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new concept for consistent and accurate proteome analysis","volume":"11","author":"LC Gillet","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"140031","DOI":"10.1038\/sdata.2014.31","article-title":"A repository of assays to quantify 10,000 human proteins by SWATH-MS","volume":"1","author":"G Rosenberger","year":"2014","journal-title":"Sci Data"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1074\/mcp.M113.035550","article-title":"Reproducible and consistent quantification of the <italic>Saccharomyces cerevisiae<\/italic> proteome by SWATH-mass spectrometry","volume":"14","author":"N Selevsek","year":"2015","journal-title":"Mol Cell Proteomics"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"e0125934","DOI":"10.1371\/journal.pone.0125934","article-title":"Evaluation of iTRAQ and SWATH-MS for the Quantification of Proteins Associated with Insulin Resistance in Human Duodenal Biopsy Samples","volume":"10","author":"S Bourassa","year":"2015","journal-title":"PLoS One"},{"key":"ref43","unstructured":"Sumethanurungkul P. Studies on physical effects on snail intermediate hosts of a liver fluke (Opisthorchis viverrini). [Master Thesis in Science]. Bangkok: Mahidol University; 1970."},{"issue":"2","key":"ref44","first-page":"235","article-title":"Laboratory studies on host-parasite relationship of Bithynia snails and the liver fluke, <italic>Opisthorchis viverrini<\/italic>","volume":"22","author":"A Chanawong","year":"1991","journal-title":"Southeast Asian J Trop Med Public Health"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00436-011-2557-3","article-title":"Light and electron microscopy observations of embryogenesis and egg development in the human liver fluke, <italic>Opisthorchis viverrini<\/italic> (Platyhelminthes, Digenea)","volume":"110","author":"P Khampoosa","year":"2012","journal-title":"Parasitol Res"},{"issue":"1","key":"ref46","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.actatropica.2008.09.015","article-title":"Discrimination of <italic>O<\/italic>. <italic>viverrini<\/italic>, <italic>C<\/italic>. <italic>sinensis<\/italic>, <italic>H<\/italic>. <italic>pumilio and H<\/italic>. <italic>taichui<\/italic> using nuclear DNA-based PCR targeting ribosomal DNA ITS regions","volume":"109","author":"M Sato","year":"2009","journal-title":"Acta Trop"},{"issue":"10","key":"ref47","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1074\/mcp.M114.038950","article-title":"Secreted proteomes of different developmental stages of the gastrointestinal nematode <italic>Nippostrongylus brasiliensis<\/italic>","volume":"13","author":"J Sotillo","year":"2014","journal-title":"Mol Cell Proteomics"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nprot.2015.015","article-title":"Building high-quality assay libraries for targeted analysis of SWATH MS data","volume":"10","author":"OT Schubert","year":"2015","journal-title":"Nat Protoc"},{"issue":"7","key":"ref49","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/bioinformatics\/btq054","article-title":"Skyline: an open source document 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Ye","year":"2006","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"ref53","doi-asserted-by":"crossref","first-page":"D1063","DOI":"10.1093\/nar\/gks1262","article-title":"The PRoteomics IDEntifications (PRIDE) database and associated tools: status in 2013","volume":"41","author":"JA Vizcaino","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"Pt 4","key":"ref54","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1017\/S0031182000080732","article-title":"Schistosomicidal activities of <italic>Lymnaea stagnalis<\/italic> haemocytes: the role of oxygen radicals","volume":"109","author":"CM Adema","year":"1994","journal-title":"Parasitology"},{"issue":"Pt 6","key":"ref55","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1017\/S003118200100782X","article-title":"Refractoriness of host haemocytes to parasite immunosuppressive factors as a putative resistance mechanism in the <italic>Biomphalaria glabrata<\/italic>-<italic>Echinostoma 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