{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:58:35Z","timestamp":1790078315167,"version":"4.0.1"},"update-to":[{"DOI":"10.1371\/journal.pntd.0005631","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000}}],"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T00:00:00Z","timestamp":1508716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["43922"],"award-info":[{"award-number":["43922"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0005631","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T17:38:51Z","timestamp":1508780331000},"page":"e0005631","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Lymphatic pathology in asymptomatic and symptomatic children with Wuchereria bancrofti infection in children from Odisha, India and its reversal with DEC and albendazole treatment"],"prefix":"10.1371","volume":"11","author":[{"given":"Shantanu K.","family":"Kar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhagirathi","family":"Dwibedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birendra K.","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bikash K.","family":"Agrawala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherubala P.","family":"Ramachandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7047-5106","authenticated-orcid":true,"given":"John","family":"Horton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,10,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1365-3156.2006.01606.x","article-title":"Model-based analysis of trial data: microfilaria and worm productivity loss after diethylcarbamazine-albendazole or ivermectin-albendazole combination therapy against <italic>Wuchereria bancrofti<\/italic>","volume":"11","author":"ME de Kraker","year":"2006","journal-title":"Trop Med Int Health"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1179\/136485905X29701","article-title":"Situation analysis in a large urban area of India, prior to launching a programme of mass drug administrations to eliminate lymphatic filariasis","volume":"99","author":"KD Ramaiah","year":"2005","journal-title":"Ann Trop Med Parasitol"},{"key":"ref3","first-page":"491","article-title":"Strategies and tools for the control\/elimination of lymphatic filariasis","volume":"75","author":"EA Ottesen","year":"1997","journal-title":"Bull WHO"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e668","DOI":"10.1371\/journal.pntd.0000668","article-title":"Feasibility and effectiveness of basic lymphedema management in Leogane, Haiti, an area endemic for bancroftian filariasis","volume":"4","author":"DG Addiss","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/j.1365-3156.2005.01442.x","article-title":"A randomized clinical trial to compare the efficacy of three treatment regimens along with foot care in the morbidity management of filarial lymphedema","volume":"10","author":"AS Kerketta","year":"2005","journal-title":"Trop Med Int Health"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1093\/clinids\/23.5.1007","article-title":"Diethylcarbamazine-induced reversal of early lymphatic dysfunction in a patient with Bancroftian filariasis: assessment with use of lymphoscintigraphy","volume":"23","author":"TA Moore","year":"1996","journal-title":"Clin Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"702","DOI":"10.4269\/ajtmh.2009.09-0155","article-title":"Macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazine","volume":"81","author":"S Mand","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"956","DOI":"10.4269\/ajtmh.2009.80.956","article-title":"Reduction in levels of plasma vascular endothelial growth factor-A and improvement in hydrocele patients by targeting endosymbiotic Wolbachia sp. in Wuchereria bancrofti with doxycycline","volume":"80","author":"AY Debrah","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/cid\/cis486","article-title":"Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial","volume":"55","author":"S Mand","year":"2012","journal-title":"Clin Infect Dis"},{"key":"ref10","first-page":"91","article-title":"Lymphoscintigraphic evidence of lymph vessel dilation in the limbs of children with Brugia malayi infection","volume":"40","author":"RK Shenoy","year":"2008","journal-title":"J Commun Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1179\/136485909X398249","article-title":"Antifilarial drugs, in the doses employed in mass drug administrations by the Global Programme to Eliminate Lymphatic Filariasis, reverse lymphatic pathology in children with Brugia malayi infection","volume":"103","author":"RK Shenoy","year":"2009","journal-title":"Ann Trop Med Parasitol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.trstmh.2008.08.006","article-title":"Antigenemia in young children living in Wuchereria bancrofti-endemic areas of Orissa, India","volume":"103","author":"MS Bal","year":"2009","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref13","article-title":"Informal consultation on evaluation of morbidity in lymphatic filariasis","year":"1992"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/1097-0142(195311)6:6<1238::AID-CNCR2820060618>3.0.CO;2-6","article-title":"Lymph node concentration of radioactive colloidal gold following interstitial injection","volume":"6","author":"A Sherman","year":"1953","journal-title":"Cancer"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/BF02987244","article-title":"The role of radionuclide lymphoscintigraphy in extremity lymphedema","volume":"20","author":"Z Yuan","year":"2006","journal-title":"Ann Nucl Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/infdis\/170.4.927","article-title":"Lymphoscintigraphic analysis of lymphatic abnormalities in symptomatic and asymptomatic human filariasis","volume":"170","author":"DO Freedman","year":"1994","journal-title":"J Infect Dis"},{"key":"ref17","first-page":"1","article-title":"Prospects of eliminating Lymphatic Filariasis in India","volume":"32","year":"2002","journal-title":"ICMR Bulletin"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"963","DOI":"10.4269\/ajtmh.2012.12-0422","article-title":"Lymphoscintigraphy in unilateral lower limb and scrotal lymphedema caused by filariasis","volume":"87","author":"S Padma","year":"2012","journal-title":"Am J Trop Med Hyg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0169-4758(95)80128-6","article-title":"Lymphatic filariasis infection and disease: control strategies","volume":"4","author":"EA Ottesen","year":"1995","journal-title":"Parasitol Today"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1017\/S0031182000066646","article-title":"Re-assessing the global prevalence and distribution of lymphatic filariasis","volume":"112","author":"E Michael","year":"1996","journal-title":"Parasitol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0035-9203(95)90092-6","article-title":"Lymphatic pathology in Wuchereria bancrofti microfilaraemic infections","volume":"89","author":"S Dissanayake","year":"1995","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"258","DOI":"10.4269\/ajtmh.1995.52.258","article-title":"Lymphoscintigraphic assessment of the effect of diethylcarbamazine treatment on lymphatic damage in human bancroftian filariasis","volume":"52","author":"DO Freedman","year":"1995","journal-title":"Am J Trop Med Hyg"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/00034983.1999.11813433","article-title":"A double blind placebo controlled study of the efficacy of oral penicillin, diethylcarbamazine or local treatment of the affected limb in preventing acute adenolymphangitis in lymphedema caused by brugian filariasis","volume":"93","author":"RK Shenoy","year":"1999","journal-title":"Ann Trop Med Parasitol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1080\/00034983.1998.11813316","article-title":"Prevention of acute adenolymphangitis in brugian filariasis: comparison of the efficacy of ivermectin and diethylcarbamazine, each combined with local treatment of the affected limb","volume":"92","author":"RK Shenoy","year":"1998","journal-title":"Ann Trop Med Parasitol"},{"key":"ref25","first-page":"151","article-title":"Lymphatic Filariasis","author":"DG Addiss","year":"2000"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0035-9203(99)90140-2","article-title":"Acute attacks in the extremities of persons living in an area endemic for bancroftian filariasis: differentiation of two syndromes","volume":"93","author":"G Dreyer","year":"1999","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"Suppl. 1","key":"ref27","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.56026\/imu.6.Suppl1.S80","article-title":"Pathology of lymphatic filariasis","volume":"6","author":"J-W Mak","year":"2012","journal-title":"IeJSME"},{"key":"ref28","unstructured":"WHO Lymphatic filariasis. Fact sheet updated October 2016, <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/mediacentre\/factsheets\/fs102\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/mediacentre\/factsheets\/fs102\/en\/<\/ext-link>."},{"key":"ref29","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1046\/j.1365-3156.2000.00620.x","article-title":"The global programme to eliminate lymphatic filariasis","volume":"5","author":"EA Ottesen","year":"2000","journal-title":"Trop Med Int Health"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1756-3305-3-100","article-title":"6th meeting of the Global Alliance to Eliminate Lymphatic Filariasis: a half-time review of lymphatic filariasis elimination and its integration with the control of other neglected tropical diseases","volume":"3","author":"D Addiss","year":"2010","journal-title":"Parasit Vectors"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1100\/2012\/372618","article-title":"Issues in delivering morbidity management for lymphatic filariasis elimination; a study in Pondichery, South India","author":"AK Kumari","year":"2012","journal-title":"Sci World J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e2100","DOI":"10.1371\/journal.pntd.0002100","article-title":"Impact of community-based lymphedema management on perceived disability among patients with lymphatic filariasis in Orissa State, India","volume":"7","author":"PJ Budge","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1111\/tmi.12376","article-title":"Non-endemic cases of lymphatic filariasis","volume":"19","author":"RT Jones","year":"2014","journal-title":"Trop Med Int Health"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1371\/journal.pntd.0000088","article-title":"Filariasis in travellers presenting to the Geo-Sentinel Surveillance Network","volume":"1","author":"EM Lipner","year":"2007","journal-title":"PLoS Negl Trop Dis"},{"key":"ref35","first-page":"103","article-title":"Lymphatic Filariasis","author":"V Kumaraswami","year":"2000"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0005631","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0005631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T01:49:37Z","timestamp":1659664177000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0005631"}},"subtitle":[],"editor":[{"given":"Marc P","family":"H\u00fcbner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,23]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0005631","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0005631","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,23]]}}}