{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:39:20Z","timestamp":1791639560196,"version":"4.3.4"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T00:00:00Z","timestamp":1482278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["282378"],"award-info":[{"award-number":["282378"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)","award":["UID\/MAT\/04561\/2013"],"award-info":[{"award-number":["UID\/MAT\/04561\/2013"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0005179","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T15:06:23Z","timestamp":1483974383000},"page":"e0005179","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":146,"title":["The Impact of the Newly Licensed Dengue Vaccine in Endemic Countries"],"prefix":"10.1371","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8354-9944","authenticated-orcid":false,"given":"Ma\u00edra","family":"Aguiar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Stollenwerk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott B.","family":"Halstead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,12,21]]},"reference":[{"issue":"Chapter 25","key":"ref1","first-page":"493","article-title":"Antibody-dependent Enhancement of Infection: A Mechanism for Indirect Virus Entry into Cells","volume":"28","author":"S. B. Halstead","year":"1994"},{"key":"ref2","first-page":"301","article-title":"Immune enhancement of viral infection","volume":"31","author":"S.B. Halstead","year":"1982"},{"key":"ref3","first-page":"421","article-title":"Neutralization and antibody-dependent enhancement of dengue viruses","volume":"60","author":"S.B. Halstead","year":"2003"},{"key":"ref4","first-page":"S98","article-title":"Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses","volume":"12","author":"J. S. Mackenzie","year":"2004"},{"key":"ref5","first-page":"745","article-title":"Cross-Reacting Antibodies Enhance Dengue Virus Infection in Humans","volume":"328","author":"W. Dejnirattisai","year":"2010"},{"key":"ref6","first-page":"S7","article-title":"Dengue: a continuing global threat","volume":"8","author":"M.G. Guzm\u00e1n","year":"2010"},{"key":"ref7","first-page":"790","article-title":"The effect of antibody-dependent enhancement on the transmission dynamics and persistence of multiple-strain pathogens","volume":"96","author":"N. Ferguson","year":"1999"},{"key":"ref8","first-page":"066201","article-title":"Chaotic desynchronization of multi-strain diseases","volume":"72","author":"I. B. Schwartz","year":"2005"},{"key":"ref9","first-page":"18","article-title":"Instabilities in multiserotype disease models with antibody-dependent enhancement","volume":"246","author":"L. Billings","year":"2007"},{"key":"ref10","first-page":"11802","article-title":"Ecological and immunological determinants of dengue epidemics","volume":"103","author":"H.J. Wearing","year":"2006"},{"key":"ref11","first-page":"2238","article-title":"Decreases in dengue transmission may act to increase the incidence of dengue hemorrhagic fever","volume":"105","author":"Y. Nagao","year":"2008"},{"key":"ref12","first-page":"2541","article-title":"Immunological serotype interactions and their effect on the epidemiological pattern of dengue","volume":"276","author":"M. Recker","year":"2009"},{"key":"ref13","first-page":"48","article-title":"Epidemiology of dengue fever: A model with temporary cross-immunity and possible secondary infection shows bifurcations and chaotic behaviour in wide parameter regions","volume":"3","author":"M. Aguiar","year":"2008"},{"key":"ref14","first-page":"181","article-title":"The role of seasonality and import in a minimalistic multi-strain dengue model capturing differences between primary and secondary infections: complex dynamics and its implications for data analysis","volume":"289","author":"M. Aguiar","year":"2011"},{"key":"ref15","first-page":"1","article-title":"Scaling of stochasticity in dengue hemorrhagic fever epidemics","volume":"7","author":"M. Aguiar","year":"2012"},{"key":"ref16","first-page":"2447","article-title":"Are we modeling the correct data set? Minimizing false predictions for dengue fever in Thailand","volume":"142","author":"M. Aguiar","year":"2014"},{"key":"ref17","first-page":"14688","article-title":"Asymptomatic humans transmit dengue virus to mosquitoes","volume":"112","author":"V. Duong","year":"2015"},{"key":"ref18","first-page":"31","article-title":"How much complexity is needed to describe the fluctuations observed in dengue hemorrhagic fever incidence data?","volume":"16","author":"M. Aguiar","year":"2013"},{"issue":"6","key":"ref19","first-page":"e0003749","article-title":"The Complexity of a Dengue Vaccine: A Review of the Human Antibody Response","volume":"9","author":"J. Flipse","year":"2015"},{"key":"ref20","first-page":"1358","article-title":"Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia:a phase 3, randomised, observer-masked, placebo-controlled trial","volume":"384","author":"M.R. Capeding","year":"2014"},{"key":"ref21","first-page":"113","article-title":"Efficacy of a tetravalent dengue vaccine in children in Latin America","volume":"372","author":"L. Villar","year":"2015"},{"key":"ref22","unstructured":"Sanofi Pasteur Press Release. July 27, 2016. Retrieved from <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.sanofipasteur.com\/en\/articles\/New-England-Journal-of-Medicine-Publishes-New-Analyses-Confirming-that-Sanofi-Pasteur-s-Vaccine-Candidate-Safely-Protects-Pre-Adolescents-to-Adults-Against-Dengue.aspx\" xlink:type=\"simple\">http:\/\/www.sanofipasteur.com\/en\/articles\/New-England-Journal-of-Medicine-Publishes-New-Analyses-Confirming-that-Sanofi-Pasteur-s-Vaccine-Candidate-Safely-Protects-Pre-Adolescents-to-Adults-Against-Dengue.aspx<\/ext-link> Last access on August 15 2016."},{"key":"ref23","article-title":"Estimation of parameters related to vaccine efficacy and dengue transmission from two large phase III studies","author":"L. Coudeville","year":"2015"},{"key":"ref24","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2016.08.050","article-title":"Potential Impact of Dengue Vaccination: Insights From Two Large-Scale Phase III Trials With a Tetravalent Dengue Vaccine","author":"L. Coudeville","year":"2016"},{"key":"ref25","first-page":"1195","article-title":"Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease","volume":"373","author":"S.R. Hadinegoro","year":"2015"},{"issue":"14","key":"ref26","first-page":"1643","article-title":"Protective and Immunological Behavior of Yellow Fever Dengue Chimeric Vaccine","volume":"34","author":"Scott B. Halstead","year":"2016"},{"key":"ref27","unstructured":"World Health Organization Strategic Advisory Group of Experts (SAGE) on Immunization. Background paper on Dengue Vaccines prepared by the SAGE working group on dengue vaccines and the WHO secretariat Retrieved from <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/immunization\/sage\/meetings\/2016\/april\/presentations_background_docs\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/immunization\/sage\/meetings\/2016\/april\/presentations_background_docs\/en\/<\/ext-link> Last access on August 12 2016."},{"key":"ref28","unstructured":"World Health Organization Strategic Advisory Group of Experts (SAGE) on Immunization. Comparative modelling of dengue vaccine public health impact (CMDVI) Flasche S. et al. Retrieved from <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/immunization\/sage\/meetings\/2016\/april\/presentations_background_docs\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/immunization\/sage\/meetings\/2016\/april\/presentations_background_docs\/en\/<\/ext-link> Last access on August 7 2016."},{"key":"ref29","first-page":"880","article-title":"SAGE committee advice on dengue vaccine","volume":"16","author":"Tikki Pang","year":"2016"},{"key":"ref30","unstructured":"Fierce Vaccines Press Release. 17th February 2016. Retrieved from <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.fiercevaccines.com\/story\/sanofi-ships-1m-dengvaxia-doses-philippines-talks-3m-more-20-dose\/2016-02-17\" xlink:type=\"simple\">http:\/\/www.fiercevaccines.com\/story\/sanofi-ships-1m-dengvaxia-doses-philippines-talks-3m-more-20-dose\/2016-02-17<\/ext-link>"},{"key":"ref31","unstructured":"Sanofi Pasteur Press Release. October 4th, 2016. Retrieved from <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.sanofipasteur.com\/en\/articles\/first_dengue_vaccine_approved_in_more_than_10_countries.aspx\" xlink:type=\"simple\">http:\/\/www.sanofipasteur.com\/en\/articles\/first_dengue_vaccine_approved_in_more_than_10_countries.aspx<\/ext-link>"},{"key":"ref32","unstructured":"Sanofi Pasteur Press Release. April 4th, 2016. Retrieved from Retrieved from <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.sanofipasteur.com\/en\/articles\/World-s-First-Public-Dengue-Immunization-Program-Starts-in-the-Philippines.aspx\" xlink:type=\"simple\">http:\/\/www.sanofipasteur.com\/en\/articles\/World-s-First-Public-Dengue-Immunization-Program-Starts-in-the-Philippines.aspx<\/ext-link>"},{"key":"ref33","unstructured":"Sanofi Pasteur Press Release. August 13th, 2016. Retrieved from Retrieved from <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.sanofipasteur.com\/en\/articles\/Dengue-Immunization-Public-Program-in-Parana-State-of-Brazil.aspx\" xlink:type=\"simple\">http:\/\/www.sanofipasteur.com\/en\/articles\/Dengue-Immunization-Public-Program-in-Parana-State-of-Brazil.aspx<\/ext-link>"},{"key":"ref34","unstructured":"Luis Mateus, Maira Aguiar and Nico Stollenwerk. (2015). Bayesian estimation of vaccine efficacy. (2015). <italic>Proceedings of the 15th International Conference on Mathematical Methods in Science and Engineering<\/italic>, <italic>CMMSE<\/italic>, pp 794-802, ISBN 978-84-617-2230-3 edited by Jesus Vigo Aguiar et al., Almer\u00eda, Spain."},{"key":"ref35","article-title":"<italic>Population Biology and Criticality: From critical birth-death processes to self-organized criticality in mutation pathogen systems<\/italic>","author":"N. Stollenwerk","year":"2011"},{"key":"ref36","first-page":"2161","article-title":"Stochastic Models in Population Biology: From Dynamic Noise to Bayesian Description and Model Comparison for Given Data Sets","volume":"90","author":"L. Mateus","year":"2013"},{"key":"ref37","first-page":"156","article-title":"Dynamic noise, chaos and parameter estimation in population biology","volume":"2","author":"N. Stollenwerk","year":"2012"},{"key":"ref38","unstructured":"Ma\u00edra Aguiar, Luis Mateus and Nico Stollenwerk. (2015). The currently best estimate for worldwide dengue vaccine efficacy. <italic>AIP Conference Proceedings<\/italic>, <italic>ICNAAM<\/italic>, 1738, 390014."},{"key":"ref39","first-page":"45","article-title":"Dengue vaccine: hypotheses to understand CYD-TDV-induced protection","volume":"14","author":"B Guy","year":"2015"},{"issue":"5","key":"ref40","first-page":"910","article-title":"Analysis of repeat hospital admissions for dengue to estimate the frequency of third or fourth dengue infections resulting in admissions and dengue hemorrhagic fever, and serotype sequences","volume":"77","author":"V. Robert","year":"2007"},{"issue":"10","key":"ref41","first-page":"2105","article-title":"Time-scale separation and center manifold analysis describing vector-borne disease dynamics","volume":"90","author":"F. Rocha","year":"2013"},{"key":"ref42","first-page":"882","article-title":"The risks behind Dengvaxia recommendation","volume":"16","author":"M. Aguiar","year":"2016"},{"key":"ref43","unstructured":"Bureau of Epidemiology, Ministry of Public Health of Thailand. Weekly epidemiological surveillance report. Retrieved from <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/boe-wesr.net\/\" xlink:type=\"simple\">http:\/\/boe-wesr.net\/<\/ext-link>"},{"key":"ref44","article-title":"Chaotic evolution and strange attractors","author":"David Ruelle","year":"1989"},{"key":"ref45","unstructured":"World Population Prospects: The 2008 Revision <italic>Population Database<\/italic>. Retrieved from <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/esa.un.org\/unpp\/index.asp?panel=2\" xlink:type=\"simple\">http:\/\/esa.un.org\/unpp\/index.asp?panel=2<\/ext-link>"},{"key":"ref46","unstructured":"World Health Organization. (2015). <italic>Dengue and Dengue Hemorrhagic Fever<\/italic> <bold>Fact sheet 117<\/bold>. Retrieved from <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/mediacentre\/factsheets\/fs117\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/mediacentre\/factsheets\/fs117\/en\/<\/ext-link>"},{"key":"ref47","first-page":"4273","article-title":"Answer to the review from Halstead and Russell \u201cProtective and immunological behaviour od chimeric yellow fever dengue vaccine\u201d","volume":"34","author":"S.R. Hadinegoro","year":"2016"},{"key":"ref48","article-title":"Populations perspectives and WHO recommendations for CYD-TDV dengue vaccine","author":"A. Wilder-Smith","year":"2016"},{"key":"ref49","first-page":"2793","article-title":"Discrimination between Primary and Secondary Dengue Virus Infection by an Immunoglobulin G Aviditnoy Test Using a Single Acute-Phase Serum Sample","volume":"43","author":"S. Matheus","year":"2005"},{"issue":"Chapter 25","key":"ref50","first-page":"493","article-title":"Antibody-dependent Enhancement of Infection: A Mechanism for Indirect Virus Entry into Cells","volume":"28","author":"S. B. Halstead","year":"1994"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0005179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T20:16:17Z","timestamp":1540325777000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0005179"}},"subtitle":[],"editor":[{"given":"Maria G","family":"Guzman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,21]]},"references-count":50,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0005179","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/074062","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,21]]}}}