{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:06:31Z","timestamp":1769159191036,"version":"3.49.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0006045","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000}}],"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T00:00:00Z","timestamp":1510099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["64760"],"award-info":[{"award-number":["64760"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0006045","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T13:44:49Z","timestamp":1510148689000},"page":"e0006045","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Quantitative label-free proteomic analysis of human urine to identify novel candidate protein biomarkers for schistosomiasis"],"prefix":"10.1371","volume":"11","author":[{"given":"Olugbenga Samson","family":"Onile","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridget","family":"Calder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson C.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiaka I.","family":"Anumudu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M.","family":"Blackburn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,11,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.bjid.2014.11.004","article-title":"Impact of human schistosomiasis in sub-Saharan Africa","volume":"19","author":"AF Adenowo","year":"2015","journal-title":"Braz. J. Infect. Dis"},{"key":"ref2","unstructured":"W.H.O. World Health Organization schistosomiasis fact sheet. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/mediacentre\/factsheets\/fs115\/en\" xlink:type=\"simple\">http:\/\/www.who.int\/mediacentre\/factsheets\/fs115\/en<\/ext-link>[accessed 2014;10.04.14]."},{"key":"ref3","first-page":"123","article-title":"Urinary tract pathology in some Schistosoma haematobium infected Nigerians","volume":"6","author":"OPG Nmorsi","year":"2007","journal-title":"Afr. J. Biotechnol"},{"key":"ref4","first-page":"1","article-title":"Water usage and transmission of schistosoma haematobium in Jalingo and Ardokola Local Government Areas of Taraba State, Nigeria","volume":"3","author":"IJ Agere","year":"2010","journal-title":"Nig J Sci Tech and Environ Edu (NIJOSTEE)"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0001-706X(00)00122-4","article-title":"The global status of schistosomiasis and its control","volume":"77","author":"L Chitsulo","year":"2000","journal-title":"Acta Trop"},{"key":"ref6","first-page":"1721","article-title":"Schistosoma Haematobium Infection Among Pupils, and Snail Intermediate Hosts in Ago- Iwoye; Ogun State, Nigeria","volume":"17","author":"OM Agbolade","year":"1996","journal-title":"Nig. J. Parasitol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1172\/JCI34261","article-title":"Helminth infections: the great neglected tropical diseases","volume":"118","author":"PJ Hotez","year":"2008","journal-title":"J. Clin. Invest"},{"key":"ref8","first-page":"846","article-title":"National Academy of Clinical Biochemistry Guidelines for the Use of Tumor Markers in Bladder Cancer; NACB: Practice Guidelines And Recommendations For Use Of Tumor Markers In The Clinic Bladder Cancer (3H) from pTa tumours","volume":"90","author":"HA Fritsche","year":"2006","journal-title":"BJU Int"},{"key":"ref9","unstructured":"European Urology Association. EAU Guidelines on muscle-invasive and mestastic bladder cancer. 2016"},{"key":"ref10","article-title":"Detection of urinary tract pathology in some Schistosoma haematobium infected Nigerian Adults","author":"OS Onile","year":"2016","journal-title":"J. Trop. Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1128\/CMR.12.1.97","article-title":"Relationship between schistosomiasis and bladder cancer","volume":"12","author":"MH Mostafa","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1586\/14789450.2016.1116390","article-title":"Clinical implications of recent findings in schistosome proteomics","volume":"13","author":"P Driguez","year":"2016","journal-title":"Exp. Rev. Prot"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.ijpara.2009.02.016","article-title":"Schistosoma haematobium total antigen and decreased apoptosis of normal epithelial cells","volume":"39","author":"M Botelho","year":"2010","journal-title":"Int. J. Parasitol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.trstmh.2005.10.010","article-title":"Ultrasound verification of bladder damage is associated with known biomarkers of bladder cancer in adults chronically infected with Schistosoma haematobium in Ghana","volume":"100","author":"C Shiff","year":"2006","journal-title":"Trans. Royal Soc. Trop. Med. and Hyg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/S0022-5347(05)67269-2","article-title":"Clinical usefulness of the novel marker BLCA-4 for the detection of bladder cancer","volume":"164","author":"BR Konety","year":"2000","journal-title":"J. Urol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ijpara.2015.03.004","article-title":"A quantitative proteomic analysis of the tegumental proteins from Schistosoma mansoni schistosomula reveals novel potential therapeutic targets","volume":"45","author":"J Sotillo","year":"2015","journal-title":"Int. J. Parasitol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/prca.201400197","article-title":"Discovery of novel candidate urinary protein biomarkers for prostate cancer in a multiethnic cohort of South African patients via label-free mass spectrometry","volume":"9","author":"HA Adeola","year":"2015","journal-title":"Proteomics Clin. Appl"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S1470-2045(06)70584-8","article-title":"Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis","volume":"7","author":"D Theodorescu","year":"2006","journal-title":"Lancet Oncol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.canlet.2004.04.011","article-title":"Investigation off genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina","volume":"211","author":"LE Moore","year":"2004","journal-title":"Cancer Letters"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1038\/nprot.2007.261","article-title":"Protocol for micropurification, enrichment, pre-fractionation and storage of peptides for proteomics using Stage Tips","volume":"2","author":"J Rappsilber","year":"2007","journal-title":"Nat. Protocols"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1074\/mcp.M113.031591","article-title":"Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ","volume":"13","author":"J Cox","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1093\/bioinformatics\/bti610","article-title":"Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research","volume":"21","author":"A Conesa","year":"2005","journal-title":"Bioinformatics"},{"key":"ref23","first-page":"17","article-title":"Human Urine Proteomics: Analytical Techniques and Clinical Applications in Renal Diseases","volume":"782798","author":"S Kalantari","year":"2015","journal-title":"Int. J. Prot"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1021\/pr2003038","article-title":"A comprehensive map of the human urinary proteome","volume":"10","author":"A Marimuthu","year":"2011","journal-title":"J. Prot. Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ijpara.2010.12.005","article-title":"The proteome of the insoluble Schistosoma mansoni eggshell skeleton","volume":"41","author":"S deWalick","year":"2011","journal-title":"Int. J. Parasitol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.ijpara.2006.02.006","article-title":"Thermoregulation in the life cycle of nematodes","volume":"36","author":"E Devaney","year":"2006","journal-title":"Int. J. Parasitol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.ijpara.2012.04.008","article-title":"Tissue expression patterns of Schistosoma mansoni Venom Allergen-Like proteins 6 and 7","volume":"42","author":"HK Rofatto","year":"2012","journal-title":"Int. J. Parasitol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ijpara.2014.04.002","article-title":"Excreted\/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression","volume":"44","author":"TP Yoshino","year":"2014","journal-title":"Int. J. Parasitol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.1016\/j.jaci.2012.04.027","article-title":"Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: implications for the development of vaccines against helminths","volume":"130","author":"DJ Diemert","year":"2012","journal-title":"J. Allergy Clin. Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/infdis\/jiu451","article-title":"Probing of a human proteome microarray with a recombinant pathogen protein reveals a novel mechanism by which hookworms suppress B-cell receptor signaling","volume":"211","author":"L Tribolet","year":"2015","journal-title":"J. Infect. Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.ijantimicag.2006.12.018","article-title":"Praziquantel binds Schistosoma mansoni adult worm actin","volume":"29","author":"T Hatem","year":"2007","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1017\/S0031182000073704","article-title":"Schistosoma mansoni: praziquantel induced tegumental lesion exposes actin of surface spines and allows binding of actin depolymerizing factor, gelsolin","volume":"105","author":"E Linder","year":"1992","journal-title":"Parasitology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/trstmh\/trs020","article-title":"Schistosome Na, K-ATPase as a therapeutic target","volume":"107","author":"AA Da\u2019dara","year":"2013","journal-title":"Trans. R. Soc. Trop. Med. Hyg"},{"key":"ref34","first-page":"116","article-title":"Membrane proteins as diagnostic biomarkers and targets for new therapies","volume":"10","author":"D Josic","year":"2008","journal-title":"Curr Opin Mol Ther"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1002\/pmic.200500368","article-title":"The tegument surface membranes of the human blood parasite Schistosoma mansoni: a proteomic analysis after differential extraction","volume":"6","author":"S Braschi","year":"2006","journal-title":"Proteomics"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ijpara.2006.12.001","article-title":"Schistosome membrane proteins as vaccines","volume":"37","author":"A Loukas","year":"2007","journal-title":"Int. J. Parasitol"},{"key":"ref37","first-page":"223","article-title":"Activity of Some Hepatic Enzymes in Schistosomiasis and Concomitant Alteration of Arylsulfatase B","volume":"37","author":"M Balbaa","year":"2004","journal-title":"J. Biochem. Mol. Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0009-8981(77)90380-1","article-title":"Urine enzyme activities in patients with transitional cell carcinoma of the bladder","volume":"74","author":"LE Poys","year":"1977","journal-title":"Clin. Chim. Acta"},{"key":"ref39","unstructured":"Thorpe, P. E., Ran, S. and Seattle, B. Methods for imaging tumour vasculature using conjugates that bind to aminophospholipids. United State Patent. 2009; US007550141B2."},{"key":"ref40","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ijid.2015.01.015","article-title":"HIV and schistosomiasis in rural Zimbabwe: the association of Retinol-binding protein with disease progression, inflammation and mortality","volume":"33","author":"SR Kotze","year":"2015","journal-title":"Int. J. Infect. Dis"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Hameed DA, El-Metwally TH. The effectiveness of retinoic acid treatment in bladder cancer-Impact on recurrence, survival and TGF\u03b1 and VEGF as end-point biomarkers. Cancer Biology and Therapy. 2008; 7:92-100.","DOI":"10.4161\/cbt.7.1.5134"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1016\/j.jprot.2011.12.031","article-title":"Multiplexed quantification of 63 proteins in human urine by multiple reaction monitoring-based mass spectrometry for discovery of potential bladder cancer biomarkers","volume":"75","author":"C Yi-Ting","year":"2012","journal-title":"J. Prot"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/ni1443","article-title":"The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection","volume":"8","author":"AH Sharpe","year":"2007","journal-title":"Nature Immunology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1086\/654932","article-title":"Role Played by the Programmed Death 1\u2013 Programmed Death Ligand Pathway during Innate Immunity against Mycobacterium tuberculosis","volume":"202","author":"IB Alvarez","year":"2010","journal-title":"J. Infect. Dis"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"946","DOI":"10.5966\/sctm.2013-0055","article-title":"Concise Review: Growth Differentiation Factor 15 in Pathology: A Clinical Role?","volume":"2","author":"J Corre","year":"2013","journal-title":"Stem Cells Translational Medicine"},{"key":"ref46","first-page":"5974","article-title":"Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer","volume":"61","author":"JB Welsh","year":"2001","journal-title":"Cancer Res"},{"key":"ref47","first-page":"4648","article-title":"Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system","volume":"63","author":"DH Lee","year":"2003","journal-title":"Cancer Res"},{"key":"ref48","first-page":"6996","article-title":"Secreted and cell surface genes expressed in benign and malignant colorectal tumors","volume":"61","author":"P Buckhaults","year":"2001","journal-title":"Cancer Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1158\/1078-0432.CCR-1167-3","article-title":"Serum diagnosis of pancreatic adenocarcinoma using surface-enhanced laser desorption and ionization mass spectrometry","volume":"10","author":"J Koopmann","year":"2004","journal-title":"Clin Cancer Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.oraloncology.2008.07.017","article-title":"Expression of growth differentiation factor 15 is positively correlated with histopathological malignant grade and in vitro cell proliferation in oral squamous cell carcinoma","volume":"45","author":"L Zhang","year":"2009","journal-title":"Oral Oncol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"91","DOI":"10.5483\/BMBRep.2010.43.2.091","article-title":"Macrophage inhibitory cytokine-1 transactivates ErbB family receptors via the activation of Src in SK-BR-3 human breast cancer cells","volume":"43","author":"YJ Park","year":"2010","journal-title":"BMB Rep"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/ng.687","article-title":"A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci","volume":"42","author":"N Rothman","year":"2010","journal-title":"Nat. Genet"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1074\/jbc.M109.055475","article-title":"Regulation of Phagocytosis in Macrophages by Neuraminidase 1","volume":"285","author":"V Seyrantepe","year":"2010","journal-title":"J. Biol. Chem"},{"key":"ref54","first-page":"e2142","article-title":"Detection of Neu1 Sialidase Activity in Regulating TOLL-like Receptor Activation","volume":"43","author":"SR Amith","year":"2010","journal-title":"J. Vis. Exp"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2174\/1871528111312010005","article-title":"The role of exosomes in infectious diseases","volume":"12","author":"HM Hosseini","year":"2013","journal-title":"Inflamm. Allergy Drug Targets"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0006045","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0006045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,5]],"date-time":"2019-10-05T17:29:04Z","timestamp":1570296544000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0006045"}},"subtitle":[],"editor":[{"given":"Aaron R.","family":"Jex","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,11,8]]},"references-count":55,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0006045","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0006045","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,8]]}}}