{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:51:56Z","timestamp":1792511516827,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0005721","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T00:00:00Z","timestamp":1500422400000}}],"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Center of Research Excellence for Avian Therapeutics for Infectious Diseases"},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-13-C-0041"],"award-info":[{"award-number":["W81XWH-13-C-0041"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0005721","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T17:29:51Z","timestamp":1499448591000},"page":"e0005721","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Dengue virus specific IgY provides protection following lethal dengue virus challenge and is neutralizing in the absence of inducing antibody dependent enhancement"],"prefix":"10.1371","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1191-1320","authenticated-orcid":true,"given":"Ashley L.","family":"Fink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis D.","family":"Alvine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Schiltz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Nilles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,7,7]]},"reference":[{"issue":"7446","key":"ref1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"S Bhatt","year":"2013","journal-title":"Nature"},{"key":"ref2","article-title":"Dengue: guidelines for diagnosis, treatment, prevention and control","year":"2009"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1128\/CMR.11.3.480","article-title":"Dengue and dengue hemorrhagic fever","volume":"11","author":"DJ Gubler","year":"1998","journal-title":"Clinical microbiology reviews"},{"issue":"4 Suppl","key":"ref4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2149\/tmh.2011-S05","article-title":"Dengue, Urbanization and Globalization: The Unholy Trinity of the 21(st) Century","volume":"39","author":"DJ Gubler","year":"2011","journal-title":"Trop Med Health"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"e1000823","DOI":"10.1371\/journal.ppat.1000823","article-title":"The development of therapeutic antibodies that neutralize homologous and heterologous genotypes of dengue virus type 1","volume":"6","author":"B Shrestha","year":"2010","journal-title":"PLoS pathogens"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"571","DOI":"10.4269\/ajtmh.1989.40.571","article-title":"Aedes aegypti and Aedes aegypti-borne disease control in the 1990s: top down or bottom up. Charles Franklin Craig Lecture","volume":"40","author":"DJ Gubler","year":"1989","journal-title":"Am J Trop Med Hyg"},{"issue":"12 Suppl","key":"ref7","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1038\/nrmicro2460","article-title":"Dengue: a continuing global threat","volume":"8","author":"MG Guzman","year":"2010","journal-title":"Nat Rev Microbiol"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"566","DOI":"10.4269\/ajtmh.1997.56.566","article-title":"Risk factors in dengue shock syndrome","volume":"56","author":"S Thein","year":"1997","journal-title":"Am J Trop Med Hyg"},{"issue":"16","key":"ref9","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1007\/s00018-010-0357-z","article-title":"Dengue virus life cycle: viral and host factors modulating infectivity","volume":"67","author":"IA Rodenhuis-Zybert","year":"2010","journal-title":"Cell Mol Life Sci"},{"issue":"Suppl 3","key":"ref10","first-page":"S673","article-title":"Clinical presentations of dengue hemorrhagic fever in infants compared to children","volume":"86","author":"S Kalayanarooj","year":"2003","journal-title":"J Med Assoc Thai"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"e3025","DOI":"10.1371\/journal.pntd.0003025","article-title":"Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions","volume":"8","author":"J Whitehorn","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"e1000790","DOI":"10.1371\/journal.ppat.1000790","article-title":"Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification","volume":"6","author":"SJ Balsitis","year":"2010","journal-title":"PLoS pathogens"},{"issue":"1","key":"ref13","first-page":"151","article-title":"Passive cutaneous anaphylaxis in the chicken. Biological fractionation of the mediating antibody population","volume":"25","author":"RE Faith","year":"1973","journal-title":"Immunology"},{"issue":"8","key":"ref14","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/0167-5699(95)80008-5","article-title":"IgY: clues to the origins of modern antibodies","volume":"16","author":"GW Warr","year":"1995","journal-title":"Immunology today"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"e0003803","DOI":"10.1371\/journal.pntd.0003803","article-title":"Antiviral Biologic Produced in DNA Vaccine\/Goose Platform Protects Hamsters Against Hantavirus Pulmonary Syndrome When Administered Post-exposure","volume":"9","author":"N Haese","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3184\/147020604783637462","article-title":"Avian egg antibodies: basic and potential applications","volume":"15","author":"J Kovacs-Nolan","year":"2004","journal-title":"Avian and Poultry Biology Reviews"},{"key":"ref17","article-title":"Avian IgY antibodies and their recombinant equivalents in research, diagnostics and therapy","author":"E Spillner","year":"2012","journal-title":"Biologicals"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nri1266","article-title":"Human antibody-Fc receptor interactions illuminated by crystal structures","volume":"4","author":"JM Woof","year":"2004","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3109\/03009739909178961","article-title":"Chicken antibodies: a clinical chemistry perspective","volume":"104","author":"D Carlander","year":"1999","journal-title":"Upsala journal of medical sciences"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1699-0463.1974.tb02286.x","article-title":"Phylogenetic aspects of staphylococcal protein A-reactive serum globulins in birds and mammals","volume":"82","author":"G Kronval","year":"1974","journal-title":"Acta Pathologica Microbiologica Scandinavica Section B Microbiology and Immunology"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0022-1759(89)90386-4","article-title":"Binding of complement components C1q, C3, C4 and C5 to a model immune complex in ELISA","volume":"119","author":"A Larsson","year":"1989","journal-title":"J Immunol Methods"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0147-9571(90)90088-B","article-title":"Chicken IgY: utilizing the evolutionary difference","volume":"13","author":"A Larsson","year":"1990","journal-title":"Comp Immunol Microbiol Infect Dis"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0022-1759(92)90013-J","article-title":"Chicken antibodies: a tool to avoid interference by complement activation in ELISA","volume":"156","author":"A Larsson","year":"1992","journal-title":"J Immunol Methods"},{"issue":"10","key":"ref24","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.3382\/ps.0721807","article-title":"Chicken antibodies: taking advantage of evolution\u2014a review","volume":"72","author":"A Larsson","year":"1993","journal-title":"Poult Sci"},{"issue":"8","key":"ref25","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1086\/500949","article-title":"Vascular Leakage in Severe Dengue Virus Infections: A Potential Role for the Nonstructural Viral Protein NS1 and Complement","volume":"193","author":"P Avirutnan","year":"2006","journal-title":"The Journal of Infectious Diseases"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"e102014","DOI":"10.1371\/journal.pone.0102014","article-title":"Down-regulation of complement receptors on the surface of host monocyte even as in vitro complement pathway blocking interferes in dengue infection","volume":"9","author":"CF Marinho","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.chom.2009.09.003","article-title":"Complement Protein C1q Reduces the Stoichiometric Threshold for Antibody-Mediated Neutralization of West Nile Virus","volume":"6","author":"E Mehlhop","year":"2009","journal-title":"Cell Host & Microbe"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.arcmed.2005.04.007","article-title":"Innate immune responses to dengue virus","volume":"36","author":"E Navarro-S\u00e1nchez","year":"2005","journal-title":"Arch Med Res"},{"issue":"20","key":"ref29","doi-asserted-by":"crossref","first-page":"10208","DOI":"10.1128\/JVI.00062-06","article-title":"Murine model for dengue virus-induced lethal disease with increased vascular permeability","volume":"80","author":"S Shresta","year":"2006","journal-title":"Journal of virology"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.virol.2012.03.003","article-title":"Antibodies targeting dengue virus envelope domain III are not required for serotype-specific protection or prevention of enhancement in vivo","volume":"429","author":"KL Williams","year":"2012","journal-title":"Virology"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"e1003157","DOI":"10.1371\/journal.ppat.1003157","article-title":"Therapeutic efficacy of antibodies lacking Fc\u03b3 receptor binding against lethal dengue virus infection is due to neutralizing potency and blocking of enhancing antibodies [corrected]","volume":"9","author":"KL Williams","year":"2013","journal-title":"PLoS Pathog"},{"issue":"13","key":"ref32","doi-asserted-by":"crossref","first-page":"7747","DOI":"10.1128\/JVI.00327-13","article-title":"Protection by immunoglobulin dual-affinity retargeting antibodies against dengue virus","volume":"87","author":"JD Brien","year":"2013","journal-title":"J Virol"},{"issue":"24","key":"ref33","doi-asserted-by":"crossref","first-page":"13975","DOI":"10.1128\/JVI.78.24.13975-13986.2004","article-title":"Localization and characterization of flavivirus envelope glycoprotein cross-reactive epitopes","volume":"78","author":"WD Crill","year":"2004","journal-title":"J Virol"},{"issue":"19","key":"ref34","doi-asserted-by":"crossref","first-page":"7439","DOI":"10.1073\/pnas.1200566109","article-title":"Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions","volume":"109","author":"R de Alwis","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"ref35","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1007\/s007050050646","article-title":"Identification of an epitope on the dengue virus membrane (M) protein defined by cross-protective monoclonal antibodies: design of an improved epitope sequence based on common determinants present in both envelope (E and M) proteins","volume":"144","author":"AK Falconar","year":"1999","journal-title":"Arch Virol"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1128\/CVI.00371-06","article-title":"Antibody responses are generated to immunodominant ELK\/KLE-type motifs on the nonstructural-1 glycoprotein during live dengue virus infections in mice and humans: implications for diagnosis, pathogenesis, and vaccine design","volume":"14","author":"AKI Falconar","year":"2007","journal-title":"Clin Vaccine Immunol"},{"issue":"Pt 7","key":"ref37","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1099\/vir.0.83648-0","article-title":"Use of synthetic peptides to represent surface-exposed epitopes defined by neutralizing dengue complex- and flavivirus group-reactive monoclonal antibodies on the native dengue type-2 virus envelope glycoprotein","volume":"89","author":"AKI Falconar","year":"2008","journal-title":"J Gen Virol"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.virol.2007.05.042","article-title":"Characterization of an antigenic site that contains a dominant, type-specific neutralization determinant on the envelope protein domain III (ED3) of dengue 2 virus","volume":"366","author":"GD Gromowski","year":"2007","journal-title":"Virology"},{"issue":"17","key":"ref39","doi-asserted-by":"crossref","first-page":"8828","DOI":"10.1128\/JVI.00606-08","article-title":"Characterization of dengue virus complex-specific neutralizing epitopes on envelope protein domain III of dengue 2 virus","volume":"82","author":"GD Gromowski","year":"2008","journal-title":"J Virol"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1096-9071(199901)57:1<1::AID-JMV1>3.0.CO;2-T","article-title":"Antibody responses to an immunodominant nonstructural 1 synthetic peptide in patients with dengue fever and dengue hemorrhagic fever","volume":"57","author":"JH Huang","year":"1999","journal-title":"J Med Virol"},{"issue":"1\u20132","key":"ref41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.virusres.2010.02.012","article-title":"Selection and identification of B-cell epitope on NS1 protein of dengue virus type 2","volume":"150","author":"L Jiang","year":"2010","journal-title":"Virus Res"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"e1636","DOI":"10.1371\/journal.pntd.0001636","article-title":"Development of a humanized antibody with high therapeutic potential against dengue virus type 2","volume":"6","author":"P-C Li","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"e1447","DOI":"10.1371\/journal.pntd.0001447","article-title":"Analysis of epitopes on dengue virus envelope protein recognized by monoclonal antibodies and polyclonal human sera by a high throughput assay","volume":"6","author":"H-E Lin","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"issue":"Pt 9","key":"ref44","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1099\/vir.0.83028-0","article-title":"Mapping to completeness and transplantation of a group-specific, discontinuous, neutralizing epitope in the envelope protein of dengue virus","volume":"88","author":"O Lisova","year":"2007","journal-title":"J Gen Virol"},{"issue":"11","key":"ref45","doi-asserted-by":"crossref","first-page":"9726","DOI":"10.1074\/jbc.M110.170993","article-title":"Molecular mimicry of human endothelial cell antigen by autoantibodies to nonstructural protein 1 of dengue virus","volume":"286","author":"I-J Liu","year":"2011","journal-title":"J Biol Chem"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"109","DOI":"10.7883\/yoken.64.109","article-title":"Highly conserved region 141\u2013168 of the NS1 protein is a new common epitope region of dengue virus","volume":"64","author":"P Masrinoul","year":"2011","journal-title":"Jpn J Infect Dis"},{"issue":"11","key":"ref47","doi-asserted-by":"crossref","first-page":"e881","DOI":"10.1371\/journal.pntd.0000881","article-title":"High Affinity Human Antibody Fragments to Dengue Virus Non-Structural Protein 3","volume":"4","author":"NJ Moreland","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/jmv.23204","article-title":"Nonstructural protein NS1 immunodominant epitope detected specifically in dengue virus infected material by a SELDI-TOF\/MS based assay","volume":"84","author":"M Steidel","year":"2012","journal-title":"J Med Virol"},{"issue":"18","key":"ref49","doi-asserted-by":"crossref","first-page":"9227","DOI":"10.1128\/JVI.01087-10","article-title":"Structure and function analysis of therapeutic monoclonal antibodies against dengue virus type 2","volume":"84","author":"S Sukupolvi-Petty","year":"2010","journal-title":"J Virol"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s00253-012-4419-z","article-title":"Identification of B cell epitopes of dengue virus 2 NS3 protein by monoclonal antibody","volume":"97","author":"Y Tian","year":"2013","journal-title":"Appl Microbiol Biotechnol"},{"issue":"2\u20133","key":"ref51","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.molimm.2009.08.033","article-title":"Anti-dengue virus nonstructural protein 1 antibodies recognize protein disulfide isomerase on platelets and inhibit platelet aggregation","volume":"47","author":"H-J Cheng","year":"2009","journal-title":"Mol Immunol"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.chom.2010.08.007","article-title":"The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity","volume":"8","author":"M Beltramello","year":"2010","journal-title":"Cell Host Microbe"},{"issue":"5979","key":"ref53","first-page":"745","article-title":"Cross-reacting antibodies enhance dengue virus infection in humans","volume":"328","author":"W Dejnirattisai","year":"2010","journal-title":"Science Signaling"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"956875","DOI":"10.1155\/2012\/956875","article-title":"Expression, purification, and evaluation of diagnostic potential and immunogenicity of a recombinant NS3 protein from all serotypes of dengue virus","volume":"2012","author":"LM Alvarez-Rodriguez","year":"2012","journal-title":"J Trop Med"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1051\/vetres:2005049","article-title":"Immunological properties of recombinant classical swine fever virus NS3 protein in vitro and in vivo","volume":"37","author":"H Rau","year":"2006","journal-title":"Vet Res"},{"issue":"5","key":"ref56","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1128\/CDLI.7.5.856-857.2000","article-title":"Human dengue antibodies against structural and nonstructural proteins","volume":"7","author":"K Vald\u00e9s","year":"2000","journal-title":"Clinical and diagnostic laboratory immunology"},{"issue":"4","key":"ref57","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1128\/JVI.02314-15","article-title":"Antibody Binding Modulates Conformational Exchange in Domain III of Dengue Virus E Protein","volume":"90","author":"AH Moraes","year":"2015","journal-title":"J Virol"},{"issue":"6","key":"ref58","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/ppul.10290","article-title":"Oral administration of specific yolk antibodies (IgY) may prevent Pseudomonas aeruginosa infections in patients with cystic fibrosis: a phase I feasibility study","volume":"35","author":"H Kollberg","year":"2003","journal-title":"Pediatric pulmonology"},{"issue":"2","key":"ref59","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1089\/jmf.2006.214","article-title":"More than 10 years&apos; continuous oral treatment with specific immunoglobulin Y for the prevention of Pseudomonas aeruginosa infections: a case report","volume":"10","author":"E Nilsson","year":"2007","journal-title":"Journal of medicinal food"},{"issue":"9","key":"ref60","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/ppul.20875","article-title":"Good effect of IgY against Pseudomonas aeruginosa infections in cystic fibrosis patients","volume":"43","author":"E Nilsson","year":"2008","journal-title":"Pediatric pulmonology"},{"issue":"17","key":"ref61","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/j.vaccine.2008.02.046","article-title":"In vitro and in vivo effectiveness of egg yolk antibody against Candida albicans (anti-CA IgY)","volume":"26","author":"SM Ibrahim el","year":"2008","journal-title":"Vaccine"},{"issue":"6","key":"ref62","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s11046-008-9097-0","article-title":"In vitro inhibition of oral Candida albicans by chicken egg yolk antibody (IgY)","volume":"165","author":"XZ Wang","year":"2008","journal-title":"Mycopathologia"},{"issue":"21","key":"ref63","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1136\/vr.143.21.579","article-title":"Development of snake antivenom antibodies in chickens and their purification from yolk","volume":"143","author":"CM Almeida","year":"1998","journal-title":"Vet Rec"},{"issue":"8","key":"ref64","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.intimp.2008.03.017","article-title":"Studies on pharmacological effects of Russell&apos;s viper and Saw-scaled viper venom and its neutralization by chicken egg yolk antibodies","volume":"8","author":"S Meenatchisundaram","year":"2008","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"ref65","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.toxicon.2008.04.179","article-title":"Neutralization of the pharmacological effects of Cobra and Krait venoms by chicken egg yolk antibodies","volume":"52","author":"S Meenatchisundaram","year":"2008","journal-title":"Toxicon"},{"issue":"2","key":"ref66","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/09540109999861","article-title":"Evaluation of allergenicity of egg yolk immunoglobulin Y and other egg proteins by passive cutaneous anaphylaxis","volume":"11","author":"EM Akita","year":"1999","journal-title":"Food Agr Immunol"},{"issue":"3\u20134","key":"ref67","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.vetimm.2005.08.016","article-title":"Immune responses after local administration of IgY loaded-PLGA microspheres in gut-associated lymphoid tissue in pigs","volume":"109","author":"AM Torche","year":"2006","journal-title":"Veterinary Immunology and Immunopathology"},{"issue":"8","key":"ref68","doi-asserted-by":"crossref","first-page":"e42788","DOI":"10.1371\/journal.pone.0042788","article-title":"IgY antibodies protect against human Rotavirus induced diarrhea in the neonatal gnotobiotic piglet disease model","volume":"7","author":"CG Vega","year":"2012","journal-title":"PloS one"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0005721","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T00:00:00Z","timestamp":1500422400000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0005721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T15:44:40Z","timestamp":1659195880000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0005721"}},"subtitle":[],"editor":[{"given":"David W.C.","family":"Beasley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,7]]},"references-count":68,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0005721","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0005721","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,7]]}}}