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Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.dndi.org\/diseases-projects\/leishmaniasis\/\" xlink:type=\"simple\">http:\/\/www.dndi.org\/diseases-projects\/leishmaniasis\/<\/ext-link>."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1586\/erv.09.45","article-title":"Vaccination approaches against <italic>Trypanosoma cruzi<\/italic> infection","volume":"8","author":"SI Cazorla","year":"2009","journal-title":"Expert Rev Vaccines"},{"key":"ref11","unstructured":"Chaturvedi D. Sesquiterpene lactones: Structural diversity and their biological activities. In: Tiwari B, Mishra B, editors. Opportunity, challenge and scope of natural products in medicinal chemistry; 2011. pp. 313\u2013334."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2008-2231-21-35","article-title":"Biogenic trypanocidal sesquiterpenes: lead compounds to design future trypanocidal drugs\u2014a mini review","volume":"21","author":"S Saeidnia","year":"2013","journal-title":"DARU J Pharm Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.2174\/092986712800229023","article-title":"The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases\u2014part I","volume":"19","author":"T Schmidt","year":"2012","journal-title":"Curr Med Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.1128\/AAC.00595-13","article-title":"Activities of psilostachyin A and cynaropicrin against <italic>Trypanosoma cruzi in vitro<\/italic> and <italic>in vivo<\/italic>","volume":"57","author":"CF da Silva","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1590\/S0102-695X2012005000099","article-title":"Genus <italic>Mikania<\/italic>: chemical composition and phytotherapeutical activity","volume":"22","author":"LC Rufatto","year":"2012","journal-title":"Rev Bras Farmacogn"},{"key":"ref16","unstructured":"Marzocca A. Vademecum de Malezas Medicinales. Buenos Aires: Orientacion Gr\u00e1fica Editor; 1997."},{"key":"ref17","unstructured":"Toursarkissian M. Plantas Medicinales de la Argentina. Buenos Aires: Ed. Hemisferio Sur; 1980."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1021\/np50057a040","article-title":"Sesquiterpene lactones from <italic>Mikania micrantha<\/italic>","volume":"51","author":"MDR Cuenca","year":"1988","journal-title":"J Nat Prod"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.bse.2004.04.013","article-title":"Phenolic constituents from <italic>Mikania micrantha<\/italic>","volume":"32","author":"X Wei","year":"2004","journal-title":"Biochem Syst Ecol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.fitote.2014.02.006","article-title":"Sesquiterpene lactones from <italic>Mikania micrantha<\/italic> and <italic>Mikania cordifolia<\/italic> and their cytotoxic and anti-inflammatory evaluation","volume":"94","author":"EV 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