{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:27:47Z","timestamp":1789093667641,"version":"build-2803163510"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["16fk0108101j0001"],"award-info":[{"award-number":["16fk0108101j0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H26-Sinkogyousei-Shitei-002"],"award-info":[{"award-number":["H26-Sinkogyousei-Shitei-002"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health, Labour and Welfare (JP)","award":["H29-Sinkogyousei-Shitei-002"],"award-info":[{"award-number":["H29-Sinkogyousei-Shitei-002"]}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H25-Shinko-Ippan-004"],"award-info":[{"award-number":["H25-Shinko-Ippan-004"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25670222"],"award-info":[{"award-number":["25670222"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0006076","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T18:24:48Z","timestamp":1513275888000},"page":"e0006076","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Virulence, pathology, and pathogenesis of Pteropine orthoreovirus (PRV) in BALB\/c mice: Development of an animal infection model for PRV"],"prefix":"10.1371","volume":"11","author":[{"given":"Kazutaka","family":"Egawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Shimojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyo","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Tani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kurosu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumpei","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuetsu","family":"Fukushi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5458-7298","authenticated-orcid":true,"given":"Masayuki","family":"Saijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/BF01249346","article-title":"Nelson Bay virus. A novel reovirus","volume":"43","author":"GP Gard","year":"1973","journal-title":"Archiv fur Die Gesamte Virusforschung"},{"issue":"27","key":"ref2","doi-asserted-by":"crossref","first-page":"11424","DOI":"10.1073\/pnas.0701372104","article-title":"A previously unknown reovirus of bat origin is associated with an acute respiratory disease in humans","volume":"104","author":"KB Chua","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"e3803","DOI":"10.1371\/journal.pone.0003803","article-title":"Identification and characterization of a new orthoreovirus from patients with acute respiratory infections","volume":"3","author":"KB Chua","year":"2008","journal-title":"PloS One"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jcv.2009.03.001","article-title":"A novel reovirus isolated from a patient with acute respiratory disease","volume":"45","author":"P Cheng","year":"2009","journal-title":"Journal of Clinical Virology"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"e25434","DOI":"10.1371\/journal.pone.0025434","article-title":"Investigation of a potential zoonotic transmission of orthoreovirus associated with acute influenza-like illness in an adult patient","volume":"6","author":"KB Chua","year":"2011","journal-title":"PloS One"},{"issue":"6","key":"ref6","first-page":"944","article-title":"Virulence potential of fusogenic orthoreoviruses","volume":"18","author":"AH Wong","year":"2012","journal-title":"Emerging Infectious Diseases"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"e92777","DOI":"10.1371\/journal.pone.0092777","article-title":"Imported case of acute respiratory tract infection associated with a member of species Nelson Bay orthoreovirus","volume":"9","author":"A Yamanaka","year":"2014","journal-title":"PloS One"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3855\/jidc.9112","article-title":"Pteropine orthoreovirus: An important emerging virus causing infectious disease in the tropics?","volume":"11","author":"YF Tan","year":"2017","journal-title":"Journal of Infection in Developing Countries"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1002\/jmv.24274","article-title":"Serological evidence of human infection with Pteropine orthoreovirus in Central Vietnam","volume":"87","author":"H Singh","year":"2015","journal-title":"Journal of Medical Virology"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1002\/jmv.24304","article-title":"Pteropine orthoreovirus infection among out-patients with acute upper respiratory tract infection in Malaysia","volume":"87","author":"K Voon","year":"2015","journal-title":"Journal of Medical Virology"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00705-005-0644-4","article-title":"Pulau virus; a new member of the Nelson Bay orthoreovirus species isolated from fruit bats in Malaysia","volume":"151","author":"LI Pritchard","year":"2006","journal-title":"Archives of Virology"},{"issue":"8","key":"ref12","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s00705-010-0690-4","article-title":"Xi River virus, a new bat reovirus isolated in southern China","volume":"155","author":"L Du","year":"2010","journal-title":"Archives of Virology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/s12866-014-0293-4","article-title":"Characterization of a novel orthoreovirus isolated from fruit bat","volume":"14","author":"T Hu","year":"2014","journal-title":"China. BMC Microbiology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.meegid.2014.12.006","article-title":"A new member of the Pteropine orthoreovirus species isolated from fruit bats imported to Italy","volume":"30","author":"A Lorusso","year":"2015","journal-title":"Infection, Genetics and Evolution"},{"key":"ref15","article-title":"First isolation and characterization of pteropine orthoreoviruses in fruit bats in the Philippines","author":"S Taniguchi","year":"2017","journal-title":"Archives of Virology"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"e1005455","DOI":"10.1371\/journal.ppat.1005455","article-title":"Reverse genetics for fusogenic bat-borne orthoreovirus associated with acute respiratory tract infections in humans: role of outer capsid protein sigmaC in viral replication and pathogenesis","volume":"12","author":"T Kawagishi","year":"2016","journal-title":"PLoS Pathogens"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"16517","DOI":"10.1038\/srep16517","article-title":"Rapid whole genome sequencing of Miyazaki-Bali\/2007 Pteropine orthoreovirus by modified rolling circular amplification with adaptor ligation\u2014next generation sequencing","volume":"5","author":"H Singh","year":"2015","journal-title":"Scientific Reports"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.5501\/wjv.v5.i2.85","article-title":"Determination of 50% endpoint titer using a simple formula","volume":"5","author":"MA Ramakrishnan","year":"2016","journal-title":"World Journal of Virology"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"e0148184","DOI":"10.1371\/journal.pone.0148184","article-title":"Neuropathogenicity of two Saffold virus type 3 isolates in mouse models","volume":"11","author":"O Kotani","year":"2016","journal-title":"PloS One"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1038\/emi.2016.35","article-title":"Serologic assays for the detection and strain identification of Pteropine orthoreovirus","volume":"5","author":"H Singh","year":"2016","journal-title":"Emerging Microbes & Infections"},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.2353\/ajpath.2008.071060","article-title":"Mouse-passaged severe acute respiratory syndrome-associated coronavirus leads to lethal pulmonary edema and diffuse alveolar damage in adult but not young mice","volume":"172","author":"N Nagata","year":"2008","journal-title":"The American Journal of Pathology"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3109\/01902148309061521","article-title":"Comparison of nonciliated tracheal epithelial cells in six mammalian species: ultrastructure and population densities","volume":"5","author":"CG Plopper","year":"1983","journal-title":"Experimental Lung Research"},{"issue":"7","key":"ref23","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1513\/pats.200803-028HR","article-title":"Knowns and unknowns of the alveolus","volume":"5","author":"EL Herzog","year":"2008","journal-title":"Proceedings of the American Thoracic Society"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1743-422X-10-67","article-title":"Respiratory infection of mice with mammalian reoviruses causes systemic infection with age and strain dependent pneumonia and encephalitis","volume":"10","author":"L Gauvin","year":"2013","journal-title":"Virology Journal"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1128\/JVI.70.1.541-548.1996","article-title":"Reovirus infection in rat lungs as a model to study the pathogenesis of viral pneumonia","volume":"70","author":"MJ Morin","year":"1996","journal-title":"Journal of Virology"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.tim.2005.08.003","article-title":"100th anniversary of Robert Koch's Nobel prize for the discovery of the tubercle bacillus","volume":"13","author":"SH Kaufmann","year":"2005","journal-title":"Trends in Microbiology"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0006076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T09:02:38Z","timestamp":1603530158000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0006076"}},"subtitle":[],"editor":[{"given":"Michael R.","family":"Holbrook","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,12,14]]},"references-count":26,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,12,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0006076","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,14]]}}}