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World Health Organization to Review Mercks Investigational Ebola Vaccine for Emergency Use Assessment and Listing; 2015. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.mercknewsroom.com\/news-release\/vaccine-news\/world-health-organization-review-mercks-investigational-ebola-vaccine-eme\" xlink:type=\"simple\">http:\/\/www.mercknewsroom.com\/news-release\/vaccine-news\/world-health-organization-review-mercks-investigational-ebola-vaccine-eme<\/ext-link>"},{"key":"ref26","unstructured":"GAVI The Vaccine Alliance. Ebola vaccine purchasing commitment from Gavi to prepare for future outbreaks; 2016. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.gavi.org\/Library\/News\/Press-releases\/2016\/Ebola-vaccine-purchasing-commitment-from-Gavi-to-prepare-for-future-outbr\" xlink:type=\"simple\">http:\/\/www.gavi.org\/Library\/News\/Press-releases\/2016\/Ebola-vaccine-purchasing-commitment-from-Gavi-to-prepare-for-future-outbr<\/ext-link>"},{"key":"ref27","article-title":"Smallpox and its eradication","author":"F Fenner","year":"1988"},{"key":"ref28","unstructured":"World Health Organization. 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