{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:17:51Z","timestamp":1767176271495,"version":"build-2238731810"},"update-to":[{"DOI":"10.1371\/journal.pntd.0005669","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:00:00Z","timestamp":1498089600000}}],"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T00:00:00Z","timestamp":1497225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI017252"],"award-info":[{"award-number":["R01AI017252"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0005669","type":"journal-article","created":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T13:35:13Z","timestamp":1497274513000},"page":"e0005669","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Identification of antigenic Sarcoptes scabiei proteins for use in a diagnostic test and of non-antigenic proteins that may be immunomodulatory"],"prefix":"10.1371","volume":"11","author":[{"given":"Marjorie S.","family":"Morgan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Dean","family":"Rider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry G.","family":"Arlian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,6,12]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.2307\/3283881","article-title":"Production of IL-1 alpha and IL-1 beta by human skin equivalents parasitized by <italic>Sarcoptes scabiei<\/italic>","volume":"82","author":"LG Arlian","year":"1996","journal-title":"J Parasitol"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"652","DOI":"10.4269\/ajtmh.2003.69.652","article-title":"Modulation of cytokine expression in human keratinocytes and fibroblasts by extracts of scabies mites","volume":"69","author":"LG Arlian","year":"2003","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1603\/0022-2585-41.1.69","article-title":"Extracts of scabies mites (Sarcoptidae: <italic>Sarcoptes scabiei<\/italic>) modulate cytokine expression by human peripheral blood mononuclear cells and dendritic cells","volume":"41","author":"LG Arlian","year":"2004","journal-title":"J Med Entomol"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1645\/GE-214R","article-title":"Skewed Th1\/Th2 immune response to <italic>Sarcoptes scabiei<\/italic>","volume":"90","author":"PN Lalli","year":"2004","journal-title":"J Parasitol"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/jmedent\/43.2.283","article-title":"Evidence that scabies mites (Acari: Sarcoptidae) influence production of interleukin-10 and the function of T-regulatory cells (Tr1) in humans","volume":"43","author":"LG Arlian","year":"2006","journal-title":"J Med Entomol"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1093\/jmedent\/43.5.910","article-title":"<italic>Sarcoptes scabiei<\/italic> (Acari: Sarcoptidae) mite extract modulates expression of cytokines and adhesion molecules by human dermal microvascular endothelial cells","volume":"43","author":"BL Elder","year":"2006","journal-title":"J Med Entomol"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1093\/jmedent\/44.6.1054","article-title":"<italic>In vivo<\/italic> evidence that <italic>Sarcoptes scabiei<\/italic> (Acari: Sarcoptidae) is the source of molecules that modulate splenic gene expression","volume":"44","author":"LG Arlian","year":"2007","journal-title":"J Med Entomol"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cyto.2009.05.008","article-title":"Modulation of human dermal microvascular endothelial cells by <italic>Sarcoptes scabiei<\/italic> in combination with proinflammatory cytokines, histamine, and lipid-derived biologic mediators","volume":"47","author":"BL Elder","year":"2009","journal-title":"Cytokine"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1603\/033.046.0415","article-title":"Extracts of <italic>Sarcoptes scabiei<\/italic> De Geer downmodulate secretion of IL-8 by skin keratinocytes and fibroblasts and of GM-CSF by fibroblasts in the presence of proinflammatory cytokines","volume":"46","author":"JS Mullins","year":"2009","journal-title":"J Med Entomol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1603\/ME10012","article-title":"Response of human skin equivalents to <italic>Sarcoptes scabiei<\/italic>","volume":"47","author":"MS Morgan","year":"2010","journal-title":"J Med Entomol"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"e71143","DOI":"10.1371\/journal.pone.0071143","article-title":"<italic>Sarcoptes scabiei<\/italic> mites modulate gene expression in human skin equivalents","volume":"8","author":"MS Morgan","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s13071-016-1663-6","article-title":"<italic>Sarcoptes scabiei<\/italic>: genomics to proteomics to biology","volume":"9","author":"LG Arlian","year":"2016","journal-title":"Parasit Vectors"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e0004188","DOI":"10.1371\/journal.pntd.0004188","article-title":"The potential for a blood test for scabies","volume":"9","author":"LG Arlian","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/jme\/tjv247","article-title":"A Proteomic Analysis of <italic>Sarcoptes scabiei<\/italic> (Acari: Sarcoptidae)","volume":"53","author":"MS Morgan","year":"2016","journal-title":"J Med Entomol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"MM Bradford","year":"1976","journal-title":"Anal Biochem"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0091-6749(97)70228-8","article-title":"Characterization of the allergens of the house dust mite <italic>Euroglyphus maynei<\/italic>","volume":"100","author":"MS Morgan","year":"1997","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1603\/0022-2585-41.1.74","article-title":"Circulating IgE in patients with ordinary and crusted scabies","volume":"41","author":"LG Arlian","year":"2004","journal-title":"J Med Entomol"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4269\/ajtmh.1997.57.190","article-title":"Skin test and radioallergosorbent test characteristics of scabietic patients","volume":"57","author":"MS Morgan","year":"1997","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0022-1759(89)90174-9","article-title":"Enhancement of immunoblot staining using a mixed chromogenic substrate","volume":"121","author":"PR Young","year":"1989","journal-title":"J Immunol Methods"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1186\/s13071-015-1198-2","article-title":"Draft genome of the scabies mite","volume":"8","author":"SD Rider","year":"2015","journal-title":"Parasites & vectors"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S1081-1206(10)61248-3","article-title":"Prevalence of serum IgE to storage mites in a southwestern Ohio population","volume":"96","author":"A Yadav","year":"2006","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0304-4017(00)00251-X","article-title":"Serum antibody to <italic>Sarcoptes scabiei<\/italic> and house dust mite prior to and during infestation with <italic>S<\/italic>. <italic>scabiei<\/italic>","volume":"90","author":"LG Arlian","year":"2000","journal-title":"Vet Parasitol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1186\/1471-2164-15-518","article-title":"A 24\u201348 h fed <italic>Amblyomma americanum<\/italic> tick saliva immuno-proteome","volume":"15","author":"ZM Radulovic","year":"2014","journal-title":"BMC Genomics"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","DOI":"10.1111\/pim.12425","article-title":"A recombinant cystatin from <italic>Ascaris lumbricoides<\/italic> attenuates inflammation of DSS-induced colitis","volume":"39","author":"S Coronado","year":"2017","journal-title":"Parasite Immunol"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0005669","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:00:00Z","timestamp":1498089600000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0005669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T08:37:38Z","timestamp":1750322258000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0005669"}},"subtitle":[],"editor":[{"given":"Joseph M.","family":"Vinetz","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,12]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0005669","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,12]]}}}