{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:16:55Z","timestamp":1787239015020,"version":"build-2736575974"},"update-to":[{"DOI":"10.1371\/journal.pntd.0005711","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000}}],"reference-count":84,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T00:00:00Z","timestamp":1499040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Research Foundation (DFG)","award":["GU 883\/4-1"],"award-info":[{"award-number":["GU 883\/4-1"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0005711","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T13:27:26Z","timestamp":1499088446000},"page":"e0005711","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Prevalence of Lassa Virus Disease (LVD) in Nigerian children with fever or fever and convulsions in an endemic area"],"prefix":"10.1371","volume":"11","author":[{"given":"Odigie C.","family":"Akhuemokhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary O.","family":"Ewah-Odiase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nosa","family":"Akpede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Ehimuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatus I.","family":"Adomeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikpomwonsa","family":"Odia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia C.","family":"Olomu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Pahlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Becker-Ziaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian T.","family":"Happi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny A.","family":"Asogun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvanus A.","family":"Okogbenin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter O.","family":"Okokhere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osagie S.","family":"Dawodu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irekpono U.","family":"Omoike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pardis C.","family":"Sabeti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"G\u00fcnther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George O.","family":"Akpede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,7,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0031-3955(16)33003-6","article-title":"The child who convulses with fever","volume":"21","author":"EM Oullette","year":"1974","journal-title":"Pediatr Clin North Am"},{"key":"ref2","first-page":"80","article-title":"Paediatric neurologic emergencies at the University of Nigeria Teaching Hospital, Enugu","volume":"16","author":"SO Iloeje","year":"1997","journal-title":"W Afr J Med"},{"key":"ref3","first-page":"245","article-title":"Aetiological considerations in the febrile unconscious child in the rain forest and arid regions of Nigeria","volume":"73","author":"GO Akpede","year":"1996","journal-title":"E Afr Med J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1136\/adc.54.11.869","article-title":"Role of viruses in febrile convulsions","volume":"54","author":"HM Lewis","year":"1979","journal-title":"Arch Dis Child"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1136\/adc.2006.110221","article-title":"Relationship between five common viruses and febrile seizures in children","volume":"92","author":"B Chung","year":"2007","journal-title":"Arch Dis Child"},{"key":"ref6","first-page":"135","article-title":"Febrile convulsions in Ibadan children","volume":"2","author":"JB Familusi","year":"1971","journal-title":"Afr J Med med Sci"},{"key":"ref7","first-page":"127","article-title":"Acute febrile encephalopathy in Ugandan children","volume":"2","author":"CC Patel","year":"1971","journal-title":"Afr J Med med Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00034983.1971.11686725","article-title":"Malaria in early childhood","volume":"65","author":"PG Hendrickse","year":"1971","journal-title":"Ann Trop Med Parasitol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0031-3955(16)33783-X","article-title":"Unsuspected bacteremia in young children. A common and important problem","volume":"26","author":"DW Teele","year":"1979","journal-title":"Pediatr Clin North Am"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/bmj.286.6360.203","article-title":"Occult pneumococcal bacteraemia and febrile convulsions","volume":"286","author":"P McIntyre","year":"1983","journal-title":"Brit Med J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0022-3476(05)83491-2","article-title":"Acute fever of unknown origin in young children in the tropics","volume":"122","author":"GO Akpede","year":"1993","journal-title":"J Pediatr"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2165\/00128072-200103030-00002","article-title":"Aetiology and management of children with acute fever of unknown origin","volume":"3","author":"GO Akpede","year":"2001","journal-title":"Paediatr Drugs"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1474-4422(07)70331-9","article-title":"Incidence and outcome of convulsive status epilepticus in Kenyan children: A cohort study","volume":"7","author":"M Sadarangani","year":"2008","journal-title":"Lancet Neurol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1177\/000992287201100509","article-title":"Virus isolates from children with febrile convulsions in Nigeria","volume":"11","author":"JB Familusi","year":"1972","journal-title":"Clin Pediatr"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.4269\/ajtmh.2006.75.1148","article-title":"Role of viruses in Kenyan children presenting with acute encephalopathy in a malaria-endemic area","volume":"75","author":"CD Schubart","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/infdis\/155.3.445","article-title":"A case-control study of the clinical diagnosis and course of Lassa fever","volume":"155","author":"JB McCormick","year":"1987","journal-title":"J Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"773","DOI":"10.4269\/ajtmh.1973.22.773","article-title":"A hospital epidemic of Lassa fever in Zorzor, Liberia, March-April 1972","volume":"22","author":"TP Monath","year":"1973","journal-title":"Am J Trop Med Hyg"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1089\/15303660160025903","article-title":"Lassa fever in Guinea: I. Epidemiology of human disease and clinical observations","volume":"1","author":"DG Bausch","year":"2001","journal-title":"Vect Borne Zoonotic Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/trstmh\/tru009","article-title":"Constraints in the diagnosis and treatment of Lassa fever and the effect on mortality in hospitalized children and women with obstetric conditions in a rural district hospital in Sierra Leone","volume":"108","author":"A Dahmane","year":"2014","journal-title":"Trans Roy Soc Trop Med Hyg"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0035-9203(84)90082-8","article-title":"Endemic Lassa fever in Liberia. I. Clinical and epidemiological aspects at Curran Lutheran Hospital, Zorzor, Liberia","volume":"78","author":"MH Monson","year":"1984","journal-title":"Trans. R Soc Trop Med Hyg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0163-4453(82)91133-1","article-title":"Lassa fever in children","volume":"4","author":"PC Sharp","year":"1982","journal-title":"J Infect"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0035-9203(86)90147-1","article-title":"Lassa fever in children in Sierra Leone, West Africa","volume":"80","author":"PA Webb","year":"1986","journal-title":"Trans. R. Soc. Trop. Med Hyg"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"408","DOI":"10.4269\/ajtmh.1987.36.408","article-title":"Paediatric Lassa fever: a review of 33 Liberian cases","volume":"36","author":"MH Monson","year":"1987","journal-title":"Am J Trop Med Hyg"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"6992","DOI":"10.1128\/JVI.74.15.6992-7004.2000","article-title":"Genetic diversity among Lassa virus strains","volume":"74","author":"MD Bowen","year":"2000","journal-title":"J Virol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1128\/JCM.01891-10","article-title":"Current molecular epidemiology of Lassa fever in Nigeria","volume":"49","author":"DU Ehichioya","year":"2011","journal-title":"J Clin Microbiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.3201\/eid1110.041343","article-title":"Lassa fever, Nigeria, 2003 and 2004","volume":"11","author":"SA Omilabu","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"ref27","first-page":"50","article-title":"Clinical presentation and constraints in the diagnosis of Lassa fever in Nigeria","volume":"1","author":"PO Okokhere","year":"2013","journal-title":"Ambrose Alli Univ Postgrad J"},{"key":"ref28","first-page":"197","article-title":"Lassa fever encephalopathy: clinical and laboratory findings","volume":"95","author":"D Cummins","year":"1992","journal-title":"J Trop Med Hyg"},{"key":"ref29","first-page":"23","article-title":"Lassa fever: Central nervous system manifestations","volume":"1","author":"MV Solbrig","year":"1991","journal-title":"J Trop Geogr Neurol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.3390\/v4102031","article-title":"Pathogenesis of Lassa fever","volume":"4","author":"NE Yun","year":"2012","journal-title":"Viruses"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev-pathol-020712-164041","article-title":"Pathogenesis of the viral hemorrhagic fevers","volume":"8","author":"S Paessler","year":"2013","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1111\/j.1365-3156.2012.03010.x","article-title":"Hospital-based surveillance for Lassa fever in Edo State, Nigeria, 2005\u20132008","volume":"17","author":"DU Ehichioya","year":"2012","journal-title":"Trop Med Intern Health"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJM198601023140104","article-title":"Lassa fever: Effective therapy with ribavirin","volume":"314","author":"JB McCormick","year":"1986","journal-title":"N Engl J Med"},{"key":"ref34","first-page":"441","article-title":"Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children","volume":"71","author":"M E Molyneux","year":"1989","journal-title":"Q J Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0140-6736(74)91639-0","article-title":"Assessment of coma and impaired consciousness: A practical scale","volume":"2","author":"G Teasdale","year":"1974","journal-title":"Lancet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1542\/peds.91.6.1196","article-title":"Enhanced urinalysis as a screening test for the diagnosis of urinary tract infection","volume":"91","author":"A Hoberman","year":"1993","journal-title":"Pediatrics"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/02724936.1992.11747603","article-title":"Indications for lumbar puncture in children with convulsions and fever of acute onset: Experience in the children\u2019s emergency room of the University of Benin Teaching Hospital, Nigeria","volume":"12","author":"GO Akpede","year":"1992","journal-title":"Ann Trop Paediatr"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1136\/bmj.303.6803.634","article-title":"Joint Working Group of the Research Unit of the Royal College of Physicians and the British Paediatric Association: Guidelines for the management of convulsions with fever","volume":"303","year":"1991","journal-title":"Br Med J"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(80)91290-8","article-title":"Lumbar puncture in children with convulsions associated with fever","volume":"i","author":"J Lorber","year":"1980","journal-title":"Lancet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1017\/S0012162200000864","article-title":"Cerebral herniation in pyogenic meningitis: prevalence and related dilemmas in emergency room populations in developing countries","volume":"42","author":"GO Akpede","year":"2000","journal-title":"Devel Med Child Neurol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1136\/adc.67.12.1417","article-title":"The place of computed tomography and lumbar puncture in suspected bacterial meningitis","volume":"67","author":"DH Mellor","year":"1992","journal-title":"Arch Dis Child"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1542\/peds.78.5.959","article-title":"Report of the Task Force on diagnosis and management of Meningitis","volume":"78","author":"JO Klein","year":"1986","journal-title":"Pediatrics"},{"issue":"Suppl","key":"ref43","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1097\/01.PCC.0000161933.42822.86","article-title":"Defining bacterial meningitis and other infections of the central nervous system","volume":"6","author":"GD Overturf","year":"2005","journal-title":"Pediatr Crit Care Med"},{"key":"ref44","first-page":"1","article-title":"Community-acquired bacterial meningitis","volume":"2","author":"D Van de Beek","year":"2016","journal-title":"Nature Rev Dis Primers"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1086\/425368","article-title":"Practice guidelines for the management of bacterial meningitis","volume":"39","author":"AR Tunkel","year":"2004","journal-title":"Clin Infect Dis"},{"issue":"Suppl","key":"ref46","first-page":"3","article-title":"Severe and complicated malaria","volume":"80","year":"1986","journal-title":"Trans Roy Soc Trop Med Hyg"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1136\/adc.52.3.188","article-title":"Role of routine investigations in children presenting with their first febrile convulsion","volume":"52","author":"N Rutter","year":"1977","journal-title":"Arch Dis Child"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e1839","DOI":"10.1371\/journal.pntd.0001839","article-title":"Molecular diagnostics for Lassa fever at Irrua Specialist Teaching Hospital, Nigeria: Lessons learnt from two years of laboratory operation","volume":"6","author":"AD Asogun","year":"2012","journal-title":"PLOS Negl Trop Dis"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/PCC.0000000000000358","article-title":"Care of the child with Ebola virus disease","volume":"16","author":"CO Erickson","year":"2015","journal-title":"Pediatr Crit care"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1001\/jamapediatrics.2014.2835","article-title":"Ebola virus disease and children: What pediatric health care professionals need to know","volume":"168","author":"G Peacock","year":"2014","journal-title":"JAMA Pediatr"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e854","DOI":"10.1371\/journal.pntd.0000854","article-title":"Viral etiology of encephalitis in southern Vietnam: results of a one-year prospective descriptive study","volume":"4","author":"L Van Tan","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/jnnp.2007.129098","article-title":"Viral encephalitis: a clinician\u2019s guide","volume":"7","author":"T Solomon","year":"2007","journal-title":"Pract Neurol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/02724939992473","article-title":"Risk factors for an adverse outcome in bacterial meningitis in the tropics\u2014a reappraisal with focus on the significance and risk of seizures","volume":"19","author":"GO Akpede","year":"1999","journal-title":"Ann Trop Paediatr"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1056\/NEJMoa1214482","article-title":"Beyond malaria\u2013Causes of fever in outpatient Tanzanian children","volume":"370","author":"V D\u2019Acremont","year":"2014","journal-title":"N Engl J Med"},{"key":"ref55","first-page":"3","article-title":"Dengue infections with central nervous system manifestations","volume":"1","author":"SK Lam","year":"1996","journal-title":"Neurol J Southeast Asia"},{"key":"ref56","first-page":"60","article-title":"Ebola haemorrhagic fever among hospitalised children and adolescents in northern Uganda: Epidemiologic and clinical observations","volume":"1","author":"E Mupere","year":"2001","journal-title":"Afr Health Sci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"160","DOI":"10.5455\/2320-6012.ijrms20140232","article-title":"A study of clinical and laboratory profile of dengue fever in a tertiary care centre of Uttarakhend, India","volume":"2","author":"R Singh","year":"2014","journal-title":"Int J Res Med Sci"},{"key":"ref58","article-title":"Factors associated with mortality in febrile patients in a government referral hospital in the Kenema District of Sierra Leone","author":"PJ Roth","year":"2014","journal-title":"Am J Trop Med Hyg"},{"issue":"Suppl 4","key":"ref59","doi-asserted-by":"crossref","first-page":"S783","DOI":"10.1093\/clinids\/11.Supplement_4.S783","article-title":"Clinical features of Lassa fever in Liberia","volume":"11","author":"JD Frame","year":"1989","journal-title":"Rev Infect Dis"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1136\/bmj.311.7009.857","article-title":"Review of nosocomial Lassa fever in Nigeria: the high price of poor medical practice","volume":"311","author":"SP Fisher-Hoch","year":"1995","journal-title":"Brit Med J"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1743-422X-10-123","article-title":"Lassa fever presenting as acute abdomen: a case series","volume":"10","author":"AE Dongo","year":"2013","journal-title":"Virology J"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jcv.2014.12.004","article-title":"Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps","volume":"64","author":"R Kerber","year":"2015","journal-title":"J Clin Virol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/jac\/dkr136","article-title":"Ribavirin for patients with Crimean-Congo haemorrhagic fever: a systematic analysis","volume":"66","author":"S Ascioglu","year":"2011","journal-title":"J Antimicrob Chemoth"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/1471-2334-10-207","article-title":"Ribavirin for Crimean-Congo hemorrhagic fever: systematic review and meta-analysis","volume":"10","author":"K Soares-Weiser","year":"2010","journal-title":"BMC Infect Dis"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"5","DOI":"10.5799\/ahinjs.02.2015.01.0166","article-title":"A nosocomial outbreak of Crimean-Congo hemorrhagic fever","volume":"5","author":"E Parlak","year":"2015","journal-title":"J Microbiol Infect Dis"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1086\/322033","article-title":"Lassa fever encephalopathy: Lassa virus in cerebrospinal fluid but not in serum","volume":"184","author":"S Gunther","year":"2001","journal-title":"J Inf Dis"},{"key":"ref67","article-title":"Aseptic meningitis caused by Lassa virus: Case series report","author":"PO Okokhere","year":"2016","journal-title":"Case Reports Neurol Med"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1056\/NEJMp0708085","article-title":"The new age of molecular diagnostics for microbial agents","volume":"358","author":"R Whitley","year":"2008","journal-title":"N Engl J Med"},{"key":"ref69","first-page":"23","article-title":"Febrile convulsions in Ilorin","volume":"18","author":"D Fabgule","year":"1991","journal-title":"Nig J Paediatr"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1093\/tropej\/39.6.350","article-title":"Convulsions with malaria: Febrile or indicative of cerebral involvement?","volume":"39","author":"GO Akpede","year":"1993","journal-title":"J Trop Pediatr"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/02724936.1994.11747719","article-title":"Childhood febrile seizures: Benin City experience","volume":"14","author":"JO Obi","year":"1994","journal-title":"Ann Trop Paediatr"},{"key":"ref72","first-page":"7","article-title":"Febrile convulsions in Jos","volume":"24","author":"IA Angyo","year":"1997","journal-title":"Nig J Paediatr"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/S0140-6736(87)92207-0","article-title":"Community-acquired bacteraemia in African children","volume":"i","author":"P Le Page","year":"1987","journal-title":"Lancet"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/qjmed\/92.3.151","article-title":"Cerebral malaria versus bacterial meningitis in children with impaired consciousness","volume":"92","author":"JA Berkley","year":"1999","journal-title":"Quart J Med"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"e2748","DOI":"10.1371\/journal.pntd.0002748","article-title":"Lassa fever in post-conflict Sierra Leone","volume":"8","author":"JG Shaffer","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2165\/00128072-200103040-00002","article-title":"Management of children with fever of unknown origin II: Aetiology and management of prolonged fever of unknown origin, and difficulties in the diagnosis and treatment of fever of unknown origin in developing countries","volume":"3","author":"GO Akpede","year":"2001","journal-title":"Paediatric Drugs"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/bmj.1.5646.761","article-title":"Fever in children in the tropics","volume":"1","author":"JP Stanfield","year":"1969","journal-title":"Brit Med J"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2217\/cpr.12.32","article-title":"Advances in laboratory diagnostic technologies in microbiology and what it means for clinical practice","volume":"9","author":"P Dokouhaki","year":"2012","journal-title":"Clin Pract"},{"key":"ref79","first-page":"54","article-title":"A hospital-based study of pyogenic meningitis in children in small urban and rural areas of Edo State","volume":"27","author":"GO Akpede","year":"2000","journal-title":"Nig J Paediatr"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jns.2004.09.026","article-title":"Referral and previous care of children with meningitis in Nigeria: implications for the presentation and outcome of meningitis in developing countries","volume":"228","author":"GO Akpede","year":"2005","journal-title":"J Neurol Sci"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/S0140-6736(12)61185-4","article-title":"Dilemmas in the diagnosis of acute community-acquired bacterial meningitis","volume":"380","author":"MC Brouwer","year":"2012","journal-title":"Lancet"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1474-4422(08)70139-X","article-title":"The diagnosis and management of acute bacterial meningitis in resource-poor settings","volume":"7","author":"M Scarborough","year":"2008","journal-title":"Lancet Neurol"},{"key":"ref83","first-page":"1","article-title":"Lassa fever in West African sub-region: an overview","volume":"44","author":"O Ogbu","year":"2007","journal-title":"J Vect Borne Dis"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"28406","DOI":"10.3402\/jchimp.v5.28406","article-title":"Association of clinical signs and symptoms of Ebola viral disease with case fatality: a systematic review and meta-analysis","volume":"5","author":"H Moole","year":"2015","journal-title":"J Comm Hosp Intern Med Perspect"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0005711","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0005711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T06:46:38Z","timestamp":1659163598000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0005711"}},"subtitle":[],"editor":[{"given":"Brian","family":"Bird","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,3]]},"references-count":84,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0005711","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,3]]}}}