{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:19:42Z","timestamp":1784297982588,"version":"3.55.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0006012","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000}}],"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["07\/IN1\/B902"],"award-info":[{"award-number":["07\/IN1\/B902"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["10\/IN.1\/B3004"],"award-info":[{"award-number":["10\/IN.1\/B3004"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0006012","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T18:46:32Z","timestamp":1509043592000},"page":"e0006012","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A"],"prefix":"10.1371","volume":"11","author":[{"given":"Achilleas","family":"Floudas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Cluxton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Fahel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan R.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Amu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Alcami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8401-7293","authenticated-orcid":true,"given":"Padraic G.","family":"Fallon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,10,26]]},"reference":[{"issue":"9936","key":"ref1","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"383","author":"DG Colley","year":"2014","journal-title":"Lancet"},{"key":"ref2","article-title":"The Global Epidemiology of Infectious Diseases","author":"KE IMC Mott","year":"2004"},{"key":"ref3","first-page":"1311","article-title":"Review series Helminth infections: the great neglected tropical diseases","volume":"118","author":"PJ Hotez","year":"2008"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.0105-2896.2004.00191.x","article-title":"Helminth parasites\u2014masters of regulation","volume":"201","author":"RM Maizels","year":"2004","journal-title":"Immunological reviews"},{"key":"ref5","first-page":"4","article-title":"Helminth therapies: Translating the unknown unknowns to known knowns","author":"AR Khan","year":"2013","journal-title":"Int J Parasitol"},{"issue":"8","key":"ref6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003080","article-title":"Cytokine Responses to Schistosoma mansoni and Schistosoma haematobium in Relation to Infection in a Co-endemic Focus in Northern Senegal","volume":"8","author":"L Meurs","year":"2014","journal-title":"Plos Neglect Trop D"},{"issue":"3","key":"ref7","first-page":"1104","article-title":"Downregulation of Th1 Cytokine Production Accompanies Induction of Th2 Responses by a Parasitic Helminth, Schistosoma mansoni","volume":"189","author":"EJ Pearce","year":"2012","journal-title":"J Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nri2039","article-title":"Suppression of TH2-type allergic reactions by helminth infection","volume":"7","author":"PG Fallon","year":"2007","journal-title":"Nature reviews Immunology"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jaci.2016.07.007","article-title":"Regulation of the host immune system by helminth parasites","volume":"138","author":"RM Maizels","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.it.2006.08.002","article-title":"Pathogen-derived immunomodulatory molecules: future immunotherapeutics?","volume":"27","author":"PG Fallon","year":"2006","journal-title":"Trends in immunology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2009.04.008","article-title":"Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity","volume":"167","author":"JP Hewitson","year":"2009","journal-title":"Mol Biochem Parasit"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nri2730","article-title":"Helminth-derived immunomodulators: can understanding the worm produce the pill?","volume":"10","author":"W Harnett","year":"2010","journal-title":"Nature reviews Immunology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-1-4419-1601-3_8","article-title":"Helminth-derived immunomodulatory molecules","volume":"666","author":"P Adisakwattana","year":"2009","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/1521-4141(200002)30:2<470::AID-IMMU470>3.0.CO;2-T","article-title":"Elevated type 1, diminished type 2 cytokines and impaired antibody response are associated with hepatotoxicity and mortalities during Schistosoma mansoni infection of CD4-depleted mice","volume":"30","author":"PG Fallon","year":"2000","journal-title":"Eur J Immunol"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/eji.201242794","article-title":"ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection","volume":"43","author":"SA Redpath","year":"2013","journal-title":"Eur J Immunol"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"e1003215","DOI":"10.1371\/journal.ppat.1003215","article-title":"Th2 cell-intrinsic hypo-responsiveness determines susceptibility to helminth infection","volume":"9","author":"N van der Werf","year":"2013","journal-title":"Plos Pathog"},{"issue":"9","key":"ref17","doi-asserted-by":"crossref","first-page":"6456","DOI":"10.4049\/jimmunol.181.9.6456","article-title":"Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite Brugia malayi","volume":"181","author":"HJ McSorley","year":"2008","journal-title":"J Immunol"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/ibd.20787","article-title":"Therapeutic potential of helminth soluble proteins in TNBS-induced colitis in mice","volume":"15","author":"NE Ruyssers","year":"2009","journal-title":"Inflamm Bowel Dis"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nri2103","article-title":"Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo","volume":"7","author":"JA Villadangos","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.toxlet.2009.06.038","article-title":"Dendritic cell biology: Current state of the art","volume":"189","author":"R Dearman","year":"2009","journal-title":"Toxicol Lett"},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.MCHD-0043-2016","article-title":"Myeloid Cell Phenotypes in Susceptibility and Resistance to Helminth Parasite Infections","volume":"4","author":"RM Maizels","year":"2016","journal-title":"Microbiol Spectr"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.4049\/jimmunol.173.2.1240","article-title":"Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages","volume":"173","author":"P Smith","year":"2004","journal-title":"J Immunol"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"6346","DOI":"10.4049\/jimmunol.173.10.6346","article-title":"Helminth infection protects mice from anaphylaxis via IL-10-producing B cells","volume":"173","author":"NE Mangan","year":"2004","journal-title":"J Immunol"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.jaci.2010.01.018","article-title":"Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model","volume":"125","author":"S Amu","year":"2010","journal-title":"J Allergy Clin Immunol"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.4049\/jimmunol.178.7.4557","article-title":"Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism","volume":"178","author":"P Smith","year":"2007","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/978-1-4939-1161-5_11","article-title":"The generation of regulatory B cells by helminth parasites","volume":"1190","author":"AR Khan","year":"2014","journal-title":"Methods in molecular biology (Clifton, NJ)"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/(SICI)1521-4141(199804)28:04<1408::AID-IMMU1408>3.0.CO;2-H","article-title":"Type 1 and type 2 cytokine-producing mouse CD4+ and CD8+ T cells in acute Schistosoma mansoni infection","volume":"28","author":"PG Fallon","year":"1998","journal-title":"European journal of immunology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"6127","DOI":"10.1021\/bi00239a007","article-title":"Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay","volume":"30","author":"JL Kofron","year":"1991","journal-title":"Biochemistry"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-1759(98)00204-X","article-title":"An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow","volume":"223","author":"MB Lutz","year":"1999","journal-title":"J Immunol Methods"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"5997","DOI":"10.1038\/ncomms6997","article-title":"PD-L1hi B cells are critical regulators of humoral immunity","volume":"6","author":"AR Khan","year":"2015","journal-title":"Nature Communications"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1074\/mcp.M800538-MCP200","article-title":"Excretory\/secretory proteome of the adult developmental stage of human blood fluke, Schistosoma japonicum","volume":"8","author":"F Liu","year":"2009","journal-title":"Molecular & cellular proteomics: MCP"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1186\/s13071-016-1799-4","article-title":"Schistosomiasis vaccines: where do we stand?","volume":"9","author":"BM Tebeje","year":"2016","journal-title":"Parasit Vectors"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4049\/jimmunol.152.1.193","article-title":"T and B epitope determination and analysis of multiple antigenic peptides for the Schistosoma mansoni experimental vaccine triose-phosphate isomerase","volume":"152","author":"SR Reynolds","year":"1994","journal-title":"Journal of immunology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0264-410X(00)00363-7","article-title":"Immunostimulatory effect of IL-18-encoding plasmid in DNA vaccination against murine Schistosoma mansoni infection","volume":"19","author":"L Dupr\u00e9","year":"2001","journal-title":"Vaccine"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1073\/pnas.93.1.269","article-title":"A Schistosoma mansoni fatty acid-binding protein, Sm14, is the potential basis of a dual-purpose anti-helminth vaccine","volume":"93","author":"M Tendler","year":"1996","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1590\/S0074-02762007000100003","article-title":"Assessment of a DNA vaccine encoding an anchored-glycosylphosphatidylinositol tegumental antigen complexed to protamine sulphate on immunoprotection against murine schistosomiasis","volume":"102","author":"EJM Nascimento","year":"2007","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0166-6851(92)90218-9","article-title":"Cloning of a 21.7-kDa vaccine-dominant antigen gene of Schistosoma mansoni reveals an EF hand-like motif","volume":"50","author":"P Francis","year":"1992","journal-title":"Mol Biochem Parasit"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1007\/s00436-009-1646-z","article-title":"Prime-boost and recombinant protein vaccination strategies using Sm-p80 protects against Schistosoma mansoni infection in the mouse model to levels previously attainable only by the irradiated cercarial vaccine","volume":"105","author":"G Ahmad","year":"2009","journal-title":"Parasitol Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0264-410X(03)00535-8","article-title":"Protection against Schistosoma mansoni utilizing DNA vaccination with genes encoding Cu\/Zn cytosolic superoxide dismutase, signal peptide-containing superoxide dismutase and glutathione peroxidase enzymes","volume":"22","author":"KA Shalaby","year":"2003","journal-title":"Vaccine"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e308","DOI":"10.1371\/journal.pntd.0000308","article-title":"Schistosoma mansoni tegument protein Sm29 is able to induce a Th1-type of immune response and protection against parasite infection","volume":"2","author":"FC Cardoso","year":"2008","journal-title":"Plos Neglect Trop D"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nm1430","article-title":"Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis","volume":"12","author":"MH Tran","year":"2006","journal-title":"Nature medicine"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.molbiopara.2007.06.002","article-title":"Proteomic analysis of Schistosoma mansoni egg secretions","volume":"155","author":"CL Cass","year":"2007","journal-title":"Mol Biochem Parasit"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.molbiopara.2009.02.007","article-title":"Mapping the complement C1q binding site in Haemonchus contortus calreticulin","volume":"166","author":"S Naresha","year":"2009","journal-title":"Mol Biochem Parasit"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.molimm.2008.10.032","article-title":"Calreticulin from the intestinal nematode Heligmosomoides polygyrus is a Th2-skewing protein and interacts with murine scavenger receptor-A","volume":"46","author":"J Rzepecka","year":"2009","journal-title":"Molecular immunology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1365-3024.2001.00366.x","article-title":"A calreticulin-like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins","volume":"23","author":"G Kasper","year":"2001","journal-title":"Parasite Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1182\/blood.V94.4.1418","article-title":"A novel serpin expressed by blood-borne microfilariae of the parasitic nematode Brugia malayi inhibits human neutrophil serine proteinases","volume":"94","author":"X Zang","year":"1999","journal-title":"Blood"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1096\/fj.08-106278","article-title":"Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages","volume":"22","author":"S Donnelly","year":"2008","journal-title":"FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1182\/blood-2003-04-1096","article-title":"Inhibition of HIV-1 infection by a CCR5-binding cyclophilin from Toxoplasma gondii","volume":"102","author":"H Golding","year":"2003","journal-title":"Blood"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"7106","DOI":"10.4049\/jimmunol.181.10.7106","article-title":"Histoplasma capsulatum cyclophilin A mediates attachment to dendritic cell VLA-5","volume":"181","author":"FJ Gomez","year":"2008","journal-title":"Journal of immunology"},{"key":"ref50","first-page":"807","article-title":"Molecular cloning and characterization of a cyclophilin A homologue from Schistosoma japonicum","author":"H Han","year":"2012"},{"issue":"12","key":"ref51","doi-asserted-by":"crossref","first-page":"7454","DOI":"10.4049\/jimmunol.173.12.7454","article-title":"Helminth antigens modulate TLR-initiated dendritic cell activation","volume":"173","author":"CM Kane","year":"2004","journal-title":"J Immunol"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.4049\/jimmunol.172.4.2016","article-title":"Cutting edge: dendritic cells copulsed with microbial and helminth antigens undergo modified maturation, segregate the antigens to distinct intracellular compartments, and concurrently induce microbe-specific Th1 and helminth-specific Th2 responses","volume":"172","author":"L Cervi","year":"2004","journal-title":"J Immunol"},{"issue":"1","key":"ref53","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molbiopara.2004.06.016","article-title":"The Schistosoma mansoni soluble proteome: a comparison across four life-cycle stages","volume":"138","author":"RS Curwen","year":"2004","journal-title":"Mol Biochem Parasitol"},{"key":"ref54","article-title":"Exploiting Helminth-Host Interactomes through Big Data","author":"J Sotillo","year":"2017","journal-title":"Trends Parasitol"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpara.2015.09.002","article-title":"Extracellular vesicles secreted by Schistosoma mansoni contain protein vaccine candidates","volume":"46","author":"J Sotillo","year":"2016","journal-title":"Int J Parasitol"},{"issue":"3","key":"ref56","doi-asserted-by":"crossref","first-page":"e2745","DOI":"10.1371\/journal.pntd.0002745","article-title":"Serological screening of the Schistosoma mansoni adult worm proteome","volume":"8","author":"F Ludolf","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"ref57","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.exppara.2011.05.005","article-title":"Schistosoma mansoni egg glycoproteins and C-type lectins of host immune cells: molecular partners that shape immune responses","volume":"132","author":"MH Meevissen","year":"2012","journal-title":"Exp Parasitol"},{"issue":"8","key":"ref58","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1002\/eji.200737063","article-title":"Immunopathology in schistosomiasis is controlled by antigen-specific regulatory T cells primed in the presence of TLR2","volume":"37","author":"LE Layland","year":"2007","journal-title":"Eur J Immunol"},{"issue":"2","key":"ref59","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.immuni.2004.07.005","article-title":"Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk","volume":"21","author":"J Colgan","year":"2004","journal-title":"Immunity"},{"issue":"1","key":"ref60","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.molbiopara.2012.04.006","article-title":"A family of cyclophilin-like molecular chaperones in Plasmodium falciparum","volume":"184","author":"A Marin-Menendez","year":"2012","journal-title":"Mol Biochem Parasitol"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nchembio.1981","article-title":"Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway","volume":"12","author":"T Saleh","year":"2016","journal-title":"Nat Chem Biol"},{"issue":"5","key":"ref62","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/jid.2010.415","article-title":"Keratinocyte secretion of cyclophilin B via the constitutive pathway is regulated through its cyclosporin-binding site","volume":"131","author":"P Fearon","year":"2011","journal-title":"J Invest Dermatol"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1476-9255-9-44","article-title":"Cyclophilin A secreted from fibroblast-like synoviocytes is involved in the induction of CD147 expression in macrophages of mice with collagen-induced arthritis","volume":"9","author":"T Nishioku","year":"2012","journal-title":"J Inflamm (Lond)"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1186\/1756-3305-6-330","article-title":"Cyclophilin A from Schistosoma japonicum promotes a Th2 response in mice","volume":"6","author":"J Li","year":"2013","journal-title":"Parasite Vector"},{"key":"ref65","first-page":"1","article-title":"Known allergen structures predict Schistosoma mansoni IgE-binding antigens in human infection","volume":"6","author":"EJ Farnell","year":"2015"},{"issue":"11","key":"ref66","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1002\/eji.201545579","article-title":"Adoptive transfer of helminth antigen-pulsed dendritic cells protects against the development of experimental colitis in mice","volume":"45","author":"CE Matisz","year":"2015","journal-title":"Eur J Immunol"},{"issue":"12","key":"ref67","doi-asserted-by":"crossref","first-page":"7098","DOI":"10.4049\/jimmunol.1003636","article-title":"Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloCD103- dendritic cells","volume":"186","author":"KA Smith","year":"2011","journal-title":"J Immunol"},{"issue":"7","key":"ref68","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1002\/eji.200636553","article-title":"Impairment of dendritic cell function by excretory-secretory products: a potential mechanism for nematode-induced immunosuppression","volume":"37","author":"M Segura","year":"2007","journal-title":"Eur J Immunol"},{"issue":"10","key":"ref69","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1002\/eji.201142161","article-title":"Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrus","volume":"42","author":"HJ McSorley","year":"2012","journal-title":"Eur J Immunol"},{"issue":"11","key":"ref70","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1084\/jem.20101074","article-title":"Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-beta pathway","volume":"207","author":"JR Grainger","year":"2010","journal-title":"J Exp Med"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nm.3867","article-title":"The Cyclophilin A\u2013CD147 complex promotes the proliferation and homing of multiple myeloma cells","volume":"21","author":"D Zhu","year":"2015","journal-title":"Nature Medicine"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0006012","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0006012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T17:01:21Z","timestamp":1693155681000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0006012"}},"subtitle":[],"editor":[{"given":"Henry John","family":"McSorley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,26]]},"references-count":71,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0006012","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0006012","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,26]]}}}