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and Infectious Diseases, Division of AIDS. Division of AIDS (DAIDS) Table for Grading the Severity of Adult and Pediatric Adverse Events, Version 2.0. [November 2014]. Available from:<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/rsc.tech-res.com\/Document\/safetyandpharmacovigilance\/DAIDS_AE_GRADING_TABLE_v2_NOV2014.pdf\" xlink:type=\"simple\">http:\/\/rsc.tech-res.com\/Document\/safetyandpharmacovigilance\/DAIDS_AE_GRADING_TABLE_v2_NOV2014.pdf<\/ext-link>."},{"issue":"11","key":"ref33","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.4155\/bio.13.74","article-title":"A simple LC-MS\/MS method for determination of kynurenine and tryptophan concentrations in human plasma from HIV-infected patients","volume":"5","author":"Y Huang","year":"2013","journal-title":"Bioanalysis"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jviromet.2008.03.026","article-title":"Standardized quantitative RT-PCR assays for quantitation of yellow fever and chimeric yellow fever-dengue vaccines","volume":"151","author":"N Mantel","year":"2008","journal-title":"J 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