{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:20:02Z","timestamp":1792790402218,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0005453","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T00:00:00Z","timestamp":1490140800000}}],"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T00:00:00Z","timestamp":1489104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0005453","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T18:36:52Z","timestamp":1489171012000},"page":"e0005453","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Murine models of scrub typhus associated with host control of Orientia tsutsugamushi infection"],"prefix":"10.1371","volume":"11","author":[{"given":"Nicole L.","family":"Mendell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald H.","family":"Bouyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3309-4360","authenticated-orcid":false,"given":"David H.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,3,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4269\/ajtmh.13-0064","article-title":"Unresolved problems related to scrub typhus: a seriously neglected life-threatening disease","volume":"89","author":"DH Paris","year":"2013","journal-title":"The American journal of tropical medicine and hygiene"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1086\/516990","article-title":"A case of scrub typhus probably acquired in Africa","volume":"25","author":"RP Ghorbani","year":"1997","journal-title":"Clinical infectious diseases"},{"key":"ref3","first-page":"50","article-title":"The prevalence of <italic>Rickettsia orientalis<\/italic> antibodies among natives and asiatics living in Ruanda-Urundi. (Belgian Congo)","volume":"44","author":"P Giroud","year":"1951","journal-title":"Bulletin de la Societe de pathologie exotique et de ses filiales"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"4404","DOI":"10.1128\/JCM.01526-10","article-title":"Isolation of a novel <italic>Orientia<\/italic> species (<italic>O<\/italic>. <italic>chuto<\/italic> sp. nov.) from a patient infected in Dubai","volume":"48","author":"L Izzard","year":"2010","journal-title":"Journal of clinical microbiology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF01964418","article-title":"A case of tsutsugamushi disease probably contracted in Africa","volume":"10","author":"K Osuga","year":"1991","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"688","DOI":"10.3201\/eid2104.141387","article-title":"High seroprevalence of antibodies against spotted fever and scrub typhus bacteria in patients with febrile Illness, Kenya","volume":"21","author":"JW Thiga","year":"2015","journal-title":"Emerging infectious diseases"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"883","DOI":"10.3201\/eid2205.150953","article-title":"Q fever, scrub typhus, and rickettsial diseases in children, Kenya, 2011\u20132012","volume":"22","author":"AN Maina","year":"2016","journal-title":"Emerging infectious diseases"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.3201\/eid1709.100960","article-title":"Endemic scrub typhus-like illness, Chile","volume":"17","author":"ME Balcells","year":"2011","journal-title":"Emerging infectious diseases"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s13071-015-0784-7","article-title":"Detection of <italic>Orientia<\/italic> sp. DNA in rodents from Asia, West Africa and Europe","volume":"8","author":"JF Cosson","year":"2015","journal-title":"Parasites & vectors"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1056\/NEJMoa1603657","article-title":"Endemic scrub typhus in South America","volume":"375","author":"T Weitzel","year":"2016","journal-title":"The New England journal of medicine"},{"key":"ref11","first-page":"389","article-title":"The ecology of scrub typhus","volume":"2","author":"JR Audy","year":"1961","journal-title":"Studies in disease ecology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1146\/annurev.en.06.010161.002135","article-title":"Arthropod vectors as reservoirs of microbial disease agents","volume":"6","author":"CB Philip","year":"1961","journal-title":"Annual review of entomology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/jmedent\/11.3.237","article-title":"The ecology of chigger-borne rickettsiosis (scrub typhus)","volume":"11","author":"R Traub","year":"1974","journal-title":"Journal of medical entomology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.actatropica.2014.10.012","article-title":"Distribution of rickettsioses in Oceania: past patterns and implications for the future","volume":"143","author":"B Derne","year":"2015","journal-title":"Acta tropica"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1471-2334-10-108","article-title":"Clinical and laboratory findings associated with severe scrub typhus","volume":"10","author":"DM Kim","year":"2010","journal-title":"BMC infectious diseases"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"924","DOI":"10.4269\/ajtmh.2011.11-0134","article-title":"Severity predictors in eschar-positive scrub typhus and role of serum osteopontin","volume":"85","author":"SW Park","year":"2011","journal-title":"The American journal of tropical medicine and hygiene"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jinf.2005.02.001","article-title":"Scrub typhus among hospitalised patients with febrile illness in South India: magnitude and clinical predictors","volume":"52","author":"GM Varghese","year":"2006","journal-title":"The Journal of infection"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijid.2014.02.009","article-title":"Clinical profile and improving mortality trend of scrub typhus in South India","volume":"23","author":"GM Varghese","year":"2014","journal-title":"International journal of infectious diseases: IJID"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.4269\/ajtmh.2012.12-0306","article-title":"Scrub typhus: surveillance, clinical profile and diagnostic issues in Shandong, China","volume":"87","author":"M Zhang","year":"2012","journal-title":"The American journal of tropical medicine and hygiene"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.4269\/ajtmh.2007.76.1148","article-title":"Acute respiratory distress syndrome in scrub typhus","volume":"76","author":"CC Wang","year":"2007","journal-title":"The American journal of tropical medicine and hygiene"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1471-2334-11-79","article-title":"Otalgia and eschar in the external auditory canal in scrub typhus complicated by acute respiratory distress syndrome and multiple organ failure","volume":"11","author":"BJ Lee","year":"2011","journal-title":"BMC infectious diseases"},{"key":"ref22","first-page":"240","article-title":"Serious complications in scrub typhus","volume":"31","author":"RW Tsay","year":"1998","journal-title":"Journal of microbiology, immunology, and infection"},{"key":"ref23","first-page":"603","article-title":"A comparative study of the pathology of scrub typhus (tsutsugamushi disease) and other rickettsial diseases","volume":"21","author":"AC Allen","year":"1945","journal-title":"Am J Pathol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1080\/00313020801911488","article-title":"Pulmonary pathology in patients associated with scrub typhus","volume":"40","author":"Y-H Hsu","year":"2008","journal-title":"Pathology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1148\/rg.271065074","article-title":"Scrub typhus: clinical, pathologic, and imaging findings","volume":"27","author":"YJ Jeong","year":"2007","journal-title":"Radiographics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e22731","DOI":"10.1371\/journal.pone.0022731","article-title":"Differences in clinical features according to Boryoung and Karp genotypes of <italic>Orientia tsutsugamushi<\/italic>","volume":"6","author":"DM Kim","year":"2011","journal-title":"PLoS One"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0002-8703(46)90313-4","article-title":"Pathologic study of thirty-one cases of scrub typhus fever with especial reference to the cardiovascular system","volume":"31","author":"HD Levine","year":"1946","journal-title":"American heart journal"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/modpathol.3880385","article-title":"Identification of the target cells of <italic>Orientia tsutsugamushi<\/italic> in human cases of scrub typhus","volume":"14","author":"CG Moron","year":"2001","journal-title":"Mod Pathol"},{"key":"ref29","first-page":"639","article-title":"A pathologic study of tsutsugamushi disease (scrub typhus) with notes on clinicopathologic correlation","volume":"30","author":"E Settle","year":"1945","journal-title":"Journal of laboratory and clinical medicine"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e66595","DOI":"10.1371\/journal.pone.0066595","article-title":"Scrub typhus meningitis in South India\u2014a retrospective study","volume":"8","author":"S Viswanathan","year":"2013","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.4269\/ajtmh.13-0224","article-title":"Scrub typhus meningitis or meningoencephalitis","volume":"89","author":"DM Kim","year":"2013","journal-title":"The American journal of tropical medicine and hygiene"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e1466","DOI":"10.1371\/journal.pntd.0001466","article-title":"<italic>Orientia tsutsugamushi<\/italic> in human scrub typhus eschars shows tropism for dendritic cells and monocytes rather than endothelium","volume":"6","author":"DH Paris","year":"2012","journal-title":"PLoS neglected tropical diseases"},{"key":"ref33","first-page":"847","article-title":"Immunity in scrub typhus: resistance to induced reinfection","volume":"50","author":"J Smadel","year":"1950","journal-title":"Arch Pathol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4269\/ajtmh.1952.1.87","article-title":"Immunization against scrub typhus- duration of immunity in volunteers following combined living vaccine and chemoprophylaxis","volume":"1","author":"JE Smadel","year":"1952","journal-title":"Am J Trop Med Hyg"},{"key":"ref35","first-page":"317","article-title":"Immunization against scrub typhus. I. Combined living vaccine and chemoprophylaxis in volunteers","volume":"53","author":"JE Smadel","year":"1951","journal-title":"American journal of hygiene"},{"key":"ref36","first-page":"18","article-title":"Antigenic diversity of <italic>Rickettsia tsutsugamushi<\/italic>: epidemiologic and ecologic significance","volume":"12","author":"BL Elisberg","year":"1968","journal-title":"J Hyg Epidemiol Microbiol Immunol"},{"key":"ref37","first-page":"61","article-title":"Physiogeographic distribution of scrub typhus in Thailand","volume":"15","author":"BL Elisberg","year":"1967","journal-title":"Acta Med Biol (Niigata)"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e752","DOI":"10.1371\/journal.pntd.0000752","article-title":"High rates of homologous recombination in the mite endosymbiont and opportunistic human pathogen <italic>Orientia tsutsugamushi<\/italic>","volume":"4","author":"P Sonthayanon","year":"2010","journal-title":"PLoS neglected tropical diseases"},{"key":"ref39","first-page":"34","article-title":"The nature of immunity against scrub typhus in guinea-pigs","volume":"1","author":"W Kouwenaar","year":"1949","journal-title":"Documenta Neerlandica et Indonesica de Morbis Tropicis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3346\/jkms.2012.27.3.231","article-title":"Persistence of <italic>Orientia tsutsugamushi<\/italic> in humans","volume":"27","author":"MH Chung","year":"2012","journal-title":"Journal of Korean medical science"},{"key":"ref41","first-page":"294","article-title":"Persistence of <italic>Rickettsia tsutsugamushi<\/italic> in tissues of patients recovered from scrub typhus","volume":"56","author":"JE Smadel","year":"1952","journal-title":"American journal of hygiene"},{"key":"ref42","first-page":"113","article-title":"A living chemo-vaccine prepared from rickettsia tsutsugamushi","volume":"15","author":"N Kekcheyeva","year":"1967","journal-title":"Acta Med Biol (Niigata)"},{"key":"ref43","first-page":"14","article-title":"Preventive immunization against tsutsugamushi fever","volume":"12","author":"N Kekcheyeva","year":"1968","journal-title":"Journal of Hygiene, Epidemiology, Microbiology and Immunology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1128\/IAI.15.1.124-131.1977","article-title":"Experimental scrub typhus immunogens: gamma-irradiated and formalinized rickettsiae","volume":"15","author":"GH Eisenberg Jr","year":"1977","journal-title":"Infection and immunity"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1128\/IAI.22.1.80-86.1978","article-title":"Gamma-irradiated scrub typhus immunogens: development and duration of immunity","volume":"22","author":"GH Eisenberg Jr","year":"1978","journal-title":"Infection and immunity"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1128\/IAI.26.1.131-136.1979","article-title":"Gamma-irradiated scrub typhus immunogens: broad-spectrum immunity with combinations of rickettsial strains","volume":"26","author":"GH Eisenberg Jr","year":"1979","journal-title":"Infection and immunity"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"431","DOI":"10.4049\/jimmunol.60.3.431","article-title":"Preparation of a serological antigen and a vaccine for experimental tsutsugamushi disease","volume":"60","author":"CA Bailey","year":"1948","journal-title":"J Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.vaccine.2005.07.113","article-title":"Long-term egg-yolk adaptation of the Orientia tsutsugamushi for preparation of a formalinized immunogen","volume":"24","author":"Y Choi","year":"2006","journal-title":"Vaccine"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1084\/jem.87.4.339","article-title":"Studies on scrub typhus (Tsutsugamushi disease) III. Heterogenicity of strains of <italic>R<\/italic>. <italic>tsutsugamushi<\/italic> as demonstrated by cross-vaccination studies","volume":"87","author":"FL Rights","year":"1948","journal-title":"The Journal of experimental medicine"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/infdis\/152.4.739","article-title":"Development of antigen-specific cell-mediated immune responses after infection of cynomolgus monkeys (<italic>Macaca fascicularis<\/italic>) with <italic>Rickettsia tsutsugamushi<\/italic>","volume":"152","author":"JG MacMillan","year":"1985","journal-title":"The Journal of infectious diseases"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/infdis\/143.4.558","article-title":"Clinical and immunologic responses of silvered leaf monkeys (Presbytis cristatus) to experimental reinfection with Rickettsia tsutsugamushi","volume":"143","author":"DM Robinson","year":"1981","journal-title":"The Journal of infectious diseases"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1128\/IAI.13.3.861-875.1976","article-title":"Host defenses in experimental scrub typhus: histopathological correlates","volume":"13","author":"PJ Catanzaro","year":"1976","journal-title":"Infection and immunity"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"67","DOI":"10.7883\/yoken1952.38.67","article-title":"Pathology of toxic death in mice following intravenous injection of Rickettsia tsutsugamushi strain gilliam: examination by light and scanning electron microscopy","volume":"38","author":"SC Oaks Jr","year":"1985","journal-title":"Jpn J Med Sci Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1128\/IAI.19.3.1068-1075.1978","article-title":"Experimental infection of mouse peritoneal mesothelium with scrub typhus rickettsiae: an ultrastructural study","volume":"19","author":"EP Ewing Jr","year":"1978","journal-title":"Infection and immunity"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"e2966","DOI":"10.1371\/journal.pntd.0002966","article-title":"Hematogenously disseminated <italic>Orientia tsutsugamushi<\/italic>-infected murine model of scrub typhus [corrected]","volume":"8","author":"TR Shelite","year":"2014","journal-title":"PLoS neglected tropical diseases"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"e0004884","DOI":"10.1371\/journal.pntd.0004884","article-title":"An intradermal inoculation mouse model for immunological investigations of acute scrub typhus and persistent infection","volume":"10","author":"L Soong","year":"2016","journal-title":"PLoS neglected tropical diseases"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"e3064","DOI":"10.1371\/journal.pntd.0003064","article-title":"Dissemination of <italic>Orientia tsutsugamushi<\/italic> and inflammatory responses in a murine model of scrub typhus","volume":"8","author":"CA Keller","year":"2014","journal-title":"PLoS neglected tropical diseases"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"772","DOI":"10.4049\/jimmunol.93.5.772","article-title":"Pathogenesis of scrub typhus infection (<italic>Rickettsia tsutsugamushi<\/italic>) as studied by immunofluorescence","volume":"93","author":"WD Kundin","year":"1964","journal-title":"Journal of immunology"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1603\/ME13025","article-title":"Establishment of <italic>Orientia tsutsugamushi<\/italic> Lc-1 (Rickettsiales: Rickettsiaceae) infection in ICR outbred mice (Rodentia: Muridae) by needle challenge","volume":"51","author":"W Lurchachaiwong","year":"2014","journal-title":"Journal of medical entomology"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1089\/vbz.2015.1773","article-title":"Development of an <italic>Orientia tsutsugamushi<\/italic> Lc-1 murine intraperitoneal challenge model for scrub typhus: Determination of murine lethal dose (MuLD50), tissue bacterial loads, and clinical outcomes","volume":"15","author":"W Lurchachaiwong","year":"2015","journal-title":"Vector borne and zoonotic diseases"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1128\/IAI.19.2.583-588.1978","article-title":"Host defenses in experimental scrub typhus: genetics of natural resistance to infection","volume":"19","author":"MG Groves","year":"1978","journal-title":"Infection and immunity"},{"key":"ref62","first-page":"142","article-title":"Different allotypic susceptibility of mice to <italic>Rickettsia tsutsugamushi<\/italic>","volume":"20","author":"NG Kekcheeva","year":"1976","journal-title":"Acta Virol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1348-0421.2005.tb03641.x","article-title":"Sequence analysis of the hypervariable regions of the 56 kDa immunodominant protein genes of <italic>Orientia tsutsugamushi<\/italic> strains in Malaysia","volume":"49","author":"ST Tay","year":"2005","journal-title":"Microbiology and immunology"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"e0004991","DOI":"10.1371\/journal.pntd.0004991","article-title":"Protective and pathogenic roles of CD8+ T lymphocytes in murine <italic>Orientia tsutsugamushi<\/italic> infection","volume":"10","author":"M Hauptmann","year":"2016","journal-title":"PLoS neglected tropical diseases"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1086\/589284","article-title":"Fibronectin facilitates the invasion of <italic>Orientia tsutsugamushi<\/italic> into host cells through interaction with a 56-kDa type-specific antigen","volume":"198","author":"JH Lee","year":"2008","journal-title":"The Journal of infectious diseases"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1128\/JCM.01040-07","article-title":"Acute renal failure due to acute tubular necrosis caused by direct invasion of Orientia tsutsugamushi","volume":"46","author":"DM Kim","year":"2008","journal-title":"Journal of clinical microbiology"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"e0003990","DOI":"10.1371\/journal.pntd.0003990","article-title":"Increased nucleosomes and neutrophil activation link to disease progression in patients with scrub typhus but not murine typhus in Laos","volume":"9","author":"DH Paris","year":"2015","journal-title":"PLoS neglected tropical diseases"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.trstmh.2003.10.011","article-title":"Paediatric scrub typhus in Thailand: a study of 73 confirmed cases","volume":"98","author":"K Silpapojakul","year":"2004","journal-title":"Transactions of the royal society of tropical medicine and hygiene"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1128\/JCM.00634-08","article-title":"Effects of antibiotic treatment on the results of nested PCRs for scrub typhus","volume":"46","author":"DM Kim","year":"2008","journal-title":"Journal of clinical microbiology"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"e3191","DOI":"10.1371\/journal.pntd.0003191","article-title":"Strong type 1, but impaired type 2, immune responses contribute to <italic>Orientia tsutsugamushi<\/italic>-induced pathology in mice","volume":"8","author":"L Soong","year":"2014","journal-title":"PLoS neglected tropical diseases"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1089\/vbz.2006.0642","article-title":"Clinical and histological features of inoculation site skin lesions in cynomolgus monkeys experimentally infected with <italic>Orientia tsutsugamushi<\/italic>","volume":"7","author":"DS Walsh","year":"2007","journal-title":"Vector borne and zoonotic diseases"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.4049\/jimmunol.1402244","article-title":"A nonhuman primate scrub typhus model: protective immune responses induced by pKarp47 DNA vaccination in cynomolgus macaques","volume":"194","author":"DH Paris","year":"2015","journal-title":"Journal of immunology"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/infdis\/134.2.193","article-title":"Clinical response of silvered leaf monkeys (<italic>Presbytis cristatus<\/italic>) to infection with strains of <italic>Rickettsia tsutsugamushi<\/italic> virulent and avirulent for mice","volume":"134","author":"DM Robinson","year":"1976","journal-title":"The Journal of infectious diseases"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"e0003971","DOI":"10.1371\/journal.pntd.0003971","article-title":"A systematic review of mortality from untreated scrub typhus (<italic>Orientia tsutsugamushi<\/italic>)","volume":"9","author":"AJ Taylor","year":"2015","journal-title":"PLoS neglected tropical diseases"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0005453","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T00:00:00Z","timestamp":1490140800000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0005453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T15:48:26Z","timestamp":1692719306000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0005453"}},"subtitle":[],"editor":[{"given":"Andrew S","family":"Azman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,10]]},"references-count":74,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0005453","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0005453","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,10]]}}}