{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:34:39Z","timestamp":1767177279275,"version":"build-2238731810"},"update-to":[{"DOI":"10.1371\/journal.pntd.0006111","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T00:00:00Z","timestamp":1513036800000}}],"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T00:00:00Z","timestamp":1512000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad Nacional de Mar del Plata (AR)","award":["EXA 760\/16 and 761\/16"],"award-info":[{"award-number":["EXA 760\/16 and 761\/16"]}]},{"DOI":"10.13039\/501100003074","name":"ANPCyT","doi-asserted-by":"crossref","award":["PICT 2012, N\u00b02668"],"award-info":[{"award-number":["PICT 2012, N\u00b02668"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002923","name":"CONICET","doi-asserted-by":"crossref","award":["PIP 2016, N\u00ba 0406"],"award-info":[{"award-number":["PIP 2016, N\u00ba 0406"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0006111","type":"journal-article","created":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T18:40:02Z","timestamp":1512067202000},"page":"e0006111","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Anthelminthic activity of glibenclamide on secondary cystic echinococcosis in mice"],"prefix":"10.1371","volume":"11","author":[{"given":"Julia A.","family":"Loos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Sandra","family":"Churio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0225-6363","authenticated-orcid":true,"given":"Andrea C.","family":"Cumino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,11,30]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1128\/CMR.17.1.107-135.2004","article-title":"Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern","volume":"17","author":"J Eckert","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3201\/eid1202.050499","article-title":"Global socioeconomic impact of cystic Echinococcosis","volume":"12","author":"CM Budke","year":"2006","journal-title":"Emerg Infect"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1586\/14787210.7.2.145","article-title":"Benzimidazoles for the treatment of cystic and alveolar echinococcosis: what is the consensus?","volume":"7","author":"DA Vuitton","year":"2009","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1017\/S0022149X0928936X","article-title":"Alveolar and cystic echinococcosis: towards novel chemotherapeutical treatment options","volume":"83","author":"A Hemphill","year":"2009","journal-title":"J Helminthol"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"737","DOI":"10.2337\/diacare.15.6.737","article-title":"Sulfonylureas in NIDDM","volume":"15","author":"LC Groop","year":"1992","journal-title":"Diabetes Care"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3727\/096504005776404526","article-title":"Effect of glibenclamide on N-nitroso-N-methylurea-induced mammary tumors in diabetic and nondiabetic rats","volume":"15","author":"C Cocca","year":"2005","journal-title":"Oncol Res"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3109\/09687689009025842","article-title":"Multiple potassium and chloride channels in the human colon carcinoma cell line SW1116","volume":"9","author":"R Etcheberrigaray","year":"1990","journal-title":"Membr Biochem"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s002329900332","article-title":"Membrane potassium channels and human bladder tumor cells: II. Growth properties","volume":"161","author":"R Wondergem","year":"1998","journal-title":"J Membr Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1111\/j.1523-1755.2005.00276.x","article-title":"The ATP-sensitive potassium channel blocker glibenclamide prevents renal ischemia\/reperfusion injury in rats","volume":"67","author":"K Pompermayer","year":"2005","journal-title":"Kidney Int"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ejphar.2006.10.065","article-title":"Effects of the treatment with glibenclamide, an ATP-sensitive potassium channel blocker, on intestinal ischemia and reperfusion injury","volume":"556","author":"K Pompermayer","year":"2007","journal-title":"Eur J Pharmacol"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"e2500","DOI":"10.1371\/journal.pntd.0002500","article-title":"Glyburide reduces bacterial dissemination in a mouse model of melioidosis","volume":"7","author":"GC Koh","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1208\/s12248-013-9514-2","article-title":"Effects of selected OATP and\/or ABC transporter inhibitors on the brain and whole-body distribution of glyburide","volume":"15","author":"N Tournier","year":"2013","journal-title":"AAPS J"},{"issue":"5239","key":"ref13","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1126\/science.270.5239.1166","article-title":"Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor","volume":"270","author":"N Inagaki","year":"1995","journal-title":"Science"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1152\/ajplung.1996.271.2.L192","article-title":"Glibenclamide blockade of CFTR chloride channels","volume":"271","author":"BD Schultz","year":"1996","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1074\/jbc.272.5.2695","article-title":"ABC1, an ATP binding cassette transporter required for phagocytosis of apoptotic cells, generates a regulated anion flux after expression in <italic>Xenopus laevis<\/italic> oocytes","volume":"272","author":"F Becq","year":"1997","journal-title":"J Biol Chem"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1007\/s004240050829","article-title":"P-glycoprotein inhibition by glibenclamide and related compounds","volume":"437","author":"PE Golstein","year":"1999","journal-title":"Pflug Arch Eur J Phy"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.bcp.2004.10.014","article-title":"Role of two adjacent cytoplasmic tyrosine residues in MRP1 (ABCC1) transport activity and sensitivity to sulfonylureas","volume":"69","author":"G Conseil","year":"2005","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/sj.bjp.0703863","article-title":"The sulphonylurea glibenclamide inhibits multidrug resistance protein (MRP1) activity in human lung cancer cells","volume":"132","author":"L Payen","year":"2001","journal-title":"Br J Pharmacol"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/iub.1147","article-title":"Mitochondria as a pharmacological target: magnum overview","volume":"65","author":"A Olszewska","year":"2013","journal-title":"IUBMB Life"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/sj.bjp.0706214","article-title":"Antidiabetic sulphonylureas activate mitochondrial permeability transition in rat skeletal muscle","volume":"145","author":"J Skalska","year":"2005","journal-title":"Br J Pharmacol"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/jbt.20022","article-title":"Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability","volume":"18","author":"MA Fernandes","year":"2004","journal-title":"J Biochem Mol Toxicol"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ijpara.2014.02.007","article-title":"Identification and pharmacological induction of autophagy in the larval stages of <italic>Echinococcus granulosus<\/italic>: an active catabolic process in calcareous corpuscles","volume":"44","author":"JA Loos","year":"2014","journal-title":"Int J Parasitol"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"e0126009","DOI":"10.1371\/journal.pone.0126009","article-title":"<italic>In vitro<\/italic> anti-echinococcal and metabolic effects of metformin involve activation of AMP-activated protein kinase in larval stages of <italic>Echinococcus granulosus<\/italic>","volume":"10","author":"JA Loos","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.ijpara.2009.11.011","article-title":"Identification of functional FKB protein in <italic>Echinococcus granulosus<\/italic>: Its involvement in the protoscolicidal action of rapamycin derivates and in calcium homeostasis","volume":"40","author":"AC Cumino","year":"2010","journal-title":"Int J Parasitol"},{"key":"ref25","first-page":"356","article-title":"Development of UV Spectrometric Method of Glibenclamide (Glyburide) in Bulk and Pharmaceutical Formulations","volume":"4","author":"C Eapen","year":"2012","journal-title":"Int J Chem Tech Res"},{"issue":"2","key":"ref26","first-page":"233","article-title":"Simultaneous spectrophotometric determination of atorvastatin calcium and ezetimibe in tablet dosage form","volume":"1","author":"RG Baldha","year":"2009","journal-title":"Int J ChemTech Res"},{"issue":"7443","key":"ref27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature12031","article-title":"The genomes of four tapeworm species reveal adaptations to parasitism","volume":"496","author":"IJ Tsai","year":"2013","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1146\/annurev.bi.64.070195.001443","article-title":"The multiplicity of domains in proteins","volume":"64","author":"RF Doolittle","year":"1995","journal-title":"Ann Rev Biochem"},{"issue":"5338","key":"ref29","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1126\/science.278.5338.631","article-title":"A genomic perspective on protein families","volume":"278","author":"RL Tatusov","year":"1997","journal-title":"Science"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1021\/bi00232a015","article-title":"J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential","volume":"30","author":"M Reers","year":"1991","journal-title":"Biochemistry"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1124\/mol.116.103861","article-title":"Modulation of ionic channels and insulin secretion by drugs and hormones in pancreatic beta cells","volume":"90","author":"M Velasco","year":"2016","journal-title":"Mol Pharmacol"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1476-5381.2009.00430.x","article-title":"Impact of OATP transporters on pharmacokinetics","volume":"158","author":"A Kalliokoski","year":"2009","journal-title":"Br J Pharmacol"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1152\/ajpcell.00436.2008","article-title":"Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters","volume":"296","author":"S Leuthold","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"issue":"10","key":"ref34","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/ng.2757","article-title":"The genome of the hydatid tapeworm <italic>Echinococcus granulosus<\/italic>","volume":"45","author":"H Zheng","year":"2013","journal-title":"Nat Genet"},{"issue":"1\u20132","key":"ref35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0014-5793(93)81462-9","article-title":"Glibenclamide and meglitinide block the transport of low molecular weight solutes into malaria-infected erythrocytes","volume":"323","author":"K Kirk","year":"1993","journal-title":"FEBS letters"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1590\/S0074-02761997000500007","article-title":"Sensitivity of <italic>Leishmania<\/italic> spp. to glibenclamide and 4-aminopiridine: a tool for the study of drug resistance development","volume":"92","author":"A Ponte-Sucre","year":"1997","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/expr.1998.4200","article-title":"<italic>Leishmania<\/italic> sp.: growth and survival are impaired by ion channel blockers","volume":"88","author":"A Ponte-Sucre","year":"1998","journal-title":"Exp. Parasitol"},{"issue":"12","key":"ref38","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1128\/AAC.00617-06","article-title":"Glibenclamide, a blocker of K+ ATP channels, shows antileishmanial activity in experimental murine cutaneous leishmaniasis","volume":"50","author":"X Serrano-Mart\u00edn","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.metabol.2015.02.006","article-title":"Counterregulatory responses to hypoglycemia differ between glimepiride and glyburide in non diabetic individuals","volume":"64","author":"NG Joy","year":"2015","journal-title":"Metabolism"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.pt.2007.01.003","article-title":"Drug transfer into target helminth parasites","volume":"23","author":"LI Alvarez","year":"2007","journal-title":"Trends Parasitol"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"842","DOI":"10.3892\/or.2013.2875","article-title":"Voltage-gated and ATP-sensitive K<sup>+<\/sup> channels are associated with cell proliferation and tumorigenesis of human glioma","volume":"31","author":"Q Ru","year":"2014","journal-title":"Oncol Rep"},{"issue":"9","key":"ref42","doi-asserted-by":"crossref","first-page":"5146","DOI":"10.1128\/AAC.02113-13","article-title":"<italic>In vitro<\/italic> and <italic>in vivo<\/italic> effects of tamoxifen against <italic>Echinococcus granulosus<\/italic> larval stage","volume":"58","author":"MC Nicolao","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1017\/S003118200999117X","article-title":"<italic>Echinococcus<\/italic> metacestodes as laboratory models for the screening of drugs against cestodes and trematodes","volume":"137","author":"A Hemphill","year":"2010","journal-title":"Parasitology"},{"issue":"2","key":"ref44","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0020-7519(94)90029-9","article-title":"The effects of albendazole and albendazole sulphoxide combination-therapy on <italic>Echinococcus granulosus in vitro<\/italic>","volume":"24","author":"J P\u00e9rez-Serrano","year":"1994","journal-title":"Int J Parasitol"},{"issue":"12","key":"ref45","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/PL00008526","article-title":"<italic>In vitro<\/italic> effect of praziquantel and albendazole combination therapy on the larval stage of <italic>Echinococcus granulosus<\/italic>","volume":"86","author":"MA Urrea-Paris","year":"2000","journal-title":"Parasitol Res"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00436-001-0519-x","article-title":"Could ivermectin have a synergic effect with albendazole in hydatidosis therapy?","volume":"88","author":"N Casado","year":"2002","journal-title":"Parasitol Res"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.parint.2013.09.017","article-title":"P-glycoprotein expression and pharmacological modulation in larval stages of <italic>Echinococcus granulosus<\/italic>","volume":"63","author":"MC Nicolao","year":"2014","journal-title":"Parasitol Int"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1124\/mol.105.019547","article-title":"Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1","volume":"70","author":"E H\u00e4nggi","year":"2006","journal-title":"Mol Pharmacol"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1124\/dmd.108.024570","article-title":"Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin","volume":"37","author":"J Niessen","year":"2009","journal-title":"Drug Metab Dispos"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"C570","DOI":"10.1152\/ajpcell.00436.2008","article-title":"Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters","volume":"296","author":"S Leuthold","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"issue":"6","key":"ref51","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1365-2125.1990.tb03688.x","article-title":"Pharmacokinetic and pharmacodynamic studies of glibenclamide in non\u2010insulin dependent diabetes mellitus","volume":"29","author":"SW Coppack","year":"1990","journal-title":"Br J Clin Pharmacol"},{"issue":"5","key":"ref52","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1177\/106002809603000507","article-title":"Pharmacokinetics and pharmacodynamics of glyburide in young and elderly patients with non-insulin-dependent diabetes mellitus","volume":"30","author":"LA Jaber","year":"1996","journal-title":"Ann Pharmacother"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.chroma.2012.09.091","article-title":"Analysis of drug interactions with modified proteins by high-performance affinity chromatography: binding of glibenclamide to normal and glycated human serum albumin","volume":"1265","author":"R Matsuda","year":"2012","journal-title":"J Chromatogr A"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.3390\/ph6101287","article-title":"Glibenclamide for the treatment of acute CNS injury","volume":"6","author":"DB Kurland","year":"2013","journal-title":"Pharmaceuticals (Basel)"},{"issue":"7","key":"ref55","doi-asserted-by":"crossref","first-page":"847","DOI":"10.2337\/diab.37.7.847","article-title":"Sulfonylurea receptors, ion channels, and fruit flies","volume":"37","author":"AE Boyd","year":"1988","journal-title":"Diabetes"},{"issue":"5250","key":"ref56","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1126\/science.271.5250.813","article-title":"PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells","volume":"271","author":"L Eliasson","year":"1996","journal-title":"Science"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"e0005370","DOI":"10.1371\/journal.pntd.0005370","article-title":"Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis","volume":"11","author":"JA Loos","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"ref58","first-page":"339","article-title":"Molecular medical parasitology","author":"R Komuniecki","year":"2003"},{"issue":"9","key":"ref59","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1039\/C6MD00235H","article-title":"Molecular localization and characterization of multiple binding sites of organic anion transporting polypeptide 2B1 (OATP2B1) as the mechanism for substrate and modulator dependent drug\u2013drug interaction","volume":"7","author":"Y Hoshino","year":"2016","journal-title":"Med Chem Commun"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0006111","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T00:00:00Z","timestamp":1513036800000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0006111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T01:59:19Z","timestamp":1570413559000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0006111"}},"subtitle":[],"editor":[{"given":"Robert M.","family":"Greenberg","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,11,30]]},"references-count":59,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0006111","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,30]]}}}