32-AI060549"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0005047","type":"journal-article","created":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T18:02:09Z","timestamp":1475776929000},"page":"e0005047","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Mechanistic Insight into the Host Transcription Inhibition Function of Rift Valley Fever Virus NSs and Its Importance in Virulence"],"prefix":"10.1371","volume":"10","author":[{"given":"Kaori","family":"Terasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney I.","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Makino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,10,6]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.coviro.2012.02.017","article-title":"Breaking the chain: Rift Valley fever virus control via livestock vaccination","volume":"2","author":"BH Bird","year":"2012","journal-title":"Curr Opin Virol"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3390\/v3050493","article-title":"The Pathogenesis of Rift Valley Fever","volume":"3","author":"T Ikegami","year":"2011","journal-title":"Viruses"},{"issue":"16","key":"ref3","doi-asserted-by":"crossref","first-page":"8274","DOI":"10.1128\/JVI.00476-06","article-title":"NSm and 78-kilodalton proteins of Rift Valley fever virus are nonessential for viral replication in cell culture","volume":"80","author":"S Won","year":"2006","journal-title":"J Virol"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"e2670","DOI":"10.1371\/journal.pntd.0002670","article-title":"Deletion of the NSm virulence gene of Rift Valley fever virus inhibits virus replication in and dissemination from the midgut of Aedes aegypti mosquitoes","volume":"8","author":"RC Kading","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"e71","key":"ref5","article-title":"The Rift Valley fever accessory proteins NSm and P78\/NSm-GN are distinct determinants of virus propagation in vertebrate and invertebrate hosts","volume":"3","author":"F Kreher","year":"2014","journal-title":"Emerg Microbes Infect"},{"issue":"24","key":"ref6","doi-asserted-by":"crossref","first-page":"13335","DOI":"10.1128\/JVI.01238-07","article-title":"NSm protein of Rift Valley fever virus suppresses virus-induced apoptosis","volume":"81","author":"S Won","year":"2007","journal-title":"J Virol"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1128\/JVI.02192-12","article-title":"The C-terminal region of Rift Valley fever virus NSm protein targets the protein to the mitochondrial outer membrane and exerts antiapoptotic function","volume":"87","author":"K Terasaki","year":"2013","journal-title":"J Virol"},{"issue":"Pt 11","key":"ref8","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1099\/vir.0.035105-0","article-title":"Recent advances in the molecular and cellular biology of bunyaviruses","volume":"92","author":"CT Walter","year":"2011","journal-title":"J Gen Virol"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1006\/viro.1999.9978","article-title":"The Rift Valley fever virus nonstructural protein NSs is phosphorylated at serine residues located in casein kinase II consensus motifs in the carboxy-terminus","volume":"263","author":"A Kohl","year":"1999","journal-title":"Virology"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"5018","DOI":"10.1128\/JVI.73.6.5018-5025.1999","article-title":"The carboxy-terminal acidic domain of Rift Valley Fever virus NSs protein is essential for the formation of filamentous structures but not for the nuclear localization of the protein","volume":"73","author":"FZ Yadani","year":"1999","journal-title":"J Virol"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1371\/journal.ppat.0040013","article-title":"A SAP30 complex inhibits IFN-beta expression in Rift Valley fever virus infected cells","volume":"4","author":"N Le May","year":"2008","journal-title":"PLoS Pathog"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0092-8674(04)00132-1","article-title":"TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus","volume":"116","author":"N Le May","year":"2004","journal-title":"Cell"},{"issue":"13","key":"ref13","doi-asserted-by":"crossref","first-page":"6234","DOI":"10.1128\/JVI.02255-10","article-title":"NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62","volume":"85","author":"B Kalveram","year":"2011","journal-title":"J Virol"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1128\/JVI.02914-13","article-title":"Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH","volume":"88","author":"M Kainulainen","year":"2014","journal-title":"J Virol"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"e1000287","DOI":"10.1371\/journal.ppat.1000287","article-title":"Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylation","volume":"5","author":"T Ikegami","year":"2009","journal-title":"PLoS Pathog"},{"issue":"9","key":"ref16","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1128\/JVI.02148-08","article-title":"NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase","volume":"83","author":"M Habjan","year":"2009","journal-title":"J Virol"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"e1005437","DOI":"10.1371\/journal.ppat.1005437","article-title":"Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 Ligase","volume":"12","author":"R Mudhasani","year":"2016","journal-title":"PLoS Pathog"},{"issue":"13","key":"ref18","doi-asserted-by":"crossref","first-page":"6140","DOI":"10.1128\/JVI.00016-16","article-title":"NSs virulence factor of Rift Valley fever virus engages the F-box proteins FBXW11 and beta-TRCP1 to degrade the antiviral protein kinase PKR","volume":"90","author":"M Kainulainen","year":"2016","journal-title":"J Virol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.virol.2013.11.023","article-title":"Reactive oxygen species activate NFkappaB (p65) and p53 and induce apoptosis in RVFV infected liver cells","volume":"449","author":"A Narayanan","year":"2014","journal-title":"Virology"},{"issue":"10","key":"ref20","doi-asserted-by":"crossref","first-page":"7399","DOI":"10.1074\/jbc.M111.296608","article-title":"Induction of DNA damage signaling upon Rift Valley fever virus infection results in cell cycle arrest and increased viral replication","volume":"287","author":"A Baer","year":"2012","journal-title":"J Biol Chem"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"e36327","DOI":"10.1371\/journal.pone.0036327","article-title":"p53 Activation following Rift Valley fever virus infection contributes to cell death and viral production","volume":"7","author":"D Austin","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1128\/JVI.01165-09","article-title":"Nonstructural NSs protein of rift valley fever virus interacts with pericentromeric DNA sequences of the host cell, inducing chromosome cohesion and segregation defects","volume":"84","author":"Z Mansuroglu","year":"2010","journal-title":"J Virol"},{"issue":"9","key":"ref23","doi-asserted-by":"crossref","first-page":"e45730","DOI":"10.1371\/journal.pone.0045730","article-title":"Functional analysis of Rift Valley fever virus NSs encoding a partial truncation","volume":"7","author":"JA Head","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1128\/JVI.80.6.2933-2940.2006","article-title":"Rescue of infectious rift valley fever virus entirely from cDNA, analysis of virus lacking the NSs gene, and expression of a foreign gene","volume":"80","author":"T Ikegami","year":"2006","journal-title":"J Virol"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1128\/JVI.73.1.251-259.1999","article-title":"Generation of bovine respiratory syncytial virus (BRSV) from cDNA: BRSV NS2 is not essential for virus replication in tissue culture, and the human RSV leader region acts as a functional BRSV genome promoter","volume":"73","author":"UJ Buchholz","year":"1999","journal-title":"J Virol"},{"issue":"Pt 10","key":"ref26","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1099\/0022-1317-66-10-2271","article-title":"Mutagen-directed attenuation of Rift Valley fever virus as a method for vaccine development","volume":"66","author":"H Caplen","year":"1985","journal-title":"J Gen Virol"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"CA Schneider","year":"2012","journal-title":"Nature Methods"},{"issue":"9","key":"ref28","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1128\/JVI.79.9.5606-5615.2005","article-title":"Rift valley fever virus nonstructural protein NSs promotes viral RNA replication and transcription in a minigenome system","volume":"79","author":"T Ikegami","year":"2005","journal-title":"J Virol"},{"issue":"9","key":"ref29","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1128\/JVI.02472-07","article-title":"Severe acute respiratory syndrome coronavirus nsp1 suppresses host gene expression, including that of type I interferon, in infected cells","volume":"82","author":"K Narayanan","year":"2008","journal-title":"J Virol"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1073\/pnas.1013155108","article-title":"Mechanism of tripartite RNA genome packaging in Rift Valley fever virus","volume":"108","author":"K Terasaki","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"405","DOI":"10.4269\/ajtmh.1995.53.405","article-title":"Characterization of clone 13, a naturally attenuated avirulent isolate of Rift Valley fever virus, which is altered in the small segment","volume":"53","author":"R Muller","year":"1995","journal-title":"Am J Trop Med Hyg"},{"issue":"19","key":"ref32","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.1073\/pnas.1503688112","article-title":"A \u2126XaV motif in the Rift Valley fever virus NSs protein is essential for degrading p62, forming nuclear filaments and virulence","volume":"112","author":"N Cyr","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"36","key":"ref33","doi-asserted-by":"crossref","first-page":"14926","DOI":"10.1073\/pnas.1112149108","article-title":"Recombinant Rift Valley fever vaccines induce protective levels of antibody in baboons and resistance to lethal challenge in mice","volume":"108","author":"JF Papin","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1159\/000373924","article-title":"Interplay between the Virus and Host in Rift Valley Fever Pathogenesis","volume":"7","author":"K Terasaki","year":"2015","journal-title":"J Innate Immun"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"e1156","DOI":"10.1371\/journal.pntd.0001156","article-title":"Host alternation is necessary to maintain the genome stability of rift valley fever virus","volume":"5","author":"S Moutailler","year":"2011","journal-title":"PLoS Negl Trop Dis"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0005047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T13:01:21Z","timestamp":1601125281000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0005047"}},"subtitle":[],"editor":[{"given":"Maya","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,6]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0005047","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,6]]}}}