{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:54:26Z","timestamp":1790477666397,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0005789","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T00:00:00Z","timestamp":1502236800000}}],"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["CNPq - 205872\/2014-0 - SWE"],"award-info":[{"award-number":["CNPq - 205872\/2014-0 - SWE"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordination for the Improvement of Higher Education Personnel","doi-asserted-by":"crossref","award":["CAPES-Parasitologia 247\/2012"],"award-info":[{"award-number":["CAPES-Parasitologia 247\/2012"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","award":["PAEF no. IOC-008-FIO-04"],"award-info":[{"award-number":["PAEF no. IOC-008-FIO-04"]}],"id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["107475\/Z\/15\/Z"],"award-info":[{"award-number":["107475\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-14-CE02-0009"],"award-info":[{"award-number":["ANR-14-CE02-0009"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0005789","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T18:15:08Z","timestamp":1501265708000},"page":"e0005789","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Double impact: natural molluscicide for schistosomiasis vector control also impedes development of Schistosoma mansoni cercariae into adult parasites"],"prefix":"10.1371","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1147-0043","authenticated-orcid":true,"given":"Ronaldo de Carvalho","family":"Augusto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Tetreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Walet-Balieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9lia Christina","family":"Mello-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Portes","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Grunau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,7,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(06)70521-7","article-title":"Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk","volume":"6","author":"P Steinmann","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"ref2","year":"2002"},{"key":"ref3","first-page":"e0004290","article-title":"Systematic review and meta-analysis of the impact of chemical-based mollusciciding for control of <italic>Schistosoma mansoni<\/italic> and <italic>S<\/italic>. <italic>haematobium<\/italic> transmission","volume":"9","author":"CH King","year":"2015","journal-title":"Plos NTD"},{"key":"ref4","year":"2014"},{"key":"ref5","first-page":"e32","article-title":"A schistosomiasis research agenda","volume":"1","author":"DG Colley","year":"2007","journal-title":"Plos NTD"},{"key":"ref6","first-page":"332","article-title":"Resistance to niclosamide in <italic>Oncomelania hupensis<\/italic>, the intermediate host of <italic>Schistosoma Japonicum<\/italic>: Should we be worried?","volume":"142","author":"JR Dai","year":"2014","journal-title":"Parasitol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1590\/S0074-02761986000400017","article-title":"Latex of &quot;Coroa de Cristo&quot; (Euphorbia splendens): an effective molluscicide","volume":"81","author":"MC Vasconcellos","year":"1986","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1590\/S0074-02761989000500008","article-title":"Plantas empregadas como moluscicidas: Uma vis\u00e3o cr\u00edtica","volume":"84","author":"P Jurberg","year":"1989","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jat.1498","article-title":"Molluscicides from some common medicinal plants of eastern Uttar Pradesh, India","volume":"30","author":"SK Singh","year":"2010","journal-title":"J. Appl. Toxicol"},{"key":"ref10","first-page":"419","article-title":"Perspectives of using <italic>Euphorbia splendens<\/italic> as a molluscicide in schistosomiasis control programs","volume":"25","author":"DF Baptista","year":"1994","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref11","first-page":"222","article-title":"Metabolic changes in <italic>Biomphalaria glabrata<\/italic> infected with <italic>Schistosoma mansoni<\/italic> exposed to latex of <italic>Euphorbia milii<\/italic> solution versus times of preparation","volume":"5","author":"MG Lima","year":"2012","journal-title":"J Nat Prod"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0001-706X(01)00126-7","article-title":"The control of the schistosome-transmitting snail <italic>Biomphalaria glabrata<\/italic> by the plant molluscicide <italic>Euphorbia splendens<\/italic> var. <italic>hislopii<\/italic> (<italic>syn<\/italic> milii Des Moul): a longitudinal field study in an endemic area in Brazil","volume":"79","author":"VT Schall","year":"2001","journal-title":"Acta Trop"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.actatropica.2010.10.007","article-title":"The influence of exposure to <italic>Euphorbia splendens<\/italic> var. <italic>hislopii<\/italic> latex on the concentrations of total proteins and nitrogen products in <italic>Biomphalaria glabrata<\/italic> infected with <italic>Schistosoma mansoni<\/italic>","volume":"117","author":"CC Mello-Silva","year":"2011","journal-title":"Acta Trop"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1590\/S0074-02761998000700042","article-title":"Effects of <italic>Euphorbia milii<\/italic> Latex on <italic>Schistosoma mansoni<\/italic>: Eggs, Miracidia and Cercariae. \u200eMem","volume":"93","author":"RR De-Carvalho","year":"1998","journal-title":"Inst. Oswaldo Cruz"},{"key":"ref15","first-page":"101","article-title":"Impact of <italic>Euphorbia milii<\/italic> latex on infectivity of <italic>Schistosoma mansoni<\/italic> larval stages to their hosts","volume":"3","author":"FA Bakry","year":"2011","journal-title":"J. Evol. Biol. Res."},{"key":"ref16","doi-asserted-by":"crossref","first-page":"R65","DOI":"10.1186\/gb-2007-8-4-r65","article-title":"Gene expression patterns during adaptation of the helminth parasite to different environmental niches","volume":"8","author":"RE Jolly","year":"2007","journal-title":"Genome Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1017\/S0031182009990692","article-title":"<italic>Schistosoma mansoni<\/italic> cercariae experience influx of macromolecules during skin penetration","volume":"136","author":"J Thornhill","year":"2009","journal-title":"Parasitol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1017\/S0031182008005210","article-title":"Parasitic helminths: a pharmacopeia of anti-inflammatory molecules","volume":"136","author":"MJ Johnston","year":"2009","journal-title":"Parasitol"},{"key":"ref19","first-page":"e0003853","article-title":"The epigenome of <italic>Schistosoma mansoni<\/italic> provides insight about how cercariae poise transcription until infection","volume":"9","author":"D Roquis","year":"2015","journal-title":"Plos NTD"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1590\/S0036-46651992000300001","article-title":"Evaluation of temporal, seasonal and geographic stability of the molluscicidal property of <italic>Euphorbia splendens<\/italic> latex","volume":"34","author":"VT Schall","year":"1992","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/expr.1997.4148","article-title":"<italic>Schistosoma mansoni<\/italic>: susceptibility differences between male and female mice can be mediated by testosterone during early infection","volume":"85","author":"M Nakazawa","year":"1997","journal-title":"Exp Parasitol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1590\/S0036-46651985000300001","article-title":"<italic>Schistosoma mansoni<\/italic>: Comparative evaluation of different routes of experimental infection","volume":"27","author":"M Tendler","year":"1985","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"key":"ref23","first-page":"5","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"A Dobin","year":"2012","journal-title":"Bioinformatics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.exppara.2012.02.010","article-title":"Combination of de novo assembly of massive sequencing reads with classical repeat prediction improves identification of repetitive sequences in <italic>Schistosoma mansoni<\/italic>","volume":"130","author":"JM Lepesant","year":"2012","journal-title":"Exp Parasitol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"C Trapnell","year":"2012","journal-title":"Nat. Protoc."},{"key":"ref26","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a Python framework to work with high-throughput sequencing data","volume":"31","author":"S Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"MI Love","year":"2014","journal-title":"Genome Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1101\/gr.4086505","article-title":"Galaxy: a platform for interactive large-scale genome analysis","volume":"15","author":"B Giardine","year":"2005","journal-title":"Genome Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"D808","DOI":"10.1093\/nar\/gks1094","article-title":"STRING v9.1: protein-protein interaction networks, with increased coverage and integration","volume":"41","author":"A Franceschini","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"ref30","year":"2017"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrg3142","article-title":"Epigenetics and the environment: emerging patterns and implications","volume":"13","author":"R Feil","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"ref32","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/1389202911314020003","article-title":"Integrated analysis of transcriptomics and proteomic data","volume":"14","author":"S Haider","year":"2013","journal-title":"Curr. Genomics"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.biosystems.2008.12.004","article-title":"Gene network inference: Data integration in dynamic models\u2013A review","volume":"96","author":"M Hecker","year":"2009","journal-title":"Biosystems"},{"key":"ref34","first-page":"1","article-title":"Revising glucose uptake and metabolism in schistosomes: new molecular insights for improved schistosomiasis therapies","volume":"5","author":"H You","year":"2014","journal-title":"Front Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0005-2760(70)90170-0","article-title":"Lipid metabolism in the parasitic and free-living flatworms, <italic>Schistosoma mansoni<\/italic> and <italic>Dugesia dorotocephala<\/italic>","volume":"210","author":"F Meyer","year":"1970","journal-title":"Biochim. Biophys. Acta"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3389\/fimmu.2015.00218","article-title":"Development of the brazilian anti schistosomiasis vaccine based on the recombinant fatty acid binding protein Sm14 plus GLA-SE adjuvant","volume":"6","author":"M Tendler","year":"2015","journal-title":"Front Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"266","DOI":"10.2307\/3283473","article-title":"Glucose-induced modulation of nutrient influx in <italic>Schistosoma mansoni<\/italic>","volume":"78","author":"EM Cornford","year":"1992","journal-title":"J Parasitol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.actatropica.2010.06.004","article-title":"Morphological tegument alterations of adult <italic>Schistosoma mansoni<\/italic>, harbored in non anti-helminthic treated, high-immunetolerogenic and low-inflammatory mice","volume":"116","author":"AM Xavier","year":"2010","journal-title":"Acta Trop"},{"key":"ref39","first-page":"724","article-title":"Artemether, an effective new agent for chemoprophylaxis against shistosomiasis in China: it\u2019s in vivo effect on the biochemical metabolism of the Asian schistosome","volume":"31","author":"X Shuhua","year":"2000","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e10451","DOI":"10.1371\/journal.pone.0010451","article-title":"The tegument of the human parasitic worm <italic>Schistosoma mansoni<\/italic> of an excretory organ: The surface aquaporin SmAQP is a lactate transport","volume":"5","author":"Z Faghiri","year":"2010","journal-title":"Plos One"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1017\/S0031182009990965","article-title":"Morphological effects and tegumental alterations induced by mefloquine on Schistosomula and adult flukes of <italic>Schistosoma mansoni<\/italic>","volume":"137","author":"T Manneck","year":"2010","journal-title":"Parasitol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature11924","article-title":"Adult somatic stem cells in the human parasite <italic>Schistosoma mansoni<\/italic>","volume":"494","author":"JJ Collins","year":"2013","journal-title":"Nature"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.devcel.2006.06.004","article-title":"A bruno-like gene is required for stem cell maintenance in planarians","volume":"11","author":"T Guo","year":"2006","journal-title":"\u200eDev. Cell"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/BF01022380","article-title":"Male-stimulated female maturation in Schistosoma: a review","volume":"12","author":"I Popiel","year":"1986","journal-title":"J. Chem. Ecol."},{"key":"ref45","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1007\/BF01929895","article-title":"<italic>Schistosoma mansoni<\/italic>: a chemoattractive factor released by males and its receptor in females","volume":"47","author":"MA Haseeb","year":"1991","journal-title":"Experientia"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1017\/S003118209700173X","article-title":"Identification of Ras, MAP kinases, and a GAP protein in <italic>Schistosoma mansoni<\/italic> by immunoblotting and their putative involvement in male-female interaction","volume":"115","author":"P Schussler","year":"1997","journal-title":"Parasitol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pt.2009.11.003","article-title":"Male-biased sex ratio: why and what consequences for the genus Schistosoma?","volume":"26","author":"S Beltran","year":"2010","journal-title":"Trends Parasitol"},{"key":"ref48","first-page":"117","article-title":"Genotype x environment interactions","volume":"4","author":"J Bowman","year":"1972","journal-title":"Ann. Genet. Sel. Anim."},{"key":"ref49","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.pt.2016.12.002","article-title":"(Epi)genetic Inheritance in <italic>Schistosoma mansoni<\/italic>: A Systems Approach","volume":"33","author":"C Cosseau","year":"2016","journal-title":"Trends Parasitol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e12473","DOI":"10.7554\/eLife.12473","article-title":"Stem cell progeny contribute to the schistosome host-parasite interface","volume":"5","author":"JJ Collins","year":"2016","journal-title":"eLife"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0005789","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T00:00:00Z","timestamp":1502236800000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0005789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T03:45:15Z","timestamp":1588995915000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0005789"}},"subtitle":[],"editor":[{"given":"Matty","family":"Knight","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,28]]},"references-count":50,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0005789","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0005789","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,28]]}}}