{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T10:16:00Z","timestamp":1776507360180,"version":"3.51.2"},"update-to":[{"DOI":"10.1371\/journal.pntd.0005349","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000}}],"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AI088752"],"award-info":[{"award-number":["U01AI088752"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0005349","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T18:36:19Z","timestamp":1485887779000},"page":"e0005349","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Distinct antibody responses of patients with mild and severe leptospirosis determined by whole proteome microarray analysis"],"prefix":"10.1371","volume":"11","author":[{"given":"Carolina","family":"Lessa-Aquino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet C.","family":"Lindow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arlo","family":"Randall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsio","family":"Wunder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jozelyn","family":"Pablo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Algis","family":"Jasinskas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaqueline S.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alcineia O.","family":"Dami\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00edvison","family":"Nery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme S.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 E.","family":"Hagan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitermayer Galv\u00e3o","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert I.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Alberto","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip L.","family":"Felgner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,1,31]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/01.qco.0000178824.05715.2c","article-title":"Leptospirosis","volume":"18","author":"AJ McBride","year":"2005","journal-title":"Current opinion in infectious diseases"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S1473-3099(03)00830-2","article-title":"Leptospirosis: a zoonotic disease of global importance","volume":"3","author":"AR Bharti","year":"2003","journal-title":"Lancet Infect Dis"},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","first-page":"e0003898","DOI":"10.1371\/journal.pntd.0003898","article-title":"Global Morbidity and Mortality of Leptospirosis: A Systematic Review","volume":"9","author":"F Costa","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nrmicro2208","article-title":"Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen","volume":"7","author":"AI Ko","year":"2009","journal-title":"Nature reviews Microbiology"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1128\/CMR.14.2.296-326.2001","article-title":"Leptospirosis","volume":"14","author":"PN Levett","year":"2001","journal-title":"Clin Microbiol Rev"},{"issue":"8","key":"ref6","doi-asserted-by":"crossref","first-page":"e71743","DOI":"10.1371\/journal.pone.0071743","article-title":"Human hemorrhagic pulmonary leptospirosis: pathological findings and pathophysiological correlations","volume":"8","author":"T De Brito","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1128\/IAI.17.1.67-72.1977","article-title":"Host immunological mechanisms in the resistance of mice to leptospiral infections","volume":"17","author":"B Adler","year":"1977","journal-title":"Infection and immunity"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1128\/IAI.14.3.703-708.1976","article-title":"Susceptibility of mice treated with cyclophosphamide to lethal infection with Leptospira interrogans Serovar pomona","volume":"14","author":"B Adler","year":"1976","journal-title":"Infection and immunity"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.4049\/jimmunol.0900506","article-title":"TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans","volume":"183","author":"C Chassin","year":"2009","journal-title":"J Immunol"},{"issue":"27","key":"ref10","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1016\/j.vaccine.2011.04.041","article-title":"Passive immunization with Leptospira LPS-specific agglutinating but not non-agglutinating monoclonal antibodies protect guinea pigs from fatal pulmonary hemorrhages induced by serovar Copenhageni challenge","volume":"29","author":"S Challa","year":"2011","journal-title":"Vaccine"},{"issue":"1","key":"ref11","first-page":"73","article-title":"An immunoprotective monoclonal antibody directed against Leptospira interrogans serovar copenhageni","volume":"135","author":"GJ Schoone","year":"1989","journal-title":"J Gen Microbiol"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1099\/00222615-22-3-269","article-title":"A monoclonal antibody reacting with a determinant on leptospiral lipopolysaccharide protects guinea pigs against leptospirosis","volume":"22","author":"BH Jost","year":"1986","journal-title":"Journal of medical microbiology"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1089\/hyb.2008.0056","article-title":"Monoclonal antibodies to LipL32 protect against heterologous Leptospira spp. challenge","volume":"27","author":"S Maneewatch","year":"2008","journal-title":"Hybridoma (Larchmt)"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1017\/S0950268800048779","article-title":"Antigens recognized by the human immune response to severe leptospirosis in Barbados","volume":"107","author":"AJ Chapman","year":"1991","journal-title":"Epidemiol Infect"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3109\/00313028009086806","article-title":"Maturation of humoral immune response determines the susceptibility of guinea-pigs to leptospirosis","volume":"12","author":"B Adler","year":"1980","journal-title":"Pathology"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1365-3083.2010.02505.x","article-title":"Leptospirosis: aspects of innate immunity, immunopathogenesis and immune evasion from the complement system","volume":"73","author":"TR Fraga","year":"2011","journal-title":"Scand J Immunol"},{"issue":"9","key":"ref17","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.2217\/fmb.10.102","article-title":"Leptospira as an emerging pathogen: a review of its biology, pathogenesis and host immune responses","volume":"5","author":"KV Evangelista","year":"2010","journal-title":"Future Microbiol"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0264-410X(00)00129-8","article-title":"Evidence of cross-protection within Leptospira interrogans in an experimental model","volume":"19","author":"C Sonrier","year":"2000","journal-title":"Vaccine"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1093\/infdis\/jiq127","article-title":"Cross-protective immunity against leptospirosis elicited by a live, attenuated lipopolysaccharide mutant","volume":"203","author":"A Srikram","year":"2011","journal-title":"J Infect Dis"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1021\/pr500718t","article-title":"Proteomic features predict seroreactivity against leptospiral antigens in leptospirosis patients","volume":"14","author":"C Lessa-Aquino","year":"2015","journal-title":"J Proteome Res"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"e2499","DOI":"10.1371\/journal.pntd.0002499","article-title":"Identification of seroreactive proteins of Leptospira interrogans serovar copenhageni using a high-density protein microarray approach","volume":"7","author":"C Lessa-Aquino","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"issue":"8","key":"ref22","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/pmic.201500429","article-title":"An overview of innovations and industrial solutions in Protein Microarray Technology","volume":"16","author":"S Gupta","year":"2016","journal-title":"Proteomics"},{"issue":"2","key":"ref23","first-page":"RESEARCH0004","article-title":"Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions","volume":"2","author":"BB Haab","year":"2001","journal-title":"Genome Biol"},{"issue":"5485","key":"ref24","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.289.5485.1760","article-title":"Printing proteins as microarrays for high-throughput function determination","volume":"289","author":"G MacBeath","year":"2000","journal-title":"Science"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1093\/infdis\/jiv356","article-title":"Antibody Signatures Reflect Different Disease Pathologies in Patients With Schistosomiasis Due to Schistosoma japonicum","volume":"213","author":"P Driguez","year":"2016","journal-title":"J Infect Dis"},{"key":"ref26","article-title":"Towards development of improved serodiagnostics for tularemia using Francisella tularensis proteome microarrays","author":"R Nakajima","year":"2016","journal-title":"J Clin Microbiol"},{"issue":"9","key":"ref27","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1093\/infdis\/jiv224","article-title":"Plasmodium falciparum Protein Microarray Antibody Profiles Correlate With Protection From Symptomatic Malaria in Kenya","volume":"212","author":"AE Dent","year":"2015","journal-title":"J Infect Dis"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1017\/S0031182014001978","article-title":"Identification of Toxoplasma gondii antigens associated with different types of infection by serum antibody profiling","volume":"142","author":"J Felgner","year":"2015","journal-title":"Parasitology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/srep01043","article-title":"Immune profiling with a Salmonella Typhi antigen microarray identifies new diagnostic biomarkers of human typhoid","volume":"3","author":"L Liang","year":"2013","journal-title":"Sci Rep"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1128\/CVI.05521-11","article-title":"Failure of the smallpox vaccine to develop a skin lesion in vaccinia virus-na\u00efve individuals is related to differences in antibody profiles before vaccination, not after","volume":"19","author":"X Tan","year":"2012","journal-title":"Clin Vaccine Immunol"},{"issue":"8","key":"ref31","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1128\/IAI.00048-08","article-title":"A genome-wide proteome array reveals a limited set of immunogens in natural infections of humans and white-footed mice with Borrelia burgdorferi","volume":"76","author":"AG Barbour","year":"2008","journal-title":"Infection and immunity"},{"issue":"9181","key":"ref32","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S0140-6736(99)80012-9","article-title":"Urban epidemic of severe leptospirosis in Brazil. Salvador Leptospirosis Study Group","volume":"354","author":"AI Ko","year":"1999","journal-title":"Lancet"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actatropica.2008.07.005","article-title":"Carriage of Leptospira interrogans among domestic rats from an urban setting highly endemic for leptospirosis in Brazil","volume":"108","author":"MT de Faria","year":"2008","journal-title":"Acta Trop"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1073\/pnas.0408782102","article-title":"Profiling the humoral immune response to infection by using proteome microarrays: high-throughput vaccine and diagnostic antigen discovery","volume":"102","author":"DH Davies","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1046\/j.1365-2958.2003.03619.x","article-title":"Pathogenic Leptospira species express surface-exposed proteins belonging to the bacterial immunoglobulin superfamily","volume":"49","author":"J Matsunaga","year":"2003","journal-title":"Mol Microbiol"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/sam.10005","article-title":"Controlling the False Discovery Rate for Feature Selection in High-resolution NMR Spectra","volume":"1","author":"SB Kim","year":"2008","journal-title":"Stat Anal Data Min"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/QCO.0b013e32814a5729","article-title":"Leptospirosis: pathogenesis, immunity, and diagnosis","volume":"20","author":"RU Palaniappan","year":"2007","journal-title":"Current opinion in infectious diseases"},{"issue":"11","key":"ref38","doi-asserted-by":"crossref","first-page":"e1878","DOI":"10.1371\/journal.pntd.0001878","article-title":"Accuracy of a dual path platform (DPP) assay for the rapid point-of-care diagnosis of human leptospirosis","volume":"6","author":"SA Nabity","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1128\/JCM.02344-06","article-title":"Leptospira immunoglobulin-like proteins as a serodiagnostic marker for acute leptospirosis","volume":"45","author":"J Croda","year":"2007","journal-title":"J Clin Microbiol"},{"issue":"33","key":"ref40","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1016\/j.vaccine.2007.05.053","article-title":"The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis","volume":"25","author":"EF Silva","year":"2007","journal-title":"Vaccine"},{"issue":"Pt 10","key":"ref41","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1099\/jmm.0.45568-0","article-title":"Expression of leptospiral immunoglobulin-like protein by Leptospira interrogans and evaluation of its diagnostic potential in a kinetic ELISA","volume":"53","author":"RU Palaniappan","year":"2004","journal-title":"Journal of medical microbiology"},{"issue":"3","key":"ref42","first-page":"291","article-title":"A sensitive and specific IgM-ELISA for the serological diagnosis of human leptospirosis using a rLipL32\/1-LipL21-OmpL1\/2 fusion protein","volume":"24","author":"A Sun","year":"2011","journal-title":"Biomed Environ Sci"},{"issue":"5","key":"ref43","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/QCO.0000000000000193","article-title":"A systems biology approach for diagnostic and vaccine antigen discovery in tropical infectious diseases","volume":"28","author":"L Liang","year":"2015","journal-title":"Current opinion in infectious diseases"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/cbdv.201100360","article-title":"Predicting antigenicity of proteins in a bacterial proteome; a protein microarray and na\u00efve Bayes classification approach","volume":"9","author":"L Liang","year":"2012","journal-title":"Chem Biodivers"},{"issue":"7","key":"ref45","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1128\/CVI.00211-16","article-title":"Immunoglobulin M for Acute Infection: True or False?","volume":"23","author":"ML Landry","year":"2016","journal-title":"Clin Vaccine Immunol"},{"issue":"11","key":"ref46","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nri2849","article-title":"The importance of natural IgM: scavenger, protector and regulator","volume":"10","author":"MR Ehrenstein","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1743-422X-8-47","article-title":"Kinetics of non-structural protein 1, IgM and IgG antibodies in dengue type 1 primary infection","volume":"8","author":"D Hu","year":"2011","journal-title":"Virol J"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","first-page":"418","DOI":"10.4269\/ajtmh.1989.40.418","article-title":"An enzyme-linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis co-circulate","volume":"40","author":"BL Innis","year":"1989","journal-title":"Am J Trop Med Hyg"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"799","DOI":"10.4161\/hv.19820","article-title":"Antibody response to Streptococcus pneumoniae proteins PhtD, LytB, PcpA, PhtE and Ply after nasopharyngeal colonization and acute otitis media in children","volume":"8","author":"ME Pichichero","year":"2012","journal-title":"Hum Vaccin Immunother"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0005349","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0005349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T03:24:06Z","timestamp":1658546646000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0005349"}},"subtitle":[],"editor":[{"given":"Joseph M.","family":"Vinetz","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,1,31]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0005349","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0005349","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,31]]}}}