{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:39:42Z","timestamp":1790098782848,"version":"4.0.1"},"update-to":[{"DOI":"10.1371\/journal.pntd.0006068","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000}}],"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T00:00:00Z","timestamp":1511740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Biologia do Ex\u00e9rcito","award":["Agreement term 0404400\/2004"],"award-info":[{"award-number":["Agreement term 0404400\/2004"]}]},{"name":"Funda\u00e7\u00e3o de Medicina Tropical Doutor Heitor Vieira Dourado","award":["Agreement term 0404401\/2005"],"award-info":[{"award-number":["Agreement term 0404401\/2005"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0006068","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T13:52:44Z","timestamp":1511790764000},"page":"e0006068","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":60,"title":["Safety and efficacy of a freeze-dried trivalent antivenom for snakebites in the Brazilian Amazon: An open randomized controlled phase IIb clinical trial"],"prefix":"10.1371","volume":"11","author":[{"given":"Iran","family":"Mendon\u00e7a-da-Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio","family":"Magela Tavares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Sachett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Felipe","family":"Sardinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian","family":"Zaparolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria F\u00e1tima","family":"Gomes Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Lacerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0848-1940","authenticated-orcid":true,"given":"Wuelton Marcelo","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,11,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1371\/journal.pmed.0050218","article-title":"The Global Burden of Snakebite: A Literature Analysis and Modelling Based on Regional Estimates of Envenoming and Deaths","volume":"5","author":"A Kasturiratne","year":"2008","journal-title":"PLoS Med"},{"key":"ref2","unstructured":"WHO. World Health Organization, 2016. Epidemiology [WWW Document]. World Heal. Organ. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/topics\/epidemiology\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/topics\/epidemiology\/en\/<\/ext-link>."},{"key":"ref3","unstructured":"Brazilian Ministry of Health (2017) Ofidismo: Situa\u00e7\u00e3o Epidemiol\u00f3gica\u2014Dados [WWW Document]. Minist. da Sa\u00fade. URL <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/portalsaude.saude.gov.br\/index.php\/o-ministerio\/principal\/leia-mais-o-ministerio\/1025-secretaria-svs\/vigilancia-de-a-a-z\/animais-peconhentos-serpentes\/l2-animais-peconhentos-serpentes\/13712-situacao-epidemiologica-dados\" xlink:type=\"simple\">http:\/\/portalsaude.saude.gov.br\/index.php\/o-ministerio\/principal\/leia-mais-o-ministerio\/1025-secretaria-svs\/vigilancia-de-a-a-z\/animais-peconhentos-serpentes\/l2-animais-peconhentos-serpentes\/13712-situacao-epidemiologica-dados<\/ext-link>. (Accessed 1.10.17)."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e0003701","DOI":"10.1371\/journal.pntd.0003701","article-title":"Snakebites and Scorpion Stings in the Brazilian Amazon: Identifying Research Priorities for a Largely Neglected Problem","volume":"9","author":"FH Wen","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e0132237","DOI":"10.1371\/journal.pone.0132237","article-title":"Older Age and Time to Medical Assistance Are Associated with Severity and Mortality of Snakebites in the Brazilian Amazon: A Case-Control Study","volume":"10","author":"EL Feitosa","year":"2015","journal-title":"PLoS One"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0035-9203(03)00005-1","article-title":"Clinical trial of two antivenoms for the treatment of <italic>Bothrops<\/italic> and <italic>Lachesis<\/italic> bites in the north eastern Amazon region of Brazil","volume":"98","author":"PPO Pardal","year":"2004","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0041-0101(95)00125-5","article-title":"High incidence of bites and stings by snakes and other animals among rubber tappers and Amazonian Indians of the Juru\u00e1 Valley, Acre State, Brazil","volume":"34","author":"SV Pierini","year":"1996","journal-title":"Toxicon"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S0035-9203(96)90442-3","article-title":"A randomized double-blind clinical trial of two antivenoms in patients bitten by <italic>Bothrops atrox<\/italic> in Colombia","volume":"90","author":"R Otero","year":"1996","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref9","first-page":"259","article-title":"Snakebite by <italic>Bothrops atrox<\/italic> (Lin. 1758) in the State of Amazonas\u2014Brazil: Study of 212 cases with identified snake","volume":"31","author":"ARB Souza","year":"2002","journal-title":"Rev Patol Trop"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0140-6736(95)92825-1","article-title":"Coagulation disorders in bushmaster envenomation","volume":"346","author":"J Torres","year":"1995","journal-title":"Lancet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/0305-0491(92)90071-X","article-title":"Biochemical and biological differentiation of the venoms of the lancehead vipers (<italic>Bothrops atrox<\/italic>, <italic>Bothrops asper<\/italic>, <italic>Bothrops marajoensis<\/italic> and <italic>Bothrops moojeni<\/italic>)","volume":"102","author":"MT Assakura","year":"1992","journal-title":"Comp. Biochem. Physiol. Part B Comp. Biochem"},{"key":"ref12","first-page":"108","article-title":"Animais Pe\u00e7onhentos no Brasil","author":"M Azevedo-Marques","year":"2009"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.biochi.2015.08.006","article-title":"Comparison of venoms from wild and long-term captive <italic>Bothrops atrox<\/italic> snakes and characterization of batroxrhagin, the predominant class PIII metalloproteinase from the venom of this species","volume":"118","author":"LA Freitas-De-Sousa","year":"2015","journal-title":"Biochimie"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e2442","DOI":"10.1371\/journal.pntd.0002442","article-title":"Comparison of Phylogeny, Venom Composition and Neutralization by Antivenom in Diverse Species of <italic>Bothrops<\/italic> Complex","volume":"7","author":"LF Sousa","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref15","first-page":"105","article-title":"The Enigma of the North Margin of the Amazon River: Proven <italic>Lachesis<\/italic> Bites in Brazil, Report of Two Cases, General Considerations about the Genus and Bibliographic Review","volume":"42","author":"RCG Souza","year":"2007","journal-title":"Bull Chicago Herpetol Soc"},{"key":"ref16","article-title":"Guidelines for the Production Control and Regulation ol Snake Antivenom Immunoglobulins","year":"2010"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1590\/0037-8682-0105-2013","article-title":"Snakebites as a largely neglected problem in the Brazilian Amazon: highlights of the epidemiological trends in the States of Amazonas","volume":"48","author":"ES Feitosa","year":"2015","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.toxicon.2014.07.015","article-title":"Freeze-dried snake antivenoms formulated with sorbitol, sucrose or mannitol: comparison of their stability in an accelerated test","volume":"90","author":"M Herrera","year":"2014","journal-title":"Toxicon"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.toxicon.2016.12.004","article-title":"Physicochemical characterization of commercial freeze-dried snake antivenoms","volume":"126","author":"M Herrera","year":"2017","journal-title":"Toxicon"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0041-0101(90)90011-U","article-title":"Effect of storage temperature on the stability of the liquid polyvalent antivenom produced in Costa Rica","volume":"28","author":"G Rojas","year":"1990","journal-title":"Toxicon"},{"key":"ref21","article-title":"Guia de Vigil\u00e2ncia em Sa\u00fade","year":"2016"},{"key":"ref22","article-title":"Farmacopeia Brasileira","year":"2000"},{"key":"ref23","article-title":"Statistical algorithms in Review Manager","volume":"5","author":"J Deeks","year":"2010","journal-title":"Statistical algorithms in Review Manager"},{"key":"ref24","article-title":"Principles of Biostatistics","author":"M Pagano","year":"2000"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1021\/js980383n","article-title":"Effects of Buffer Composition and Processing Conditions on Aggregation of Bovine IgG during Freeze-Drying","volume":"88","author":"J-M Sarciaux","year":"1999","journal-title":"J Pharm Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0041-0101(86)90147-9","article-title":"A critical reappraisal of the use of enzyme-linked immunosorbent assays in the study of snake bite","volume":"24","author":"M Ho","year":"1986","journal-title":"Toxicon"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/0041-0101(94)90388-3","article-title":"Reliability of the simple 20 minute whole blood clotting test (WBCT20) as an indicator of low plasma fibrinogen concentration in patients envenomed by <italic>Bothrops<\/italic> snakes","volume":"32","author":"IS Sano-Martins","year":"1994","journal-title":"Toxicon"},{"key":"ref28","first-page":"468","article-title":"Venomous animals in Brazil: biology, clinic and therapeutics of envenomations","author":"JLC Cardoso","year":"2003"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.toxicon.2009.07.001","article-title":"Epidemiological, clinical and therapeutic aspects of Bothrops asper bites","volume":"54","author":"R Otero-Pati\u00f1o","year":"2009","journal-title":"Toxicon"},{"key":"ref30","first-page":"709","article-title":"Venomous Reptiles of the Western Hemisphere","author":"DA Warrell","year":"2004"},{"key":"ref31","first-page":"315","article-title":"Randomized comparative trial of three antivenoms in the treatment of envenoming by lance-headed vipers (<italic>Bothrops jararaca<\/italic>) in S\u00e3o Paulo, Brazil","volume":"85","author":"JLC Cardoso","year":"1993","journal-title":"Q J Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.toxicon.2011.11.017","article-title":"Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab\u2019)2] antivenoms, in <italic>Bothrops asper<\/italic> bites in Colombia","volume":"59","author":"R Otero-Pati\u00f1o","year":"2012","journal-title":"Toxicon"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4269\/ajtmh.1998.58.183","article-title":"A randomized, blinded, comparative trial of one pepsin-digested and two whole IgG antivenoms for <italic>Bothrops<\/italic> snake bites in Uraba, Colombia. The Regional Group on Antivenom Therapy Research (REGATHER)","volume":"58","author":"R Otero-Pati\u00f1o","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0035-9203(95)90678-9","article-title":"A randomized \u201cblinded\u201d comparison of two doses of antivenom in the treatment of <italic>Bothrops<\/italic> envenoming in Sao Paulo, Brazil","volume":"89","author":"MT Jorge","year":"1995","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1590\/S0036-46651986000400003","article-title":"Insufici\u00eancia renal aguda secund\u00e1ria a acidentes of\u00eddicos botr\u00f3pico e crot\u00e1lico. An\u00e1lise de 63 casos","volume":"28","author":"CFS Amaral","year":"1986","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S0041-0101(02)00104-6","article-title":"Complications of <italic>Bothrops<\/italic>, <italic>Porthidium<\/italic>, and <italic>Bothriechis<\/italic> snakebites in Colombia. A clinical and epidemiological study of 39 cases attended in a university hospital","volume":"40","author":"R Otero","year":"2002","journal-title":"Toxicon"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/0041-0101(87)90134-6","article-title":"Evidence that <italic>Crotalus durissus terrificus<\/italic> (South American rattlesnake) envenomation in human causes myolysis rather than hemolysis","volume":"11","author":"MM Azevedo-Marques","year":"1987","journal-title":"Toxicon"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0035-9203(90)90358-L","article-title":"Acute myocardial infarction-like enzyme profile in human victims of <italic>Crotalus durissus terrificus<\/italic> envenoming","volume":"84","author":"P Cupo","year":"1990","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.trstmh.2006.01.006","article-title":"Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without beta-propiolactone, in the treatment of <italic>Bothrops asper<\/italic> bites in Colombia","volume":"100","author":"R Otero","year":"2006","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0041-0101(98)00220-7","article-title":"A randomized blinded clinical trial of two antivenoms, prepared by caprylic acid or ammonium sulphate fractionation of IgG, in <italic>Bothrops<\/italic> and <italic>Porthidium<\/italic> snake bites in Colombia: correlation between safety and biochemical characteristics of antivenoms","volume":"37","author":"R Otero","year":"1999","journal-title":"Toxicon"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.toxicon.2004.03.020","article-title":"Preclinical testing of three south American antivenoms against the venoms of five medically-important Peruvian snake venoms","volume":"44","author":"GD Laing","year":"2004","journal-title":"Toxicon"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.actatropica.2004.09.008","article-title":"Neutralization of four Peruvian Bothrops sp. snake venoms by polyvalent antivenoms produced in Per\u00fa and Costa Rica: Preclinical assessment","volume":"93","author":"E Rojas","year":"2005","journal-title":"Acta Trop"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1136\/bmj.329.7475.1129","article-title":"Crotaline snake bite in the Ecuadorian Amazon: randomised double blind comparative trial of three South American polyspecific antivenoms","volume":"329","author":"R Smalligan","year":"2004","journal-title":"BMJ"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/0035-9203(95)90105-1","article-title":"Treatment of snake bites by <italic>Bothrops<\/italic> species and <italic>Lachesis muta<\/italic> in Ecuador: laboratory screening of candidate antivenoms","volume":"89","author":"R Theakston","year":"1995","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0041-0101(91)90106-2","article-title":"Comparative study of nine <italic>Bothrops<\/italic> snake venoms from adult female snakes and their offspring","volume":"29","author":"MFD Furtado","year":"1991","journal-title":"Toxicon"},{"key":"ref46","first-page":"37","article-title":"Rattlesnake bites in southern California and rationale for recommended treatment","volume":"148","author":"WA Wingert","year":"1988","journal-title":"West J Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"E572","DOI":"10.1208\/aapsj080366","article-title":"Protein aggregation and bioprocessing","volume":"8","author":"MEM Cromwell","year":"2006","journal-title":"AAPS J"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0041-0101(97)00101-3","article-title":"Thermal stability studies of hyperimmune horse antivenoms","volume":"37","author":"R Rodrigues-Silva","year":"1999","journal-title":"Toxicon"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S0041-0101(97)00015-9","article-title":"Purification and stability studies of immunoglobulins from <italic>Lachesis muta muta<\/italic> antivenom","volume":"35","author":"R Rodrigues-Silva","year":"1997","journal-title":"Toxicon"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.toxicon.2009.01.012","article-title":"Stability of equine IgG antivenoms obtained by caprylic acid precipitation: Towards a liquid formulation stable at tropical room temperature","volume":"53","author":"A Segura","year":"2009","journal-title":"Toxicon"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1136\/bmj.318.7196.1451","article-title":"Sequential randomised and double blind trial of promethazine prophylaxis against early anaphylactic reactions to antivenom for bothrops snake bites","volume":"318","author":"FH Wen","year":"1999","journal-title":"BMJ"},{"key":"ref52","first-page":"451","article-title":"Snake bites in children: antivenom early reaction frequency in patients pretreated with histamine antagonists H1 and H2 and hydrocortisone","volume":"36","author":"F Bucaretchi","year":"1994","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"869","DOI":"10.2165\/11592050-000000000-00000","article-title":"Effect of pre-medication on early adverse reactions following antivenom use in snakebite: A systematic review and meta-analysis","volume":"34","author":"AG Habib","year":"2011","journal-title":"Drug Saf"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4269\/ajtmh.1995.52.419","article-title":"Prevention of thromboses in human patients with <italic>Bothrops lanceolatus<\/italic> envenoming in Martinique: failure of anticoagulants and efficacy of a monospecific antivenom. Research Group on Snake Bites in Martinique","volume":"52","author":"L Thomas","year":"1995","journal-title":"Am J Trop Med Hyg"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1592\/phco.2005.25.6.886","article-title":"Intravenous immunoglobulin-associated acute renal failure: case series and literature review","volume":"25","author":"YM Itkin","year":"2005","journal-title":"Pharmacother"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0041-0101(00)00198-7","article-title":"Time to reconstitution: Purified Fab antivenom vs. unpurified IgG antivenom","volume":"39","author":"RE Hill","year":"2001","journal-title":"Toxicon"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ajem.2009.02.008","article-title":"Improving Crotalidae polyvalent immune Fab reconstitution times","volume":"28","author":"AN Quan","year":"2010","journal-title":"Am J Emerg Med"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1002\/jps.22000","article-title":"Systematic Investigation of the Effect of Lyophilizate Collapse on Pharmaceutically Relevant Proteins I: Stability after Freeze-Drying","volume":"99","author":"K Schersch","year":"2010","journal-title":"J Pharm Sci"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/jps.1040","article-title":"Annealing to optimize the primary drying rate, reduce freezing-induced drying rate heterogeneity, and determine T(g)&apos; pharmaceutical lyophilization","volume":"90","author":"JA Searles","year":"2001","journal-title":"J Pharm Sci"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.toxicon.2012.12.005","article-title":"Validating a faster method for reconstitution of Crotalidae Polyvalent Immune Fab (ovine)","volume":"69","author":"D Gerring","year":"2013","journal-title":"Toxicon"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0041-0101(02)00393-8","article-title":"Report of a WHO workshop on the standardization and control of antivenoms","volume":"41","author":"RDG Theakston","year":"2003","journal-title":"Toxicon"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.toxicon.2017.02.008","article-title":"Thermal stabilization of anti-\u03b1-cobratoxin single domain antibodies","volume":"129","author":"GP Anderson","year":"2017","journal-title":"Toxicon"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0006068","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000}},{"DOI":"10.1371\/journal.pntd.0010031","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0006068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T11:59:40Z","timestamp":1540209580000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0006068"}},"subtitle":[],"editor":[{"given":"Juan J","family":"Calvete","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,11,27]]},"references-count":62,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0006068","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,27]]}}}